JP2003504051A - β−チューブリンをコードするＤＮＡおよびその使用 - Google Patents

β−チューブリンをコードするＤＮＡおよびその使用

Info

Publication number: JP2003504051A
Authority: JP; Japan
Prior art keywords: dna; seq; tubulin; set forth; polypeptide
Prior art date: 1999-07-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2001509485A

Other languages

English (en)

Japanese (ja)

Inventor

フオン・ザムゾン−ヒメルストイエルナ，ゲオルク

ハルダー，アヒム

シユニーダー，トマス

パペ，ミヒヤエラ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-09

Filing date

2000-06-30

Publication date

2003-02-04

2000-06-30 Application filed by Bayer AG filed Critical Bayer AG

2003-02-04 Publication of JP2003504051A publication Critical patent/JP2003504051A/ja

Status Pending legal-status Critical Current

Links

108090000704 Tubulin Proteins 0.000 title claims abstract description 149
208000036815 beta tubulin Diseases 0.000 title claims abstract description 85
102000000131 Beta tubulin Human genes 0.000 title 1
102000004243 Tubulin Human genes 0.000 claims abstract description 140
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 87
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 86
229920001184 polypeptide Polymers 0.000 claims abstract description 85
238000000034 method Methods 0.000 claims abstract description 58
241000244206 Nematoda Species 0.000 claims abstract description 47
230000000507 anthelmentic effect Effects 0.000 claims abstract description 11
229960005486 vaccine Drugs 0.000 claims abstract description 7
108020004414 DNA Proteins 0.000 claims description 107
239000012634 fragment Substances 0.000 claims description 49
238000012360 testing method Methods 0.000 claims description 47
108091034117 Oligonucleotide Proteins 0.000 claims description 44
239000000126 substance Substances 0.000 claims description 38
108091028043 Nucleic acid sequence Proteins 0.000 claims description 35
230000014509 gene expression Effects 0.000 claims description 33
125000003275 alpha amino acid group Chemical group 0.000 claims description 31
230000003993 interaction Effects 0.000 claims description 24
230000000295 complement effect Effects 0.000 claims description 23
102000040430 polynucleotide Human genes 0.000 claims description 22
108091033319 polynucleotide Proteins 0.000 claims description 22
239000002157 polynucleotide Substances 0.000 claims description 22
239000013598 vector Substances 0.000 claims description 21
238000001514 detection method Methods 0.000 claims description 18
108020004705 Codon Proteins 0.000 claims description 14
230000027455 binding Effects 0.000 claims description 14
238000002405 diagnostic procedure Methods 0.000 claims description 12
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 9
238000011282 treatment Methods 0.000 claims description 7
230000010721 Tubulin Interactions Effects 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
108091092724 Noncoding DNA Proteins 0.000 claims description 4
239000005645 nematicide Substances 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
241000904766 Coronocyclus coronatus Species 0.000 claims description 2
230000002141 anti-parasite Effects 0.000 claims description 2
239000003096 antiparasitic agent Substances 0.000 claims description 2
108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
230000037429 base substitution Effects 0.000 claims 1
230000003449 preventive effect Effects 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 14
230000003071 parasitic effect Effects 0.000 abstract description 14
239000000921 anthelmintic agent Substances 0.000 abstract description 11
238000003745 diagnosis Methods 0.000 abstract description 4
241000894006 Bacteria Species 0.000 abstract description 2
206010059866 Drug resistance Diseases 0.000 abstract description 2
230000003115 biocidal effect Effects 0.000 abstract description 2
241001126263 Strongylidae Species 0.000 abstract 1
241000894007 species Species 0.000 description 92
102000053602 DNA Human genes 0.000 description 66
210000004027 cell Anatomy 0.000 description 34
108090000623 proteins and genes Proteins 0.000 description 33
150000007523 nucleic acids Chemical group 0.000 description 30
102000004169 proteins and genes Human genes 0.000 description 25
102000039446 nucleic acids Human genes 0.000 description 23
108020004707 nucleic acids Proteins 0.000 description 23
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 22
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 20
238000003752 polymerase chain reaction Methods 0.000 description 18
102000037865 fusion proteins Human genes 0.000 description 17
108020001507 fusion proteins Proteins 0.000 description 17
244000045947 parasite Species 0.000 description 14
241001465754 Metazoa Species 0.000 description 13
239000002299 complementary DNA Substances 0.000 description 13
238000009396 hybridization Methods 0.000 description 13
230000035772 mutation Effects 0.000 description 13
150000001413 amino acids Chemical class 0.000 description 11
