BRPI0920053A2 - pirazolilaminopiridinas como inibidores da fak - Google Patents

pirazolilaminopiridinas como inibidores da fak

Info

Publication number: BRPI0920053A2
Authority: BR; Brazil
Prior art keywords: pyrazolylaminopyridines; fak inhibitors; fak; inhibitors
Prior art date: 2008-10-27

Application number

BRPI0920053A

Other languages

English (en)

Inventor

Hong Lin

Jerry Leroy Adams

Jiri Kasparec

Mark Mellinger

Neil W Johnson

Ren Xie

Thomas H Faitg

Xin Peng

Original Assignee

Glaxosmithkline Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-27

Filing date

2009-10-27

Publication date

2015-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42132177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0920053(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-10-27 Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc

2015-12-15 Publication of BRPI0920053A2 publication Critical patent/BRPI0920053A2/pt

2019-11-26 Publication of BRPI0920053B1 publication Critical patent/BRPI0920053B1/pt

2021-05-25 Publication of BRPI0920053B8 publication Critical patent/BRPI0920053B8/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- G01N33/5752—

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Immunology (AREA)
Pyridine Compounds (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Cell Biology (AREA)
Oncology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Hospice & Palliative Care (AREA)
Food Science & Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0920053A 2008-10-27 2009-10-27 composto pirazolilaminopiridina, composição contendo o dito composto e uso do mesmo para tratar câncer BRPI0920053B8 (pt)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US10856808P	2008-10-27	2008-10-27
US61/108,568		2008-10-27
US17851709P	2009-05-15	2009-05-15
US61/178,517		2009-05-15
US24243209P	2009-09-15	2009-09-15
US61/242.432		2009-09-15
PCT/US2009/062163 WO2010062578A1 (en)	2008-10-27	2009-10-27	Pyrazolylaminopyridines as inhibitors of fak

Publications (3)

Publication Number	Publication Date
BRPI0920053A2 true BRPI0920053A2 (pt)	2015-12-15
BRPI0920053B1 BRPI0920053B1 (pt)	2019-11-26
BRPI0920053B8 BRPI0920053B8 (pt)	2021-05-25

Family

ID=42132177

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0920053A BRPI0920053B8 (pt)	2008-10-27	2009-10-27	composto pirazolilaminopiridina, composição contendo o dito composto e uso do mesmo para tratar câncer

Country Status (35)

