LT3178819T - 5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak inhibitoriai - Google Patents

5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak inhibitoriai

Info

Publication number: LT3178819T
Authority: LT; Lithuania
Prior art keywords: carboxamides; triazolo; pyridin; phenyl; jak inhibitors
Prior art date: 2009-06-26

Application number

LTEP17152084.4T

Other languages

English (en)

Inventor

Christel Jeanne Marie Menet

Koen Kurt Smits

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-26

Filing date

2010-06-25

Publication date

2020-01-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42562363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3178819(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-06-25 Application filed by Galapagos Nv filed Critical Galapagos Nv

2020-01-27 Publication of LT3178819T publication Critical patent/LT3178819T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Hematology (AREA)
Oncology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Cardiology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

LTEP17152084.4T 2009-06-26 2010-06-25 5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak inhibitoriai LT3178819T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US22068809P	2009-06-26	2009-06-26

Publications (1)

Publication Number	Publication Date
LT3178819T true LT3178819T (lt)	2020-01-27

Family

ID=42562363

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
LTEP10724881.7T LT2445911T (lt)	2009-06-26	2010-06-25	5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak slopikliai
LTEP17152084.4T LT3178819T (lt)	2009-06-26	2010-06-25	5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak inhibitoriai
LTPA2021504C LTC2445911I2 (lt)	2009-06-26	2021-03-19	5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai, kaip jak slopikliai

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LTEP10724881.7T LT2445911T (lt)	2009-06-26	2010-06-25	5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai kaip jak slopikliai

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTPA2021504C LTC2445911I2 (lt)	2009-06-26	2021-03-19	5-fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai, kaip jak slopikliai

Country Status (43)

