IT1317031B1 - Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. - Google Patents

Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Info

Publication number: IT1317031B1
Authority: IT; Italy
Prior art keywords: preparation; androstane; dione; analogues; ethoxy
Prior art date: 2000-05-17

Application number

IT2000RM000266A

Other languages

English (en)

Inventor

Mauro Gobbini

Giulio Carzana

Simona Sputore

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2000-05-17

Publication date

2003-05-26

2000-05-17 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2000-05-17 Publication of ITRM20000266A0 publication Critical patent/ITRM20000266A0/it

2000-05-17 Priority to IT2000RM000266A priority Critical patent/IT1317031B1/it

2001-05-10 Priority to US09/852,265 priority patent/US6384250B2/en

2001-05-14 Priority to AT01830306T priority patent/ATE355296T1/de

2001-05-14 Priority to EP01830306A priority patent/EP1156058B1/en

2001-05-14 Priority to DK01830306T priority patent/DK1156058T3/da

2001-05-14 Priority to PT01830306T priority patent/PT1156058E/pt

2001-05-14 Priority to ES01830306T priority patent/ES2282225T3/es

2001-05-14 Priority to DE60126864T priority patent/DE60126864T2/de

2001-11-19 Publication of ITRM20000266A1 publication Critical patent/ITRM20000266A1/it

2003-05-26 Application granted granted Critical

2003-05-26 Publication of IT1317031B1 publication Critical patent/IT1317031B1/it

2007-05-09 Priority to CY20071100620T priority patent/CY1107662T1/el

Links

238000000034 method Methods 0.000 title abstract 2
-1 3- (2-AMINO-ETHOXY) -ANDROSTANE-6, 17-DIONE Chemical compound 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
MPYLDWFDPHRTEG-IFVNMTGRSA-N (5s,8r,9s,10r,13s,14s)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione Chemical compound C1C(=NOCCN)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=O)[C@H]21 MPYLDWFDPHRTEG-IFVNMTGRSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT2000RM000266A 2000-05-17 2000-05-17 Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. IT1317031B1 (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US09/852,265 US6384250B2 (en)	2000-05-17	2001-05-10	Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues
DK01830306T DK1156058T3 (da)	2000-05-17	2001-05-14	Fremgangsmåde til fremstilling af (E,Z) 3-(2-aminoethoxyimino)-androstan-6,17-dion og analoger deraf
EP01830306A EP1156058B1 (en)	2000-05-17	2001-05-14	Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione and its analogues
AT01830306T ATE355296T1 (de)	2000-05-17	2001-05-14	Verfahren zur herstellung von (e,z) 3-(2- aminoethoxyimino)-androstane-6,17-dione und analoge
PT01830306T PT1156058E (pt)	2000-05-17	2001-05-14	Processo para a preparação de ( e, z )-3- (2-aminoetoxi-imino )-androstano -6, 17- diona e dos seus análogos.
ES01830306T ES2282225T3 (es)	2000-05-17	2001-05-14	Proceso para la prepacion de (e,z) 3-(2-aminoetoxiimino)-androstane-6,17-diona y sus analogos.
DE60126864T DE60126864T2 (de)	2000-05-17	2001-05-14	Verfahren zur Herstellung von (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione und Analoge
CY20071100620T CY1107662T1 (el)	2000-05-17	2007-05-09	Μεθοδος παρασκευης της (ε, ζ) 3-(2-aminoethoxyimino)-androstane-6,17-dione και αναλογων της

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Publications (3)

Publication Number	Publication Date
ITRM20000266A0 ITRM20000266A0 (it)	2000-05-17
ITRM20000266A1 ITRM20000266A1 (it)	2001-11-19
IT1317031B1 true IT1317031B1 (it)	2003-05-26

Family

ID=11454735

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Country Status (9)

Country	Link
US (1)	US6384250B2 (it)
EP (1)	EP1156058B1 (it)
AT (1)	ATE355296T1 (it)
CY (1)	CY1107662T1 (it)
DE (1)	DE60126864T2 (it)
DK (1)	DK1156058T3 (it)
ES (1)	ES2282225T3 (it)
IT (1)	IT1317031B1 (it)
PT (1)	PT1156058E (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10174070B2 (en) *	2005-09-30	2019-01-08	Endece Llc	6-substituted estradiol derivatives and methods of use
US8168621B2 (en)	2005-09-30	2012-05-01	Endece, Llc	6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) *	2005-09-30	2008-05-22	James Yarger	6-alkoxyalkyl estradiol derivatives and methods of use
WO2008067450A2 (en)	2006-11-30	2008-06-05	Endece, Llc	6-alkoxyalkyl estradiol derivatives and methods of use
NZ584429A (en) *	2007-10-12	2011-08-26	Sigma Tau Ind Farmaceuti	Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
WO2010149666A1 (en)	2009-06-22	2010-12-29	Medexis S.A.	Methods for treating neoplasia
BR112013005843A2 (pt)	2010-09-14	2019-12-10	Endece Llc	derivativos de er-beta 6-substituído por desmetil-estradiol
CN103315968B (zh) *	2013-06-26	2015-04-01	中国生命药物治疗有限公司	一种注射用粉针剂及其制备方法
CN103360457B (zh) *	2013-07-31	2015-10-07	中国生命药物治疗有限公司	一种雄甾烷二酮衍生物晶型及其制备方法
JP7560134B2 (ja)	2019-03-05	2024-10-02	ウインドトゥリー・セラピューティクス・インコーポレイテッド	急性心不全（ａｈｆ）の治療のためのイスタロキシム含有静脈用製剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19633349A1 (de) *	1996-08-19	1998-02-26	Sigma Tau Ind Farmaceuti	Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

2000
- 2000-05-17 IT IT2000RM000266A patent/IT1317031B1/it active
2001
- 2001-05-10 US US09/852,265 patent/US6384250B2/en not_active Expired - Lifetime
- 2001-05-14 AT AT01830306T patent/ATE355296T1/de active
- 2001-05-14 PT PT01830306T patent/PT1156058E/pt unknown
- 2001-05-14 EP EP01830306A patent/EP1156058B1/en not_active Expired - Lifetime
- 2001-05-14 DE DE60126864T patent/DE60126864T2/de not_active Expired - Lifetime
- 2001-05-14 ES ES01830306T patent/ES2282225T3/es not_active Expired - Lifetime
- 2001-05-14 DK DK01830306T patent/DK1156058T3/da active
2007
- 2007-05-09 CY CY20071100620T patent/CY1107662T1/el unknown

Also Published As

Publication number	Publication date
DK1156058T3 (da)	2007-06-18
ATE355296T1 (de)	2006-03-15
EP1156058A2 (en)	2001-11-21
PT1156058E (pt)	2007-05-31
US20010056182A1 (en)	2001-12-27
ES2282225T3 (es)	2007-10-16
EP1156058B1 (en)	2007-02-28
DE60126864D1 (de)	2007-04-12
CY1107662T1 (el)	2013-04-18
ITRM20000266A0 (it)	2000-05-17
DE60126864T2 (de)	2007-09-06
EP1156058A3 (en)	2005-06-08
ITRM20000266A1 (it)	2001-11-19
US6384250B2 (en)	2002-05-07

Publication	Publication Date	Title
ZA200309887B (en)	2004-07-20	Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
PT931788E (pt)	2003-01-31	Inibidores de metaloprotease
NO20034011L (no)	2003-11-12	Steroider som agonister for FXR
ES2172864T3 (es)	2002-10-01	2-metoxibenzofenonas fungicidas.
CY1107662T1 (el)	2013-04-18	Μεθοδος παρασκευης της (ε, ζ) 3-(2-aminoethoxyimino)-androstane-6,17-dione και αναλογων της
DE69920923D1 (de)	2004-11-11	Anthranilsäurederivate
NO995963D0 (no)	1999-12-03	Karboksamider anvendelige som 5-HTIF-agonister
EA199900798A1 (ru)	2000-04-24	Соединения
TR200402546T4 (tr)	2004-12-21	Taksan türevleri hazırlamak için işlem.
BR9713176A (pt)	2000-02-08	Benzotiofenos amorfos,métodos de preparação e métodos de uso
WO2003018565A8 (en)	2003-08-07	Method for synthesizing oxazinones
DK1619185T3 (da)	2011-07-18	4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf
AU2002342498A1 (en)	2003-06-17	Organic compounds
PL349933A1 (en)	2002-05-06	Novel compounds beta-hydroxyalylamides, method of obtaining them and their application
BR9902096A (pt)	2000-04-11	Pitazóis.
ATE282608T1 (de)	2004-12-15	Chinoxalindionen
CO5160345A1 (es)	2002-05-30	Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona
PT1004241E (pt)	2004-09-30	Agentes insecticidas e acaricidas de 2-aril-delta 2-1,3,4-(oxa e tia) diazolina
DK1392672T3 (da)	2005-08-29	Chlormethylering af thiopen
DE60039695D1 (de)	2008-09-11	Antifucoidan antikörper
BR0210201A (pt)	2004-06-08	Composição
PL366546A1 (en)	2005-02-07	Sulfate of cephem compound
BR0013100A (pt)	2002-04-30	Processo para a preparação de um composto de 2-arilvinil alquil éter
DE69915688D1 (de)	2004-05-13	Benzonaphtyridin-1,8 derivate
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων