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LT2008068A - Escitalopramo gamybos būdas - Google Patents

Escitalopramo gamybos būdas

Info

Publication number
LT2008068A
LT2008068A LT2008068A LT2008068A LT2008068A LT 2008068 A LT2008068 A LT 2008068A LT 2008068 A LT2008068 A LT 2008068A LT 2008068 A LT2008068 A LT 2008068A LT 2008068 A LT2008068 A LT 2008068A
Authority
LT
Lithuania
Prior art keywords
benzonitrile
hydroxybutyl
fluorophenyl
hydroxymethyl
dimethylamino
Prior art date
Application number
LT2008068A
Other languages
English (en)
Other versions
LT5577B (lt
Inventor
Carla De Faveri
Florian Anton Martin Huber
Robert James Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2008068(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of LT2008068A publication Critical patent/LT2008068A/lt
Publication of LT5577B publication Critical patent/LT5577B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Šis patentas atskleidžia 4-[4-(dimetilamino)-1-(4'-fluorfenil)-1-hidroksibutil]-3 (hidroksimetil)benzonitrilo, kaip raceminių arba neraceminių enantiomerų mišinio, perskyrimo į jo išskirtus enantiomerus būdą, kai minėtas būdas apima 4-[4-(dimetilamino)-1-(4'-fluorfenil)-1-hidroksibutil]-3-(hidroksimetil)benzonitrilo, kaip druskos su O,O'-di-p-toluil-vyno rūgšties (+)-(S,S) arba (-)-(R,R)-enantiomerų frakcinės kristalizacijos pakopą tirpiklių sistemoje, apimančioje 1-propanolį, etanolį arba acetonitrilą.
LT2008068A 2007-09-11 2008-09-03 Escitalopramo gamybos būdas LT5577B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11

Publications (2)

Publication Number Publication Date
LT2008068A true LT2008068A (lt) 2009-03-25
LT5577B LT5577B (lt) 2009-06-25

Family

ID=39735675

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2008068A LT5577B (lt) 2007-09-11 2008-09-03 Escitalopramo gamybos būdas

Country Status (52)

Country Link
EP (2) EP2397461A1 (lt)
JP (1) JP4966933B2 (lt)
KR (1) KR101054224B1 (lt)
CN (1) CN101386583A (lt)
AR (2) AR068174A1 (lt)
AT (2) ATE518829T1 (lt)
AU (1) AU2008212055C1 (lt)
BE (1) BE1017548A6 (lt)
BG (1) BG110206A (lt)
BR (1) BRPI0804121B1 (lt)
CA (1) CA2638499C (lt)
CH (1) CH697885B1 (lt)
CL (1) CL2008002686A1 (lt)
CO (1) CO6140012A1 (lt)
CY (2) CY2600B1 (lt)
CZ (1) CZ2008537A3 (lt)
DE (1) DE102008046530A1 (lt)
DK (2) DK177075B1 (lt)
EA (1) EA012787B1 (lt)
EE (1) EE00864U1 (lt)
ES (2) ES2334875B1 (lt)
FI (1) FI121570B (lt)
FR (1) FR2920766A1 (lt)
GB (1) GB2448848B (lt)
GR (1) GR1006595B (lt)
HR (2) HRP20080425A2 (lt)
HU (1) HUP0800549A2 (lt)
IE (1) IES20080708A2 (lt)
IL (1) IL193845A (lt)
IS (1) IS8758A (lt)
LT (1) LT5577B (lt)
LU (1) LU91479B1 (lt)
LV (1) LV13813B (lt)
ME (1) ME00176B (lt)
MX (1) MX2008011451A (lt)
MY (1) MY144210A (lt)
NL (1) NL2001953C2 (lt)
NO (1) NO20083756L (lt)
NZ (1) NZ570884A (lt)
PL (2) PL386026A1 (lt)
PT (2) PT104169A (lt)
RO (1) RO125301A2 (lt)
RS (2) RS20080401A (lt)
SE (1) SE533041C2 (lt)
SG (1) SG151195A1 (lt)
SI (2) SI22567A2 (lt)
SK (1) SK500302008A3 (lt)
TR (2) TR200907629A2 (lt)
TW (1) TWI391383B (lt)
UA (2) UA43461U (lt)
WO (1) WO2009033488A1 (lt)
ZA (1) ZA200807753B (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939680B2 (en) 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
ES2881105T3 (es) 2014-11-14 2021-11-26 Zhejiang Huahai Pharm Co Ltd Método para la resolución del producto intermedio de citalopram 5-cianodiol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
PL207847B1 (pl) 2002-12-23 2011-02-28 Lundbeck & Co As H Sposób wytwarzania racemicznego 4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1- hydroksybutylo]-3-(hydroksymetylo)-benzonitrylu) i /lub R-lub S-4-[4-(dimetyloamino)-1-(4'-fluorofenylo)-1-hydroksybutylo]-3-( hydroksymetylo)- benzonitrylu) i sposób wytwarzania racemicznego citalopramu, R-citalopramu i/lub S-citalopramu
WO2004065375A1 (en) * 2003-01-17 2004-08-05 Natco Pharma Limited Processes for the preparation of escitalopram and its precursor
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram

Also Published As

Publication number Publication date
PT2061753E (pt) 2011-09-14
HRP20080425A2 (hr) 2010-04-30
BRPI0804121A8 (pt) 2021-04-13
TW200906814A (en) 2009-02-16
CZ2008537A3 (cs) 2009-03-18
SE0801929L (sv) 2009-03-12
RS20080401A (sr) 2010-03-02
PT104169A (pt) 2009-02-02
FI121570B (fi) 2011-01-14
EE00864U1 (et) 2009-10-15
CY1111924T1 (el) 2015-11-04
BE1017548A6 (fr) 2008-11-04
CH697885B1 (de) 2009-03-13
WO2009033488A1 (en) 2009-03-19
IL193845A (en) 2011-03-31
PL386026A1 (pl) 2009-02-16
ES2334875B1 (es) 2010-10-27
MX2008011451A (es) 2009-03-10
CA2638499A1 (en) 2008-11-21
TWI391383B (zh) 2013-04-01
GB0815773D0 (en) 2008-10-08
HUP0800549A2 (en) 2009-03-02
SG151195A1 (en) 2009-04-30
DE102008046530A1 (de) 2009-03-19
ME00176B (me) 2011-02-10
LT5577B (lt) 2009-06-25
CY2600B1 (en) 2010-03-03
MY144210A (en) 2011-08-15
EP2061753B1 (en) 2011-08-03
SK500302008A3 (sk) 2009-04-06
RS51909B (sr) 2012-02-29
BG110206A (en) 2009-03-31
PL2061753T3 (pl) 2011-12-30
GB2448848B (en) 2011-01-26
AU2008212055B2 (en) 2010-08-12
EA012787B1 (ru) 2009-12-30
BRPI0804121B1 (pt) 2022-04-12
RO125301A2 (ro) 2010-03-30
MEP10108A (bs) 2010-10-10
AR068174A1 (es) 2009-11-11
KR101054224B1 (ko) 2011-08-08
IES20080708A2 (en) 2009-03-18
EP2397461A1 (en) 2011-12-21
JP2009149600A (ja) 2009-07-09
FI20085807A0 (fi) 2008-08-29
HU0800549D0 (en) 2008-10-28
SI2061753T1 (sl) 2011-10-28
SI22567A2 (sl) 2008-12-31
ES2368294T3 (es) 2011-11-16
AU2008212055A1 (en) 2009-03-26
ATE518829T1 (de) 2011-08-15
GR20080100581A (el) 2009-04-30
CA2638499C (en) 2010-09-28
NL2001953A1 (nl) 2008-12-22
HRP20110636T1 (hr) 2011-10-31
EA200801797A2 (ru) 2008-12-30
UA41919U (uk) 2009-06-10
IS8758A (is) 2009-03-12
NZ570884A (en) 2010-03-26
CN101386583A (zh) 2009-03-18
EA200801797A3 (ru) 2009-02-27
FI20085807L (fi) 2009-03-12
LU91479B1 (fr) 2010-03-11
TR200806903A2 (tr) 2009-03-23
TR200907629A2 (tr) 2009-11-23
KR20090027185A (ko) 2009-03-16
CO6140012A1 (es) 2010-03-19
LV13813B (en) 2008-11-20
DK200801265A (en) 2009-03-12
BRPI0804121A2 (pt) 2009-09-29
NO20083756L (no) 2009-03-12
ES2334875A1 (es) 2010-03-16
ZA200807753B (en) 2009-04-29
NL2001953C2 (en) 2009-05-07
CL2008002686A1 (es) 2009-01-02
AT10984U1 (de) 2010-02-15
AR108885A2 (es) 2018-10-03
DK177075B1 (da) 2011-06-14
EP2061753A1 (en) 2009-05-27
SE533041C2 (sv) 2010-06-15
GB2448848A (en) 2008-10-29
FR2920766A1 (fr) 2009-03-13
UA43461U (uk) 2009-08-25
GR1006595B (el) 2009-11-16
DK2061753T3 (da) 2011-09-26
JP4966933B2 (ja) 2012-07-04
AU2008212055C1 (en) 2011-06-02

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Effective date: 20110903