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KR900007797A - (s)-α-에틸-2-옥소-1-피롤리딘 아세트아미드의 제법 - Google Patents

(s)-α-에틸-2-옥소-1-피롤리딘 아세트아미드의 제법 Download PDF

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Publication number
KR900007797A
KR900007797A KR1019890017038A KR890017038A KR900007797A KR 900007797 A KR900007797 A KR 900007797A KR 1019890017038 A KR1019890017038 A KR 1019890017038A KR 890017038 A KR890017038 A KR 890017038A KR 900007797 A KR900007797 A KR 900007797A
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KR
South Korea
Prior art keywords
oxo
ethyl
preparation
pyrrolidineacetamide
desulfurization agent
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KR1019890017038A
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English (en)
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KR0157610B1 (ko
Inventor
에릭 코세망
제네비에베 모떼
장-피에르 제이르츠
장 고베르
Original Assignee
알. 두 셀도르프, 아이. 씨. 아이. 에이
유씨비 에스. 에이.
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Publication of KR900007797A publication Critical patent/KR900007797A/ko
Application granted granted Critical
Publication of KR0157610B1 publication Critical patent/KR0157610B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

(s)-α-에틸-2-옥소-1-피롤리딘 아세트아미드의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. (s)-α-에틸-2-옥소-1-피롤리딘아세트아미드의 제조방법에 있어서, (s)-α-[2-(메틸티오)에틸]-옥소-1-피롤리딘아세트아미드를 탈황제로 가수소분해 시킴을 특징으로 하는 (s)-α-에틸-2-옥소-1-피롤리딘아세트아미드의 제법.
  2. 제1항에 있어서, 그 탈황제가 라니 니켈 T-1임을 특징으로 하는 방법.
  3. 제1항에 있어서, 그 탈황제가 NaBH4/NiCl2·6H2O임을 특징으로 하는 방법.
  4. 제1항에 있어서, 그 탈황제가 라니 니켈 w-2임을 특징으로 하는 방법.
  5. 제1 내지 4항중의 어느 한항에 있어서, 그 가수소분해 반응을 50과 100℃ 사이의 온도, 물중에서 수행함을 특징으로 하는 방법.
  6. (s)-α-[2-(메틸티오)에틸]-옥소-1-피롤리딘아세트아미드 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890017038A 1988-11-23 1989-11-23 (S)-α-에틸-2-옥소-1-피롤리딘아세트 아미드의 제법 Expired - Fee Related KR0157610B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888827389A GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB8827389.1 1988-11-23

Publications (2)

Publication Number Publication Date
KR900007797A true KR900007797A (ko) 1990-06-02
KR0157610B1 KR0157610B1 (ko) 1998-11-16

Family

ID=10647345

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890017038A Expired - Fee Related KR0157610B1 (ko) 1988-11-23 1989-11-23 (S)-α-에틸-2-옥소-1-피롤리딘아세트 아미드의 제법

Country Status (17)

Country Link
KR (1) KR0157610B1 (ko)
CN (1) CN1020604C (ko)
AT (1) AT392781B (ko)
BG (1) BG51041A3 (ko)
CY (1) CY1672A (ko)
ES (1) ES2023532A6 (ko)
FI (1) FI91961C (ko)
GB (2) GB8827389D0 (ko)
GR (1) GR1000719B (ko)
HK (1) HK102492A (ko)
HU (1) HU204508B (ko)
NO (1) NO173823C (ko)
PH (1) PH26332A (ko)
PL (1) PL161781B1 (ko)
PT (1) PT92365B (ko)
RU (1) RU1797607C (ko)
SG (1) SG89392G (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319732D0 (en) 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
YU37602A (sh) 1999-12-01 2005-07-19 Ucb S.A. Derivat pirolidinacetamida sam ili u kombinaciji za tretman poremećaja cns
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
RU2216322C1 (ru) * 2002-02-28 2003-11-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Средство, обладающее антиишемической, гипотензивной, противоаритмической и ноотропной активностью
US7132552B2 (en) * 2003-02-03 2006-11-07 Teva Pharmaceutical Industries, Ltd. Process for producing levetiracetam
ES2214147B1 (es) * 2003-02-28 2005-10-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
WO2005028435A1 (en) * 2003-09-24 2005-03-31 Ucb, S.A. Process for preparing 2-oxo-1-pyrrolidine derivatives
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
EP2308867A3 (en) 2005-06-01 2011-10-19 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
US8338621B2 (en) 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2009050735A1 (en) * 2007-10-15 2009-04-23 Lupin Limited A novel polymorph of levetiracetam and a process for its preparation
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
PH12021552653A1 (en) 2014-01-21 2023-07-17 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition

Also Published As

Publication number Publication date
HUT53072A (en) 1990-09-28
SG89392G (en) 1992-12-04
NO894649L (no) 1990-05-25
GB8926244D0 (en) 1990-01-10
RU1797607C (ru) 1993-02-23
NO173823B (no) 1993-11-01
FI91961B (fi) 1994-05-31
GB2225322A (en) 1990-05-30
ES2023532A6 (es) 1992-01-16
AT392781B (de) 1991-06-10
HU896132D0 (en) 1990-02-28
PL161781B1 (en) 1993-07-30
GB2225322B (en) 1992-03-25
CN1020604C (zh) 1993-05-12
NO894649D0 (no) 1989-11-22
BG51041A3 (bg) 1993-01-15
PT92365A (pt) 1990-05-31
PT92365B (pt) 1995-07-18
ATA266689A (de) 1990-11-15
GR890100769A (en) 1990-12-31
HU204508B (en) 1992-01-28
GR1000719B (el) 1992-11-23
PH26332A (en) 1992-04-29
KR0157610B1 (ko) 1998-11-16
CN1042904A (zh) 1990-06-13
NO173823C (no) 1994-02-09
FI91961C (fi) 1994-09-12
FI895562A0 (fi) 1989-11-22
GB8827389D0 (en) 1988-12-29
HK102492A (en) 1992-12-24
CY1672A (en) 1993-05-14

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