IL98110A0 - N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use - Google Patents

N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use

Info

Publication number: IL98110A0
Authority: IL; Israel
Prior art keywords: phosphonylmethoxypropyl; purine; fluoro; derivatives; preparation
Prior art date: 1990-04-24

Application number

IL98110A

Other languages

English (en)

Original Assignee

Ceskoslovenska Akademie Ved

Univ Rega Katholieke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-24

Filing date

1991-05-10

Publication date

1992-06-21

1991-05-10 Application filed by Ceskoslovenska Akademie Ved, Univ Rega Katholieke filed Critical Ceskoslovenska Akademie Ved

1992-06-21 Publication of IL98110A0 publication Critical patent/IL98110A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

IL98110A 1990-04-24 1991-05-10 N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use IL98110A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS902047A CZ285420B6 (cs)	1990-04-24	1990-04-24	N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití

Publications (1)

Publication Number	Publication Date
IL98110A0 true IL98110A0 (en)	1992-06-21

Family

ID=5356430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL98110A IL98110A0 (en)	1990-04-24	1991-05-10	N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use

Country Status (15)

Country	Link
US (1)	US5733896A (xx)
EP (1)	EP0454427B1 (xx)
JP (1)	JP2937532B2 (xx)
AT (1)	ATE131171T1 (xx)
AU (1)	AU7533091A (xx)
CA (1)	CA2040982C (xx)
CZ (1)	CZ285420B6 (xx)
DE (1)	DE69115108T2 (xx)
FI (1)	FI911980A7 (xx)
IE (1)	IE911356A1 (xx)
IL (1)	IL98110A0 (xx)
NO (1)	NO911600L (xx)
PT (1)	PT97478B (xx)
SK (1)	SK280313B6 (xx)
ZA (1)	ZA913033B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ284678B6 (cs) *	1991-05-20	1999-01-13	Ústav Organické Chemie A Biochemie Avčr	Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
US6057305A (en) *	1992-08-05	2000-05-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiretroviral enantiomeric nucleotide analogs
US5977061A (en) *	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use
US6093816A (en)	1996-06-27	2000-07-25	Isis Pharmaceuticals, Inc.	Cationic lipids
JP2002500880A (ja)	1998-01-23	2002-01-15	ニューバイオティックスインコーポレイテッド	酵素に触媒される治療剤
US7462605B2 (en) *	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
WO2001007088A2 (en)	1999-07-22	2001-02-01	Newbiotics, Inc.	Methods for treating therapy-resistant tumors
US6683061B1 (en) *	1999-07-22	2004-01-27	Newbiotics, Inc.	Enzyme catalyzed therapeutic activation
WO2001044257A1 (en) *	1999-12-17	2001-06-21	Ariad Pharmaceuticals, Inc.	Proton pump inhibitors
NZ535408A (en)	2000-07-21	2006-09-29	Gilead Sciences Inc	Method for selecting prodrugs of phosphonate nucleotide analogues
US6747132B2 (en)	2000-11-29	2004-06-08	Apex Biosciences, Inc.	Methods for the synthesis of a modified hemoglobin solution
BRPI0210746B8 (pt)	2001-06-29	2021-05-25	Inst Of Organic Chemistry And Biochemistry Ascr	derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação
KR101102815B1 (ko)	2003-06-16	2012-01-05	케이.유.루벤 리서치 앤드 디벨럽먼트	항바이러스 뉴클레오티드 유사체인 포스포네이트기를 갖는 피리미딘 화합물
EP1831235B1 (en)	2004-12-16	2013-02-20	The Regents of The University of California	Lung-targeted drugs
WO2006130217A2 (en) *	2005-04-01	2006-12-07	The Regents Of The University Of California	Substituted phosphate esters of nucleoside phosphonates
JP2009502964A (ja) *	2005-07-27	2009-01-29	ギリアードサイエンシーズ，インコーポレイテッド	Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体
TWI444384B (zh)	2008-02-20	2014-07-11	Gilead Sciences Inc	核苷酸類似物及其在治療惡性腫瘤上的用途
HRP20180063T1 (hr) *	2008-10-24	2018-02-23	Glaxosmithkline Biologicals Sa	Lipidirani derivati imidazokinolina
ES2874774T3 (es)	2011-12-22	2021-11-05	Geron Corp	Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
BR112015023705A8 (pt)	2013-03-15	2020-03-17	Univ California	compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
CN106795188B (zh)	2014-09-15	2021-02-09	加利福尼亚大学董事会	核苷酸类似物
EP3350191B9 (en)	2015-09-15	2021-12-22	The Regents of the University of California	Nucleotide analogs
CN117186092A (zh) *	2018-11-07	2023-12-08	四川科伦博泰生物医药股份有限公司	并环化合物、其制备方法及用途
CA3262284A1 (en)	2022-07-21	2024-01-25	Antiva Biosciences, Inc.	Pharmaceutical compositions and forms for the treatment of human papillomavirus (HPV) infection and HPV-induced neoplasm

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4199574A (en) *	1974-09-02	1980-04-22	Burroughs Wellcome Co.	Methods and compositions for treating viral infections and guanine acyclic nucleosides
IL64501A (en) *	1980-12-22	1985-07-31	Astra Laekemedel Ab	9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US5047533A (en) *	1983-05-24	1991-09-10	Sri International	Acyclic purine phosphonate nucleotide analogs
CS264222B1 (en) *	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU8092587A (en) *	1986-11-18	1988-05-19	Bristol-Myers Squibb Company	Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
AU613592B2 (en) *	1986-11-18	1991-08-08	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
US4808419A (en) *	1987-02-02	1989-02-28	Hsu Edward J	Automated method for a semi-solid fermentation used in the production of ancient quality rice vinegar and/or rice wine
EP0338168A1 (en) *	1988-04-19	1989-10-25	Merrell Dow Pharmaceuticals Inc.	Phosphonoalkylpurine derivatives
ATE98249T1 (de) *	1988-04-19	1993-12-15	Merrell Dow Pharma	Phosphonoalkylpurin-derivate.
JPH0296589A (ja) *	1988-09-30	1990-04-09	Asahi Glass Co Ltd	ヌクレオシド類