Country	Link
US (9)	US8088764B2 (lt)
EP (2)	EP2445911B1 (lt)
JP (2)	JP5591925B2 (lt)
KR (3)	KR101850716B1 (lt)
CN (2)	CN104262337A (lt)
AR (1)	AR077220A1 (lt)
AU (3)	AU2010264633B2 (lt)
BR (1)	BRPI1015569B8 (lt)
CA (1)	CA2765985C (lt)
CL (1)	CL2011003247A1 (lt)
CO (1)	CO6491040A2 (lt)
CR (1)	CR20120016A (lt)
CY (3)	CY1119214T1 (lt)
DK (2)	DK2445911T3 (lt)
DO (1)	DOP2011000388A (lt)
EA (1)	EA021637B1 (lt)
EC (1)	ECSP12011626A (lt)
ES (2)	ES2766573T3 (lt)
FR (1)	FR21C1011I2 (lt)
GB (1)	GB2483424B (lt)
HR (2)	HRP20170826T1 (lt)
HU (3)	HUE047478T2 (lt)
IL (1)	IL216667A (lt)
LT (3)	LT2445911T (lt)
MA (1)	MA33448B1 (lt)
ME (1)	ME02699B (lt)
MX (1)	MX344951B (lt)
MY (1)	MY156664A (lt)
NI (1)	NI201100222A (lt)
NL (1)	NL301096I2 (lt)
NO (1)	NO2021013I1 (lt)
NZ (1)	NZ596838A (lt)
PE (1)	PE20121032A1 (lt)
PL (2)	PL3178819T3 (lt)
PT (2)	PT3178819T (lt)
RS (1)	RS56035B1 (lt)
SG (2)	SG10201703497YA (lt)
SI (2)	SI3178819T1 (lt)
SM (1)	SMT201700265T1 (lt)
TW (1)	TWI462920B (lt)
UA (1)	UA107935C2 (lt)
WO (1)	WO2010149769A1 (lt)
ZA (1)	ZA201109386B (lt)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO3041B1 (ar)	2008-07-25	2016-09-05	Galapagos Nv	مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
JO3030B1 (ar)	2009-06-26	2016-09-05	Galapagos Nv	مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
TWI462920B (zh) *	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
WO2011064631A1 (en)	2009-10-02	2011-06-03	Foamix Ltd.	Surfactant-free, water-free, foamable compositions and breakable foams and their uses
EP2343294A1 (en)	2009-11-30	2011-07-13	Bayer Schering Pharma AG	Substituted triazolopyridines
AR086042A1 (es) *	2011-04-28	2013-11-13	Galapagos Nv	Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
JP2014532654A (ja) *	2011-10-26	2014-12-08	シュタイン, エミリー, エイ.STEIN, Emily, A.	神経機能に影響を及ぼす薬剤、方法、およびデバイス
WO2013173506A2 (en)	2012-05-16	2013-11-21	Rigel Pharmaceuticals, Inc.	Method of treating muscular degradation
CN104379173A (zh) *	2012-06-22	2015-02-25	加拉帕戈斯股份有限公司	用于治疗炎症的氨基三唑并吡啶及其药物组合物
GB201302036D0 (en) *	2013-02-05	2013-03-20	Queen Mary & Westfield College	Diagnosis
JP2016540009A (ja) *	2013-12-11	2016-12-22	セファロンインコーポレイテッド	１，２，４‐トリアゾロ［１，５ａ］ピリジン誘導体を用いた多発性硬化症の処置
GB201402071D0 (en) *	2014-02-07	2014-03-26	Galapagos Nv	Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en)	2014-02-07	2014-03-26	Galapagos Nv	Pharmaceutical compositions for the treatment of inflammatory disorders
TWI679205B (zh)	2014-09-02	2019-12-11	日商日本新藥股份有限公司	吡唑并噻唑化合物及醫藥
MA41252A (fr)	2014-12-23	2017-10-31	Gilead Sciences Inc	Formes solides d'un inhibiteur d'ask 1
PL3283114T3 (pl)	2015-04-13	2024-01-03	Galapagos Nv	Sposoby leczenia zaburzeń sercowo-naczyniowych
CN107531694A (zh) *	2015-04-13	2018-01-02	加拉帕戈斯股份有限公司	用于治疗炎性疾病的方法
WO2016179207A1 (en) *	2015-05-05	2016-11-10	Concert Pharmaceuticals, Inc.	Deuterated filgotinib
CN105061420B (zh) *	2015-06-04	2017-09-05	南京旗昌医药科技有限公司	一种jak抑制剂的晶型及其制备方法和应用
CN104987333B (zh) *	2015-07-14	2017-01-11	苏州富士莱医药股份有限公司	一种Filgotinib的合成方法
WO2017012773A1 (en)	2015-07-23	2017-01-26	Ratiopharm Gmbh	Solid forms of filgotinib free base
WO2017012771A1 (en)	2015-07-23	2017-01-26	Ratiopharm Gmbh	Crystalline filgotinib sulfonic acid addition salts
WO2017012770A1 (en)	2015-07-23	2017-01-26	Ratiopharm Gmbh	Acid addition salts of filgotinib
CN105111206B (zh) *	2015-09-18	2017-07-25	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物e晶型及其制备方法
CN105218539B (zh) *	2015-09-18	2017-07-25	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物b晶型及其制备方法
CN105198877B (zh) *	2015-09-18	2017-09-22	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物g晶型及其制备方法
CN105198880B (zh) *	2015-09-18	2017-07-25	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物a晶型及其制备方法
CN105198879B (zh) *	2015-09-18	2017-09-22	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物c晶型及其制备方法
CN105111207B (zh) *	2015-09-18	2017-07-25	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物d晶型及其制备方法
CN105198878B (zh) *	2015-09-18	2017-07-25	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物f晶型及其制备方法
CN105198876B (zh) *	2015-09-18	2017-09-29	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物h晶型及其制备方法
US20170173034A1 (en)	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
WO2017106566A1 (en)	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and an mmp9 binding protein for treating inflammatory disorders
WO2017106568A1 (en) *	2015-12-17	2017-06-22	Gilead Sciences, Inc.	Combination of a jak inhibitor and a bromodomain inhibitor for treating cancer
CN108349974B (zh) *	2016-02-02	2021-04-30	深圳市塔吉瑞生物医药有限公司	一种取代的吡啶酰胺类化合物及其应用
TWI712604B (zh)	2016-03-01	2020-12-11	日商日本新藥股份有限公司	具jak抑制作用之化合物之結晶
CN105669669A (zh) *	2016-03-04	2016-06-15	上海宣创生物科技有限公司	一种环丙烷甲酰胺衍生物的a晶型、b晶型、d晶型、g晶型和m晶型及其制备方法
CN109071531A (zh) *	2016-03-21	2018-12-21	苏州晶云药物科技股份有限公司	用于治疗或预防jak相关疾病药物的盐酸盐晶型及其制备方法
US10071079B2 (en) *	2016-06-29	2018-09-11	Bristol-Myers Squibb Company	[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
US11414413B2 (en)	2016-07-26	2022-08-16	Suzhou Longbiotech Pharmaceuticals Co., Ltd.	Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
AU2017307208B2 (en)	2016-07-30	2021-01-21	Bristol-Myers Squibb Company	Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors
CN107759587B (zh) *	2016-08-19	2021-01-26	中国医药研究开发中心有限公司	[1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途
