AU2002345016A1 - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents

Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Info

Publication number: AU2002345016A1
Authority: AU; Australia
Prior art keywords: production; drug; anticholinergic; crystalline; crystalline anticholinergic
Prior art date: 2001-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2002345016A

Other versions

AU2002345016B2 (en

Inventor

Peter Sieger

Ulrike Werthmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Boehringer Ingelheim Pharma GmbH and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-22

Filing date

2002-06-08

Publication date

2003-06-19

2002-06-08 Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG

2002-06-08 Priority claimed from PCT/EP2002/006291 external-priority patent/WO2003000265A1/en

2003-06-19 Publication of AU2002345016A1 publication Critical patent/AU2002345016A1/en

2008-04-17 Application granted granted Critical

2008-04-17 Publication of AU2002345016B2 publication Critical patent/AU2002345016B2/en

2022-06-08 Anticipated expiration legal-status Critical

Status Expired legal-status Critical Current

Links

AU2002345016A 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug Expired AU2002345016B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE10129710.6		2001-06-22
DE10129710		2001-06-22
DE10215436		2002-04-08
DE10215436.8		2002-04-08
PCT/EP2002/006291 WO2003000265A1 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Publications (2)

Publication Number	Publication Date
AU2002345016A1 true AU2002345016A1 (en)	2003-06-19
AU2002345016B2 AU2002345016B2 (en)	2008-04-17

Family

ID=26009556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2002345016A Expired AU2002345016B2 (en)	2001-06-22	2002-06-08	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Country Status (37)

