[go: up one dir, main page]

JP2000508670A - ピペリジン化合物およびピロリジン化合物 - Google Patents

ピペリジン化合物およびピロリジン化合物

Info

Publication number
JP2000508670A
JP2000508670A JP9537685A JP53768597A JP2000508670A JP 2000508670 A JP2000508670 A JP 2000508670A JP 9537685 A JP9537685 A JP 9537685A JP 53768597 A JP53768597 A JP 53768597A JP 2000508670 A JP2000508670 A JP 2000508670A
Authority
JP
Japan
Prior art keywords
formula
ethyl
pyridyl
compound
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9537685A
Other languages
English (en)
Japanese (ja)
Inventor
メルツ,ヨアヒム
ベットヒャー,ヘニング
デバント,ラルフ
グライナー,ハルトムート
バルトツィク,ゲルト
ハルティンク,ユルゲン
ゼイフリート,クリストフ
ベンクト,ロニー,アンダーソン
ハンソン,ラース,オロフ
ソネソン,クラス,アーケ
スチェアルノフ,ニルス,ペーター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2000508670A publication Critical patent/JP2000508670A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
JP9537685A 1996-04-18 1997-04-14 ピペリジン化合物およびピロリジン化合物 Pending JP2000508670A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (de) 1996-04-18 1996-04-18 Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
DE19615232.1 1996-04-18
PCT/EP1997/001853 WO1997040038A1 (en) 1996-04-18 1997-04-14 Piperidines and pyrrolidines

Publications (1)

Publication Number Publication Date
JP2000508670A true JP2000508670A (ja) 2000-07-11

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9537685A Pending JP2000508670A (ja) 1996-04-18 1997-04-14 ピペリジン化合物およびピロリジン化合物

Country Status (15)

Country Link
EP (1) EP0898569A1 (es)
JP (1) JP2000508670A (es)
KR (1) KR20000005505A (es)
AR (1) AR006690A1 (es)
AU (1) AU2696797A (es)
BR (1) BR9708677A (es)
CA (1) CA2252385A1 (es)
CZ (1) CZ330598A3 (es)
DE (1) DE19615232A1 (es)
HU (1) HUP9901389A3 (es)
NO (1) NO984861D0 (es)
PL (1) PL329351A1 (es)
SK (1) SK141998A3 (es)
WO (1) WO1997040038A1 (es)
ZA (1) ZA973301B (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007501828A (ja) * 2003-08-13 2007-02-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換された3−ピロリジン−インドール−誘導体
JP2008118991A (ja) * 2000-12-27 2008-05-29 Axiogenesis Ag 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム
JP2017537080A (ja) * 2014-11-05 2017-12-14 フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. 免疫調節剤
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (de) * 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
PT1068199E (pt) * 1998-04-08 2003-02-28 Wyeth Corp N-ariloxietil-indoli-alquilaminas para o tratamento da depressao
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AR015035A1 (es) * 1998-04-29 2001-04-11 American Home Prod Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento
CA2334254A1 (en) * 1998-06-15 1999-12-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
WO2000035874A1 (en) * 1998-12-17 2000-06-22 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives having 5ht1a receptor activity
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
WO2000035875A1 (en) * 1998-12-17 2000-06-22 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity
JP2002535365A (ja) * 1999-01-28 2002-10-22 ブリストル−マイヤーズ スクイブ カンパニー 抗うつ性複素環化合物
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물
BR112023025340A2 (pt) * 2021-06-02 2024-02-20 Compass Pathfinder Ltd Compostos de triptamina fluorada, análogos dos mesmos e métodos usando os mesmos
KR20240144259A (ko) 2022-01-29 2024-10-02 수벤 라이프 사이언시스 리미티드 정신 장애 치료를 위한 벤조이소티아졸 및 벤조이속사졸 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008118991A (ja) * 2000-12-27 2008-05-29 Axiogenesis Ag 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム
JP2007501828A (ja) * 2003-08-13 2007-02-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換された3−ピロリジン−インドール−誘導体
JP4866730B2 (ja) * 2003-08-13 2012-02-01 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換された3−ピロリジン−インドール−誘導体
JP2017537080A (ja) * 2014-11-05 2017-12-14 フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. 免疫調節剤
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
US11932601B2 (en) 2014-11-05 2024-03-19 Flexus Biosciences, Inc. Immunoregulatory agents

Also Published As

Publication number Publication date
WO1997040038A1 (en) 1997-10-30
HUP9901389A2 (hu) 1999-08-30
PL329351A1 (en) 1999-03-29
CZ330598A3 (cs) 1999-01-13
AR006690A1 (es) 1999-09-08
KR20000005505A (ko) 2000-01-25
ZA973301B (en) 1997-10-24
SK141998A3 (en) 1999-03-12
NO984861L (no) 1998-10-16
NO984861D0 (no) 1998-10-16
EP0898569A1 (en) 1999-03-03
AU2696797A (en) 1997-11-12
HUP9901389A3 (en) 2000-09-28
BR9708677A (pt) 1999-08-03
CA2252385A1 (en) 1997-10-30
DE19615232A1 (de) 1997-10-23

Similar Documents

Publication Publication Date Title
JP2000508670A (ja) ピペリジン化合物およびピロリジン化合物
JP5586632B2 (ja) 5員の複素環式化合物のアザスピラニル−アルキルカルバメートの誘導体、この調製およびこの治療的使用
JP5798115B2 (ja) 置換ヒドロキサム酸およびその使用
JP3477138B2 (ja) 含窒素複素環化合物
CN101903372B (zh) 作为食欲肽受体拮抗剂的杂芳基衍生物
MXPA04008822A (es) Aroilpiridinonas monociclicas.
US7393845B2 (en) Heteroaryl derivates, their preparation and use
JP2007507529A (ja) 複素環式アミドおよびスルホンアミド
JP2011519849A (ja) ピペリジン及びピロリジン化合物
JPH08507067A (ja) Hiv逆転写酵素阻害剤
CN117999265A (zh) 取代的融合双环大环化合物及其相关治疗方法
JP2001512727A (ja) 5ht−1受容体のリガンドとしてのニ環式化合物
MX2013001202A (es) Compuestos de piridina de anillo fusionado.
KR20100135248A (ko) 인돌리논 화합물
JPH09500124A (ja) 5‐ht1a受容体拮抗物質としてのn‐(ピペリジニル‐1‐アルキル)‐置換シクロヘキサンカルボン酸アミド
JP2002529463A (ja) 化合物
KR20060010839A (ko) 세로토닌 재흡수 저해제로서의 인돌 유도체
JP6943239B2 (ja) Kcnq2〜5チャネル活性化剤
AU2002344949A1 (en) Novel heteroaryl derivatives, their preparation and use
JPH08508031A (ja) 5‐ht1aリガンドとしてのアミド誘導体
JPH09509957A (ja) 免疫調節剤としてのキノリン誘導体
JP5142152B2 (ja) 4,5−ジアリールピロール誘導体、この調製方法および治療におけるこの使用
ES2247347T3 (es) Nuevos derivados de indol.
CN119768169A (zh) 取代的稠合二环化合物以及相关的治疗方法
CN1440412A (zh) 噻吩并吡咯烷酮