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IT1199871B - Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento - Google Patents

Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento

Info

Publication number
IT1199871B
IT1199871B IT67297/85A IT6729785A IT1199871B IT 1199871 B IT1199871 B IT 1199871B IT 67297/85 A IT67297/85 A IT 67297/85A IT 6729785 A IT6729785 A IT 6729785A IT 1199871 B IT1199871 B IT 1199871B
Authority
IT
Italy
Prior art keywords
procedure
morfina
noroxymorphone
preparation
intermediate compounds
Prior art date
Application number
IT67297/85A
Other languages
English (en)
Other versions
IT8567297A0 (it
IT8567297A1 (it
Inventor
A Wallace Rebecca
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of IT8567297A0 publication Critical patent/IT8567297A0/it
Publication of IT8567297A1 publication Critical patent/IT8567297A1/it
Application granted granted Critical
Publication of IT1199871B publication Critical patent/IT1199871B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT67297/85A 1984-03-27 1985-03-26 Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento IT1199871B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59374484A 1984-03-27 1984-03-27
US71393285A 1985-03-20 1985-03-20

Publications (3)

Publication Number Publication Date
IT8567297A0 IT8567297A0 (it) 1985-03-26
IT8567297A1 IT8567297A1 (it) 1986-09-26
IT1199871B true IT1199871B (it) 1989-01-05

Family

ID=27081787

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67297/85A IT1199871B (it) 1984-03-27 1985-03-26 Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento

Country Status (6)

Country Link
EP (1) EP0158476B1 (it)
JP (1) JPH0651705B2 (it)
DE (1) DE3581423D1 (it)
ES (1) ES8606356A1 (it)
FR (1) FR2562072B1 (it)
IT (1) IT1199871B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
PL368732A1 (en) 2001-08-23 2005-04-04 Akzo Nobel N.V. C-14 oxidation of morphine derivatives
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
US8067597B2 (en) * 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
EP2222642B1 (en) * 2007-12-17 2014-02-12 Mallinckrodt LLC Process and compounds for the production of (+) opiates
EP2222643B1 (en) * 2007-12-17 2019-03-20 SpecGx LLC Sinomenine derivatives and processes for their synthesis
CA2709872C (en) * 2007-12-17 2016-06-14 Peter X. Wang Processes for the preparation of normorphinan salts
CA2709886C (en) 2007-12-17 2016-10-25 Mallinckrodt Inc. Processes for the production of (+)-"nal" morphinan compounds
EP2262813A4 (en) * 2008-03-31 2011-10-12 Sun Pharmaceutical Ind Ltd IMPROVED PROCESS FOR THE PREPARATION OF MORPHINANE ANALOGS
ES2549904T3 (es) * 2008-05-27 2015-11-03 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
WO2011154827A2 (en) * 2010-06-11 2011-12-15 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
PL2753622T3 (pl) 2011-09-08 2016-07-29 SpecGx LLC Wytwarzanie alkaloidów bez oddzielania związków pośrednich
EP2829541A1 (en) 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
JP7773548B2 (ja) * 2020-12-28 2025-11-19 ナヴィン サクセナ リサーチ アンド テクノロジー ピーブイティー．エルティーディー． モルヒネからのノルオキシモルフォンの合成のための新規方法
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE408870C (de) * 1923-09-11 1925-01-24 Merck Chem Fab E Verfahren zur Darstellung von Kodeienon
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
EP0158476B1 (en) 1991-01-23
FR2562072A1 (fr) 1985-10-04
IT8567297A0 (it) 1985-03-26
DE3581423D1 (de) 1991-02-28
JPH0651705B2 (ja) 1994-07-06
ES8606356A1 (es) 1986-04-01
EP0158476A1 (en) 1985-10-16
ES541631A0 (es) 1986-04-01
FR2562072B1 (fr) 1989-07-07
IT8567297A1 (it) 1986-09-26
JPS60252481A (ja) 1985-12-13

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980327