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KR20000023813A - Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors - Google Patents

Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors Download PDF

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Publication number
KR20000023813A
KR20000023813A KR1019997000299A KR19997000299A KR20000023813A KR 20000023813 A KR20000023813 A KR 20000023813A KR 1019997000299 A KR1019997000299 A KR 1019997000299A KR 19997000299 A KR19997000299 A KR 19997000299A KR 20000023813 A KR20000023813 A KR 20000023813A
Authority
KR
South Korea
Prior art keywords
heteroaromatic compounds
bicyclic heteroaromatic
tyrosine kinase
protein tyrosine
kinase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019997000299A
Other languages
English (en)
Inventor
George Stuart Cockerill
Malcolm Clive Carter
Stephen Barry Guntrip
Kathryn Jane Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614756.6A external-priority patent/GB9614756D0/en
Priority claimed from GBGB9625495.8A external-priority patent/GB9625495D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of KR20000023813A publication Critical patent/KR20000023813A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C07C217/86—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019997000299A 1996-07-13 1999-01-13 Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors Withdrawn KR20000023813A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614756.6A GB9614756D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GBGB9625495.8A GB9625495D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
KR20000023813A true KR20000023813A (en) 2000-04-25

Family

ID=26309691

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997000299A Withdrawn KR20000023813A (en) 1996-07-13 1999-01-13 Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Country Status (22)

Country Link
US (1) US6207669B1 (ko)
EP (1) EP0912572B1 (ko)
JP (1) JP2000515136A (ko)
KR (1) KR20000023813A (ko)
CN (1) CN1230185A (ko)
AP (1) AP9901435A0 (ko)
AR (1) AR007855A1 (ko)
AT (1) ATE231148T1 (ko)
AU (1) AU3693697A (ko)
BR (1) BR9710362A (ko)
CA (1) CA2260058A1 (ko)
CZ (1) CZ8799A3 (ko)
DE (1) DE69718472T2 (ko)
EA (1) EA199900021A1 (ko)
ES (1) ES2191187T3 (ko)
ID (1) ID19430A (ko)
IS (1) IS4936A (ko)
NO (1) NO990123L (ko)
PE (1) PE91098A1 (ko)
PL (1) PL331154A1 (ko)
TR (1) TR199900048T2 (ko)
WO (1) WO1998002437A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020051675A (ko) * 2000-12-23 2002-06-29 이상남 4-페닐아미노티에노 [3,2-디] 피리미딘 유도체 및 이의제조방법

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KR20020051675A (ko) * 2000-12-23 2002-06-29 이상남 4-페닐아미노티에노 [3,2-디] 피리미딘 유도체 및 이의제조방법

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AR007855A1 (es) 1999-11-24
CZ8799A3 (cs) 1999-06-16
WO1998002437A1 (en) 1998-01-22
ES2191187T3 (es) 2003-09-01
PL331154A1 (en) 1999-06-21
ATE231148T1 (de) 2003-02-15
DE69718472T2 (de) 2003-11-06
US6207669B1 (en) 2001-03-27
ID19430A (id) 1998-07-09
IS4936A (is) 1998-12-29
PE91098A1 (es) 1999-01-15
BR9710362A (pt) 1999-08-17
JP2000515136A (ja) 2000-11-14
EA199900021A1 (ru) 1999-08-26
AU3693697A (en) 1998-02-09
NO990123L (no) 1999-01-13
CN1230185A (zh) 1999-09-29
EP0912572A1 (en) 1999-05-06
NO990123D0 (no) 1999-01-12
CA2260058A1 (en) 1998-01-22
TR199900048T2 (xx) 1999-04-21
DE69718472D1 (de) 2003-02-20
AP9901435A0 (en) 1999-03-31
EP0912572B1 (en) 2003-01-15

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