Country	Link
EP (1)	EP1401445B1 (en)
JP (1)	JP2005504015A (en)
KR (2)	KR100971616B1 (en)
CN (1)	CN100586948C (en)
AR (1)	AR037491A1 (en)
AT (1)	ATE337006T1 (en)
AU (1)	AU2002345016B2 (en)
BG (1)	BG66303B1 (en)
BR (1)	BR0210537A (en)
CA (1)	CA2450961C (en)
CO (1)	CO5550423A2 (en)
CY (1)	CY1105223T1 (en)
CZ (1)	CZ302786B6 (en)
DE (1)	DE50207943D1 (en)
DK (1)	DK1401445T3 (en)
EA (1)	EA005813B1 (en)
EE (1)	EE05316B1 (en)
EG (1)	EG24851A (en)
ES (1)	ES2271280T3 (en)
HR (1)	HRP20031066B1 (en)
HU (1)	HUP0400333A3 (en)
IL (2)	IL159238A0 (en)
ME (1)	ME00412B (en)
MX (1)	MXPA03011718A (en)
MY (1)	MY122779A (en)
NO (1)	NO334301B1 (en)
NZ (1)	NZ530690A (en)
PE (2)	PE20030130A1 (en)
PL (1)	PL208137B1 (en)
PT (1)	PT1401445E (en)
RS (1)	RS50441B (en)
SA (1)	SA02230255B1 (en)
SI (1)	SI1401445T1 (en)
SK (1)	SK287262B6 (en)
TW (2)	TWI261589B (en)
UY (1)	UY27342A1 (en)
WO (1)	WO2003000265A1 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
US20050038004A1 (en) *	2003-07-31	2005-02-17	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
DK1682542T3 (en) *	2003-11-03	2010-05-10	Boehringer Ingelheim Int	New crystalline anhydrate with anticholinergic effect
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
PL2422786T3 (en)	2004-04-22	2015-02-27	Boehringer Ingelheim Int	New combinations of medicaments for the treatment of respiratory diseases
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
EP1632229B1 (en)	2004-08-11	2009-04-01	Boehringer Ingelheim Pharma GmbH & Co. KG	Medicaments for the treatment of urinary tract disorders comprising anticholinergic agents
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
WO2006111549A1 (en)	2005-04-21	2006-10-26	Boehringer Ingelheim International Gmbh	Dihydrothienopyrimidines for the treatment of inflammatory diseases
WO2006114371A1 (en)	2005-04-28	2006-11-02	Boehringer Ingelheim International Gmbh	Novel compounds for treating inflammatory diseases
CN101203513A (en) *	2005-05-02	2008-06-18	贝林格尔·英格海姆国际有限公司	Crystal form of tiotropium bromide
SI1881980T1 (en) *	2005-05-02	2012-12-31	Boehringer Ingelheim International Gmbh	Novel crystalline forms of tiotropium bromide
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
EP1917253B1 (en)	2005-08-15	2015-01-07	Boehringer Ingelheim International Gmbh	Method for producing betamimetics
TWI396541B (en) *	2005-10-10	2013-05-21	Boehringer Ingelheim Int	Novel combinations of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN102731494A (en)	2005-12-19	2012-10-17	西科尔公司	Novel forms of tiotropium bromide and processes for preparation thereof
CN100999521B (en) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	crystalline anticholinergic tiotropium bromide
EP1847543A1 (en)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidines for the treatment of inflammatory diseases
WO2008017637A1 (en)	2006-08-07	2008-02-14	Boehringer Ingelheim International Gmbh	Drug combinations for the treatment of respiratory tract diseases
PE20080610A1 (en)	2006-08-22	2008-07-15	Boehringer Ingelheim Int	NEW ENANTHOMERICALLY PURE BETA-AGONISTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
US8754073B2 (en)	2007-10-19	2014-06-17	Boehringer Ingelheim International Gmbh	Substituted piperazino-dihydrothienopyrimidines
EP2093219A1 (en)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Crystalline enantiomer free salt form of a betamimetic and its use as medicine
EA020548B1 (en)	2008-12-19	2014-12-30	Бёрингер Ингельхайм Интернациональ Гмбх	Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
WO2010101538A2 (en)	2009-03-06	2010-09-10	Bilgic Mahmut	New crystal forms
US20130143905A1 (en)	2009-12-17	2013-06-06	Boehringer Ingelheim International Gmbh	Novel antagonists for ccr2 and uses thereof
MX346393B (en)	2009-12-17	2017-03-17	Centrexion Therapeutics Corp	NEW ANTAGONISTS OF THE CCR2 RECEIVER AND USES OF THE SAME.
BR112012018865A2 (en)	2010-01-29	2016-04-12	Boehringer Ingelheim Int	substituted naphthyridines and their use as syk kinase inhibitors
WO2011141474A1 (en)	2010-05-12	2011-11-17	Boehringer Ingelheim International Gmbh	Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5646736B2 (en)	2010-05-12	2014-12-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Novel CCR2 receptor antagonists, methods for their preparation, and their use as drugs
WO2011144501A1 (en)	2010-05-17	2011-11-24	Boehringer Ingelheim International Gmbh	Ccr2 antagonists and uses thereof
EP2576542B1 (en)	2010-05-25	2015-04-22	Boehringer Ingelheim International GmbH	Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
WO2011151251A1 (en)	2010-06-01	2011-12-08	Boehringer Ingelheim International Gmbh	New ccr2 antagonists
TR201007108A2 (en) *	2010-08-25	2012-03-21	B�Lg�� Mahmut	New tiotropium bromide crystal and production method.
EP2668177B1 (en)	2011-01-28	2014-10-22	Boehringer Ingelheim International GmbH	Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (en)	2011-02-28	2012-09-21	Bi̇lgi̇ç Mahmut	Crystal material containing tiotropium bromide
TR201102068A2 (en)	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Crystalline substances containing tiotropium bromide
TR201111589A2 (en) *	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropium bromide anhydrous crystal form.
WO2012171863A1 (en)	2011-06-16	2012-12-20	Boehringer Ingelheim International Gmbh	New selective ccr2 antagonists
WO2013010839A1 (en)	2011-07-15	2013-01-24	Boehringer Ingelheim International Gmbh	Novel and selective ccr2 antagonists
EA024845B1 (en)	2011-07-26	2016-10-31	Бёрингер Ингельхайм Интернациональ Гмбх	Substituted quinolines and their use as medicaments
US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CN105503867B (en)	2011-11-25	2019-01-11	阿德弗里奥药品有限责任公司	The method for being used to prepare the fluoro- 1H- pyrazolo-pyridines of substituted 5-
CZ304368B6 (en)	2011-11-28	2014-04-02	Zentiva, K.S.	Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (en) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	PROCESS FOR THE PREPARATION OF TIOTROPE BROMIDE
US9096579B2 (en)	2012-04-20	2015-08-04	Boehringer Ingelheim International Gmbh	Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014042605A1 (en) *	2012-09-11	2014-03-20	Mahmut Bilgic	New tiotropium bromide crystalline form
PT2914593T (en)	2012-11-05	2017-04-03	Zentiva Ks	Stabilization of tiotropium solvates
CN104341412A (en) *	2013-07-29	2015-02-11	天津金耀集团有限公司	Anhydrous tiotropium bromide crystal preparation method
HRP20191364T1 (en)	2014-03-19	2019-11-01	Boehringer Ingelheim Int	Heteroaryl sik inhibitors
US10034866B2 (en)	2014-06-19	2018-07-31	Teva Branded Pharmaceutical Products R&D, Inc.	Inhalable medicament comprising tiotropium
CR20170146A (en)	2014-10-21	2017-08-10	Ariad Pharma Inc	CRYSTAL FORMS OF 5-CHLORINE-N4 - [- 2- (DIMETHYLPHOSPHORIL) PHENYL] -N2- {2-METOXI-4- [4- (4-METHYLIPIPERAZIN-1-YL) PIPERIDIN-1-IL] PYRIMIDINE-2, 4-DIAMINE
WO2017138896A1 (en) *	2016-02-11	2017-08-17	Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti	Crystalline form of tiotropium bromide anhydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3931041C2 (en) *	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
US5610163A (en) *	1989-09-16	1997-03-11	Boehringer Ingelheim Gmbh	Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
IL155335A0 (en) *	2000-10-12	2003-11-23	Boehringer Ingelheim Pharma	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DE10064816A1 (en) *	2000-12-22	2002-06-27	Boehringer Ingelheim Pharma	Production of tiotropium bromide useful as an anticholinergic comprises oxidation of di-(2-thienyl)-glycolic acid tropenol ester and subsequent quaternisation

