IS2339B - Kristallað tíótrópíumbrómíðmónóhýdrat, aðferð viðað framleiða það og notkun þess í framleiðslu á lyfi - Google Patents

Kristallað tíótrópíumbrómíðmónóhýdrat, aðferð viðað framleiða það og notkun þess í framleiðslu á lyfi

Info

Publication number: IS2339B
Authority: IS; Iceland
Prior art keywords: manufacture; medicament; tiotropium bromide; bromide monohydrate; crystalline tiotropium
Prior art date: 2000-10-12

Application number

IS6772A

Other languages

English (en)

Other versions

IS6772A (is

Inventor

Banholzer Rolf

Sieger Peter

Kulinna Christian

Trunk Michael

Ludwig August Graulich Manfred

Specht Peter

Meissner Helmut

Mathes Andreas

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2003-04-09

Publication date

2008-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS2339(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-09 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg

2003-04-09 Publication of IS6772A publication Critical patent/IS6772A/is

2008-02-15 Publication of IS2339B publication Critical patent/IS2339B/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IS6772A 2000-10-12 2003-04-09 Kristallað tíótrópíumbrómíðmónóhýdrat, aðferð viðað framleiða það og notkun þess í framleiðslu á lyfi IS2339B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (de)	2000-10-12	2001-09-28	Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number	Publication Date
IS6772A IS6772A (is)	2003-04-09
IS2339B true IS2339B (is)	2008-02-15

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6772A IS2339B (is)	2000-10-12	2003-04-09	Kristallað tíótrópíumbrómíðmónóhýdrat, aðferð viðað framleiða það og notkun þess í framleiðslu á lyfi

Country Status (46)

Country	Link
EP (2)	EP1326862B1 (is)
JP (1)	JP3764422B2 (is)
KR (1)	KR100823860B1 (is)
CN (2)	CN100519558C (is)
AP (1)	AP1572A (is)
AR (2)	AR034389A1 (is)
AT (1)	ATE276253T1 (is)
AU (2)	AU2002214996B2 (is)
BG (1)	BG66161B1 (is)
BR (1)	BR0114584A (is)
CA (1)	CA2425539C (is)
CR (1)	CR6938A (is)
CZ (1)	CZ301841B6 (is)
DE (1)	DE50103666D1 (is)
DK (1)	DK1326862T3 (is)
DZ (1)	DZ3478A1 (is)
EA (1)	EA004381B1 (is)
EC (1)	ECSP034540A (is)
EE (1)	EE04567B1 (is)
EG (1)	EG24142A (is)
ES (1)	ES2228965T3 (is)
GE (1)	GEP20063905B (is)
HR (1)	HRP20030276B1 (is)
HU (1)	HU226830B1 (is)
IL (2)	IL155335A0 (is)
IS (1)	IS2339B (is)
MA (1)	MA25842A1 (is)
ME (2)	ME00243B (is)
MX (1)	MXPA03003221A (is)
MY (1)	MY126931A (is)
NO (1)	NO328465B1 (is)
NZ (1)	NZ525733A (is)
OA (1)	OA12403A (is)
PE (1)	PE20020422A1 (is)
PL (1)	PL207870B1 (is)
PT (1)	PT1326862E (is)
RS (1)	RS50218B (is)
SA (1)	SA01220412B1 (is)
SI (1)	SI1326862T1 (is)
SK (1)	SK287009B6 (is)
TR (1)	TR200402579T4 (is)
TW (1)	TW589313B (is)
UA (1)	UA74215C2 (is)
UY (2)	UY26962A1 (is)
WO (1)	WO2002030928A1 (is)
ZA (1)	ZA200302500B (is)

