AR006690A1 - Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas. - Google Patents
Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas.Info
- Publication number
- AR006690A1 AR006690A1 ARP970101562A ARP970101562A AR006690A1 AR 006690 A1 AR006690 A1 AR 006690A1 AR P970101562 A ARP970101562 A AR P970101562A AR P970101562 A ARP970101562 A AR P970101562A AR 006690 A1 AR006690 A1 AR 006690A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical preparations
- prepare
- procedure
- hal
- mono
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- -1 3-indolyl Chemical group 0.000 abstract 1
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000020358 Learning disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 201000003723 learning disability Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 239000003727 serotonin 1A antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Derivados de la piperidina y pirrolidina de fórmula (I), en donde: R1 es fenilo no sustituido, o bien mono-, di o trisustituido con A, A-O-, Hal, CN,NO2, NH2, Ph,-O-SO2A y/o -O-SO2CF3, 2- o 3-indolilo no sustituido, o bien mono o disustituido con A, A-O-, OH, Hal y/o CN, 1,4-benzodioxan-5- o 6-ilo, o1- o 2-naftilo; R2 es fenilo o piridilo no sustituido, o bien mono o disustituido con A, A-O, OH, Hal y/o CN; R3 es H, A, A-O-, Ph, NHR4 o NR5R6;k, l son independientemente 0 o1; m es 0, 1 o 2 y n es 1 o 2 o sus sales y productos intermedios. También se refiere a un procedimiento para prepararestos compuestos y sus sales aceptables desde el punto de vista fisiológico, a preparaciones farmacéuticas que los contieneny al empleo de los mismospara combatir los trastornos alimenticios, trastornos en el aprendizaje, los trastornos de la memoria dependientes de la edad, la discinesia taría y paraejercer una influencia positiva sobre el comportamiento en situaciones de tensión. Los compuestos de fórmula (I) presentan una acción antagonista dereceptor 5-HT1A e inhiben la reabsorción de 5-HT. Estos compuestos pueden ser empleados para preparar medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19615232A DE19615232A1 (de) | 1996-04-18 | 1996-04-18 | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006690A1 true AR006690A1 (es) | 1999-09-08 |
Family
ID=7791576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101562A AR006690A1 (es) | 1996-04-18 | 1997-04-18 | Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0898569A1 (es) |
| JP (1) | JP2000508670A (es) |
| KR (1) | KR20000005505A (es) |
| AR (1) | AR006690A1 (es) |
| AU (1) | AU2696797A (es) |
| BR (1) | BR9708677A (es) |
| CA (1) | CA2252385A1 (es) |
| CZ (1) | CZ330598A3 (es) |
| DE (1) | DE19615232A1 (es) |
| HU (1) | HUP9901389A3 (es) |
| NO (1) | NO984861D0 (es) |
| PL (1) | PL329351A1 (es) |
| SK (1) | SK141998A3 (es) |
| WO (1) | WO1997040038A1 (es) |
| ZA (1) | ZA973301B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
| PT1068199E (pt) * | 1998-04-08 | 2003-02-28 | Wyeth Corp | N-ariloxietil-indoli-alquilaminas para o tratamento da depressao |
| US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| AR015035A1 (es) * | 1998-04-29 | 2001-04-11 | American Home Prod | Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
| CA2334254A1 (en) * | 1998-06-15 | 1999-12-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
| US6376494B1 (en) | 1998-06-15 | 2002-04-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
| US6326381B1 (en) | 1998-12-17 | 2001-12-04 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates |
| WO2000035874A1 (en) * | 1998-12-17 | 2000-06-22 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine amide derivatives having 5ht1a receptor activity |
| US6239126B1 (en) | 1998-12-17 | 2001-05-29 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives |
| WO2000035875A1 (en) * | 1998-12-17 | 2000-06-22 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1a receptor activity |
| JP2002535365A (ja) * | 1999-01-28 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | 抗うつ性複素環化合物 |
| JP4159358B2 (ja) * | 2000-12-27 | 2008-10-01 | アクシオジェネシス アーゲー | 分化中の胚幹細胞、成体幹細胞および胚生殖系細胞を細胞特異的および成長特異的に選択するためのシステム |
| KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
| DE10337184A1 (de) * | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| US11242319B2 (en) | 2014-11-05 | 2022-02-08 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| BR112023025340A2 (pt) * | 2021-06-02 | 2024-02-20 | Compass Pathfinder Ltd | Compostos de triptamina fluorada, análogos dos mesmos e métodos usando os mesmos |
| KR20240144259A (ko) | 2022-01-29 | 2024-10-02 | 수벤 라이프 사이언시스 리미티드 | 정신 장애 치료를 위한 벤조이소티아졸 및 벤조이속사졸 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226392A (en) * | 1960-03-07 | 1965-12-28 | Sterling Drug Inc | 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts |
| US3647790A (en) * | 1969-04-08 | 1972-03-07 | American Home Prod | Ouinoxalinyl-oxazolidines and -oxazines |
| US4782071A (en) * | 1986-11-03 | 1988-11-01 | Warner-Lambert Company | Tetrasubstituted urea cholinergic agents |
| MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
| FR2706894A1 (en) * | 1993-06-22 | 1994-12-30 | Synthelabo | N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1996
- 1996-04-18 DE DE19615232A patent/DE19615232A1/de not_active Withdrawn
-
1997
- 1997-04-14 SK SK1419-98A patent/SK141998A3/sk unknown
- 1997-04-14 HU HU9901389A patent/HUP9901389A3/hu unknown
- 1997-04-14 WO PCT/EP1997/001853 patent/WO1997040038A1/en not_active Ceased
- 1997-04-14 BR BR9708677A patent/BR9708677A/pt not_active Application Discontinuation
- 1997-04-14 JP JP9537685A patent/JP2000508670A/ja active Pending
- 1997-04-14 EP EP97920673A patent/EP0898569A1/en not_active Withdrawn
- 1997-04-14 PL PL97329351A patent/PL329351A1/xx unknown
- 1997-04-14 CZ CZ983305A patent/CZ330598A3/cs unknown
- 1997-04-14 KR KR1019980708295A patent/KR20000005505A/ko not_active Withdrawn
- 1997-04-14 CA CA002252385A patent/CA2252385A1/en not_active Abandoned
- 1997-04-14 AU AU26967/97A patent/AU2696797A/en not_active Abandoned
- 1997-04-17 ZA ZA9703301A patent/ZA973301B/xx unknown
- 1997-04-18 AR ARP970101562A patent/AR006690A1/es unknown
-
1998
- 1998-10-16 NO NO984861A patent/NO984861D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997040038A1 (en) | 1997-10-30 |
| HUP9901389A2 (hu) | 1999-08-30 |
| PL329351A1 (en) | 1999-03-29 |
| CZ330598A3 (cs) | 1999-01-13 |
| KR20000005505A (ko) | 2000-01-25 |
| ZA973301B (en) | 1997-10-24 |
| SK141998A3 (en) | 1999-03-12 |
| NO984861L (no) | 1998-10-16 |
| NO984861D0 (no) | 1998-10-16 |
| EP0898569A1 (en) | 1999-03-03 |
| AU2696797A (en) | 1997-11-12 |
| HUP9901389A3 (en) | 2000-09-28 |
| BR9708677A (pt) | 1999-08-03 |
| JP2000508670A (ja) | 2000-07-11 |
| CA2252385A1 (en) | 1997-10-30 |
| DE19615232A1 (de) | 1997-10-23 |
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