2002
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/en not_active Expired - Lifetime
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 HR HR20031066A patent/HRP20031066B1/en not_active IP Right Cessation
- 2002-06-08 ES ES02743165T patent/ES2271280T3/en not_active Expired - Lifetime
- 2002-06-08 CN CN02812303A patent/CN100586948C/en not_active Expired - Lifetime
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/en active IP Right Grant
- 2002-06-08 DE DE50207943T patent/DE50207943D1/en not_active Expired - Lifetime
- 2002-06-08 PT PT02743165T patent/PT1401445E/en unknown
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/en not_active Application Discontinuation
- 2002-06-08 SK SK52-2004A patent/SK287262B6/en unknown
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/en unknown
- 2002-06-08 EA EA200301293A patent/EA005813B1/en not_active IP Right Cessation
- 2002-06-08 PL PL364489A patent/PL208137B1/en unknown
- 2002-06-08 DK DK02743165T patent/DK1401445T3/en active
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/en not_active Ceased
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/en active Pending
- 2002-06-08 RS YUP-997/03A patent/RS50441B/en unknown
- 2002-06-08 SI SI200230431T patent/SI1401445T1/en unknown
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/en unknown
- 2002-06-08 AT AT02743165T patent/ATE337006T1/en active
- 2002-06-08 EP EP02743165A patent/EP1401445B1/en not_active Expired - Lifetime
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/en not_active Expired - Lifetime
- 2002-06-08 EE EEP200400029A patent/EE05316B1/en unknown
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/en not_active IP Right Cessation
- 2002-06-08 IL IL15923802A patent/IL159238A0/en unknown
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-19 TW TW091113373A patent/TWI261589B/en not_active IP Right Cessation
- 2002-06-19 EG EG2002060698A patent/EG24851A/en active
- 2002-06-19 TW TW095100968A patent/TW200617007A/en unknown
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-20 UY UY27342A patent/UY27342A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/en active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/en not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/en not_active Application Discontinuation
- 2002-08-19 SA SA2230255A patent/SA02230255B1/en unknown
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/en unknown
- 2003-12-19 NO NO20035696A patent/NO334301B1/en not_active IP Right Cessation
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/en not_active Application Discontinuation
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/en unknown

Publication	Publication Date	Title
AU2002345016A1 (en)	2003-06-19	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
IL159238A0 (en)	2004-06-01	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
AU2002214996A1 (en)	2002-06-27	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
IL155335A0 (en)	2003-11-23	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
AU2002213977A1 (en)	2002-04-29	Novel anticholinergics, method for the production thereof and use thereof as medicaments
AU2002213975A1 (en)	2002-07-04	Novel anticholinergic agents that can be used as medicaments and method for the production thereof
AU2001262318A1 (en)	2002-03-07	Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament
AU2002234640A1 (en)	2003-03-06	Xanthine derivative, production and use thereof as a medicament
AU2003282094A1 (en)	2004-06-15	Novel dihydroxy-methylphenyl derivatives, method for the production and use thereof as medicaments
AU2002337047A1 (en)	2003-06-05	Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
AU2003206760A1 (en)	2003-09-18	Anticholinergic agents, method for producing the same and use thereof as medicaments
AU2002219174A1 (en)	2002-09-05	Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof
AU3162001A (en)	2001-07-03	Medicament, a method for its production and the use thereof
AU2001284021A1 (en)	2002-03-13	Quinazoline derivatives, medicaments containing these compounds, their use, and methods for the production thereof
TWI345975B (en)	2011-08-01	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
PL369889A1 (en)	2005-05-02	Anticholinergic agents, method for producing the same and use thereof as medicaments
AU2003260984A1 (en)	2004-04-30	S-(-)-amlodipine nicotinate and process for the preparation thereof
TWI318211B (en)	2009-12-11	Novel derivatives of 4a, 5, 9, 10, 11, 12-hexahydrobenzofuro [3a, 2, 2] [2] -benzazepine, method for the production thereof and use thereof in the production of medicaments
AU2003225370A1 (en)	2003-11-03	Amlodipine nicotinate and process for the preparation thereof
AU2001262229A1 (en)	2002-01-31	Cyclipostins, a method for their production and the use of the same
AU6222901A (en)	2001-11-12	Cyclipostins, a method for their production and the use of the same
AU2001289844A1 (en)	2002-03-13	Amifostine-monohydrate and a method for the production thereof
AU2002348998A1 (en)	2003-07-24	N-methyl-homocystines, use thereof and method for the production thereof
ZA200308591B (en)	2004-05-12	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug.
AU2002333449A1 (en)	2003-06-05	C2-substituted indane-1-ols and their derivatives, method for their production and their use as medicaments