MX377365B (es)	2016-09-08	2025-03-10	Journey Medical Corp	Composiciones y métodos para tratar rosácea y acné.
JP7028861B2 (ja)	2016-09-09	2022-03-02	ブリストル－マイヤーズスクイブカンパニー	ピリジル置換のインドール化合物
CN107880038B (zh) *	2016-09-30	2021-09-28	中国医药研究开发中心有限公司	[1,2,4]三唑并[1,5-a]吡啶类化合物及其制备方法和医药用途
AU2017358703A1 (en)	2016-11-10	2019-05-09	Galapagos Nv	Compounds and pharmaceutical compositions thereof for the treatment of inflammatory diseases
EA039344B1 (ru) *	2017-01-19	2022-01-17	Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд.	Гетероциклическое соединение в качестве ингибитора jak и его соли и терапевтическое применение
GB201702603D0 (en)	2017-02-17	2017-04-05	Galápagos Nv	Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
JOP20180018A1 (ar)	2017-03-14	2019-01-30	Gilead Sciences Inc	تركيبات صيدلية تتضمن مثبط jak
CN110997670B (zh)	2017-08-04	2022-11-01	百时美施贵宝公司	[1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物
ES2909401T3 (es)	2017-08-04	2022-05-06	Bristol Myers Squibb Co	Compuestos de indol sustituidos útiles como inhibidores de TLR7/8/9
KR102849449B1 (ko)	2017-11-14	2025-08-21	브리스톨-마이어스 스큅 컴퍼니	치환된 인돌 화합물
BR112020011668A2 (pt)	2017-12-15	2020-11-17	Bristol-Myers Squibb Company	compostos de éter de indol substituído
WO2019125977A1 (en)	2017-12-18	2019-06-27	Bristol-Myers Squibb Company	4-azaindole compounds
SG11202005700SA (en)	2017-12-19	2020-07-29	Bristol Myers Squibb Co	Amide substituted indole compounds useful as tlr inhibitors
EP3728225B1 (en)	2017-12-19	2022-11-09	Bristol-Myers Squibb Company	Substituted indole compounds useful as tlr inhibitors
CA3085761A1 (en)	2017-12-19	2019-06-27	Bristol-Myers Squibb Company	Triazole n-linked carbamoylcyclohexyl acids as lpa antagonists
EP3728188B1 (en)	2017-12-20	2023-10-11	Bristol-Myers Squibb Company	Aryl and heteroaryl substituted indole compounds
BR112020011984A2 (pt)	2017-12-20	2020-11-17	Bristol-Myers Squibb Company	compostos de amino indol úteis como inibidores de tlr
SG11202005733QA (en)	2017-12-20	2020-07-29	Bristol Myers Squibb Co	Diazaindole compounds
GB201808575D0 (en) *	2018-05-24	2018-07-11	Galapagos Nv	Methods for the treatment of psoriatic arthrits
US10815227B2 (en)	2018-08-27	2020-10-27	Cadila Healthcare Limited	Processes for the preparation of filgotinib
EP3870583A1 (en)	2018-10-24	2021-09-01	Bristol-Myers Squibb Company	Substituted indole and indazole compounds
US11998537B2 (en)	2018-10-24	2024-06-04	Bristol-Myers Squibb Company	Substituted indole dimer compounds
CN115029299B (zh) *	2018-11-07	2023-11-14	杭州瑞普晨创科技有限公司	JAK2抑制剂在胰岛β细胞诱导分化中的应用
WO2020177705A1 (zh) *	2019-03-05	2020-09-10	苏州科睿思制药有限公司	Filgotinib的马来酸盐晶型CSI及其制备方法和用途
EP3939979A4 (en)	2019-03-14	2022-04-06	Shanghai Synergy Pharmaceutical Sciences Co., Ltd	Jak kinase inhibitor, preparation method for same, and applications thereof in field of medicine
EP3942045A1 (en)	2019-03-21	2022-01-26	Onxeo	A dbait molecule in combination with kinase inhibitor for the treatment of cancer
PH12021552354A1 (en)	2019-03-30	2022-09-05	Unichem Lab Ltd	Novel process for the preparation of filgotinib and intermediates thereof
WO2020227484A1 (en)	2019-05-09	2020-11-12	Bristol-Myers Squibb Company	Substituted benzimidazolone compounds
CN110204542B (zh) *	2019-05-23	2022-05-20	四川伊诺达博医药科技有限公司	一种JAK1抑制剂Filgotinib的合成方法
CN110151738A (zh) *	2019-06-03	2019-08-23	上海基科生物化学有限公司	一种Jak2抑制剂联合虎杖苷雾化剂及其制备方法和应用
KR20220075381A (ko)	2019-10-01	2022-06-08	브리스톨-마이어스 스큅 컴퍼니	치환된 비시클릭 헤테로아릴 화합물
ES2965164T3 (es)	2019-10-04	2024-04-11	Bristol Myers Squibb Co	Compuestos de carbazol sustituidos
IT201900020240A1 (it)	2019-11-04	2021-05-04	Advitech Advisory And Tech Sa	Procedimento per la preparazione di Filgotinib e intermedi di sintesi
JP2023500906A (ja)	2019-11-08	2023-01-11	インサーム（インスティテュナシオナルドゥラサンテエドゥラルシェルシェメディカル）	キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
CN110878097B (zh) *	2019-11-29	2021-11-02	杭州科巢生物科技有限公司	菲格替尼的制备方法
CN111072655B (zh) *	2019-12-30	2021-12-10	深圳市坤健创新药物研究院	一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
US12419873B2 (en)	2020-02-13	2025-09-23	Zhuhai United Laboratories Co., Ltd.	Use of JAK inhibitors in preparation of drugs for treating JAK kinase-related diseases
ES3037893T3 (en)	2020-02-21	2025-10-07	Zhuhai United Laboratories Co Ltd	Crystalline form of jak inhibitor and application thereof
US20240325393A1 (en) *	2020-08-17	2024-10-03	Vyne Therapeutics Inc.	Tofacitinib-containing anhydrous elastomer-based gel formulations
WO2022072238A1 (en) *	2020-10-02	2022-04-07	University Of Massachusetts	Targeting polycythemia vera (pv)-initiating cells by blocking leukotriene binding to their receptors
CN115368389A (zh) *	2021-05-19	2022-11-22	奥锐特药业(天津)有限公司	一种Filgotinib中间体的制备方法
CN113773322B (zh) *	2021-11-10	2022-02-11	奥锐特药业(天津)有限公司	一种Filgotinib的制备方法
CN114409675B (zh) *	2022-01-07	2023-08-04	重庆医科大学	螺环异恶唑酮色满衍生物在制备用于治疗jak1介导的疾病药物中的用途
CN116496268A (zh) *	2022-01-18	2023-07-28	盛世泰科生物医药技术(苏州)有限公司	一种含环丙酰胺化合物及其应用
WO2023194842A1 (en)	2022-04-05	2023-10-12	Unichem Laboratories Limited	Substituted tricyclic compounds and their use in rheumatoid arthritis
WO2026027676A1 (en)	2024-07-31	2026-02-05	Alfasigma S.P.A.	Biomarkers for determining treatment of ulcerative colitis with filgotinib
WO2026027669A1 (en)	2024-07-31	2026-02-05	Alfasigma S.P.A.	Biomarkers for determining treatment of ulcerative colitis with filgotinib

