JP2000051685A - Aseptic tank apparatus fitted with weighing function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide the subject apparatus employing a technique performing the charging work of a raw material or the like to the charging part of a tank directly in a clean room, constituted so as to be capable of performing the weighing related to a charging amt. at a time of the charging and capable of contracting the size of the clean room to the limit necessary for the charging work. SOLUTION: A weighing means such as a load cell 4 is arranged to the support part 3 of a tank 1 and a liquid seal means 5 is provided to the body side part of the tank 1 positioned between the weighing means and the charging part 2 provided to the tank 1 and a clean room 6 is formed so as to surround the charging part 2 while the tank 1 is sealed in a relatively up and down movable state through the liquid seal means 5 and the charging work of a raw material is performed in the clean room through the charging part 2 and the charging amt. of the raw material is calculated from the value measured by the weighing means.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is intended to simplify the operation of charging raw materials and the like to a sterile tank such as a preparation tank used in a sterile production line of a drug and to measure the amount of the raw material. To an aseptic tank device with a weighing function.

[0002]

2. Description of the Related Art In an aseptic production line for injections, eye drops, etc., a predetermined amount of raw materials is put into a preparation tank maintained in an aseptic state, and preparation operations such as dissolution processing are performed in a sterile atmosphere. It is important to implement in And
In order to maintain sterility at the time of charging the raw material into the tank, a predetermined amount of raw material is stored in a sterile container, and connected to a charging section of the preparation tank via a sterile connector to perform a charging operation. The method is widely known. However, this method has a problem in workability in that an operation of attaching and detaching a sterile container to and from a charging section of a tank is required every time charging is performed. In addition, it is also possible to omit the assembling and dismounting operation of the aseptic container by adopting a method in which a preparation tank is installed in a clean room of, for example, a class of about 10,000 level, and a raw material is introduced in the clean room. It is. In this case, the measurement of the input amount generally performed at the time of the input of the raw material in order to ensure a higher degree of accuracy of the input amount is also performed by adding a measuring means such as a load cell. Easy to do. However, in order to adopt this method, it is necessary to form a clean room large enough to surround the entire tank including the measuring means, so that a large clean room is required and various pipes and the like are brought into the clean room. Therefore, there is a problem that it costs much to maintain and maintain the clean level.

[0003]

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems of the prior art.
In order to omit the assembling and dismounting work of the aseptic container which is performed at the time of the above-mentioned charging, the method of directly charging the raw material etc. to the charging section of the tank in the clean room is adopted, It is an object of the present invention to provide an aseptic tank device with a measuring function, which is configured to be able to perform the measuring operation, and that can reduce the size of the clean room to a limit required for the charging operation.

[0004]

According to the present invention, in order to solve the above-mentioned problems, a measuring means is provided on a supporting portion for supporting a tank, and between the measuring means and a charging section provided in the tank. A liquid sealing means is provided on the body side of the tank located, and a clean room is formed so as to surround the charging section while sealing in a vertically movable state via the liquid sealing means, and the clean room is formed in the clean room. A technical means is employed in which a raw material or the like is charged through a charging section, and a charged amount is obtained from a value measured by the measuring means. As described above, in the present invention, the clean room is formed so as to be relatively vertically movable via the liquid sealing means. Since it is absorbed by the means, the size of the clean room can be reduced without impairing sterility. Note that a liquid supply pipe may be connected to the tank so that a liquid material or the like can be supplied via the liquid supply pipe in addition to the charging section. Further, if the internal pressure in the clean room can be controlled to be constant, an accurate charging amount can be always obtained based on the value from the measuring means.

[0005]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention is suitable as an aseptic tank device for preparation used in an aseptic production line of pharmaceuticals. It can be effectively applied to other aseptic tank devices as long as it is used for measuring the amount of water. Further, the object to be charged into the tank is not limited to the raw material.
Furthermore, when adding a liquid material to the tank,
A liquid supply pipe can be connected and supplied. In addition, the clean room is generally set to a positive pressure, but is not limited to this. Then, the fluctuation of the internal pressure of the clean room, that is, the fluctuation relating to the differential pressure from the external air pressure naturally affects the value measured by the measuring means. Measures are needed. Measures include a system that can control the internal pressure of the clean room to be strictly constant, a method that does not use the measurement result from the weighing means while the differential pressure is outside the allowable value, and a method that allows the differential pressure to be There may be a method of correcting the measurement result according to the fluctuation of the differential pressure, including the case where the value deviates from the value.

[0006]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a schematic configuration diagram showing a main part of an embodiment according to the present invention, and FIG. 2 is a partially enlarged view showing the liquid seal portion in an enlarged manner. In the figure, reference numeral 1 denotes a preparation tank to which the present invention is applied, and an upper portion thereof is formed with a charging section 2 for charging raw materials. A load cell 4 as a weighing means is provided in the middle of each of the support portions 3 provided at the lower portion, and is configured to measure the weight of the entire tank 1. Then, the input amount is obtained by subtracting the weight of the tank 1 from the measurement result. In this case, the input amount may be obtained by using an appropriate arithmetic circuit, or if the reference point of the load cell 4 is adjusted to the weight of the tank 1, the input amount can be read immediately. .

The tank 1 located between the load cell 4 as a measuring means and the charging section 2 provided in the tank 1
A liquid sealing means 5 is provided on the side of the body, and a clean room 6 is formed so as to surround the charging section 2 while sealing in a vertically movable state via the liquid sealing means 5. That is, as shown in FIG. 2, a liquid sealing tank is formed by the ring-shaped wall plates 8 and 9 which are provided on the bottom plate 7 side forming the clean room 6, and the liquid sealing tank is formed between the ring-shaped wall plates 8 and 9. The liquid sealing means 5 is constituted by inserting a partition plate 10 provided on the body side of the tank 1 into
The tank 1 is sealed so as to be vertically movable relative to the bottom plate 7 of the clean room 6. A liquid supply tank 11 and a liquid discharge pipe 12 for the seal liquid are connected to the liquid seal tank formed by the ring-shaped wall plates 8 and 9, so that the amount of the seal liquid can be adjusted. Have been. In this embodiment, since the clean room 6 is set at a slightly positive pressure, as shown in the drawing, the liquid surface outside the partition plate 10 communicating with the clean room 6 communicates with the outside air.
It is slightly lower than the liquid level inside 0.

When the raw materials and the like are charged into the tank 1 during the preparation operation, for example, the half suit 13 formed from a flexible sheet so as to completely separate the clean room 6 from the outside is used. The upper part of the body is inserted into the inside, the lid of the charging unit 2 is manually opened, and a predetermined amount of raw material or the like is charged while observing the measured value from the load cell 4. In this case, since the above-mentioned sterile container is not used, it is needless to say that the workability for charging is improved because the dismounting operation is not bothersome. The differential pressure detector 1
4 detects the differential pressure between the internal pressure and the external pressure in the clean room 6 and manages the influence on the load cell 4, and uses the measurement result from the load cell 4 while the differential pressure is out of the allowable value as described above. It can be configured not to perform the measurement or to correct the measurement result according to the fluctuation of the differential pressure.

FIG. 3 is a schematic configuration diagram showing a main part of an embodiment in which the above-described embodiment is further embodied. Hereinafter, components similar to those of the above-described embodiment will be denoted by the same reference numerals. Also in this embodiment, the feature is that the tank 1
A load cell 4 as a measuring means is disposed on a supporting part 3 for supporting the liquid crystal, and a liquid sealing means 5 is provided on a body side of the tank 1 located between the load cell 4 and the charging part 2 provided on the tank 1. The point is that the clean room 6 is formed so as to surround the charging section 2 while providing and sealing the upper and lower parts in a relatively vertically movable state. In this embodiment, an air supply line 15 for supplying sterile air to the clean room 6 and an exhaust line 16 are connected, and the amount of air supplied from the air supply line 15 and the exhaust line 16 are connected.
By adjusting the amount of exhaust air from the clean room 6
Is configured to be able to control the internal pressure, that is, the differential pressure from the external pressure to a predetermined value.

