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JO3083B1 - عملية جديدة لتخليق إيفابرادين وأملاحه المضافة مع حمض مقبول صيدلانيا - Google Patents

عملية جديدة لتخليق إيفابرادين وأملاحه المضافة مع حمض مقبول صيدلانيا

Info

Publication number
JO3083B1
JO3083B1 JOP/2012/0370A JOP20120370A JO3083B1 JO 3083 B1 JO3083 B1 JO 3083B1 JO P20120370 A JOP20120370 A JO P20120370A JO 3083 B1 JO3083 B1 JO 3083B1
Authority
JO
Jordan
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
addition salts
acceptable acid
Prior art date
Application number
JOP/2012/0370A
Other languages
English (en)
Inventor
Lecouve Jean-Pierre
Renaud Jean-Luc
Gaillard Sylvain
Vaysse-Ludot Lucile
Pannetier Nicolas
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47355960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3083(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of JO3083B1 publication Critical patent/JO3083B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

عملية لتخليق إيفابرادين من الصيغة (I): وأملاحه المضافة مع حمض مقبول صيدلانيا، وهيدراته. أدوية
JOP/2012/0370A 2011-12-20 2012-12-06 عملية جديدة لتخليق إيفابرادين وأملاحه المضافة مع حمض مقبول صيدلانيا JO3083B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103934A FR2984320B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
JO3083B1 true JO3083B1 (ar) 2017-03-15

Family

ID=47355960

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0370A JO3083B1 (ar) 2011-12-20 2012-12-06 عملية جديدة لتخليق إيفابرادين وأملاحه المضافة مع حمض مقبول صيدلانيا

Country Status (34)

Country Link
US (1) US8507668B2 (ar)
EP (1) EP2607354B1 (ar)
JP (1) JP5531084B2 (ar)
KR (1) KR101479986B1 (ar)
CN (1) CN103172567B (ar)
AR (1) AR089325A1 (ar)
AU (1) AU2012261583B2 (ar)
BR (1) BR102012032562A2 (ar)
CA (1) CA2798633C (ar)
CL (1) CL2012003579A1 (ar)
CY (1) CY1115620T1 (ar)
DK (1) DK2607354T3 (ar)
EA (1) EA021713B1 (ar)
ES (1) ES2516290T3 (ar)
FR (1) FR2984320B1 (ar)
GE (1) GEP20156245B (ar)
HR (1) HRP20140839T1 (ar)
JO (1) JO3083B1 (ar)
MA (1) MA34868B1 (ar)
MD (1) MD4275C1 (ar)
MX (1) MX2012014321A (ar)
MY (1) MY160928A (ar)
PE (1) PE20131325A1 (ar)
PL (1) PL2607354T3 (ar)
PT (1) PT2607354E (ar)
RS (1) RS53470B (ar)
SA (1) SA112340106B1 (ar)
SG (1) SG191498A1 (ar)
SI (1) SI2607354T1 (ar)
TW (1) TWI440628B (ar)
UA (1) UA111156C2 (ar)
UY (1) UY34508A (ar)
WO (1) WO2013093333A1 (ar)
ZA (1) ZA201209369B (ar)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
RU2473544C2 (ru) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2010096416A1 (en) * 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
FR2943668B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.

Also Published As

Publication number Publication date
MD4275B1 (en) 2014-02-28
GEP20156245B (en) 2015-02-10
JP2013129656A (ja) 2013-07-04
JP5531084B2 (ja) 2014-06-25
FR2984320B1 (fr) 2013-11-29
FR2984320A1 (fr) 2013-06-21
MA34868B1 (fr) 2014-02-01
UA111156C2 (uk) 2016-04-11
CN103172567B (zh) 2015-08-12
CL2012003579A1 (es) 2014-09-05
NZ604890A (en) 2014-03-28
MX2012014321A (es) 2013-06-19
SI2607354T1 (sl) 2014-10-30
HK1186734A1 (en) 2014-03-21
DK2607354T3 (da) 2014-10-13
EA021713B1 (ru) 2015-08-31
CY1115620T1 (el) 2017-01-04
PE20131325A1 (es) 2013-11-15
TWI440628B (zh) 2014-06-11
ES2516290T3 (es) 2014-10-30
EP2607354A1 (fr) 2013-06-26
KR20130071389A (ko) 2013-06-28
US20130158257A1 (en) 2013-06-20
AR089325A1 (es) 2014-08-13
PT2607354E (pt) 2014-08-27
TW201331183A (zh) 2013-08-01
HRP20140839T1 (hr) 2014-10-24
ZA201209369B (en) 2013-08-28
AU2012261583B2 (en) 2014-01-16
AU2012261583A1 (en) 2013-07-04
CA2798633C (fr) 2014-08-19
MY160928A (en) 2017-03-31
PL2607354T3 (pl) 2014-10-31
SA112340106B1 (ar) 2015-07-09
WO2013093333A1 (fr) 2013-06-27
EP2607354B1 (fr) 2014-07-16
UY34508A (es) 2013-06-28
RS53470B (sr) 2014-12-31
US8507668B2 (en) 2013-08-13
EA201201571A1 (ru) 2013-07-30
CA2798633A1 (fr) 2013-06-20
CN103172567A (zh) 2013-06-26
SG191498A1 (en) 2013-07-31
MD4275C1 (ro) 2014-09-30
KR101479986B1 (ko) 2015-01-08
BR102012032562A2 (pt) 2013-11-12

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