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ208996A (en)	1983-07-28	1989-08-29	American Cyanamid Co	5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
AU2318600A (en)	1999-01-29	2000-08-18	Chugai Seiyaku Kabushiki Kaisha	Chondrongenesis promotors and indolin-2-one derivatives
WO2002087620A1 (en)	2001-04-27	2002-11-07	Chugai Seiyaku Kabushiki Kaisha	Chondrogenesis promoters
US6514989B1 (en) *	2001-07-20	2003-02-04	Hoffmann-La Roche Inc.	Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
JP2006517580A (ja)	2003-02-14	2006-07-27	ファイザー・プロダクツ・インク	抗炎症化合物としてのトリアゾロピリジン
US20050222171A1 (en)	2004-01-22	2005-10-06	Guido Bold	Organic compounds
WO2005124342A2 (en)	2004-06-21	2005-12-29	Galapagos N.V.	Methods and means for treatment of osteoarthritis
MX2007002050A (es)	2004-08-18	2007-03-29	Pharmacia & Upjohn Co Llc	Compuestos de triazolopiridina.
EP1799680A2 (en)	2004-10-07	2007-06-27	Warner-Lambert Company LLC	Triazolopyridine derivatives as antibacterial agents
GB0515026D0 (en)	2005-07-21	2005-08-31	Novartis Ag	Organic compounds
BRPI0716239A2 (pt)	2006-08-30	2013-08-13	Cellzome Ltd	derivados de triazol como inibidores de cinase
CL2008001626A1 (es)	2007-06-05	2009-06-05	Takeda Pharmaceuticals Co	Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
US8053574B2 (en)	2007-07-18	2011-11-08	Novartis Ag	Organic compounds
WO2009017954A1 (en) *	2007-08-01	2009-02-05	Phenomix Corporation	Inhibitors of jak2 kinase
EA201070328A1 (ru)	2007-08-31	2010-08-30	Мерк Сероно С.А.	Соединения триазолопиридина и их применение в качестве ингибиторов ask
GB0719803D0 (en) *	2007-10-10	2007-11-21	Cancer Rec Tech Ltd	Therapeutic compounds and their use
PE20110545A1 (es) *	2008-06-20	2011-08-18	Genentech Inc	Compuestos de triazolopiridina como inhibidores de jak
WO2009155565A1 (en)	2008-06-20	2009-12-23	Genentech, Inc.	Triazolopyridine jak inhibitor compounds and methods
WO2010010189A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010010187A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010010186A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
JO3041B1 (ar)	2008-07-25	2016-09-05	Galapagos Nv	مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010010188A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases.
WO2010010184A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	[1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors
BRPI1009637A2 (pt)	2009-06-05	2019-04-30	Cephalon, Inc	composto, composição e uso de um composto
TWI462920B (zh) *	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar)	2009-06-26	2016-09-05	Galapagos Nv	مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
WO2013173506A2 (en)	2012-05-16	2013-11-21	Rigel Pharmaceuticals, Inc.	Method of treating muscular degradation
CN104379173A (zh)	2012-06-22	2015-02-25	加拉帕戈斯股份有限公司	用于治疗炎症的氨基三唑并吡啶及其药物组合物

