GB2225322B - A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide - Google Patents

A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Info

Publication number: GB2225322B
Authority: GB; United Kingdom
Prior art keywords: pyrrolidineacetamide; oxo; alpha; ethyl; preparation
Prior art date: 1988-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB8926244A

Other versions

GB8926244D0 (en

GB2225322A (en

Inventor

Eric Cossement

Genevieve Motte

Jean-Pierre Geerts

Jean Gobert

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UCB SA

Original Assignee

UCB SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-23

Filing date

1989-11-21

Publication date

1992-03-25

1989-11-21 Application filed by UCB SA filed Critical UCB SA

1990-01-10 Publication of GB8926244D0 publication Critical patent/GB8926244D0/en

1990-05-30 Publication of GB2225322A publication Critical patent/GB2225322A/en

1992-03-25 Application granted granted Critical

1992-03-25 Publication of GB2225322B publication Critical patent/GB2225322B/en

2009-11-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

GB8926244A 1988-11-23 1989-11-21 A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide Expired - Lifetime GB2225322B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888827389A GB8827389D0 (en)	1988-11-23	1988-11-23	Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Publications (3)

Publication Number	Publication Date
GB8926244D0 GB8926244D0 (en)	1990-01-10
GB2225322A GB2225322A (en)	1990-05-30
GB2225322B true GB2225322B (en)	1992-03-25

Family

ID=10647345

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB888827389A Pending GB8827389D0 (en)	1988-11-23	1988-11-23	Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB8926244A Expired - Lifetime GB2225322B (en)	1988-11-23	1989-11-21	A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GB888827389A Pending GB8827389D0 (en)	1988-11-23	1988-11-23	Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Country Status (17)

Country	Link
KR (1)	KR0157610B1 (en)
CN (1)	CN1020604C (en)
AT (1)	AT392781B (en)
BG (1)	BG51041A3 (en)
CY (1)	CY1672A (en)
ES (1)	ES2023532A6 (en)
FI (1)	FI91961C (en)
GB (2)	GB8827389D0 (en)
GR (1)	GR1000719B (en)
HK (1)	HK102492A (en)
HU (1)	HU204508B (en)
NO (1)	NO173823C (en)
PH (1)	PH26332A (en)
PL (1)	PL161781B1 (en)
PT (1)	PT92365B (en)
RU (1)	RU1797607C (en)
SG (1)	SG89392G (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319732D0 (en)	1993-09-24	1993-11-10	Ucb Sa	Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6107492A (en) *	1998-05-08	2000-08-22	Ucb, S.A.	Process for the preparation of levetiracetam
JP4249415B2 (en)	1999-12-01	2009-04-02	ユセベ，ソシエテアノニム	Pyrrolidineacetamide derivatives alone or in combination for the treatment of CNS diseases
GB0004297D0 (en)	2000-02-23	2000-04-12	Ucb Sa	2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
RU2216322C1 (en) *	2002-02-28	2003-11-20	Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации"	Agent eliciting anti-ischemic, hypotensive, anti- -arrhythmic and nootropic activity
US7132552B2 (en) *	2003-02-03	2006-11-07	Teva Pharmaceutical Industries, Ltd.	Process for producing levetiracetam
ES2214147B1 (en) *	2003-02-28	2005-10-01	Farma-Lepori S.A.	PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT.
JP4658937B2 (en) *	2003-09-24	2011-03-23	ユセベファルマソシエテアノニム	Method for producing 2-oxo-1-pyrrolidine derivative
CA2488325C (en)	2004-11-22	2010-08-24	Apotex Pharmachem Inc.	Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2006128693A2 (en)	2005-06-01	2006-12-07	Ucb Pharma, S.A.	2 -oxo-i -pyrrolidine derivatives/ processes for preparing them and their therapeutic use on the central nervous system
US8338621B2 (en)	2005-12-21	2012-12-25	Ucb S.A.	Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2009050735A1 (en) *	2007-10-15	2009-04-23	Lupin Limited	A novel polymorph of levetiracetam and a process for its preparation
EP2147911A1 (en)	2008-07-24	2010-01-27	ZaCh System S.p.A.	Process for the preparation of levetiracetam
US7939676B2 (en)	2009-09-17	2011-05-10	Zach System S.P.A.	Process for the preparation of levetiracetam
PH12019500127B1 (en)	2014-01-21	2022-05-04	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
SMT201900545T1 (en)	2014-01-21	2019-11-13	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1309692A (en) *	1970-02-13	1973-03-14	Ucb Sa	N-substituted lactams
EP0162036A1 (en) *	1984-05-15	1985-11-21	U C B, S.A.	(S)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8412358D0 (en) *	1984-05-15	1984-06-20	Ucb Sa	Pharmaceutical composition

1988
- 1988-11-23 GB GB888827389A patent/GB8827389D0/en active Pending
1989
- 1989-11-20 GR GR890100769A patent/GR1000719B/en not_active IP Right Cessation
- 1989-11-20 BG BG090398A patent/BG51041A3/en unknown
- 1989-11-21 PT PT92365A patent/PT92365B/en not_active IP Right Cessation
- 1989-11-21 GB GB8926244A patent/GB2225322B/en not_active Expired - Lifetime
- 1989-11-22 NO NO894649A patent/NO173823C/en unknown
- 1989-11-22 AT AT2666/89A patent/AT392781B/en not_active IP Right Cessation
- 1989-11-22 ES ES8903978A patent/ES2023532A6/en not_active Expired - Lifetime
- 1989-11-22 CN CN89108764A patent/CN1020604C/en not_active Expired - Fee Related
- 1989-11-22 FI FI895562A patent/FI91961C/en active IP Right Grant
- 1989-11-22 HU HU896132A patent/HU204508B/en not_active IP Right Cessation
- 1989-11-22 RU SU4742434A patent/RU1797607C/en active
- 1989-11-22 PL PL89282413A patent/PL161781B1/en unknown
- 1989-11-23 PH PH39568A patent/PH26332A/en unknown
- 1989-11-23 KR KR1019890017038A patent/KR0157610B1/en not_active Expired - Fee Related
1992
- 1992-09-05 SG SG893/92A patent/SG89392G/en unknown
- 1992-12-17 HK HK1024/92A patent/HK102492A/en not_active IP Right Cessation
1993
- 1993-05-14 CY CY1672A patent/CY1672A/en unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1309692A (en) *	1970-02-13	1973-03-14	Ucb Sa	N-substituted lactams
EP0162036A1 (en) *	1984-05-15	1985-11-21	U C B, S.A.	(S)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide

Also Published As

Publication number	Publication date
FI895562A0 (en)	1989-11-22
GB8926244D0 (en)	1990-01-10
GB8827389D0 (en)	1988-12-29
HK102492A (en)	1992-12-24
PT92365B (en)	1995-07-18
SG89392G (en)	1992-12-04
HU204508B (en)	1992-01-28
NO173823B (en)	1993-11-01
FI91961C (en)	1994-09-12
CN1042904A (en)	1990-06-13
PL161781B1 (en)	1993-07-30
GB2225322A (en)	1990-05-30
NO173823C (en)	1994-02-09
ATA266689A (en)	1990-11-15
AT392781B (en)	1991-06-10
NO894649D0 (en)	1989-11-22
HU896132D0 (en)	1990-02-28
FI91961B (en)	1994-05-31
CY1672A (en)	1993-05-14
CN1020604C (en)	1993-05-12
GR890100769A (en)	1990-12-31
GR1000719B (en)	1992-11-23
PH26332A (en)	1992-04-29
NO894649L (en)	1990-05-25
BG51041A3 (en)	1993-01-15
HUT53072A (en)	1990-09-28
KR900007797A (en)	1990-06-02
ES2023532A6 (en)	1992-01-16
RU1797607C (en)	1993-02-23
PT92365A (en)	1990-05-31
KR0157610B1 (en)	1998-11-16

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Legal Events

Date	Code	Title	Description
2008-07-23	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 20071121