Country	Link
US (6)	US20100113475A1 (pt)
EP (1)	EP2421537B1 (pt)
JP (1)	JP5642689B2 (pt)
KR (1)	KR101512217B1 (pt)
CN (1)	CN102264371B (pt)
AR (1)	AR073993A1 (pt)
AU (1)	AU2009320144B2 (pt)
BR (1)	BRPI0920053B8 (pt)
CA (1)	CA2741760C (pt)
CL (1)	CL2011000933A1 (pt)
CO (1)	CO6361929A2 (pt)
CR (1)	CR20110264A (pt)
CY (1)	CY1116399T1 (pt)
DK (1)	DK2421537T3 (pt)
DO (1)	DOP2011000113A (pt)
EA (1)	EA021927B1 (pt)
ES (1)	ES2539835T3 (pt)
HR (1)	HRP20150531T1 (pt)
IL (1)	IL212444A (pt)
JO (1)	JO3067B1 (pt)
MA (1)	MA32727B1 (pt)
MX (1)	MX2011004369A (pt)
MY (1)	MY161890A (pt)
NZ (1)	NZ592477A (pt)
PE (1)	PE20110941A1 (pt)
PL (1)	PL2421537T3 (pt)
PT (1)	PT2421537E (pt)
RS (1)	RS54045B1 (pt)
SG (1)	SG195608A1 (pt)
SI (1)	SI2421537T1 (pt)
SM (1)	SMT201500157B (pt)
TW (1)	TWI454467B (pt)
UY (1)	UY32200A (pt)
WO (1)	WO2010062578A1 (pt)
ZA (1)	ZA201102892B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8338441B2 (en)	2009-05-15	2012-12-25	Gilead Sciences, Inc.	Inhibitors of human immunodeficiency virus replication
US20120244141A1 (en)	2010-09-28	2012-09-27	Boehringer Ingelheim International Gmbh	Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
CA2825790A1 (en) *	2011-01-26	2012-08-02	Board Of Regents The University Of Texas System	Combinations
CA2827172C (en)	2011-02-17	2019-02-26	Cancer Therapeutics Crc Pty Limited	Selective fak inhibitors
WO2012110773A1 (en)	2011-02-17	2012-08-23	Cancer Therapeutics Crc Pty Limited	Fak inhibitors
BR112013034066A2 (pt) *	2011-06-28	2017-02-07	Glaxosmithkline Intellectual Property (No 2) Ltd	método de administração e tratamento
US10106834B2 (en)	2013-10-09	2018-10-23	The General Hospital Corporation	Methods of diagnosing and treating B cell acute lymphoblastic leukemia
CA3244408A1 (en)	2015-06-29	2025-06-13	Verastem, Inc.	Therapeutic compositions, combinations, and methods of use
CN108948019B (zh) *	2017-05-18	2022-07-08	广东东阳光药业有限公司	黏着斑激酶抑制剂及其用途
WO2019117813A1 (en) *	2017-12-15	2019-06-20	National University Of Singapore	Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
CN112218658A (zh)	2018-03-12	2021-01-12	国家健康科学研究所	热量限制模拟物用于增强癌症治疗的化学免疫疗法的用途
CN108912095B (zh) *	2018-08-09	2019-08-20	广州安岩仁医药科技有限公司	苯并咪唑类化合物及其制备方法和应用
WO2020069117A1 (en) *	2018-09-27	2020-04-02	Dana-Farber Cancer Institute, Inc.	Degradation of fak or fak and alk by conjugation of fak and alk inhibitors with e3 ligase ligands and methods of use
US12194040B2 (en) *	2018-12-27	2025-01-14	Hinova Pharmaceuticals Inc.	FAK inhibitor and drug combination thereof
CN113811300B (zh) *	2019-03-15	2024-10-29	总医院公司	Tead转录因子的新型小分子抑制剂
CN113387947B (zh) *	2021-07-12	2022-07-01	中国科学院成都生物研究所	调节雌激素受体合成活性的吡唑并吡啶衍生物
TW202508595A (zh)	2023-05-04	2025-03-01	美商銳新醫藥公司	用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en)	2023-08-07	2025-02-13	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025080946A2 (en)	2023-10-12	2025-04-17	Revolution Medicines, Inc.	Ras inhibitors
WO2025171296A1 (en)	2024-02-09	2025-08-14	Revolution Medicines, Inc.	Ras inhibitors
WO2025240847A1 (en)	2024-05-17	2025-11-20	Revolution Medicines, Inc.	Ras inhibitors
WO2025255438A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en)	2024-06-21	2025-12-26	Revolution Medicines, Inc.	Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en)	2024-06-28	2026-01-02	Revolution Medicines, Inc.	Ras inhibitors
WO2026015801A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015796A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015790A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015825A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Use of ras inhibitor for treating pancreatic cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US166139A (en) *		1875-07-27		Improvement in dental pluggers
DE69928411D1 (de) *	1998-09-08	2005-12-22	Agouron Pharma	Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung
US7102009B2 (en) *	2001-01-12	2006-09-05	Amgen Inc.	Substituted amine derivatives and methods of use
EP2287156B1 (en) *	2003-08-15	2013-05-29	Novartis AG	2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
GB0419161D0 (en) *	2004-08-27	2004-09-29	Novartis Ag	Organic compounds
GB0419160D0 (en) *	2004-08-27	2004-09-29	Novartis Ag	Organic compounds
EP1746096A1 (en) *	2005-07-15	2007-01-24	4Sc Ag	2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
DK2134689T3 (da) *	2007-03-16	2014-06-30	Scripps Research Inst	Inhibitorer af fokal adhæsionskinase
JP2011512413A (ja) *	2008-02-19	2011-04-21	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	Ｆａｋの阻害剤としてのアニリノピリジン
WO2009153589A1 (en) *	2008-06-17	2009-12-23	Astrazeneca Ab	Pyridine compounds

2009
- 2009-10-25 JO JOP/2009/0395A patent/JO3067B1/ar active
- 2009-10-26 TW TW98136145A patent/TWI454467B/zh not_active IP Right Cessation
- 2009-10-26 UY UY32200A patent/UY32200A/es not_active Application Discontinuation
- 2009-10-27 US US12/606,390 patent/US20100113475A1/en not_active Abandoned
- 2009-10-27 CN CN2009801526261A patent/CN102264371B/zh active Active
- 2009-10-27 WO PCT/US2009/062163 patent/WO2010062578A1/en not_active Ceased
- 2009-10-27 SG SG2013079579A patent/SG195608A1/en unknown
- 2009-10-27 NZ NZ59247709A patent/NZ592477A/xx not_active IP Right Cessation
- 2009-10-27 PT PT98295801T patent/PT2421537E/pt unknown
- 2009-10-27 PE PE2011000920A patent/PE20110941A1/es not_active Application Discontinuation
- 2009-10-27 MY MYPI2011001828A patent/MY161890A/en unknown
- 2009-10-27 US US13/126,064 patent/US20110207743A1/en not_active Abandoned
- 2009-10-27 HR HRP20150531TT patent/HRP20150531T1/hr unknown
- 2009-10-27 EP EP20090829580 patent/EP2421537B1/en active Active
- 2009-10-27 MX MX2011004369A patent/MX2011004369A/es active IP Right Grant
- 2009-10-27 PL PL09829580T patent/PL2421537T3/pl unknown
- 2009-10-27 CA CA2741760A patent/CA2741760C/en active Active
- 2009-10-27 KR KR1020117011999A patent/KR101512217B1/ko not_active Expired - Fee Related
- 2009-10-27 DK DK09829580.1T patent/DK2421537T3/da active
- 2009-10-27 EA EA201170617A patent/EA021927B1/ru not_active IP Right Cessation
- 2009-10-27 AU AU2009320144A patent/AU2009320144B2/en not_active Ceased
- 2009-10-27 BR BRPI0920053A patent/BRPI0920053B8/pt active IP Right Grant
- 2009-10-27 RS RS20150365A patent/RS54045B1/sr unknown
- 2009-10-27 JP JP2011533421A patent/JP5642689B2/ja active Active
- 2009-10-27 SI SI200931192T patent/SI2421537T1/sl unknown
- 2009-10-27 ES ES09829580.1T patent/ES2539835T3/es active Active
- 2009-10-27 AR ARP090104137 patent/AR073993A1/es not_active Application Discontinuation
2011
- 2011-04-17 IL IL212444A patent/IL212444A/en not_active IP Right Cessation
- 2011-04-18 ZA ZA2011/02892A patent/ZA201102892B/en unknown
- 2011-04-22 MA MA33791A patent/MA32727B1/fr unknown
- 2011-04-26 CL CL2011000933A patent/CL2011000933A1/es unknown
- 2011-04-27 DO DO2011000113A patent/DOP2011000113A/es unknown
- 2011-04-29 US US13/097,271 patent/US20110269774A1/en not_active Abandoned
- 2011-05-11 CO CO11058067A patent/CO6361929A2/es active IP Right Grant
- 2011-05-17 CR CR20110264A patent/CR20110264A/es unknown
2013
- 2013-10-07 US US14/047,688 patent/US9012479B2/en active Active
2015
- 2015-03-30 US US14/672,477 patent/US20150265589A1/en not_active Abandoned
- 2015-05-22 CY CY20151100462T patent/CY1116399T1/el unknown
- 2015-07-03 SM SM201500157T patent/SMT201500157B/xx unknown
- 2015-10-20 US US14/887,763 patent/US9446034B2/en active Active

