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IT1273391B - Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono - Google Patents

Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono

Info

Publication number
IT1273391B
IT1273391B ITMI940610A ITMI940610A IT1273391B IT 1273391 B IT1273391 B IT 1273391B IT MI940610 A ITMI940610 A IT MI940610A IT MI940610 A ITMI940610 A IT MI940610A IT 1273391 B IT1273391 B IT 1273391B
Authority
IT
Italy
Prior art keywords
platino
contain
pharmaceutical compositions
pct
cationic complexes
Prior art date
Application number
ITMI940610A
Other languages
English (en)
Inventor
Mariella Valsecchi
Marco Conti
Greco Luisa Del
Carlo Bugatti
Ernesto Menta
Ferdinando Giuliani
Carla Manzotti
Silvano Spinelli
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ITMI940610A0 publication Critical patent/ITMI940610A0/it
Priority to ITMI940610A priority Critical patent/IT1273391B/it
Priority to CZ19962849A priority patent/CZ286404B6/cs
Priority to AU21109/95A priority patent/AU682105B2/en
Priority to CA002186731A priority patent/CA2186731C/en
Priority to NZ283143A priority patent/NZ283143A/en
Priority to AT95930319T priority patent/ATE176478T1/de
Priority to RU96119798A priority patent/RU2130941C1/ru
Priority to DE69507694T priority patent/DE69507694T2/de
Priority to JP7525386A priority patent/JP2761297B2/ja
Priority to US08/714,083 priority patent/US5744497A/en
Priority to HU9602663A priority patent/HU215129B/hu
Priority to ES95930319T priority patent/ES2129847T3/es
Priority to CN95192295A priority patent/CN1065537C/zh
Priority to EP95930319A priority patent/EP0753000B1/en
Priority to DK95930319T priority patent/DK0753000T3/da
Priority to KR1019960705451A priority patent/KR100239787B1/ko
Priority to PCT/EP1995/001074 priority patent/WO1995026968A1/en
Priority to ZA952636A priority patent/ZA952636B/xx
Publication of ITMI940610A1 publication Critical patent/ITMI940610A1/it
Priority to NO963926A priority patent/NO308078B1/no
Priority to FI963859A priority patent/FI116058B/fi
Application granted granted Critical
Publication of IT1273391B publication Critical patent/IT1273391B/it
Priority to GR990401125T priority patent/GR3030048T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ITMI940610A 1994-03-31 1994-03-31 Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono IT1273391B (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
ITMI940610A IT1273391B (it) 1994-03-31 1994-03-31 Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
HU9602663A HU215129B (hu) 1994-03-31 1995-03-22 Daganatellenes hatású, trinukleáris kationos platinakomplexek, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
CN95192295A CN1065537C (zh) 1994-03-31 1995-03-22 具有抗肿瘤活性的三核阳离子铂络合物及含有它们的药用组合物
CA002186731A CA2186731C (en) 1994-03-31 1995-03-22 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
NZ283143A NZ283143A (en) 1994-03-31 1995-03-22 Tri-platinum amine cationic complexes; antitumour pharmaceuticals
AT95930319T ATE176478T1 (de) 1994-03-31 1995-03-22 Trinukleare kationische platinkomplexe mit antitumor wirkung sowie diese enthaltende pharmazeutische zusammensetzungen
RU96119798A RU2130941C1 (ru) 1994-03-31 1995-03-22 Трехъядерные катионные комплексы платины, проявляющие противоопухолевую активность, способ их получения и фармацевтические композиции, содержащие эти комплексы
DE69507694T DE69507694T2 (de) 1994-03-31 1995-03-22 Trinukleare kationische platinkomplexe mit antitumor wirkung sowie diese enthaltende pharmazeutische zusammensetzungen
JP7525386A JP2761297B2 (ja) 1994-03-31 1995-03-22 抗腫瘍活性を有する三核カチオン性プラチナ錯体、及びこれを含有する医薬組成物
US08/714,083 US5744497A (en) 1994-03-31 1995-03-22 Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them
CZ19962849A CZ286404B6 (en) 1994-03-31 1995-03-22 Platinum complex compounds, process of their preparation and pharmaceutical preparation containing thereof
ES95930319T ES2129847T3 (es) 1994-03-31 1995-03-22 Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen.
AU21109/95A AU682105B2 (en) 1994-03-31 1995-03-22 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
EP95930319A EP0753000B1 (en) 1994-03-31 1995-03-22 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
DK95930319T DK0753000T3 (da) 1994-03-31 1995-03-22 Trinukleare kationiske platinkomplekser med antitumoraktivitet og farmaceutiske præparater indeholdende dem
KR1019960705451A KR100239787B1 (ko) 1994-03-31 1995-03-22 항종양 활성을 지니는 삼핵의 양이온성 백금 착물 및 이를 포함하는 약학적 조성물
PCT/EP1995/001074 WO1995026968A1 (en) 1994-03-31 1995-03-22 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
ZA952636A ZA952636B (en) 1994-03-31 1995-03-30 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
NO963926A NO308078B1 (no) 1994-03-31 1996-09-19 Trinukleære kationiske platinakomplekser med antitumoraktivitet og farmasøytiske sammensetninger inneholdende dem
FI963859A FI116058B (fi) 1994-03-31 1996-09-27 Kolme ydintä käsittävät kationiset platinakompleksit, joilla on kasvaimenvastainen vaikutus, sekä niitä sisältävät farmaseuttiset koostumukset
GR990401125T GR3030048T3 (en) 1994-03-31 1999-04-26 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940610A IT1273391B (it) 1994-03-31 1994-03-31 Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
ITMI940610A0 ITMI940610A0 (it) 1994-03-31
ITMI940610A1 ITMI940610A1 (it) 1995-10-01
IT1273391B true IT1273391B (it) 1997-07-08