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US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
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US7311894B2 (en)	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
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DE10214263A1 (de) *	2002-03-28	2003-10-16	Boehringer Ingelheim Pharma	HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
JP4553902B2 (ja) *	2003-11-03	2010-09-29	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	抗コリン作用を有する新規結晶性無水物
US8686148B2 (en) *	2003-11-03	2014-04-01	Boehringer Ingelheim International Gmbh	Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof
PE20050485A1 (es) *	2003-11-03	2005-10-05	Boehringer Ingelheim Int	Nuevas sales de tiotropio, procedimiento para su preparacion, asi como formulaciones medicamentosas que las contienen
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
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DE102004048389A1 (de)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
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JP2008532973A (ja) *	2005-03-09	2008-08-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	抗コリン作用薬とｐｄｅ５−阻害剤に基づく新規な医薬組成物
EA013239B1 (ru)	2005-04-28	2010-04-30	Бёрингер Ингельхайм Интернациональ Гмбх	Новые соединения для лечения воспалительных заболеваний
WO2006117299A2 (en)	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Novel crystalline forms of tiotropium bromide
CA2606552A1 (en) *	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Crystalline forms of tiotropium bromide
AU2006259202B2 (en) *	2005-06-15	2012-05-10	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
CA2617717C (en) *	2005-08-06	2014-02-11	Boehringer Ingelheim International Gmbh	Use of tiotropium salts in the treatment of severe persistant asthma
MX2008001976A (es)	2005-08-15	2008-03-25	Boehringer Ingelheim Int	Procedimiento para la preparacion de betamimeticos.
US20070086957A1 (en)	2005-10-10	2007-04-19	Thierry Bouyssou	Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) *	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
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EP2201934A1 (en)	2008-12-23	2010-06-30	CHIESI FARMACEUTICI S.p.A.	Tiotropium aerosol formulation products with improved chemical stability
WO2010101538A2 (en)	2009-03-06	2010-09-10	Bilgic Mahmut	New crystal forms
US8697719B2 (en)	2009-08-07	2014-04-15	Generics [Uk] Limited	Anhydrate of tiotropium bromide
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US20130143905A1 (en)	2009-12-17	2013-06-06	Boehringer Ingelheim International Gmbh	Novel antagonists for ccr2 and uses thereof
EA201201052A1 (ru)	2010-01-29	2013-02-28	Бёрингер Ингельхайм Интернациональ Гмбх	Замещенные нафтиридины и их применение в качестве ингибиторов киназы syk
EP2569298B1 (en)	2010-05-12	2015-11-25	Boehringer Ingelheim International GmbH	Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (ja)	2010-05-12	2014-12-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用
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WO2012101013A1 (en)	2011-01-28	2012-08-02	Boehringer Ingelheim International Gmbh	Substituted pyridinyl-pyrimidines and their use as medicaments
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EP2721025B1 (en)	2011-06-16	2015-11-25	Boehringer Ingelheim International Gmbh	New selective ccr2 antagonists
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JP5860960B2 (ja)	2011-07-26	2016-02-16	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	置換キノリン類及び医薬としてのそれらの使用
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JP6416275B2 (ja)	2014-03-19	2018-10-31	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ヘテロアリールｓｙｋ阻害剤
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RU2567539C1 (ru) *	2015-02-04	2015-11-10	Индивидуальный предприниматель Михайлов Олег Ростиславович	КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
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2001
- 2001-09-28 EP EP01983510A patent/EP1326862B1/de not_active Expired - Lifetime
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt not_active Application Discontinuation
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/zh not_active Ceased
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 DK DK01983510T patent/DK1326862T3/da active
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/ko not_active Expired - Lifetime
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/xx unknown