Also Published As

Publication number	Publication date
TW201028394A (en)	2010-08-01
AR073993A1 (es)	2010-12-15
EP2421537A1 (en)	2012-02-29
HRP20150531T1 (hr)	2015-06-19
EP2421537A4 (en)	2012-06-13
DOP2011000113A (es)	2011-07-15
BRPI0920053B8 (pt)	2021-05-25
AU2009320144A1 (en)	2010-06-03
CR20110264A (es)	2011-10-04
US20100113475A1 (en)	2010-05-06
ZA201102892B (en)	2012-02-29
CY1116399T1 (el)	2017-02-08
PT2421537E (pt)	2015-07-03
MX2011004369A (es)	2011-05-25
CN102264371B (zh)	2013-10-02
JP5642689B2 (ja)	2014-12-17
MA32727B1 (fr)	2011-10-02
US20150265589A1 (en)	2015-09-24
US20160095841A1 (en)	2016-04-07
US20140107131A1 (en)	2014-04-17
RS54045B1 (sr)	2015-10-30
CA2741760A1 (en)	2010-06-03
CA2741760C (en)	2016-02-23
US9446034B2 (en)	2016-09-20
JP2012506876A (ja)	2012-03-22
CO6361929A2 (es)	2012-01-20
CN102264371A (zh)	2011-11-30
KR101512217B1 (ko)	2015-04-15
AU2009320144B2 (en)	2013-11-21
US20110269774A1 (en)	2011-11-03
US20110207743A1 (en)	2011-08-25
KR20110080172A (ko)	2011-07-12
HK1161680A1 (en)	2012-08-03
ES2539835T3 (es)	2015-07-06
PL2421537T3 (pl)	2015-08-31
MY161890A (en)	2017-05-15
IL212444A0 (en)	2011-06-30
CL2011000933A1 (es)	2011-10-21
TWI454467B (zh)	2014-10-01
EP2421537B1 (en)	2015-04-08
EA201170617A1 (ru)	2011-12-30
SG195608A1 (en)	2013-12-30
DK2421537T3 (da)	2015-06-22
EA021927B1 (ru)	2015-09-30
NZ592477A (en)	2013-01-25
SMT201500157B (it)	2015-09-07
BRPI0920053B1 (pt)	2019-11-26
UY32200A (es)	2010-05-31
IL212444A (en)	2015-11-30
PE20110941A1 (es)	2012-02-08
WO2010062578A1 (en)	2010-06-03
US9012479B2 (en)	2015-04-21
JO3067B1 (ar)	2017-03-15
SI2421537T1 (sl)	2015-06-30

Publication	Publication Date	Title
BRPI0920053A2 (pt)	2015-12-15	pirazolilaminopiridinas como inibidores da fak
BRPI0913879A2 (pt)	2019-09-24	fenilpirazinonas como inibidores de quinase
BR112012000525A2 (pt)	2015-09-15	inibidores da bace
SMT201600307B (it)	2016-11-10	Composizione liposomiale
BRPI0922845A2 (pt)	2015-12-29	pirazol-4-n-alcoxicarboxamidas como microbiocidas
BRPI0920135A2 (pt)	2019-09-24	imidazopiridazinacarbonitrilos úteis como inibidores de quinase
BRPI1013588A2 (pt)	2016-04-19	composição
BRPI0811639A2 (pt)	2014-09-30	Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
BRPI1015474A2 (pt)	2016-04-26	composição
DK2349143T3 (da)	2013-08-12	Indføringsinstrument
BRPI0811044A2 (pt)	2014-12-09	2-morfolin-4-il-pirimidinas como inibidores de p13k.
BR112012005382A2 (pt)	2016-03-29	inibidores de jak
BR112012004964A2 (pt)	2016-04-05	girocóptero
BRPI1008070A2 (pt)	2016-03-15	tricianoboratos
DK2379722T3 (da)	2017-01-02	Ekspressionsvektor
BRPI1005290A2 (pt)	2016-03-22	composição
EP2394634A4 (en)	2012-08-29	COMPOSITION CONTAINING HESPERIDINE
EP2413905A4 (en)	2012-10-31	FORMULATION
BRPI0918062A2 (pt)	2015-08-11	Tienilaminopirimidinas como fungicidas
BR112012003616A2 (pt)	2016-02-23	metilpirroloprimidinacarboxamidas
DK2405753T3 (da)	2014-01-13	Insektfrastødende sammensætning
DK2501251T3 (da)	2013-11-25	Funktionel indersål
BRPI1005328A2 (pt)	2019-09-24	derivados de pirimidopiridazina úteis como inibidores de mapk p38
BRPI0924033A2 (pt)	2016-01-26	compostos heterocíclicos como inibidores de metap-2
FR2948536B1 (fr)	2016-09-23	Composition desinfectante

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-03-26	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-06-11	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-11-05	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-11-26	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/11/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/11/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF