LT2928923T - Anti-kraujo dendritinių ląstelių antigeno 2 antikūnai ir jų panaudojimas - Google Patents

Anti-kraujo dendritinių ląstelių antigeno 2 antikūnai ir jų panaudojimas

Info

Publication number: LT2928923T
Authority: LT; Lithuania
Prior art keywords: antibodies; dendritic cell; cell antigen; blood dendritic; blood
Prior art date: 2012-12-10

Application number

LTEP13814340.9T

Other languages

English (en)

Inventor

Justin A. Caravella

Ellen A. Garber Stark

Dania Mounir RABAH

Frederick R. Taylor

Original Assignee

Biogen Ma Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-12-10

Filing date

2013-12-10

Publication date

2020-02-25

2013-12-10 Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.

2020-02-25 Publication of LT2928923T publication Critical patent/LT2928923T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Transplantation (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

LTEP13814340.9T 2012-12-10 2013-12-10 Anti-kraujo dendritinių ląstelių antigeno 2 antikūnai ir jų panaudojimas LT2928923T (lt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261735362P	2012-12-10	2012-12-10
US201361763270P	2013-02-11	2013-02-11
PCT/US2013/074208 WO2014093396A1 (en)	2012-12-10	2013-12-10	Anti-blood dendritic cell antigen 2 antibodies and uses thereof

Publications (1)

Publication Number	Publication Date
LT2928923T true LT2928923T (lt)	2020-02-25

Family

ID=49883267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP13814340.9T LT2928923T (lt)	2012-12-10	2013-12-10	Anti-kraujo dendritinių ląstelių antigeno 2 antikūnai ir jų panaudojimas

Country Status (25)

Country	Link
US (3)	US9902775B2 (lt)
EP (2)	EP2928923B1 (lt)
JP (4)	JP6490591B2 (lt)
KR (2)	KR20150094658A (lt)
CN (2)	CN111961134B (lt)
AU (1)	AU2013359419B2 (lt)
BR (1)	BR122020023058B1 (lt)
CA (1)	CA2893375A1 (lt)
CY (1)	CY1122956T1 (lt)
DK (1)	DK2928923T3 (lt)
EA (1)	EA034757B1 (lt)
ES (1)	ES2780398T3 (lt)
HR (1)	HRP20200174T1 (lt)
HU (1)	HUE047874T2 (lt)
IL (2)	IL238804B (lt)
LT (1)	LT2928923T (lt)
MX (1)	MX363407B (lt)
NZ (1)	NZ708033A (lt)
PL (1)	PL2928923T3 (lt)
PT (1)	PT2928923T (lt)
RS (1)	RS60084B1 (lt)
SI (1)	SI2928923T1 (lt)
SM (1)	SMT202000193T1 (lt)
WO (1)	WO2014093396A1 (lt)
ZA (1)	ZA201503881B (lt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2968561B1 (fr) †	2010-12-13	2013-08-09	Lfb Biotechnologies	Utilisation d'un anticorps dirige contre une proteine membranaire
CA2933199A1 (en)	2013-12-16	2015-06-25	The University Of North Carolina At Chapel Hill	Depletion of plasmacytoid dendritic cells
CA2934604A1 (en) *	2013-12-24	2015-07-02	Astellas Pharma Inc.	Novel anti-human bdca-2 antibody
FR3034420A1 (fr)	2015-03-31	2016-10-07	Lab Francais Du Fractionnement	Anticorps monoclonaux anti-cd303
FR3045386B1 (fr)	2015-12-16	2018-02-02	Laboratoire Francais Du Fractionnement Et Des Biotechnologies	Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire
BR112018072125A2 (pt) *	2016-04-28	2019-03-19	Biogen Ma, Inc.	"composições farmacêuticas e regimes de dosagem para uso clínico de anticorpos de antiantígeno sanguíneo de célula dendrítica 2
CN110283803B (zh) *	2016-06-02	2021-08-03	天津科技大学	一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法
WO2018185284A1 (en) *	2017-04-07	2018-10-11	Miltenyi Biotec Gmbh	POLYPEPTIDES WITH MUTANT HUMAN IgG4
US20210239681A1 (en) *	2018-04-27	2021-08-05	Advaxis, Inc.	Compositions and methods for evaluating potency of listeria-based immunotherapeutics
WO2019236417A1 (en) *	2018-06-04	2019-12-12	Biogen Ma Inc.	Anti-vla-4 antibodies having reduced effector function
WO2020097350A1 (en)	2018-11-08	2020-05-14	Orionis Biosciences, Inc.	Modulation of dendritic cell lineages
EP4010374A1 (en) *	2019-08-05	2022-06-15	Capella Bioscience Ltd	Anti bdca-2 antibodies
MX2023006474A (es) *	2020-12-03	2023-08-16	Biogen Ma Inc	Metodos de tratamiento del lupus eritematoso cutaneo y lupus eritematoso sistemico.
KR20230120665A (ko) *	2020-12-17	2023-08-17	에프. 호프만-라 로슈 아게	항-hla-g 항체 및 이의 용도
CN113484512B (zh) *	2021-06-01	2023-06-27	中国农业科学院油料作物研究所	黄曲霉毒素风险预警智能感知卡及其应用
TW202400652A (zh) *	2022-05-25	2024-01-01	大陸商映恩生物製藥（蘇州）有限公司	抗ｂｄｃａ２抗體及其用途
WO2024010118A1 (ko) *	2022-07-07	2024-01-11	주식회사 유틸렉스	항 bdca-2 항체 및 이의 용도
IL321721A (en)	2022-12-28	2025-08-01	Duality Biologics Shanghai Co Ltd	Antidote conjugation against BDCA2 and its use
WO2024230774A1 (en) *	2023-05-10	2024-11-14	Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd.	Bdca2-targeting antibodies and uses thereof
CN119119267A (zh) *	2023-06-12	2024-12-13	三生国健药业（上海）股份有限公司	抗bdca2抗体
WO2025051083A1 (zh) *	2023-09-05	2025-03-13	上海宏成药业有限公司	抗bdca-2特异性抗体及其用途
WO2025091023A1 (en) *	2023-10-27	2025-05-01	Northwestern University	Engineered cell transfected by all-in-one vector for therapeutic agents production and delivery and applications thereof
CN120098124A (zh) *	2023-12-05	2025-06-06	苏州普乐康医药科技有限公司	一种抗bdca-2抗体及其制备方法和应用
CN118638234B (zh) *	2024-07-04	2025-10-14	杭州博之锐生物制药有限公司	抗bdca2抗体及其制备方法和应用
WO2026008012A1 (zh) *	2024-07-04	2026-01-08	杭州博之锐生物制药有限公司	抗bdca2抗体及其用途
CN119591712B (zh) *	2024-11-27	2025-11-21	纽迈生物科技(苏州)有限公司	靶向人类浆细胞样树突状细胞的单克隆抗体及其应用

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5179017A (en)	1980-02-25	1993-01-12	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en)	1980-02-25	1983-08-16	The Trustees Of Columbia University	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en)	1980-02-25	1987-01-06	The Trustees Of Columbia University In The City Of New York	Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4475196A (en)	1981-03-06	1984-10-02	Zor Clair G	Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en)	1981-04-10	1984-05-08	Parker-Hannifin Corporation	Medication infusion pump
US5156840A (en)	1982-03-09	1992-10-20	Cytogen Corporation	Amine-containing porphyrin derivatives
US4439196A (en)	1982-03-18	1984-03-27	Merck & Co., Inc.	Osmotic drug delivery system
US4447224A (en)	1982-09-20	1984-05-08	Infusaid Corporation	Variable flow implantable infusion apparatus
US4487603A (en)	1982-11-26	1984-12-11	Cordis Corporation	Implantable microinfusion pump system
US4486194A (en)	1983-06-08	1984-12-04	James Ferrara	Therapeutic device for administering medicaments through the skin
US4596556A (en)	1985-03-25	1986-06-24	Bioject, Inc.	Hypodermic injection apparatus
US5057313A (en)	1986-02-25	1991-10-15	The Center For Molecular Medicine And Immunology	Diagnostic and therapeutic antibody conjugates
WO1987005330A1 (en)	1986-03-07	1987-09-11	Michel Louis Eugene Bergh	Method for enhancing glycoprotein stability
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
WO1988007089A1 (en)	1987-03-18	1988-09-22	Medical Research Council	Altered antibodies
US4790824A (en)	1987-06-19	1988-12-13	Bioject, Inc.	Non-invasive hypodermic injection device
US4941880A (en)	1987-06-19	1990-07-17	Bioject, Inc.	Pre-filled ampule and non-invasive hypodermic injection device assembly
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
DE768377T1 (de)	1988-09-02	1998-01-02	Dyax Corp	Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
IL162181A (en)	1988-12-28	2006-04-10	Pdl Biopharma Inc	A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5064413A (en)	1989-11-09	1991-11-12	Bioject, Inc.	Needleless hypodermic injection device
US5312335A (en)	1989-11-09	1994-05-17	Bioject Inc.	Needleless hypodermic injection device
US5859205A (en)	1989-12-21	1999-01-12	Celltech Limited	Humanised antibodies
US5427908A (en)	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
ATE185601T1 (de)	1990-07-10	1999-10-15	Cambridge Antibody Tech	Verfahren zur herstellung von spezifischen bindungspaargliedern
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
DE69129154T2 (de)	1990-12-03	1998-08-20	Genentech, Inc., South San Francisco, Calif.	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US5370901A (en)	1991-02-15	1994-12-06	Bracco International B.V.	Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
DK1279731T3 (da)	1991-03-01	2007-09-24	Dyax Corp	Fremgangsmåde til udvikling af bindende miniproteiner
ATE269401T1 (de)	1991-04-10	2004-07-15	Scripps Research Inst	Bibliotheken heterodimerer rezeptoren mittels phagemiden
JP4124480B2 (ja)	1991-06-14	2008-07-23	ジェネンテック・インコーポレーテッド	免疫グロブリン変異体
DE4122599C2 (de)	1991-07-08	1993-11-11	Deutsches Krebsforsch	Phagemid zum Screenen von Antikörpern
WO1993011161A1 (en)	1991-11-25	1993-06-10	Enzon, Inc.	Multivalent antigen-binding proteins
DE69233782D1 (de)	1991-12-02	2010-05-20	Medical Res Council	Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken
US5667988A (en)	1992-01-27	1997-09-16	The Scripps Research Institute	Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5714350A (en)	1992-03-09	1998-02-03	Protein Design Labs, Inc.	Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
SE9201984D0 (sv)	1992-06-29	1992-06-29	Pharmacia Biosensor Ab	Improvement in optical assays
US5383851A (en)	1992-07-24	1995-01-24	Bioject Inc.	Needleless hypodermic injection device
US6210671B1 (en)	1992-12-01	2001-04-03	Protein Design Labs, Inc.	Humanized antibodies reactive with L-selectin
CA2163345A1 (en)	1993-06-16	1994-12-22	Susan Adrienne Morgan	Antibodies
US5827690A (en)	1993-12-20	1998-10-27	Genzyme Transgenics Corporatiion	Transgenic production of antibodies in milk
US5731168A (en)	1995-03-01	1998-03-24	Genentech, Inc.	Method for making heteromultimeric polypeptides
US5869046A (en)	1995-04-14	1999-02-09	Genentech, Inc.	Altered polypeptides with increased half-life
DE69637481T2 (de)	1995-04-27	2009-04-09	Amgen Fremont Inc.	Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
AU2466895A (en)	1995-04-28	1996-11-18	Abgenix, Inc.	Human antibodies derived from immunized xenomice
DK1143006T3 (da)	1995-08-18	2008-07-14	Morphosys Ip Gmbh	Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker
CA2273194C (en)	1996-12-03	2011-02-01	Abgenix, Inc.	Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
ATE319745T1 (de)	1997-05-21	2006-03-15	Biovation Ltd	Verfahren zur herstellung von nicht-immunogenen proteinen
US6242195B1 (en)	1998-04-02	2001-06-05	Genentech, Inc.	Methods for determining binding of an analyte to a receptor
US6528624B1 (en)	1998-04-02	2003-03-04	Genentech, Inc.	Polypeptide variants
US6194551B1 (en)	1998-04-02	2001-02-27	Genentech, Inc.	Polypeptide variants
US6201671B1 (en)	1998-12-04	2001-03-13	International Business Machines Corporation	Seed layer for a nickel oxide pinning layer for increasing the magnetoresistance of a spin valve sensor
CA2342967A1 (en)	1998-12-08	2000-06-15	Biovation Limited	Modifying protein immunogenicity
US7183387B1 (en)	1999-01-15	2007-02-27	Genentech, Inc.	Polypeptide variants with altered effector function
EP1141024B1 (en)	1999-01-15	2018-08-08	Genentech, Inc.	POLYPEPTIDE COMPRISING A VARIANT HUMAN IgG1 Fc REGION
US6737056B1 (en)	1999-01-15	2004-05-18	Genentech, Inc.	Polypeptide variants with altered effector function
CA2664137C (en) *	1999-11-15	2012-09-25	Miltenyi Biotec Gmbh	Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
US7030228B1 (en) *	1999-11-15	2006-04-18	Miltenyi Biotec Gmbh	Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
US7317091B2 (en)	2002-03-01	2008-01-08	Xencor, Inc.	Optimized Fc variants
US8188231B2 (en)	2002-09-27	2012-05-29	Xencor, Inc.	Optimized FC variants
US20040132101A1 (en)	2002-09-27	2004-07-08	Xencor	Optimized Fc variants and methods for their generation
US20070148171A1 (en)	2002-09-27	2007-06-28	Xencor, Inc.	Optimized anti-CD30 antibodies
WO2004009777A2 (en) *	2002-07-18	2004-01-29	Dana-Farber Cancer Institute, Inc.	Compositions and methods to select dendritic cells from a heterogeneous cell population
US20060235208A1 (en)	2002-09-27	2006-10-19	Xencor, Inc.	Fc variants with optimized properties
AU2004204494B2 (en)	2003-01-09	2011-09-29	Macrogenics, Inc.	Identification and engineering of antibodies with variant Fc regions and methods of using same
US7960512B2 (en)	2003-01-09	2011-06-14	Macrogenics, Inc.	Identification and engineering of antibodies with variant Fc regions and methods of using same
EP1585767A2 (en)	2003-01-16	2005-10-19	Genentech, Inc.	Synthetic antibody phage libraries
US20050008625A1 (en)	2003-02-13	2005-01-13	Kalobios, Inc.	Antibody affinity engineering by serial epitope-guided complementarity replacement
EP1594955B1 (en)	2003-02-14	2012-04-11	Biogen Idec MA Inc.	An expression cassette and vector for transient or stable expression of exogenous molecules
KR20120090094A (ko)	2003-06-13	2012-08-16	바이오겐 아이덱 엠에이 인코포레이티드	아글리코실 항-ｃｄ154(ｃｄ40 리간드) 항체 및 이의 용도
AU2004266159A1 (en)	2003-08-22	2005-03-03	Biogen Idec Ma Inc.	Improved antibodies having altered effector function and methods for making the same
US20060134105A1 (en)	2004-10-21	2006-06-22	Xencor, Inc.	IgG immunoglobulin variants with optimized effector function
WO2005035557A2 (en) *	2003-10-14	2005-04-21	The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin	Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease
GB0324368D0 (en)	2003-10-17	2003-11-19	Univ Cambridge Tech	Polypeptides including modified constant regions
WO2005063815A2 (en)	2003-11-12	2005-07-14	Biogen Idec Ma Inc.	Fcϝ receptor-binding polypeptide variants and methods related thereto
EP1737890A2 (en)	2004-03-24	2007-01-03	Xencor, Inc.	Immunoglobulin variants outside the fc region
CN101001872A (zh) *	2004-04-16	2007-07-18	宏观基因有限公司	FcγRIIB－特异性抗体及其使用方法
CA2566473A1 (en) *	2004-05-17	2005-12-08	Board Of Trustees Of The University Of Illinois	Uses of bispecific antibody (biab) coated dendritic cells pulsed with antigens
JP5055603B2 (ja)	2004-08-04	2012-10-24	メントリック・バイオテック・リミテッド・ライアビリティ・カンパニー	変異Ｆｃ領域
DK2573114T3 (en)	2005-08-10	2016-07-04	Macrogenics Inc	The identification and production of antibodies with variant Fc regions, and methods of using same
EP2129692A4 (en) *	2007-02-23	2010-12-15	Baylor Res Inst	ACTIVATION OF CELLS WITH HUMAN ANTIGENES BY CLEC-6
US8282964B2 (en) *	2007-10-27	2012-10-09	Medical Diagnostic Laboratories, Llc	Ex-vivo treatment of peripheral plasmacytoid dendritic cells with IFN-lambda
EP2282773B2 (en)	2008-05-02	2025-03-05	Seagen Inc.	Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
EP2361263A1 (en) *	2008-10-31	2011-08-31	Abbott Biotherapeutics Corp.	Use of anti-cs1 antibodies for treatment of rare lymphomas
AR075989A1 (es)	2009-04-10	2011-05-11	Lilly Co Eli	Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria
TWI412375B (zh)	2009-08-28	2013-10-21	Roche Glycart Ag	人類化抗ｃｄｃｐ１抗體
FR2968561B1 (fr) *	2010-12-13	2013-08-09	Lfb Biotechnologies	Utilisation d'un anticorps dirige contre une proteine membranaire

2013
- 2013-12-10 SM SM20200193T patent/SMT202000193T1/it unknown
- 2013-12-10 EA EA201591113A patent/EA034757B1/ru unknown
- 2013-12-10 US US14/649,297 patent/US9902775B2/en active Active
- 2013-12-10 EP EP13814340.9A patent/EP2928923B1/en active Active
- 2013-12-10 WO PCT/US2013/074208 patent/WO2014093396A1/en not_active Ceased
- 2013-12-10 AU AU2013359419A patent/AU2013359419B2/en active Active
- 2013-12-10 HR HRP20200174TT patent/HRP20200174T1/hr unknown
- 2013-12-10 CN CN202010418430.0A patent/CN111961134B/zh active Active
- 2013-12-10 HU HUE13814340A patent/HUE047874T2/hu unknown
- 2013-12-10 EP EP19209959.6A patent/EP3686218A1/en active Pending
- 2013-12-10 LT LTEP13814340.9T patent/LT2928923T/lt unknown
- 2013-12-10 PL PL13814340T patent/PL2928923T3/pl unknown
- 2013-12-10 NZ NZ708033A patent/NZ708033A/en active IP Right Revival
- 2013-12-10 PT PT138143409T patent/PT2928923T/pt unknown
- 2013-12-10 CA CA2893375A patent/CA2893375A1/en active Pending
- 2013-12-10 ES ES13814340T patent/ES2780398T3/es active Active
- 2013-12-10 BR BR122020023058-4A patent/BR122020023058B1/pt active IP Right Grant
- 2013-12-10 CN CN201380071162.8A patent/CN105452295B/zh active Active
- 2013-12-10 KR KR1020157017299A patent/KR20150094658A/ko not_active Withdrawn
- 2013-12-10 JP JP2015545935A patent/JP6490591B2/ja active Active
- 2013-12-10 MX MX2015007034A patent/MX363407B/es unknown
- 2013-12-10 DK DK13814340.9T patent/DK2928923T3/da active
- 2013-12-10 RS RS20200365A patent/RS60084B1/sr unknown
- 2013-12-10 SI SI201331663T patent/SI2928923T1/sl unknown
- 2013-12-10 KR KR1020207031486A patent/KR102344907B1/ko active Active
2015
- 2015-05-13 IL IL238804A patent/IL238804B/en unknown
- 2015-05-29 ZA ZA2015/03881A patent/ZA201503881B/en unknown
2018
- 2018-01-12 US US15/869,514 patent/US20180362652A1/en not_active Abandoned
2019
- 2019-02-27 JP JP2019034198A patent/JP6889741B2/ja active Active
2020
- 2020-03-19 CY CY20201100263T patent/CY1122956T1/el unknown
2021
- 2021-05-21 JP JP2021086053A patent/JP2021130677A/ja active Pending
- 2021-08-09 IL IL285475A patent/IL285475A/en unknown
2024
- 2024-01-18 JP JP2024006009A patent/JP2024045253A/ja active Pending
2025
- 2025-01-27 US US19/037,765 patent/US20250304700A1/en active Pending

Also Published As

Publication number	Publication date
EA201591113A1 (ru)	2015-09-30
JP2016505556A (ja)	2016-02-25
US20180362652A1 (en)	2018-12-20
EP3686218A1 (en)	2020-07-29
HUE047874T2 (hu)	2020-05-28
PL2928923T3 (pl)	2020-11-16
SMT202000193T1 (it)	2020-05-08
CN105452295B (zh)	2020-06-12
ES2780398T3 (es)	2020-08-25
CY1122956T1 (el)	2021-10-29
IL285475A (en)	2021-09-30
CN111961134A (zh)	2020-11-20
JP6490591B2 (ja)	2019-03-27
PT2928923T (pt)	2020-03-27
MX2015007034A (es)	2016-02-11
KR102344907B1 (ko)	2021-12-28
US9902775B2 (en)	2018-02-27
IL238804B (en)	2021-08-31
RS60084B1 (sr)	2020-05-29
WO2014093396A1 (en)	2014-06-19
AU2013359419B2 (en)	2018-03-15
BR122020023058B1 (pt)	2023-12-05
KR20150094658A (ko)	2015-08-19
IL238804A0 (en)	2015-06-30
AU2013359419A1 (en)	2015-06-04
HK1216027A1 (en)	2016-10-07
ZA201503881B (en)	2018-11-28
SI2928923T1 (sl)	2020-03-31
JP2021130677A (ja)	2021-09-09
DK2928923T3 (da)	2020-02-17
EA034757B1 (ru)	2020-03-17
JP2019146567A (ja)	2019-09-05
JP2024045253A (ja)	2024-04-02
EP2928923B1 (en)	2020-01-22
MX363407B (es)	2019-03-22
US20150299325A1 (en)	2015-10-22
KR20200130468A (ko)	2020-11-18
CN105452295A (zh)	2016-03-30
BR112015012942A2 (pt)	2017-09-12
HRP20200174T1 (hr)	2020-05-29
NZ708033A (en)	2020-03-27
CA2893375A1 (en)	2014-06-19
JP6889741B2 (ja)	2021-06-18
US20250304700A1 (en)	2025-10-02
EP2928923A1 (en)	2015-10-14
CN111961134B (zh)	2024-04-05

Publication	Publication Date	Title
ZA201503881B (en)	2018-11-28	Anti-blood dendritic cell antigen 2 antibodies and uses thereof
IL272831B (en)	2021-12-01	Meditops and Meditop binding antibodies and their use
IL256716A (en)	2018-03-29	Antibodies against hla–b*27 and their uses
IL259436A (en)	2018-07-31	Antibodies against 3angptl and their uses
IL233757A0 (en)	2014-09-30	Anti '1m e-gi antibodies and methods of using them
IL232399A0 (en)	2014-06-30	Anti-2fgfr antibodies and their use
IL231318B (en)	2018-03-29	Antibodies against 3erbb and their uses
PL2946791T3 (pl)	2022-02-21	Przeciwciała anty-CD277 i ich zastosowania
IL254416B (en)	2018-03-29	Anti-asic1 antibodies and their uses
GB201208372D0 (en)	2012-06-27	Antibodies and uses thereof