- 2001-09-28 ES ES01983510T patent/ES2228965T3/es not_active Expired - Lifetime
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/es active IP Right Grant
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/me unknown
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/fr active
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/xx unknown
- 2001-09-28 SI SI200130219T patent/SI1326862T1/xx unknown
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 EA EA200300457A patent/EA004381B1/ru not_active IP Right Cessation
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 HU HU0301022A patent/HU226830B1/hu unknown
- 2001-09-28 AT AT01983510T patent/ATE276253T1/de active
- 2001-09-28 RS YU27303A patent/RS50218B/sr unknown
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de not_active Ceased
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active
- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
- 2001-09-28 PL PL366041A patent/PL207870B1/pl unknown
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 SK SK436-2003A patent/SK287009B6/sk not_active IP Right Cessation
- 2001-09-28 EE EEP200300171A patent/EE04567B1/xx unknown
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/ja not_active Expired - Lifetime
- 2001-09-28 DE DE50103666T patent/DE50103666D1/de not_active Expired - Lifetime
- 2001-09-28 OA OA1200300107A patent/OA12403A/fr unknown
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/cs not_active IP Right Cessation
- 2001-10-02 SA SA01220412A patent/SA01220412B1/ar unknown
- 2001-10-09 TW TW090124963A patent/TW589313B/zh active
- 2001-10-09 EG EG20011058A patent/EG24142A/xx active
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/es active IP Right Grant
- 2001-10-10 UY UY26962A patent/UY26962A1/es not_active Application Discontinuation
- 2001-10-12 AR ARP010104782A patent/AR034389A1/es active IP Right Grant
2003
- 2003-03-26 CR CR6938A patent/CR6938A/es unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/bg unknown
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/es unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/fr unknown
- 2003-04-09 IS IS6772A patent/IS2339B/is unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/no not_active IP Right Cessation
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/es unknown
2013
- 2013-07-11 UY UY34901A patent/UY34901A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2228965T3 (es)	2005-04-16
CN1469877A (zh)	2004-01-21
BG66161B1 (bg)	2011-09-30
CN100519558C (zh)	2009-07-29
HRP20030276B1 (en)	2006-02-28
JP3764422B2 (ja)	2006-04-05
SK287009B6 (sk)	2009-09-07
GEP20063905B (en)	2006-08-25
UY26962A1 (es)	2002-06-20
EE200300171A (et)	2003-06-16
HRP20030276A2 (en)	2005-02-28
CR6938A (es)	2004-10-28
PT1326862E (pt)	2004-11-30
SA01220412B1 (ar)	2006-11-05
PE20020422A1 (es)	2002-06-28
WO2002030928A1 (de)	2002-04-18
CN1221549C (zh)	2005-10-05
EP1468998A1 (de)	2004-10-20
BG107687A (bg)	2003-09-30
MXPA03003221A (es)	2004-12-03
YU27303A (sh)	2006-05-25
JP2004526668A (ja)	2004-09-02
HU226830B1 (en)	2009-11-30
CZ301841B6 (cs)	2010-07-07
AU2002214996B2 (en)	2007-03-15
DK1326862T3 (da)	2004-11-22
AR068527A2 (es)	2009-11-18
TR200402579T4 (tr)	2004-12-21
AR034389A1 (es)	2004-02-25
TW589313B (en)	2004-06-01
HUP0301022A3 (en)	2005-12-28
HK1060567A1 (en)	2004-08-13
ZA200302500B (en)	2004-04-22
ME00243B (me)	2011-05-10
OA12403A (en)	2006-04-18
IL155335A0 (en)	2003-11-23
ECSP034540A (es)	2003-07-25
ATE276253T1 (de)	2004-10-15
EE04567B1 (et)	2005-12-15
CN1733761A (zh)	2006-02-15
CA2425539C (en)	2007-04-03
EP1326862B1 (de)	2004-09-15
EA200300457A1 (ru)	2003-10-30
PL366041A1 (en)	2005-01-24
SK4362003A3 (en)	2003-08-05
HK1086557A1 (zh)	2006-09-22
KR20030042008A (ko)	2003-05-27
MA25842A1 (fr)	2003-07-01
NO20031694L (no)	2003-04-11
NO328465B1 (no)	2010-02-22
HUP0301022A2 (hu)	2003-10-28
CA2425539A1 (en)	2003-04-11
BR0114584A (pt)	2003-08-26
IL155335A (en)	2009-02-11
SI1326862T1 (sl)	2005-02-28
MEP40008A (en)	2011-02-10
DE50103666D1 (de)	2004-10-21
EG24142A (en)	2008-08-06
UY34901A (es)	2015-02-27
AP1572A (en)	2006-02-13
AU1499602A (en)	2002-04-22
MY126931A (en)	2006-10-31
UA74215C2 (uk)	2005-11-15
KR100823860B1 (ko)	2008-04-21
DZ3478A1 (fr)	2002-04-18
IS6772A (is)	2003-04-09
EP1326862A1 (de)	2003-07-16
EA004381B1 (ru)	2004-04-29
NO20031694D0 (no)	2003-04-11
PL207870B1 (pl)	2011-02-28
AP2003002775A0 (en)	2003-03-31
NZ525733A (en)	2005-01-28
RS50218B (sr)	2009-07-15

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