IT1249711B - Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. - Google Patents
Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali.Info
- Publication number
- IT1249711B IT1249711B ITRM910730A ITRM910730A IT1249711B IT 1249711 B IT1249711 B IT 1249711B IT RM910730 A ITRM910730 A IT RM910730A IT RM910730 A ITRM910730 A IT RM910730A IT 1249711 B IT1249711 B IT 1249711B
- Authority
- IT
- Italy
- Prior art keywords
- action
- scavengers
- pharmaceutical compositions
- indicated
- therapy
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 2
- 239000001301 oxygen Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 238000005502 peroxidation Methods 0.000 abstract 3
- 210000001539 phagocyte Anatomy 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010048768 Dermatosis Diseases 0.000 abstract 1
- 206010051814 Eschar Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000004210 Pressure Ulcer Diseases 0.000 abstract 1
- 208000002847 Surgical Wound Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 230000033077 cellular process Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 231100000333 eschar Toxicity 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 206010040872 skin infection Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229930003799 tocopherol Natural products 0.000 abstract 1
- 239000011732 tocopherol Substances 0.000 abstract 1
- 235000019149 tocopherols Nutrition 0.000 abstract 1
- 239000003440 toxic substance Substances 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
E' noto che i radicali liberi dell'ossigeno, tramite reazioni di perossidazione, risultano altamente aggressivi verso le membrane cellulari i che detti radicali di formano "in vivo" sia nello svolgimento dei normali processi cellulari, sia principalmente per l'azione delle cellule fagocitiche sicuramente presenti, in ogni stato infiammatorio, acuto o cronico.E' anche noto che un certo numero di sostanze agiscono da inibitori e "scavengers", bloccando le reazioni di perossidazione.Oggetto della presente invenzione sono composizioni farmaceutiche che presentano le seguenti caratteristiche:a) azione di inibizione sulle reazioni di perossidazione da radicali liberi che si sviluppa mediante due meccanismi di azione diversi e complementari relativi a due "scavengers" opportunamente scelti e associati (tocoferoli + chelante);b) azione sinergica tra i due componenti dovuta a effetto protettivo;c) azione antisettica, assicurata da un antimicrobico, per impedire la formazione di flogosi da proliferazione batterica e inibire l'attivazione dei fagociti da parte dei batteri stessi;d) uso topico per ottenere elevate concentrazioni dei principi attivi nei tessuti bersaglio e trascurabile tossicità, anche per sostanze tossiche per via sistematica.Le composizioni sopra citate sono indicate nella terapia topica di ulcere, escare, piaghe atone e da decubito, piccole ferite accidentali e chirurgiche, ustioni, infezioni cutanee, dermatosi.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910730A IT1249711B (it) | 1991-09-30 | 1991-09-30 | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. |
| DE69227745T DE69227745T2 (de) | 1991-09-30 | 1992-09-16 | Pharmazeutische Zusammensetzungen zur topischen Anwendung die ein Chelatierungsmittel, ein Tocopherol und einen antimikrobiellen Wirkstoff enthalten |
| EP92115818A EP0535446B1 (en) | 1991-09-30 | 1992-09-16 | Pharmaceutical compositions for topical use containing a chelating agent, a tocopheral and an antimicrobial agent |
| AT92115818T ATE173930T1 (de) | 1991-09-30 | 1992-09-16 | Pharmazeutische zusammensetzungen zur topischen anwendung die ein chelatierungsmittel, ein tocopherol und einen antimikrobiellen wirkstoff enthalten |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910730A IT1249711B (it) | 1991-09-30 | 1991-09-30 | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM910730A0 ITRM910730A0 (it) | 1991-09-30 |
| ITRM910730A1 ITRM910730A1 (it) | 1993-03-30 |
| IT1249711B true IT1249711B (it) | 1995-03-09 |
Family
ID=11400382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM910730A IT1249711B (it) | 1991-09-30 | 1991-09-30 | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0535446B1 (it) |
| AT (1) | ATE173930T1 (it) |
| DE (1) | DE69227745T2 (it) |