230000003321 amplification Effects 0.000 description 10
238000003199 nucleic acid amplification method Methods 0.000 description 10
229940124339 anthelmintic agent Drugs 0.000 description 9
239000013604 expression vector Substances 0.000 description 9
244000000013 helminth Species 0.000 description 8
239000003446 ligand Substances 0.000 description 8
108020004999 messenger RNA Proteins 0.000 description 8
230000002163 immunogen Effects 0.000 description 7
125000003729 nucleotide group Chemical group 0.000 description 7
239000000523 sample Substances 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 6
108090000790 Enzymes Proteins 0.000 description 6
241000588724 Escherichia coli Species 0.000 description 6
241001494479 Pecora Species 0.000 description 6
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 6
239000002773 nucleotide Substances 0.000 description 6
229920002477 rna polymer Polymers 0.000 description 6
238000006467 substitution reaction Methods 0.000 description 6
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 6
241000283073 Equus caballus Species 0.000 description 5
241000282412 Homo Species 0.000 description 5
238000003556 assay Methods 0.000 description 5
150000001556 benzimidazoles Chemical class 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
230000005764 inhibitory process Effects 0.000 description 5
239000013612 plasmid Substances 0.000 description 5
239000000047 product Substances 0.000 description 5
238000000746 purification Methods 0.000 description 5
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
229930024421 Adenine Natural products 0.000 description 4
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 4
241000283086 Equidae Species 0.000 description 4
102000005720 Glutathione transferase Human genes 0.000 description 4
108010070675 Glutathione transferase Proteins 0.000 description 4
241000124008 Mammalia Species 0.000 description 4
102000029749 Microtubule Human genes 0.000 description 4
108091022875 Microtubule Proteins 0.000 description 4
108020005187 Oligonucleotide Probes Proteins 0.000 description 4
240000004808 Saccharomyces cerevisiae Species 0.000 description 4
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 4
229960000643 adenine Drugs 0.000 description 4
238000013459 approach Methods 0.000 description 4
239000011324 bead Substances 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 4
230000000694 effects Effects 0.000 description 4
230000004927 fusion Effects 0.000 description 4
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
239000004005 microsphere Substances 0.000 description 4
210000004688 microtubule Anatomy 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000002751 oligonucleotide probe Substances 0.000 description 4
230000008569 process Effects 0.000 description 4
230000001105 regulatory effect Effects 0.000 description 4
238000002821 scintillation proximity assay Methods 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
108700024394 Exon Proteins 0.000 description 3
241000238631 Hexapoda Species 0.000 description 3
241000282414 Homo sapiens Species 0.000 description 3
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
241001126829 Nosema Species 0.000 description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
108700008625 Reporter Genes Proteins 0.000 description 3
241000607715 Serratia marcescens Species 0.000 description 3
241000187747 Streptomyces Species 0.000 description 3
230000009471 action Effects 0.000 description 3
230000000692 anti-sense effect Effects 0.000 description 3
230000034994 death Effects 0.000 description 3
238000011161 development Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
201000010099 disease Diseases 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
230000006870 function Effects 0.000 description 3
230000028993 immune response Effects 0.000 description 3
230000003053 immunization Effects 0.000 description 3
238000002649 immunization Methods 0.000 description 3
231100000782 microtubule inhibitor Toxicity 0.000 description 3
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical class N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
239000011574 phosphorus Substances 0.000 description 3
229910052698 phosphorus Inorganic materials 0.000 description 3
230000000069 prophylactic effect Effects 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
229940113082 thymine Drugs 0.000 description 3
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
229940035893 uracil Drugs 0.000 description 3
238000005406 washing Methods 0.000 description 3
241001547413 Amidostomum Species 0.000 description 2
241001056488 Anatis Species 0.000 description 2
241000244023 Anisakis Species 0.000 description 2
241000238421 Arthropoda Species 0.000 description 2
241000244186 Ascaris Species 0.000 description 2
241000223836 Babesia Species 0.000 description 2
244000063299 Bacillus subtilis Species 0.000 description 2
235000014469 Bacillus subtilis Nutrition 0.000 description 2
241000931178 Bunostomum Species 0.000 description 2
241000244203 Caenorhabditis elegans Species 0.000 description 2
241000223782 Ciliophora Species 0.000 description 2
108091026890 Coding region Proteins 0.000 description 2
241000522487 Cylicocyclus nassatus Species 0.000 description 2
241000495917 Cystoisospora ohioensis Species 0.000 description 2
230000006820 DNA synthesis Effects 0.000 description 2
241001098070 Echinorhynchus truttae Species 0.000 description 2
241001043461 Eimeria arloingi Species 0.000 description 2
241001662550 Eimeria falciformis Species 0.000 description 2
241000223934 Eimeria maxima Species 0.000 description 2
241001485868 Eimeria media Species 0.000 description 2
241000224432 Entamoeba histolytica Species 0.000 description 2
241000701959 Escherichia virus Lambda Species 0.000 description 2
241000986243 Filaroides Species 0.000 description 2
241000287828 Gallus gallus Species 0.000 description 2
241000224466 Giardia Species 0.000 description 2
241000243976 Haemonchus Species 0.000 description 2
241000243974 Haemonchus contortus Species 0.000 description 2
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 2
241000243190 Microsporidia Species 0.000 description 2
238000000636 Northern blotting Methods 0.000 description 2
241000243981 Onchocerca Species 0.000 description 2
241000243795 Ostertagia Species 0.000 description 2
241000648839 Parabronema Species 0.000 description 2
240000009188 Phyllostachys vivax Species 0.000 description 2
241000224016 Plasmodium Species 0.000 description 2
241000223960 Plasmodium falciparum Species 0.000 description 2
241000223821 Plasmodium malariae Species 0.000 description 2
206010035501 Plasmodium malariae infection Diseases 0.000 description 2
241000233872 Pneumocystis carinii Species 0.000 description 2
241000282849 Ruminantia Species 0.000 description 2
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 2
241000224003 Sarcocystis Species 0.000 description 2
241001473628 Sarcocystis suihominis Species 0.000 description 2
241000232088 Setaria <nematode> Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000002105 Southern blotting Methods 0.000 description 2
241000122932 Strongylus Species 0.000 description 2
241000282887 Suidae Species 0.000 description 2
241000191771 Teladorsagia circumcincta Species 0.000 description 2
241000244031 Toxocara Species 0.000 description 2
241000223104 Trypanosoma Species 0.000 description 2
241000223099 Trypanosoma vivax Species 0.000 description 2
230000004913 activation Effects 0.000 description 2
238000000137 annealing Methods 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
201000008680 babesiosis Diseases 0.000 description 2
238000010804 cDNA synthesis Methods 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
230000008859 change Effects 0.000 description 2
238000012512 characterization method Methods 0.000 description 2
239000000460 chlorine Substances 0.000 description 2
229940104302 cytosine Drugs 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
238000012217 deletion Methods 0.000 description 2
230000037430 deletion Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
230000024293 detection of nematode Effects 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003623 enhancer Substances 0.000 description 2
229940007078 entamoeba histolytica Drugs 0.000 description 2
210000003527 eukaryotic cell Anatomy 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
230000001418 larval effect Effects 0.000 description 2
229960001614 levamisole Drugs 0.000 description 2
230000001320 lysogenic effect Effects 0.000 description 2
210000000653 nervous system Anatomy 0.000 description 2
239000002245 particle Substances 0.000 description 2
230000004481 post-translational protein modification Effects 0.000 description 2
230000009465 prokaryotic expression Effects 0.000 description 2
229940081969 saccharomyces cerevisiae Drugs 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000012163 sequencing technique Methods 0.000 description 2
230000002103 transcriptional effect Effects 0.000 description 2
238000010396 two-hybrid screening Methods 0.000 description 2
241000701447 unidentified baculovirus Species 0.000 description 2
241001515965 unidentified phage Species 0.000 description 2
-1 while At the end Proteins 0.000 description 2
101150084750 1 gene Proteins 0.000 description 1
NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 description 1
UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 description 1
241000224422 Acanthamoeba Species 0.000 description 1
241000224424 Acanthamoeba sp. Species 0.000 description 1
241000700606 Acanthocephala Species 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
240000006108 Allium ampeloprasum Species 0.000 description 1
235000005254 Allium ampeloprasum Nutrition 0.000 description 1
241000057602 Amallothrix tropica Species 0.000 description 1
241001147657 Ancylostoma Species 0.000 description 1
241000272517 Anseriformes Species 0.000 description 1
241000224482 Apicomplexa Species 0.000 description 1
241000256836 Apis Species 0.000 description 1
241000256844 Apis mellifera Species 0.000 description 1
241000204727 Ascaridia Species 0.000 description 1
241000204725 Ascaridia galli Species 0.000 description 1
241000244176 Ascaridida Species 0.000 description 1
241000760149 Aspiculuris Species 0.000 description 1
241000271566 Aves Species 0.000 description 1
241000223838 Babesia bovis Species 0.000 description 1
241000223846 Babesia canis Species 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
241001235572 Balantioides coli Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
229910001369 Brass Inorganic materials 0.000 description 1
241000243982 Brugia pahangi Species 0.000 description 1
241000389783 Bulbonaricus brucei Species 0.000 description 1
241000191796 Calyptosphaeria tropica Species 0.000 description 1
241000282832 Camelidae Species 0.000 description 1
241000253350 Capillaria Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
241000242722 Cestoda Species 0.000 description 1
241000893172 Chabertia Species 0.000 description 1
108010062745 Chloride Channels Proteins 0.000 description 1
102000011045 Chloride Channels Human genes 0.000 description 1
108700010070 Codon Usage Proteins 0.000 description 1
102100033779 Collagen alpha-4(IV) chain Human genes 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
241001126268 Cooperia Species 0.000 description 1
241000986238 Crenosoma Species 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
241000718530 Cryptoses Species 0.000 description 1
241000223935 Cryptosporidium Species 0.000 description 1
241000904768 Cyathostominae Species 0.000 description 1
241000611737 Cyathostomum catinatum Species 0.000 description 1
241000520249 Cylicocyclus Species 0.000 description 1
241000252233 Cyprinus carpio Species 0.000 description 1
206010011732 Cyst Diseases 0.000 description 1
241000205707 Cystoisospora belli Species 0.000 description 1
241000303991 Cystoisospora canis Species 0.000 description 1
241000205706 Cystoisospora felis Species 0.000 description 1
241000209630 Cystoisospora suis Species 0.000 description 1
108020003215 DNA Probes Proteins 0.000 description 1
239000003298 DNA probe Substances 0.000 description 1
102000052510 DNA-Binding Proteins Human genes 0.000 description 1
101710096438 DNA-binding protein Proteins 0.000 description 1
241000255925 Diptera Species 0.000 description 1
241000243990 Dirofilaria Species 0.000 description 1
235000003550 Dracunculus Nutrition 0.000 description 1
241000316827 Dracunculus <angiosperm> Species 0.000 description 1
102100021238 Dynamin-2 Human genes 0.000 description 1
241000223931 Eimeria acervulina Species 0.000 description 1
241000289819 Eimeria adenoeides Species 0.000 description 1
241000406205 Eimeria alabamensis Species 0.000 description 1
241000994379 Eimeria anseris Species 0.000 description 1
241001218115 Eimeria auburnensis Species 0.000 description 1
241000223933 Eimeria bovis Species 0.000 description 1
241000499566 Eimeria brunetti Species 0.000 description 1
241000646177 Eimeria chinchillae Species 0.000 description 1
241001327860 Eimeria dispersa Species 0.000 description 1
241000013739 Eimeria faurei Species 0.000 description 1
241001485852 Eimeria magna Species 0.000 description 1
241001452550 Eimeria meleagridis Species 0.000 description 1
241000179199 Eimeria mitis Species 0.000 description 1
241000499563 Eimeria necatrix Species 0.000 description 1
241001485851 Eimeria perforans Species 0.000 description 1
241001485850 Eimeria piriformis Species 0.000 description 1
241000499544 Eimeria praecox Species 0.000 description 1
241000886136 Eimeria scabra Species 0.000 description 1
241000223932 Eimeria tenella Species 0.000 description 1
241001439622 Elaphostrongylus Species 0.000 description 1
241000974840 Ellipes Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
108010067770 Endopeptidase K Proteins 0.000 description 1
241000578375 Enoplida Species 0.000 description 1
241000498256 Enterobius Species 0.000 description 1
241000011458 Epistylis Species 0.000 description 1
241000283074 Equus asinus Species 0.000 description 1
241001245650 Eragrostis truncata Species 0.000 description 1
241001494608 Eucalyptus tenera Species 0.000 description 1
241001063424 Euxoa tritici Species 0.000 description 1
108091029865 Exogenous DNA Proteins 0.000 description 1
241000073845 Eysarcoris aeneus Species 0.000 description 1
230000010190 G1 phase Effects 0.000 description 1
241000866662 Gigantorhynchida Species 0.000 description 1
241001508494 Glugea Species 0.000 description 1
108010036164 Glutathione synthase Proteins 0.000 description 1
102100034294 Glutathione synthetase Human genes 0.000 description 1
241000880292 Gnathostoma Species 0.000 description 1
102100036738 Guanine nucleotide-binding protein subunit alpha-11 Human genes 0.000 description 1
241001636403 Gyalocephalus Species 0.000 description 1
101150009006 HIS3 gene Proteins 0.000 description 1
241000315566 Habronema Species 0.000 description 1
241000224492 Hartmannella Species 0.000 description 1
241000149124 Hepatozoon canis Species 0.000 description 1
241000920462 Heterakis Species 0.000 description 1
101000710870 Homo sapiens Collagen alpha-4(IV) chain Proteins 0.000 description 1
101000817607 Homo sapiens Dynamin-2 Proteins 0.000 description 1
101100283445 Homo sapiens GNA11 gene Proteins 0.000 description 1
101000929583 Homo sapiens N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Proteins 0.000 description 1
101000879758 Homo sapiens Sjoegren syndrome nuclear autoantigen 1 Proteins 0.000 description 1
241001547406 Hyostrongylus Species 0.000 description 1
102100034343 Integrase Human genes 0.000 description 1
108091092195 Intron Proteins 0.000 description 1
241000624722 Isospora rivolta Species 0.000 description 1
206010023076 Isosporiasis Diseases 0.000 description 1
108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
241000222727 Leishmania donovani Species 0.000 description 1
208000004554 Leishmaniasis Diseases 0.000 description 1
241000270322 Lepidosauria Species 0.000 description 1
241000283986 Lepus Species 0.000 description 1
241000244011 Litomosoides Species 0.000 description 1
241000866639 Macracanthorhynchus Species 0.000 description 1
241000133232 Marshallia Species 0.000 description 1
241001375804 Mastigophora Species 0.000 description 1
241000700601 Moniliformis Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
101100042271 Mus musculus Sema3b gene Proteins 0.000 description 1
241000693084 Mycoplasma ovis Species 0.000 description 1
241001494182 Myxosporea Species 0.000 description 1
241001494184 Myxozoa Species 0.000 description 1
102100036658 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Human genes 0.000 description 1
241001137882 Nematodirus Species 0.000 description 1
241001147662 Neospora caninum Species 0.000 description 1
241001492486 Nosema apis Species 0.000 description 1
241000520254 Oesophagodontus Species 0.000 description 1
241000510960 Oesophagostomum Species 0.000 description 1
241000863910 Ollulanus Species 0.000 description 1
241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241001221709 Oxyurida Species 0.000 description 1
241000904715 Oxyuris Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229930012538 Paclitaxel Natural products 0.000 description 1
241000545637 Parafilaroides Species 0.000 description 1
241000244187 Parascaris Species 0.000 description 1
241001344126 Parelaphostrongylus Species 0.000 description 1
241000069686 Passalurus Species 0.000 description 1
241000021737 Pezicula sp. 1-40 Species 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
241001277123 Physaloptera Species 0.000 description 1
206010035226 Plasma cell myeloma Diseases 0.000 description 1
241000224017 Plasmodium berghei Species 0.000 description 1
206010035500 Plasmodium falciparum infection Diseases 0.000 description 1
241001505293 Plasmodium ovale Species 0.000 description 1
206010035502 Plasmodium ovale infection Diseases 0.000 description 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
206010057190 Respiratory tract infections Diseases 0.000 description 1
101100394989 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) hisI gene Proteins 0.000 description 1
241000223929 Sarcocystidae Species 0.000 description 1
235000005775 Setaria Nutrition 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
201000010001 Silicosis Diseases 0.000 description 1
241001633559 Simulium aureum G Species 0.000 description 1
241000053486 Simulium equinum Species 0.000 description 1
102100037330 Sjoegren syndrome nuclear autoantigen 1 Human genes 0.000 description 1
241000244042 Spirurida Species 0.000 description 1
241001316739 Stefania evansi Species 0.000 description 1
241001617580 Stephanurus Species 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
241000243788 Strongylida Species 0.000 description 1
241000244174 Strongyloides Species 0.000 description 1
241001220316 Syngamus Species 0.000 description 1
241000975704 Syphacia Species 0.000 description 1
241000921519 Syrrhopodon sp. Species 0.000 description 1
241000545125 Tetragoneuria canis Species 0.000 description 1
241001477954 Thelazia Species 0.000 description 1
108091036066 Three prime untranslated region Proteins 0.000 description 1
241000607216 Toxascaris Species 0.000 description 1
241000223996 Toxoplasma Species 0.000 description 1
241000223997 Toxoplasma gondii Species 0.000 description 1
241000869417 Trematodes Species 0.000 description 1
241001061558 Trichomonadidae Species 0.000 description 1
241000893962 Trichophyton equinum Species 0.000 description 1
241000243797 Trichostrongylus Species 0.000 description 1
241001489151 Trichuris Species 0.000 description 1
241000530048 Triodontophorus Species 0.000 description 1
241000223107 Trypanosoma congolense Species 0.000 description 1
241000557167 Trypanosoma percae Species 0.000 description 1
241000224553 Trypanosoma simiae Species 0.000 description 1
241000222714 Trypanosomatidae Species 0.000 description 1
241001440802 Ugia Species 0.000 description 1
241000571986 Uncinaria Species 0.000 description 1
206010047505 Visceral leishmaniasis Diseases 0.000 description 1
241000244002 Wuchereria Species 0.000 description 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001409 amidines Chemical class 0.000 description 1
230000002788 anti-peptide Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
210000000628 antibody-producing cell Anatomy 0.000 description 1
238000003491 array Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
208000007456 balantidiasis Diseases 0.000 description 1
230000003851 biochemical process Effects 0.000 description 1
230000036782 biological activation Effects 0.000 description 1
239000010951 brass Substances 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
210000005056 cell body Anatomy 0.000 description 1
230000032823 cell division Effects 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000012707 chemical precursor Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
230000001713 cholinergic effect Effects 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000010367 cloning Methods 0.000 description 1
239000000306 component Substances 0.000 description 1
238000004590 computer program Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
208000031513 cyst Diseases 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
230000000368 destabilizing effect Effects 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
244000079386 endoparasite Species 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
239000002532 enzyme inhibitor Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
210000003495 flagella Anatomy 0.000 description 1
238000013467 fragmentation Methods 0.000 description 1
238000006062 fragmentation reaction Methods 0.000 description 1
239000013505 freshwater Substances 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
238000001641 gel filtration chromatography Methods 0.000 description 1
238000012248 genetic selection Methods 0.000 description 1
125000003147 glycosyl group Chemical group 0.000 description 1
210000004209 hair Anatomy 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
230000012447 hatching Effects 0.000 description 1
210000003128 head Anatomy 0.000 description 1
230000005802 health problem Effects 0.000 description 1
244000144980 herd Species 0.000 description 1
210000004408 hybridoma Anatomy 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
238000003119 immunoblot Methods 0.000 description 1
238000011532 immunohistochemical staining Methods 0.000 description 1
238000001114 immunoprecipitation Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000010354 integration Effects 0.000 description 1
230000006525 intracellular process Effects 0.000 description 1
230000010189 intracellular transport Effects 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
230000007794 irritation Effects 0.000 description 1
238000002372 labelling Methods 0.000 description 1
150000002596 lactones Chemical class 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
230000007653 larval development Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
244000144972 livestock Species 0.000 description 1
210000001699 lower leg Anatomy 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000029115 microtubule polymerization Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
229960005121 morantel Drugs 0.000 description 1
238000002703 mutagenesis Methods 0.000 description 1
231100000350 mutagenesis Toxicity 0.000 description 1
201000000050 myeloid neoplasm Diseases 0.000 description 1
230000001069 nematicidal effect Effects 0.000 description 1
230000000474 nursing effect Effects 0.000 description 1
238000011275 oncology therapy Methods 0.000 description 1
229960001592 paclitaxel Drugs 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
239000002213 purine nucleotide Substances 0.000 description 1
YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
229960005134 pyrantel Drugs 0.000 description 1
239000002719 pyrimidine nucleotide Substances 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
230000005258 radioactive decay Effects 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
238000010839 reverse transcription Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
238000011895 specific detection Methods 0.000 description 1
210000003046 sporozoite Anatomy 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
229910052712 strontium Inorganic materials 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000006918 subunit interaction Effects 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
239000002966 varnish Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

JP2001509485A 1999-07-09 2000-06-30 β−チューブリンをコードするＤＮＡおよびその使用 Pending JP2003504051A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19931883A DE19931883A1 (de)	1999-07-09	1999-07-09	DNA kodierend für Beta-Tubulin und deren Verwendung
DE19931883.2		1999-07-09
PCT/EP2000/006104 WO2001004281A2 (de)	1999-07-09	2000-06-30	Dna kodierend für beta-tubulin und deren verwendung

Publications (1)

Publication Number	Publication Date
JP2003504051A true JP2003504051A (ja)	2003-02-04

Family

ID=7914118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2001509485A Pending JP2003504051A (ja)	1999-07-09	2000-06-30	β−チューブリンをコードするＤＮＡおよびその使用

Country Status (9)

Country	Link
EP (1)	EP1208199A2 (de)
JP (1)	JP2003504051A (de)
CN (1)	CN1382216A (de)
AU (1)	AU6821500A (de)
BR (1)	BR0012274A (de)
CA (1)	CA2378407A1 (de)
DE (1)	DE19931883A1 (de)
HK (1)	HK1050026A1 (de)
WO (1)	WO2001004281A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2765191B1 (de) *	2008-05-29	2015-12-30	Kao Corporation	Verfahren zum Nachweis von Paecilomyces variotii
CN102492775B (zh) *	2011-12-15	2013-09-11	童永清	抗微管化疗药物基因TUBB3 mRNA表达量快速检测试剂盒
CN115282267A (zh) *	2022-04-29	2022-11-04	浙江师范大学	一种多子小瓜虫β-微管蛋白核酸疫苗的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL9001832A (nl) *	1990-08-16	1992-03-16	Rijksuniversiteit	Specifieke sequenties van dna van een nematode die toegepast kunnen worden bij de diagnostiek van infektie met de nematode.

1999
- 1999-07-09 DE DE19931883A patent/DE19931883A1/de not_active Withdrawn
2000
- 2000-06-30 JP JP2001509485A patent/JP2003504051A/ja active Pending
- 2000-06-30 HK HK03102122.4A patent/HK1050026A1/zh unknown
- 2000-06-30 WO PCT/EP2000/006104 patent/WO2001004281A2/de not_active Ceased
- 2000-06-30 CA CA002378407A patent/CA2378407A1/en not_active Abandoned
- 2000-06-30 CN CN00810121A patent/CN1382216A/zh active Pending
- 2000-06-30 EP EP00956159A patent/EP1208199A2/de not_active Withdrawn
- 2000-06-30 AU AU68215/00A patent/AU6821500A/en not_active Abandoned
- 2000-06-30 BR BR0012274-2A patent/BR0012274A/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6821500A (en)	2001-01-30
BR0012274A (pt)	2002-03-12
CN1382216A (zh)	2002-11-27
CA2378407A1 (en)	2001-01-18
DE19931883A1 (de)	2001-01-11
EP1208199A2 (de)	2002-05-29
WO2001004281A3 (de)	2001-07-12
WO2001004281A2 (de)	2001-01-18
HK1050026A1 (zh)	2003-06-06

Publication	Publication Date	Title
CN111518788B (zh)	2022-11-08	一种柔嫩艾美耳球虫敏感株与耐药株的分子标记及其应用
AU694767B2 (en)	1998-07-30	Dirofilaria Immitis Gp29 proteins, nucleic acid molecules and uses thereof
US5977306A (en)	1999-11-02	Parasitic helminth P39 proteins, and uses thereof
CN101300346A (zh)	2008-11-05	新型生理物质nesfatin及其相关物质、以及它们的用途
JP2003504051A (ja)	2003-02-04	β−チューブリンをコードするＤＮＡおよびその使用
US5681724A (en)	1997-10-28	Parasitic helminth macrophage inhibitory factor nucleic acid molecules and uses thereof
US7671181B2 (en)	2010-03-02	Polynucleotides encoding coccidian parasite casein kinase I, a chemotherapeutic target for antiprotozoal agents
US5795768A (en)	1998-08-18	Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
US6060281A (en)	2000-05-09	Parasitic helminth PLA2 proteins and nucleic acid molecules
US5789194A (en)	1998-08-04	Parasitic helminth venom allergen antigen 5-like genes and proteins
US20040229267A1 (en)	2004-11-18	Tumor suppressor pathway in C. elegans
US6365392B1 (en)	2002-04-02	Filariid nematode cysteine protease nucleic acid molecules and uses thereof
US20040242484A1 (en)	2004-12-02	Nematode PAN and ZP receptor-like sequences
CA2347654A1 (en)	2000-04-27	Human rna binding proteins
US6114142A (en)	2000-09-05	Parasitic helminth nucleic acid molecules/and uses thereof
US6673916B1 (en)	2004-01-06	Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof
US9409962B2 (en)	2016-08-09	Methods and compositions for expressing functional class XIV myosin
MXPA99009998A (en)	2001-05-17	Methods for detecting and reversing resistance to macrocyclic lactone compounds
JP2004519218A (ja)	2004-07-02	単離ヒトトランスポータータンパク、ヒトトランスポータータンパクをコード化する核酸分子、及びその使用
KR20030064271A (ko)	2003-07-31	신규한 ｇ 단백질 시그날링 조절인자인 ｒｇｓ18을암호화하는 핵산, 및 이의 용도
PT1664289E (pt)	2011-03-17	Fosfodiesterases específicas de nucleótido, cíclicas, de leishmania, e suas utilizações
JP2004537259A (ja)	2004-12-16	単離ヒトトランスポータータンパク、ヒトトランスポータータンパクをコード化する核酸分子、及びその使用
JP2004537255A (ja)	2004-12-16	単離ヒトトランスポータータンパク、ヒトトランスポータータンパクをコード化する核酸分子、及びその使用
Welz	2007	Identification, characterization, and expression of latrophilin-like proteins in parasitic nematodes
WO2002070701A9 (fr)	2007-06-28	Nouveau recepteur gnrh humain