The tank 1 has a charging section 2 and a valve 1
7. Liquid supply pipe 1 via flexible flexible pipe 18 and the like
9 is connected so that a liquid material or the like can be added through the liquid supply pipe 19. Further, inside the tank 1, a stirring blade 21 that is driven to rotate by a motor 20 is provided. Further, in the outer peripheral portion of the tank 1 exposed below the bottom plate 7 forming the clean room 6, there are formed gap portions 22 through which a heat medium such as heated or cooled water can flow. The temperature inside the tank 1 can be maintained at a predetermined processing temperature by flowing a heat medium through a supply pipe 27 and a discharge pipe 28 connected via a universal pipe 24, universal pipes 25 and 26, and the like. . The supply pipe 27 and the discharge pipe 28
May be used upside down according to the temperature of the heat medium. Further, a heat insulating material may be wound around the universal tubes 25, 26 and the like. A discharge pipe 30 is connected to the bottom of the tank 1 via a universal pipe 29. Further, an air supply pipe 32 and an exhaust pipe 33 for ventilation are connected to a space 31 formed below the bottom plate 7 of the clean room 6, and the universal pipe 2 is provided.
It is configured to suppress the generation of bacteria and the like on the heat insulating material portion wound around 5, 26 or the like.

[0011]

According to the present invention, the operation of charging the raw materials and the like to the tank is performed directly to the charging section in the clean room, so that the conventional operation of attaching and detaching the aseptic container is omitted, and the workability is improved. In addition, it is possible to measure the input amount at the time of charging, and it is possible to reduce the size of the clean room to the limit required for the charging operation. Therefore, the installation space of the clean room can be reduced, and the cost for maintaining and maintaining the clean level is also effective.

[Brief description of the drawings]

FIG. 1 is a schematic configuration diagram showing a main part of an embodiment of the present invention.

FIG. 2 is a partially enlarged view showing the liquid seal portion of the embodiment in an enlarged manner.

FIG. 3 is a schematic configuration diagram showing a main part of an embodiment in which the embodiment is further embodied.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Tank, 2 ... Input part, 3 ... Support part, 4 ... Load cell, 5 ... Liquid sealing means, 6 ... Clean room, 7 ... Bottom plate, 8, 9 ... Ring-shaped wall plate, 10 ... Partition plate, 11 ... Liquid supply Pipe, 12: drain pipe, 13: half suit, 14: differential pressure detector, 15: air supply line, 16: exhaust line, 17 ...
Valve, 18: universal tube, 19: liquid supply tube, 20: motor, 21: blade for stirring, 22: gap, 23, 24 ...
Valves, 25, 26: universal pipe, 27: supply pipe, 28: discharge pipe, 29: universal pipe, 30: discharge pipe, 31: space, 3
2 ... air supply pipe, 33 ... exhaust pipe

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C058 AA22 BB02 CC04 CC05 CC10 DD06 DD11 4G075 AA01 AA61 AA65 CA61 EA01 EB01

Claims (3)

[Claims] 1. A weighing means is provided on a supporting portion for supporting a tank, and a liquid sealing means is provided on a body side of the tank located between the weighing means and a charging section provided in the tank, A clean room is formed so as to surround the charging section while sealing in a relatively vertically movable state through the liquid sealing means, and charging of raw materials and the like is performed through the charging section in the clean room. An aseptic tank device with a measuring function, characterized in that an input amount is obtained from a value measured by the measuring means. 2. The aseptic tank device with a measuring function according to claim 1, wherein a liquid supply pipe is connected to the tank, and a liquid material or the like can be supplied through the liquid supply pipe. 3. The aseptic tank device with a measuring function according to claim 1, wherein the internal pressure in the clean room can be controlled to be constant.