JP2000508670A - ピペリジン化合物およびピロリジン化合物 - Google Patents
ピペリジン化合物およびピロリジン化合物Info
- Publication number
- JP2000508670A JP2000508670A JP9537685A JP53768597A JP2000508670A JP 2000508670 A JP2000508670 A JP 2000508670A JP 9537685 A JP9537685 A JP 9537685A JP 53768597 A JP53768597 A JP 53768597A JP 2000508670 A JP2000508670 A JP 2000508670A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- ethyl
- pyridyl
- compound
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19615232A DE19615232A1 (de) | 1996-04-18 | 1996-04-18 | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
| DE19615232.1 | 1996-04-18 | ||
| PCT/EP1997/001853 WO1997040038A1 (en) | 1996-04-18 | 1997-04-14 | Piperidines and pyrrolidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000508670A true JP2000508670A (ja) | 2000-07-11 |
Family
ID=7791576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9537685A Pending JP2000508670A (ja) | 1996-04-18 | 1997-04-14 | ピペリジン化合物およびピロリジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0898569A1 (es) |
| JP (1) | JP2000508670A (es) |
| KR (1) | KR20000005505A (es) |
| AR (1) | AR006690A1 (es) |
| AU (1) | AU2696797A (es) |
| BR (1) | BR9708677A (es) |
| CA (1) | CA2252385A1 (es) |
| CZ (1) | CZ330598A3 (es) |
| DE (1) | DE19615232A1 (es) |
| HU (1) | HUP9901389A3 (es) |
| NO (1) | NO984861D0 (es) |
| PL (1) | PL329351A1 (es) |
| SK (1) | SK141998A3 (es) |
| WO (1) | WO1997040038A1 (es) |
| ZA (1) | ZA973301B (es) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007501828A (ja) * | 2003-08-13 | 2007-02-01 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換された3−ピロリジン−インドール−誘導体 |
| JP2008118991A (ja) * | 2000-12-27 | 2008-05-29 | Axiogenesis Ag | 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム |
| JP2017537080A (ja) * | 2014-11-05 | 2017-12-14 | フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. | 免疫調節剤 |
| US11242319B2 (en) | 2014-11-05 | 2022-02-08 | Flexus Biosciences, Inc. | Immunoregulatory agents |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
| PT1068199E (pt) * | 1998-04-08 | 2003-02-28 | Wyeth Corp | N-ariloxietil-indoli-alquilaminas para o tratamento da depressao |
| US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| AR015035A1 (es) * | 1998-04-29 | 2001-04-11 | American Home Prod | Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
| CA2334254A1 (en) * | 1998-06-15 | 1999-12-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
| US6376494B1 (en) | 1998-06-15 | 2002-04-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
| US6326381B1 (en) | 1998-12-17 | 2001-12-04 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates |
| WO2000035874A1 (en) * | 1998-12-17 | 2000-06-22 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives having 5ht1a receptor activity |
| US6239126B1 (en) | 1998-12-17 | 2001-05-29 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives |
| WO2000035875A1 (en) * | 1998-12-17 | 2000-06-22 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity |
| JP2002535365A (ja) * | 1999-01-28 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | 抗うつ性複素環化合物 |
| KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
| BR112023025340A2 (pt) * | 2021-06-02 | 2024-02-20 | Compass Pathfinder Ltd | Compostos de triptamina fluorada, análogos dos mesmos e métodos usando os mesmos |
| KR20240144259A (ko) | 2022-01-29 | 2024-10-02 | 수벤 라이프 사이언시스 리미티드 | 정신 장애 치료를 위한 벤조이소티아졸 및 벤조이속사졸 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226392A (en) * | 1960-03-07 | 1965-12-28 | Sterling Drug Inc | 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts |
| US3647790A (en) * | 1969-04-08 | 1972-03-07 | American Home Prod | Ouinoxalinyl-oxazolidines and -oxazines |
| US4782071A (en) * | 1986-11-03 | 1988-11-01 | Warner-Lambert Company | Tetrasubstituted urea cholinergic agents |
| MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
| FR2706894A1 (en) * | 1993-06-22 | 1994-12-30 | Synthelabo | N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1996
- 1996-04-18 DE DE19615232A patent/DE19615232A1/de not_active Withdrawn
-
1997
- 1997-04-14 SK SK1419-98A patent/SK141998A3/sk unknown
- 1997-04-14 HU HU9901389A patent/HUP9901389A3/hu unknown
- 1997-04-14 WO PCT/EP1997/001853 patent/WO1997040038A1/en not_active Ceased
- 1997-04-14 BR BR9708677A patent/BR9708677A/pt not_active Application Discontinuation
- 1997-04-14 JP JP9537685A patent/JP2000508670A/ja active Pending
- 1997-04-14 EP EP97920673A patent/EP0898569A1/en not_active Withdrawn
- 1997-04-14 PL PL97329351A patent/PL329351A1/xx unknown
- 1997-04-14 CZ CZ983305A patent/CZ330598A3/cs unknown
- 1997-04-14 KR KR1019980708295A patent/KR20000005505A/ko not_active Withdrawn
- 1997-04-14 CA CA002252385A patent/CA2252385A1/en not_active Abandoned
- 1997-04-14 AU AU26967/97A patent/AU2696797A/en not_active Abandoned
- 1997-04-17 ZA ZA9703301A patent/ZA973301B/xx unknown
- 1997-04-18 AR ARP970101562A patent/AR006690A1/es unknown
-
1998
- 1998-10-16 NO NO984861A patent/NO984861D0/no unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008118991A (ja) * | 2000-12-27 | 2008-05-29 | Axiogenesis Ag | 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム |
| JP2007501828A (ja) * | 2003-08-13 | 2007-02-01 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換された3−ピロリジン−インドール−誘導体 |
| JP4866730B2 (ja) * | 2003-08-13 | 2012-02-01 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換された3−ピロリジン−インドール−誘導体 |
| JP2017537080A (ja) * | 2014-11-05 | 2017-12-14 | フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. | 免疫調節剤 |
| US11242319B2 (en) | 2014-11-05 | 2022-02-08 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| US11932601B2 (en) | 2014-11-05 | 2024-03-19 | Flexus Biosciences, Inc. | Immunoregulatory agents |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997040038A1 (en) | 1997-10-30 |
| HUP9901389A2 (hu) | 1999-08-30 |
| PL329351A1 (en) | 1999-03-29 |
| CZ330598A3 (cs) | 1999-01-13 |
| AR006690A1 (es) | 1999-09-08 |
| KR20000005505A (ko) | 2000-01-25 |
| ZA973301B (en) | 1997-10-24 |
| SK141998A3 (en) | 1999-03-12 |
| NO984861L (no) | 1998-10-16 |
| NO984861D0 (no) | 1998-10-16 |
| EP0898569A1 (en) | 1999-03-03 |
| AU2696797A (en) | 1997-11-12 |
| HUP9901389A3 (en) | 2000-09-28 |
| BR9708677A (pt) | 1999-08-03 |
| CA2252385A1 (en) | 1997-10-30 |
| DE19615232A1 (de) | 1997-10-23 |
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