| IT (1) | IT1249711B (it) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717079B1 (fr) * | 1994-03-11 | 1996-04-12 | Oreal | Composition contenant un oxyde de métal non photocatalytique et du tocophérol, son utilisation dans le domaine cosmétique et/ou dermatologique et procédés la mettant en Óoeuvre. |
| KR0163563B1 (ko) * | 1994-03-23 | 1998-12-01 | 김종인 | 피부질환 치료용 의약조성물 |
| FR2738487B1 (fr) * | 1995-09-11 | 1997-11-28 | Medix Lab | Composition dermatologique antiseptique et son procede de fabrication |
| ITMI981586A1 (it) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
| FR2809310B1 (fr) | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
| DE10104847B4 (de) * | 2000-06-09 | 2006-12-21 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Tocopherol-Konzentrat und Verfahren zu seiner Herstellung |
| FR2825920B1 (fr) * | 2001-06-15 | 2006-04-28 | Oreal | Desferal comme inhibiteur de no-synthase et utilisations |
| CZ295826B6 (cs) * | 2003-04-28 | 2005-11-16 | Ústav Makromolekulární Chemie Av Čr | Materiál pro krytí ran obsahující lapače radikálů |
| WO2009145619A1 (en) * | 2008-04-17 | 2009-12-03 | Prosensa Holding Bv | Antibiotic composition |
| JP6266510B2 (ja) * | 2011-06-08 | 2018-01-24 | キレーション パートナーズ インコーポレイテッド | 生きている細胞または生物体の増殖または活性を制御するための金属キレート組成物および方法 |
| US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
| SG11202111349QA (en) | 2019-04-12 | 2021-11-29 | Geltor Inc | Recombinant elastin and production thereof |
-
1991
- 1991-09-30 IT ITRM910730A patent/IT1249711B/it active IP Right Grant
-
1992
- 1992-09-16 EP EP92115818A patent/EP0535446B1/en not_active Expired - Lifetime
- 1992-09-16 DE DE69227745T patent/DE69227745T2/de not_active Expired - Fee Related
- 1992-09-16 AT AT92115818T patent/ATE173930T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0535446A1 (en) | 1993-04-07 |
| DE69227745D1 (de) | 1999-01-14 |
| ITRM910730A0 (it) | 1991-09-30 |
| EP0535446B1 (en) | 1998-12-02 |
| ITRM910730A1 (it) | 1993-03-30 |
| ATE173930T1 (de) | 1998-12-15 |
| DE69227745T2 (de) | 1999-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Barraud et al. | Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases | |
| ES2810158T3 (es) | Composiciones biocidas y métodos para usarlas | |
| EP2693884B1 (en) | Antimicrobial composition comprising silver ions, a quaternary cationic surfactant and an edta salt | |
| IT1249711B (it) | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" di radicali liberi dell'ossigeno e antibatterici,indicate nella terapia dei tessuti superficiali. | |
| HK1246086A1 (en) | Antimicrobial compositions | |
| DE69332204D1 (de) | Minocyclin und EDTA enthaltende Beschichtungszusammensetzung für Medizinische Geräte | |
| DE69942977D1 (de) | Pharmazeutische zusammenstellungen zur behandlung von hautzuständen | |
| AR029226A1 (es) | Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales | |
| US20080020025A1 (en) | Composition for wound care and method of using same | |
| BR0311460A (pt) | Composição farmacêutica de liberação modificada, uso de uma formulação, e, método para tratar um distúrbio cardiovascular em um paciente | |
| DK0868909T3 (da) | Opthalmisk bæreropløsning | |
| AU2010328283A1 (en) | Inhibiting bacterial infection and biofilm formation | |
| ES2836299T3 (es) | Composiciones antimicrobianas | |
| PA8485601A1 (es) | Azalidas de 13 miembros y su uso como agentes antibioticos. | |
| Pona et al. | Review of the use of gentian violet in dermatology practice | |
| IT1256702B (it) | Formulazione proteica coadiuvante nella prevenzione e cura delle parodontiti e di altre patologie batteriche del cavo orale. | |
| DE50109650D1 (de) | Topische behandlung bei der mastalgie | |
| ATE108655T1 (de) | Topisch angebrachter goldorganokomplex. | |
| US4535078A (en) | Antibacterial composition comprising silver sulfadiazine and sodium piperacillin | |
| ES2059204T3 (es) | Derivados del acido hidroxamico inhibidores de lipoxigenasa. | |
| SE0000307D0 (sv) | Method and formulation för treatment of vasoconstriction | |
| Kaye et al. | Topical antibacterial agents | |
| BR0014751A (pt) | Composto, estereoisÈmero ou mistura de estereoisÈmeros, composição farmacêutica, método de tratamento de um paciente em necessidade de tratamento antimicrobiano, e, uso de um composto | |
| TR199801835A2 (xx) | Antimikrobiyal kompozisyonlar. | |
| JP4022432B2 (ja) | 消毒剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960925 |