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LT2588480T - 3,4-dihidropolo[1,2-a]pirazin-2,8(1h)-dikarboksamido dariniai, jų gamyba ir terapinis panaudojimas - Google Patents

3,4-dihidropolo[1,2-a]pirazin-2,8(1h)-dikarboksamido dariniai, jų gamyba ir terapinis panaudojimas

Info

Publication number
LT2588480T
LT2588480T LTEP11781590.2T LT11781590T LT2588480T LT 2588480 T LT2588480 T LT 2588480T LT 11781590 T LT11781590 T LT 11781590T LT 2588480 T LT2588480 T LT 2588480T
Authority
LT
Lithuania
Prior art keywords
dihydropyrrolo
pyrazine
preparation
therapeutic use
dicarboxamide derivatives
Prior art date
Application number
LTEP11781590.2T
Other languages
English (en)
Inventor
Sylvain Cote-Des-Combes
Jacques Froissant
Jean-Francois Gibert
Frank Marguet
Christophe Pacaud
Frédéric Puech
Antoine Ravet
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42697541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2588480(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi filed Critical Sanofi
Publication of LT2588480T publication Critical patent/LT2588480T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEP11781590.2T 2010-06-03 2011-06-01 3,4-dihidropolo[1,2-a]pirazin-2,8(1h)-dikarboksamido dariniai, jų gamyba ir terapinis panaudojimas LT2588480T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1054372A FR2960876B1 (fr) 2010-06-03 2010-06-03 Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
PCT/IB2011/001594 WO2011161537A2 (en) 2010-06-03 2011-06-01 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof

Publications (1)

Publication Number Publication Date
LT2588480T true LT2588480T (lt) 2016-12-12

Family

ID=42697541

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11781590.2T LT2588480T (lt) 2010-06-03 2011-06-01 3,4-dihidropolo[1,2-a]pirazin-2,8(1h)-dikarboksamido dariniai, jų gamyba ir terapinis panaudojimas

Country Status (39)

