LT3431590T - Aktyvinto hepatocitų augimo faktoriaus (hgfa) gamybos būdas - Google Patents
Aktyvinto hepatocitų augimo faktoriaus (hgfa) gamybos būdasInfo
- Publication number
- LT3431590T LT3431590T LTEPPCT/JP2017/010355T LTJP2017010355T LT3431590T LT 3431590 T LT3431590 T LT 3431590T LT JP2017010355 T LTJP2017010355 T LT JP2017010355T LT 3431590 T LT3431590 T LT 3431590T
- Authority
- LT
- Lithuania
- Prior art keywords
- hepatococytic
- hgfa
- activated
- production
- growth factor
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21034—Plasma kallikrein (3.4.21.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016054128 | 2016-03-17 | ||
| PCT/JP2017/010355 WO2017159722A1 (ja) | 2016-03-17 | 2017-03-15 | 活性型肝細胞増殖因子（ｈｇｆ）の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3431590T true LT3431590T (lt) | 2021-09-10 |
Family
ID=59850449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/JP2017/010355T LT3431590T (lt) | 2016-03-17 | 2017-03-15 | Aktyvinto hepatocitų augimo faktoriaus (hgfa) gamybos būdas |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11548926B2 (lt) |
| EP (1) | EP3431590B1 (lt) |
| JP (1) | JP6861201B2 (lt) |
| KR (1) | KR102275262B1 (lt) |
| CN (1) | CN109196099B (lt) |
| AU (1) | AU2017232582B2 (lt) |
| CA (1) | CA3014567C (lt) |
| DK (1) | DK3431590T3 (lt) |
| ES (1) | ES2894477T3 (lt) |
| HU (1) | HUE055414T2 (lt) |
| IL (1) | IL261066B (lt) |
| LT (1) | LT3431590T (lt) |
| MX (1) | MX395311B (lt) |
| RU (1) | RU2747977C2 (lt) |
| SG (1) | SG11201806843UA (lt) |
| WO (1) | WO2017159722A1 (lt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017159722A1 (ja) | 2016-03-17 | 2017-09-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 活性型肝細胞増殖因子（ｈｇｆ）の製造方法 |
| CN110606883A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的制备方法 |
| CN110607304A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的重组表达方法 |
| WO2024096038A1 (ja) * | 2022-11-01 | 2024-05-10 | クリングルファーマ株式会社 | 活性型ｈｇｆの製造方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2564486B2 (ja) | 1986-07-14 | 1996-12-18 | 修治 橋本 | 肝細胞増殖因子 |
| NZ232813A (en) | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| JP2706704B2 (ja) | 1989-06-05 | 1998-01-28 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子 |
| JP2577091B2 (ja) | 1989-08-11 | 1997-01-29 | 三菱化学株式会社 | 肝実質細胞増殖因子及びそれをコードする遺伝子 |
| JP3036782B2 (ja) | 1990-04-03 | 2000-04-24 | 三菱化学株式会社 | ヒト肝実質細胞増殖因子の生産方法および該因子を産生する形質転換体 |
| JP2777678B2 (ja) | 1990-06-11 | 1998-07-23 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子及びその製造方法 |
| JP3072628B2 (ja) | 1990-11-19 | 2000-07-31 | 敏一 中村 | ヒト肝実質細胞増殖因子をコードする染色体ｄｎａ |
| JP3213985B2 (ja) | 1991-10-18 | 2001-10-02 | 三菱化学株式会社 | 新規なタンパク質 |
| JP3232714B2 (ja) | 1992-11-20 | 2001-11-26 | 三菱化学株式会社 | 新規なタンパク質およびそれをコードする遺伝子 |
| CA2102463A1 (en) * | 1992-11-05 | 1994-05-06 | Mitsubishi Chemical Corporation | Protein and gene encoding said protein |
| WO1994019020A1 (en) | 1993-02-23 | 1994-09-01 | Genentech, Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| JP2577091Y2 (ja) | 1993-06-23 | 1998-07-23 | 賢一 片山 | 分流装置の合成樹脂製サドル |
| JP3680114B2 (ja) * | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| JP2747979B2 (ja) | 1994-08-19 | 1998-05-06 | 雪印乳業株式会社 | ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬 |
| JP3927248B2 (ja) | 1995-07-11 | 2007-06-06 | 第一製薬株式会社 | Ｈｇｆ凍結乾燥製剤 |
| JP2859577B2 (ja) | 1996-03-27 | 1999-02-17 | 三菱化学株式会社 | 肝実質細胞増殖因子 |
| JP4463885B2 (ja) | 1996-12-05 | 2010-05-19 | 敏一 中村 | 劇症肝炎疾患治療剤 |
| JP2980888B2 (ja) | 1998-07-09 | 1999-11-22 | 三菱化学株式会社 | 肝実質細胞増殖因子をコードする遺伝子 |
| CN100448482C (zh) | 1999-05-31 | 2009-01-07 | 三菱化学株式会社 | Hgf冻干制剂 |
| JP3072628U (ja) | 2000-02-17 | 2000-10-24 | 輝夫 尾形 | ステンドグラス製文字入り記念楯 |
| JP4090236B2 (ja) * | 2000-12-05 | 2008-05-28 | 三菱化学株式会社 | 活性型肝細胞増殖因子アクティベーターに対する特異的抗体とその使用法 |
| US7045602B2 (en) * | 2000-12-05 | 2006-05-16 | Mitsubishi Chemical Corporation | Specific antibody directed to active hepatocyte growth factor activator and method for using the same |
| DE10204792A1 (de) | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| CA2570323C (en) | 2004-07-26 | 2014-08-26 | Genentech, Inc. | Methods and compositions for modulating hepatocyte growth factor activation |
| US7741096B2 (en) * | 2004-12-10 | 2010-06-22 | Genentech, Inc. | Crystal structure of hepatocyte growth factor activator complexed with Kunitz domain inhibitor |
| BRPI0618488A2 (pt) * | 2005-11-10 | 2011-08-30 | Receptor Biologix Inc | proteìnas de fusão de ìntron de fator de crescimento de hepatócito |
| JP5093783B2 (ja) | 2006-04-20 | 2012-12-12 | クリングルファーマ株式会社 | Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質 |
| WO2008078189A2 (en) | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | Factor vii and viia compositions |
| WO2008102452A1 (ja) | 2007-02-22 | 2008-08-28 | Kringle Pharma Inc. | Ｈｇｆ製剤 |
| US9393304B2 (en) | 2008-10-29 | 2016-07-19 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
| CN101649320B (zh) * | 2009-09-15 | 2011-06-15 | 上海交通大学医学院附属仁济医院 | 重组人源hgf激活因子及其应用 |
| KR20120106940A (ko) * | 2009-10-19 | 2012-09-27 | 제넨테크, 인크. | 간세포 성장 인자 활성화제의 조절제 |
| WO2011102845A1 (en) | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| JP2012051822A (ja) | 2010-08-31 | 2012-03-15 | Institute Of Physical & Chemical Research | 肺癌診断用ポリペプチド、肺癌の検出方法、および治療効果の評価方法 |
| US9272018B2 (en) | 2011-04-18 | 2016-03-01 | Kyoto University | Acute hepatic insufficiency depressant and method for evaluating drug efficacy thereof |
| US20130071931A1 (en) | 2011-08-02 | 2013-03-21 | National Cancer Center | Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby |
| AU2013201422B2 (en) * | 2012-01-23 | 2015-04-09 | Ablynx Nv | Sequences directed against hepatocyte growth factor (HFG) and polypeptides comprising the same for the treatment of cancers and/or tumors |
| CN105209074A (zh) | 2012-10-20 | 2015-12-30 | 得克萨斯大学体系董事会 | 癌细胞陷阱 |
| RU2506946C1 (ru) | 2012-11-28 | 2014-02-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Технология лиофилизации обогащенной тромбоцитами плазмы с сохранением жизнеспособности факторов tgf pdgf vegf |
| TWI728409B (zh) | 2014-04-28 | 2021-05-21 | 日商衛材R&D企管股份有限公司 | Hgf冷凍乾燥製劑 |
| WO2017159722A1 (ja) | 2016-03-17 | 2017-09-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 活性型肝細胞増殖因子（ｈｇｆ）の製造方法 |
| JP6800208B2 (ja) | 2016-03-18 | 2020-12-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝細胞増殖因子（ｈｇｆ）のｐｄマーカー |
| CN208371461U (zh) | 2017-08-21 | 2019-01-15 | 潍坊鸿旺工贸有限公司 | 一种晾衣架用连接构件及晾衣架 |
-
2017
- 2017-03-15 WO PCT/JP2017/010355 patent/WO2017159722A1/ja not_active Ceased
- 2017-03-15 DK DK17766718.5T patent/DK3431590T3/da active
- 2017-03-15 EP EP17766718.5A patent/EP3431590B1/en active Active
- 2017-03-15 JP JP2018505972A patent/JP6861201B2/ja active Active
- 2017-03-15 SG SG11201806843UA patent/SG11201806843UA/en unknown
- 2017-03-15 LT LTEPPCT/JP2017/010355T patent/LT3431590T/lt unknown
- 2017-03-15 CA CA3014567A patent/CA3014567C/en active Active
- 2017-03-15 HU HUE17766718A patent/HUE055414T2/hu unknown
- 2017-03-15 AU AU2017232582A patent/AU2017232582B2/en active Active
- 2017-03-15 MX MX2018010283A patent/MX395311B/es unknown
- 2017-03-15 ES ES17766718T patent/ES2894477T3/es active Active
- 2017-03-15 CN CN201780013057.7A patent/CN109196099B/zh active Active
- 2017-03-15 KR KR1020187024470A patent/KR102275262B1/ko active Active
- 2017-03-15 US US16/078,568 patent/US11548926B2/en active Active
- 2017-03-15 RU RU2018130530A patent/RU2747977C2/ru active
-
2018
- 2018-08-08 IL IL261066A patent/IL261066B/en unknown
-
2022
- 2022-05-05 US US17/737,343 patent/US20220267393A1/en not_active Abandoned
-
2024
- 2024-02-01 US US18/429,738 patent/US12384824B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3431590A4 (en) | 2019-11-20 |
| US20190062390A1 (en) | 2019-02-28 |
| CA3014567C (en) | 2024-02-20 |
| US12384824B2 (en) | 2025-08-12 |
| IL261066B (en) | 2021-08-31 |
| US11548926B2 (en) | 2023-01-10 |
| RU2747977C2 (ru) | 2021-05-18 |
| RU2018130530A (ru) | 2020-04-17 |
| EP3431590A1 (en) | 2019-01-23 |
| SG11201806843UA (en) | 2018-09-27 |
| KR20180127322A (ko) | 2018-11-28 |
| JPWO2017159722A1 (ja) | 2019-01-24 |
| AU2017232582B2 (en) | 2022-07-14 |
| AU2017232582A1 (en) | 2018-08-30 |
| WO2017159722A1 (ja) | 2017-09-21 |
| JP6861201B2 (ja) | 2021-04-21 |
| ES2894477T3 (es) | 2022-02-14 |
| RU2018130530A3 (lt) | 2020-08-13 |
| KR102275262B1 (ko) | 2021-07-12 |
| EP3431590B1 (en) | 2021-07-28 |
| MX395311B (es) | 2025-03-25 |
| HUE055414T2 (hu) | 2021-11-29 |
| US20240218035A1 (en) | 2024-07-04 |
| MX2018010283A (es) | 2019-01-31 |
| CA3014567A1 (en) | 2017-09-21 |
| US20220267393A1 (en) | 2022-08-25 |
| CN109196099B (zh) | 2022-01-11 |
| CN109196099A (zh) | 2019-01-11 |
| IL261066A (en) | 2018-10-31 |
| DK3431590T3 (da) | 2021-10-11 |
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