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Publication	Publication Date	Title
LTPA2021504I1 (lt)	2021-04-12	5-Fenil-[1,2,4]triazolo[1,5-a]piridin-2-ilo karboksamidai, kaip JAK slopikliai
ZA201105896B (en)	2012-03-28	[1,2,4] triazolo [1,5-a] pyridines as kinase inhibitors
ZA201108541B (en)	2018-11-28	3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4yl)-1hpyrazol-1yl]octane-or heptane-nitrile as jak inhibitors
ZA201203326B (en)	2013-03-27	Imidazopyridine derivatives as jak inhibitors
ZA201302128B (en)	2014-08-27	4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta-secretase (bace)
IL230511B (en)	2019-05-30	(s)-4-(8-amino-3-(1-but-2-ynoyl-pyrrolidin-2-yl)imidazo[5,1-a]pyrazin-1-yl)-n-(pyridin-2- l) Benzamide as a btk inhibitor
IL228158A0 (en)	2013-11-25	History of 7,6-dihydro-pyrazolo[5,1-a]pyrazine-4-ylamine used as betascartase inhibitors
ZA201304646B (en)	2014-12-23	5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (bace)
ZA201107350B (en)	2015-06-24	Imidazo [2 1 b] [1, 3, 4] thiadiazole derivatives
IL229993A (en)	2015-10-29	8 - Alkoxy [1,2,4] triazolo [5,1 – c] pyrimidine– 2
IL221479A0 (en)	2012-10-31	Triazolo [4,5-b] pyridin derivatives
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