Country Link
US (2) US8791119B2 (lt)
EP (1) EP2588480B1 (lt)
JP (1) JP5995841B2 (lt)
KR (1) KR20130113928A (lt)
CN (1) CN103168041B (lt)
AR (1) AR081832A1 (lt)
AU (1) AU2011268651B2 (lt)
BR (1) BR112012030697A2 (lt)
CA (1) CA2801154C (lt)
CL (1) CL2012003360A1 (lt)
CO (1) CO6602113A2 (lt)
CR (1) CR20120595A (lt)
CY (1) CY1118512T1 (lt)
DK (1) DK2588480T3 (lt)
DO (1) DOP2012000296A (lt)
EA (1) EA201291364A1 (lt)
EC (1) ECSP12012322A (lt)
ES (1) ES2603420T3 (lt)
FR (1) FR2960876B1 (lt)
GT (1) GT201200319A (lt)
HR (1) HRP20161494T1 (lt)
HU (1) HUE030650T2 (lt)
IL (1) IL223364A (lt)
LT (1) LT2588480T (lt)
MA (1) MA34360B1 (lt)
MX (1) MX2012014084A (lt)
NI (1) NI201200176A (lt)
NZ (1) NZ603947A (lt)
PE (1) PE20130259A1 (lt)
PH (1) PH12012502353A1 (lt)
PL (1) PL2588480T3 (lt)
PT (1) PT2588480T (lt)
SG (1) SG186143A1 (lt)
SI (1) SI2588480T1 (lt)
TN (1) TN2012000520A1 (lt)
TW (1) TWI487707B (lt)
UY (1) UY33428A (lt)
WO (1) WO2011161537A2 (lt)
ZA (1) ZA201209071B (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
TW201605859A (zh) * 2013-11-14 2016-02-16 必治妥美雅史谷比公司 作為酪蛋白激酶１δ／ε抑制劑之新穎經取代之吡唑并－哌
JP6307989B2 (ja) * 2014-04-02 2018-04-11 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
WO2018191389A1 (en) * 2017-04-12 2018-10-18 Roche Sequencing Solutions, Inc. A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction
US11247998B2 (en) * 2017-07-27 2022-02-15 Jiangsu Hengrui Medicine Co., Ltd. Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine
US20250382297A1 (en) * 2022-06-29 2025-12-18 Insilico Medicine Ip Limited Inhibitors of fgfr2 and fgfr3 and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01007850A (es) 1999-02-01 2002-08-20 Univ Virginia Composiciones para tratar respuesta inflamatoria.
HUP0401982A3 (en) * 2001-09-19 2012-09-28 Aventis Pharma Sa Indolizine derivates, process for their preparation and pharmaceutical compositions containing the compounds
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
BRPI0417520A (pt) 2003-12-11 2007-03-06 Aventis Pharma Inc 1h-pirrolo[3,2-b, 3,2-c, e 2,3-c]piridina-2-carboxamidas substituìdas e análogos relatados como inibidores de caseìna cinase i-epsilon
GB0328900D0 (en) 2003-12-12 2004-01-14 Glaxo Group Ltd Novel compounds
WO2008147713A1 (en) * 2007-05-24 2008-12-04 The Regents Of The University Of California Wnt signaling inhibitors, and methods for making and using them
MX2010001076A (es) * 2007-07-27 2010-03-09 Sanofi Aventis Derivados de 1,2,3,4-tetrahidropirrolo-[1,2-a]-pirazina-6-carboxam ida y 2,3,4,5-tetrahidropirrollo [1,2,a] [1,4]-diazepina-7-carboxa mida, preparacion y su uso terapeutico.
EP2229395A1 (en) * 2008-01-17 2010-09-22 Grünenthal GmbH Substituted sulfonamide derivatives
US20090192147A1 (en) * 2008-01-30 2009-07-30 Wyeth [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
FR2960876B1 (fr) * 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
IL223364A (en) 2015-06-30
HUE030650T2 (en) 2017-05-29
CO6602113A2 (es) 2013-01-18
KR20130113928A (ko) 2013-10-16
US20130090340A1 (en) 2013-04-11
GT201200319A (es) 2014-01-17
BR112012030697A2 (pt) 2019-09-24
EP2588480A2 (en) 2013-05-08
US8791119B2 (en) 2014-07-29
JP2013527226A (ja) 2013-06-27
EP2588480B1 (en) 2016-08-17
US9233965B2 (en) 2016-01-12
TWI487707B (zh) 2015-06-11
SG186143A1 (en) 2013-01-30
JP5995841B2 (ja) 2016-09-21
PT2588480T (pt) 2016-11-21
CN103168041B (zh) 2015-08-26
CL2012003360A1 (es) 2013-04-01
DOP2012000296A (es) 2013-02-28
AU2011268651B2 (en) 2016-09-01
EA201291364A1 (ru) 2013-05-30
US20140336189A1 (en) 2014-11-13
CN103168041A (zh) 2013-06-19
CY1118512T1 (el) 2017-07-12
CA2801154C (en) 2018-01-09
NI201200176A (es) 2013-02-06
SI2588480T1 (sl) 2016-12-30
FR2960876A1 (fr) 2011-12-09
FR2960876B1 (fr) 2012-07-27
PE20130259A1 (es) 2013-03-22
DK2588480T3 (en) 2016-12-12
AR081832A1 (es) 2012-10-24
UY33428A (es) 2011-12-30
MA34360B1 (fr) 2013-07-03
PL2588480T3 (pl) 2017-08-31
ZA201209071B (en) 2014-02-26
HRP20161494T1 (hr) 2016-12-16
ECSP12012322A (es) 2013-03-28
TN2012000520A1 (en) 2014-04-01
CR20120595A (es) 2013-01-03
WO2011161537A2 (en) 2011-12-29
ES2603420T3 (es) 2017-02-27
AU2011268651A1 (en) 2012-12-20
CA2801154A1 (en) 2011-12-29
TW201202248A (en) 2012-01-16
PH12012502353A1 (en) 2014-10-22
NZ603947A (en) 2014-12-24
WO2011161537A3 (en) 2012-03-01
MX2012014084A (es) 2013-01-29

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