Family

ID=11368427

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940610A IT1273391B (it) 1994-03-31 1994-03-31 Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono

Country Status (21)

Country Link
US (1) US5744497A (it)
EP (1) EP0753000B1 (it)
JP (1) JP2761297B2 (it)
KR (1) KR100239787B1 (it)
CN (1) CN1065537C (it)
AT (1) ATE176478T1 (it)
AU (1) AU682105B2 (it)
CA (1) CA2186731C (it)
CZ (1) CZ286404B6 (it)
DE (1) DE69507694T2 (it)
DK (1) DK0753000T3 (it)
ES (1) ES2129847T3 (it)
FI (1) FI116058B (it)
GR (1) GR3030048T3 (it)
HU (1) HU215129B (it)
IT (1) IT1273391B (it)
NO (1) NO308078B1 (it)
NZ (1) NZ283143A (it)
RU (1) RU2130941C1 (it)
WO (1) WO1995026968A1 (it)
ZA (1) ZA952636B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
IT1271089B (it) * 1994-11-24 1997-05-26 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
IT1292481B1 (it) * 1997-07-04 1999-02-08 Boehringer Mannheim Italia Platino complessi cationici tetra- e penta-nucleari ad attivita' antitumorale
KR100314720B1 (ko) * 1999-03-26 2001-11-26 박호군 포스파젠 삼합체에 도입된 백금 착물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
EP1215199A1 (en) * 2000-12-08 2002-06-19 Sony International (Europe) GmbH Linker molecules for selective metallisation of nucleic acids and their uses
JP4007000B2 (ja) * 2001-12-25 2007-11-14 富士ゼロックス株式会社 導電性有機高分子
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2006090931A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物の抗癌剤との新規併用
CN102516315B (zh) * 2011-12-12 2014-12-10 中山大学 一种具有y型结构的三核铂配合物及其对人胃腺癌细胞的靶向性
RU2613513C2 (ru) * 2015-07-17 2017-03-16 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения комплексов платины (IV) с аминонитроксильными радикалами
RU2726826C2 (ru) * 2016-12-27 2020-07-15 Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей
CN109988185B (zh) * 2019-05-09 2021-03-19 邵阳学院 具有抗肿瘤选择性的铂镝杂金属化合物及其制备方法
WO2021083358A1 (zh) 2019-10-31 2021-05-06 中国石油化工股份有限公司 用于制备烯烃-极性单体共聚物的方法
CN112745426B (zh) * 2019-10-31 2022-03-01 中国石油化工股份有限公司 用于制备烯烃-烯烃醇共聚物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364072A (en) * 1978-03-17 1982-12-14 Zaidan Hojin Handotai Kenkyu Shinkokai Static induction type semiconductor device with multiple doped layers for potential modification
SU1570649A3 (ru) * 1984-09-12 1990-06-07 Чугаи Сейяку Кабусики Кайся (Фирма) Способ получени комплексных соединений платины
US5107007A (en) * 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
EP0265719B1 (en) * 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
US5049686A (en) * 1989-09-13 1991-09-17 Warner-Lambert Company Novel large-ring diamine platinum(II) and platinum(IV) chelates
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes

Also Published As

Publication number Publication date
CA2186731C (en) 2005-06-07
KR100239787B1 (ko) 2000-02-01
AU2110995A (en) 1995-10-23
CN1065537C (zh) 2001-05-09
ZA952636B (en) 1996-01-02
HU9602663D0 (en) 1996-11-28
EP0753000B1 (en) 1999-02-03
GR3030048T3 (en) 1999-07-30
NO308078B1 (no) 2000-07-17
AU682105B2 (en) 1997-09-18
DK0753000T3 (da) 1999-09-20
FI963859A0 (fi) 1996-09-27
JP2761297B2 (ja) 1998-06-04
FI963859L (fi) 1996-09-27
CZ284996A3 (en) 1997-04-16
CA2186731A1 (en) 1995-10-12
ATE176478T1 (de) 1999-02-15
DE69507694T2 (de) 1999-07-22
NZ283143A (en) 1997-09-22
WO1995026968A1 (en) 1995-10-12
RU2130941C1 (ru) 1999-05-27
HU215129B (hu) 1998-09-28
NO963926D0 (no) 1996-09-19
HUT76293A (en) 1997-07-28
ITMI940610A0 (it) 1994-03-31
DE69507694D1 (de) 1999-03-18
ES2129847T3 (es) 1999-06-16
EP0753000A1 (en) 1997-01-15
FI116058B (fi) 2005-09-15
KR970702287A (ko) 1997-05-13
ITMI940610A1 (it) 1995-10-01
CZ286404B6 (en) 2000-04-12
CN1145624A (zh) 1997-03-19
US5744497A (en) 1998-04-28
NO963926L (no) 1996-09-19
JPH09506633A (ja) 1997-06-30

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970329