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BRPI0804121A8 - métodos para a resolução de 4-[4-(dimetil-amino)-1-(4'fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi-metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados e para a manufatura de escitalopram - Google Patents

métodos para a resolução de 4-[4-(dimetil-amino)-1-(4'fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi-metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados e para a manufatura de escitalopram

Info

Publication number
BRPI0804121A8
BRPI0804121A8 BRPI0804121A BRPI0804121A BRPI0804121A8 BR PI0804121 A8 BRPI0804121 A8 BR PI0804121A8 BR PI0804121 A BRPI0804121 A BR PI0804121A BR PI0804121 A BRPI0804121 A BR PI0804121A BR PI0804121 A8 BRPI0804121 A8 BR PI0804121A8
Authority
BR
Brazil
Prior art keywords
hydroxy
enanciomers
racemic
benzonitrile
fluoro
Prior art date
Application number
BRPI0804121A
Other languages
English (en)
Inventor
De Faveri Carla
Anton Martin Huber Florian
James Dancer Robert
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0804121(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BRPI0804121A2 publication Critical patent/BRPI0804121A2/pt
Publication of BRPI0804121A8 publication Critical patent/BRPI0804121A8/pt
Publication of BRPI0804121B1 publication Critical patent/BRPI0804121B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

métodos para a resolução de 4-[4-(dimetil-amino)-1-(4'-fluoro-fenil)- 1-hidróxi-butil]-3-(hidróxi-metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados e para a manufatura de escitalopram. esta patente descreve um método para a resolução de 4-[4-(dimetil-amino)-1-(4'-fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi-metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados, o citado método compreendendo as etapas de fracionadamente cristalizar 4-[4-(dimetil-amino)-1-(4'-fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi-metil)-benzonitrila como um sal com o (+)-(s,s) ou (-)-(r,r)-enanciômero de ácido o,o'-di-p-toluoil-tartárico em um sistema de solvente compreendendo 1-propanol, etanol ou acetonitrila.
BRPI0804121-0A 2007-09-11 2008-09-11 Método para a resolução de 4-[4-(dimetil-amino)-1-(4'fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi- metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados BRPI0804121B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701314 2007-09-11
DKPA200701314 2007-09-11

Publications (3)

Publication Number Publication Date
BRPI0804121A2 BRPI0804121A2 (pt) 2009-09-29
BRPI0804121A8 true BRPI0804121A8 (pt) 2021-04-13
BRPI0804121B1 BRPI0804121B1 (pt) 2022-04-12

Family

ID=39735675

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0804121-0A BRPI0804121B1 (pt) 2007-09-11 2008-09-11 Método para a resolução de 4-[4-(dimetil-amino)-1-(4'fluoro-fenil)-1-hidróxi-butil]-3-(hidróxi- metil)-benzonitrila como uma mistura racêmica ou não-racêmica de enanciômeros em seus enanciômeros isolados

Country Status (52)

Country Link
EP (2) EP2061753B1 (pt)
JP (1) JP4966933B2 (pt)
KR (1) KR101054224B1 (pt)
CN (1) CN101386583A (pt)
AR (2) AR068174A1 (pt)
AT (2) ATE518829T1 (pt)
AU (1) AU2008212055C1 (pt)
BE (1) BE1017548A6 (pt)
BG (1) BG110206A (pt)
BR (1) BRPI0804121B1 (pt)
CA (1) CA2638499C (pt)
CH (1) CH697885B1 (pt)
CL (1) CL2008002686A1 (pt)
CO (1) CO6140012A1 (pt)
CY (2) CY2600B1 (pt)
CZ (1) CZ2008537A3 (pt)
DE (1) DE102008046530A1 (pt)
DK (2) DK177075B1 (pt)
EA (1) EA012787B1 (pt)
EE (1) EE00864U1 (pt)
ES (2) ES2368294T3 (pt)
FI (1) FI121570B (pt)
FR (1) FR2920766A1 (pt)
GB (1) GB2448848B (pt)
GR (1) GR1006595B (pt)
HR (2) HRP20080425A2 (pt)
HU (1) HUP0800549A2 (pt)
IE (1) IES20080708A2 (pt)
IL (1) IL193845A (pt)
IS (1) IS8758A (pt)
LT (1) LT5577B (pt)
LU (1) LU91479B1 (pt)
LV (1) LV13813B (pt)
ME (1) ME00176B (pt)
MX (1) MX2008011451A (pt)
MY (1) MY144210A (pt)
NL (1) NL2001953C2 (pt)
NO (1) NO20083756L (pt)
NZ (1) NZ570884A (pt)
PL (2) PL386026A1 (pt)
PT (2) PT104169A (pt)
RO (1) RO125301A2 (pt)
RS (2) RS20080401A (pt)
SE (1) SE533041C2 (pt)
SG (1) SG151195A1 (pt)
SI (2) SI22567A2 (pt)
SK (1) SK500302008A3 (pt)
TR (2) TR200907629A2 (pt)
TW (1) TWI391383B (pt)
UA (2) UA43461U (pt)
WO (1) WO2009033488A1 (pt)
ZA (1) ZA200807753B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1987016A1 (en) 2005-07-27 2008-11-05 Aurobindo Pharma Limited An improved process for the preparation of escitalopram
CN102796065A (zh) * 2011-05-27 2012-11-28 江苏豪森医药集团连云港宏创医药有限公司 一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) * 2013-04-23 2014-10-29 中国人民解放军军事医学科学院毒物药物研究所 (S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) * 2013-10-10 2016-01-27 南昌大学 一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) * 2014-08-08 2014-10-29 广东东阳光药业有限公司 S-西酞普兰的制备方法
CN107074750B (zh) 2014-11-14 2022-03-25 浙江华海药业股份有限公司 一种拆分西酞普兰中间体5-氰二醇的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
CA2511143C (en) 2002-12-23 2011-06-28 H. Lundbeck A/S Preparation of racemic and/or s- or r-citalopram diols and their use for the preparation racemic and/or s- or r-citalopram
AU2003242990A1 (en) * 2003-01-17 2004-08-13 Pulla Reddy Muddasani Processes for the preparation of escitalopram and its precursor
WO2005047274A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1877394A1 (en) * 2005-04-04 2008-01-16 Jubilant Organosys Limited Process for the preparation of escitalopram or its acid addition salts
EP1987016A1 (en) * 2005-07-27 2008-11-05 Aurobindo Pharma Limited An improved process for the preparation of escitalopram

Also Published As

Publication number Publication date
HUP0800549A2 (en) 2009-03-02
HU0800549D0 (en) 2008-10-28
FI20085807A0 (fi) 2008-08-29
SE0801929L (sv) 2009-03-12
NZ570884A (en) 2010-03-26
TWI391383B (zh) 2013-04-01
TW200906814A (en) 2009-02-16
CZ2008537A3 (cs) 2009-03-18
ES2334875A1 (es) 2010-03-16
EE00864U1 (et) 2009-10-15
IL193845A (en) 2011-03-31
CO6140012A1 (es) 2010-03-19
AT10984U1 (de) 2010-02-15
FI121570B (fi) 2011-01-14
MY144210A (en) 2011-08-15
AU2008212055B2 (en) 2010-08-12
BRPI0804121A2 (pt) 2009-09-29
IS8758A (is) 2009-03-12
EP2397461A1 (en) 2011-12-21
LT5577B (lt) 2009-06-25
ZA200807753B (en) 2009-04-29
GR1006595B (el) 2009-11-16
PT2061753E (pt) 2011-09-14
EP2061753B1 (en) 2011-08-03
SK500302008A3 (sk) 2009-04-06
FR2920766A1 (fr) 2009-03-13
PL2061753T3 (pl) 2011-12-30
BG110206A (en) 2009-03-31
JP4966933B2 (ja) 2012-07-04
SG151195A1 (en) 2009-04-30
SE533041C2 (sv) 2010-06-15
AR108885A2 (es) 2018-10-03
MEP10108A (bs) 2010-10-10
UA41919U (uk) 2009-06-10
CH697885B1 (de) 2009-03-13
CN101386583A (zh) 2009-03-18
AU2008212055A1 (en) 2009-03-26
AU2008212055C1 (en) 2011-06-02
CA2638499C (en) 2010-09-28
RS51909B (sr) 2012-02-29
CA2638499A1 (en) 2008-11-21
RO125301A2 (ro) 2010-03-30
SI22567A2 (sl) 2008-12-31
KR20090027185A (ko) 2009-03-16
NO20083756L (no) 2009-03-12
ES2368294T3 (es) 2011-11-16
PT104169A (pt) 2009-02-02
DK2061753T3 (da) 2011-09-26
LU91479B1 (fr) 2010-03-11
TR200907629A2 (tr) 2009-11-23
ME00176B (me) 2011-02-10
WO2009033488A1 (en) 2009-03-19
BE1017548A6 (fr) 2008-11-04
PL386026A1 (pl) 2009-02-16
UA43461U (uk) 2009-08-25
MX2008011451A (es) 2009-03-10
EA200801797A2 (ru) 2008-12-30
HRP20080425A2 (hr) 2010-04-30
EA012787B1 (ru) 2009-12-30
GB2448848A (en) 2008-10-29
RS20080401A (sr) 2010-03-02
LT2008068A (en) 2009-03-25
CL2008002686A1 (es) 2009-01-02
LV13813B (en) 2008-11-20
IES20080708A2 (en) 2009-03-18
TR200806903A2 (tr) 2009-03-23
GB2448848B (en) 2011-01-26
DK200801265A (en) 2009-03-12
EA200801797A3 (ru) 2009-02-27
ES2334875B1 (es) 2010-10-27
NL2001953C2 (en) 2009-05-07
JP2009149600A (ja) 2009-07-09
EP2061753A1 (en) 2009-05-27
NL2001953A1 (nl) 2008-12-22
DK177075B1 (da) 2011-06-14
GR20080100581A (el) 2009-04-30
SI2061753T1 (sl) 2011-10-28
CY2600B1 (en) 2010-03-03
ATE518829T1 (de) 2011-08-15
DE102008046530A1 (de) 2009-03-19
FI20085807L (fi) 2009-03-12
BRPI0804121B1 (pt) 2022-04-12
KR101054224B1 (ko) 2011-08-08
AR068174A1 (es) 2009-11-11
HRP20110636T1 (hr) 2011-10-31
CY1111924T1 (el) 2015-11-04
GB0815773D0 (en) 2008-10-08

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Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO O PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO.

B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: ANULADA A EXIGENCIA PUBLICADA NA RPI 2004 DE 02/06/2009, POR MOTIVO DE A MESMA TER SIDO INDEVIDA.

B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
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