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KR830006311A - 7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트아미도]-3-[(1,2,3-티아졸-5-일티오)메틸]-3-세펨-4-카르복시산 및 C₁-C6 알킬 유도체 제조방법 - Google Patents

7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트아미도]-3-[(1,2,3-티아졸-5-일티오)메틸]-3-세펨-4-카르복시산 및 C₁-C6 알킬 유도체 제조방법 Download PDF

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Publication number
KR830006311A
KR830006311A KR1019810002904A KR810002904A KR830006311A KR 830006311 A KR830006311 A KR 830006311A KR 1019810002904 A KR1019810002904 A KR 1019810002904A KR 810002904 A KR810002904 A KR 810002904A KR 830006311 A KR830006311 A KR 830006311A
Authority
KR
South Korea
Prior art keywords
cepem
aminothiazol
ylthio
methoxyimino
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019810002904A
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English (en)
Other versions
KR840002163B1 (ko
Inventor
빈센트 커랜 윌리암
쉬넬러 로스 애드머
Original Assignee
죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 죤 제이 헤이간, 아메리칸 사이아나밋드 캄파니 filed Critical 죤 제이 헤이간
Publication of KR830006311A publication Critical patent/KR830006311A/ko
Application granted granted Critical
Publication of KR840002163B1 publication Critical patent/KR840002163B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트 아미도]-3-[(1, 2, 3-티아졸-5-일티오)메틸]-3-세펨-4-카르복시산 및 C1-C6알킬 유도체 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반화학식(A)의 화합물과 일반화학식(B)의 화합물을 극성용매중에서 pH6-7.5정도에서 40-70℃에서 약 4-12시간 반응시키고 냉각하여 반응혼합물을 pH2.5-3.0정도로 산성화한 후 일반화학식(I)의 화합물을 분리함을 특징으로 하는 일반화학식(1)의 화합물 제조방법.
    단, 위의 식에서
    R : 수소 또는 R1(R1:C1-O6알킬기)
    R : 식 (Ⅰ)에서 정의된 바와 같음
    M : 수소 또는 알칼리 금속 양이온
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019810002904A 1980-08-11 1981-08-10 7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트 아미도]-3-[(1,2,3-티아디아졸-5-일) 티오메틸]-3-세펨-4-카르복시산 및 C_1-C_6 알킬 유도체 제조방법. Expired KR840002163B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17688980A 1980-08-11 1980-08-11
US176889 1980-08-11
US281438 1981-07-08
US06/281,438 US4399132A (en) 1980-08-11 1981-07-08 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof

Publications (2)

Publication Number Publication Date
KR830006311A true KR830006311A (ko) 1983-09-20
KR840002163B1 KR840002163B1 (ko) 1984-11-24

Family

ID=26872715

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002904A Expired KR840002163B1 (ko) 1980-08-11 1981-08-10 7-β-[α-syn-메톡시이미노-α-(2-아미노티아졸-4-일)-아세트 아미도]-3-[(1,2,3-티아디아졸-5-일) 티오메틸]-3-세펨-4-카르복시산 및 C_1-C_6 알킬 유도체 제조방법.

Country Status (25)

Country Link
US (1) US4399132A (ko)
JP (1) JPS5759895A (ko)
KR (1) KR840002163B1 (ko)
AR (1) AR228869A1 (ko)
AT (1) AT389639B (ko)
AU (1) AU545895B2 (ko)
BE (1) BE889913A (ko)
CA (1) CA1175417A (ko)
CH (1) CH648561A5 (ko)
DD (1) DD202164A5 (ko)
DE (1) DE3130404A1 (ko)
DK (1) DK155945C (ko)
FI (1) FI74020C (ko)
FR (1) FR2488258A1 (ko)
GB (1) GB2083461B (ko)
GR (1) GR75676B (ko)
HK (1) HK52089A (ko)
HU (1) HU185644B (ko)
IE (1) IE51486B1 (ko)
IL (1) IL63531A (ko)
NL (1) NL8103751A (ko)
NO (1) NO161566C (ko)
NZ (1) NZ197965A (ko)
PL (1) PL131457B1 (ko)
SE (1) SE452324B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4927922A (en) * 1986-07-08 1990-05-22 American Cyanamid Company 7β-(substituted)amino-3-substituted cephalosporanic acids and esters
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
EP0257275A3 (en) * 1986-07-28 1990-05-23 American Cyanamid Company Cephalosporin and penicillin derivatives
US5066799A (en) * 1986-07-28 1991-11-19 American Cyanamid Company Intermediates for the preparation of aminothiazoloximino cephalosporins
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
AT394196B (de) * 1990-01-22 1992-02-10 Biochemie Gmbh (6r,7r)-7-((2-(2-amino-4-thiazolyl) -2oxoacetamido)-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carbons|urenitrat
CN105646538B (zh) * 2016-03-09 2018-04-24 上海宁瑞生化技术有限公司 一种头孢唑南的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2856404A1 (de) * 1978-12-28 1980-07-17 Dynamit Nobel Ag 1,2,3-thiadiazol-5-yl-thioglycolsaeure, deren derivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
GR75676B (ko) 1984-08-02
JPS5759895A (en) 1982-04-10
AU545895B2 (en) 1985-08-08
PL232568A1 (en) 1983-06-06
NZ197965A (en) 1984-03-16
FI74020C (fi) 1987-12-10
NO812701L (no) 1982-02-12
CA1175417A (en) 1984-10-02
IL63531A (en) 1985-07-31
IL63531A0 (en) 1981-11-30
JPS6141517B2 (ko) 1986-09-16
AR228869A1 (es) 1983-04-29
NO161566B (no) 1989-05-22
SE452324B (sv) 1987-11-23
CH648561A5 (ko) 1985-03-29
FI812470L (fi) 1982-02-12
NL8103751A (nl) 1982-03-01
DE3130404A1 (de) 1982-06-16
DD202164A5 (de) 1983-08-31
HK52089A (en) 1989-07-07
GB2083461B (en) 1984-04-11
NO161566C (no) 1989-08-30
FR2488258B1 (ko) 1984-08-24
DK355081A (da) 1982-02-12
KR840002163B1 (ko) 1984-11-24
SE8104771L (sv) 1982-02-12
IE811811L (en) 1982-02-11
DK155945C (da) 1989-12-04
AU7384881A (en) 1982-02-18
GB2083461A (en) 1982-03-24
DE3130404C2 (ko) 1990-07-19
BE889913A (fr) 1982-02-10
PL131457B1 (en) 1984-11-30
DK155945B (da) 1989-06-05
FI74020B (fi) 1987-08-31
AT389639B (de) 1990-01-10
ATA307683A (de) 1989-06-15
FR2488258A1 (fr) 1982-02-12
US4399132A (en) 1983-08-16
IE51486B1 (en) 1987-01-07
HU185644B (en) 1985-03-28

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