1990
- 1990-04-24 SK SK2047-90A patent/SK280313B6/sk not_active IP Right Cessation
- 1990-04-24 CZ CS902047A patent/CZ285420B6/cs not_active IP Right Cessation
1991
- 1991-04-23 CA CA002040982A patent/CA2040982C/en not_active Expired - Lifetime
- 1991-04-23 AU AU75330/91A patent/AU7533091A/en not_active Abandoned
- 1991-04-23 IE IE135691A patent/IE911356A1/en unknown
- 1991-04-23 NO NO91911600A patent/NO911600L/no unknown
- 1991-04-23 ZA ZA913033A patent/ZA913033B/xx unknown
- 1991-04-24 EP EP91303664A patent/EP0454427B1/en not_active Expired - Lifetime
- 1991-04-24 PT PT97478A patent/PT97478B/pt not_active IP Right Cessation
- 1991-04-24 AT AT91303664T patent/ATE131171T1/de not_active IP Right Cessation
- 1991-04-24 DE DE69115108T patent/DE69115108T2/de not_active Expired - Lifetime
- 1991-04-24 JP JP3094138A patent/JP2937532B2/ja not_active Expired - Lifetime
- 1991-04-24 FI FI911980A patent/FI911980A7/fi not_active Application Discontinuation
- 1991-05-10 IL IL98110A patent/IL98110A0/xx unknown
1994
- 1994-03-18 US US08/210,255 patent/US5733896A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CZ285420B6 (cs)	1999-08-11
ZA913033B (en)	1992-01-29
PT97478A (pt)	1992-01-31
CS9002047A2 (en)	1991-11-12
CA2040982A1 (en)	1991-10-25
FI911980L (fi)	1991-10-25
EP0454427B1 (en)	1995-12-06
JP2937532B2 (ja)	1999-08-23
JPH06206888A (ja)	1994-07-26
DE69115108T2 (de)	1996-07-04
IE911356A1 (en)	1991-11-06
ATE131171T1 (de)	1995-12-15
FI911980A7 (fi)	1991-10-25
CA2040982C (en)	2001-12-04
NO911600D0 (no)	1991-04-23
NO911600L (no)	1991-10-25
SK280313B6 (sk)	1999-11-08
PT97478B (pt)	1998-08-31
US5733896A (en)	1998-03-31
AU7533091A (en)	1991-11-07
FI911980A0 (fi)	1991-04-24
EP0454427A1 (en)	1991-10-30
DE69115108D1 (de)	1996-01-18

Publication	Publication Date	Title
IL98110A0 (en)	1992-06-21	N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use
IL98378A0 (en)	1992-07-15	Substituted phthalides and heterocyclic phthalides,their preparation and their use as herbicides
DK1002534T3 (da)	2006-01-23	Anvendelse af fire K-252a-derivater
DK224286D0 (da)	1986-05-14	2',3'-dideoxy-nucleosider
FI913477L (fi)	1992-01-22	Menetelmä uusien terapeuttisesti käyttökelpoisten imidatsoli-fenyyli-imidatso/1,2-a/pyridiini- ja imidatsoli-fenyyli-imidatso/1,2-a/pyrimidiinijohdannaisten valmistamiseksi
DK172089D0 (da)	1989-04-10	1,3-dioxolanderivater samt fremgangsmaade til fremstilling deraf
NZ233735A (en)	1992-10-28	Heterocyclic substituted aminophenol derivatives
DK0509398T3 (da)	2002-01-14	Quinoxaliner, fremgangsmåder til deres fremstilling samt deres anvendelse
AU6822190A (en)	1991-07-04	Pyrimidine or triazine derivatives and herbicidal composition containing the same
DE68915128D1 (de)	1994-06-09	Derivate von 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynylcytidin, Uridin und Guanosin.
DK122587D0 (da)	1987-03-10	Pyrazolo(3,4-d)pyrimidinderivater og fremstilling og anvendelse deraf
DE3774347D1 (de)	1991-12-12	Sechsgliedrige heterocyclische derivate von n'-substituierten n,n'-diacylhydrazinen.
CA2086756A1 (en)	1992-01-08	Penciclovir and famciclovir and related guanine derivatives for the treatment of the hiv-1 infections
DE3884347D1 (de)	1993-10-28	Pyrimidinderivate.
EG18453A (en)	1993-04-30	Five membered heterocyclic derivatives of n'-substituted-n,n'-diacylhidrazines
FI912963A0 (fi)	1991-06-18	Hjaernverksamheten oekande pyrimidinylderivat.
PH23905A (en)	1989-12-18	Anticonvulsant agents
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
ATE89732T1 (de)	1993-06-15	Bakterientoetende gemische.
FI890173L (fi)	1989-01-13	Isoxazoler med nootropisk verkan.
DK0483063T3 (da)	1994-11-14	Ergolinderivater
DK514686A (da)	1987-04-30	5-naphthyl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner og tautomer deraf, deres fremstilling og anvendelse som antidepressive midler
SU1602007A1 (ru)	2006-12-20	6-(4,5-Дифенилтиенил-2)-3-тиа-1,2,4-триазин-5-он, проявляющий противовоспалительную и антимикробную активность
IE863201L (en)	1987-06-06	Diamino pyrimidine derivatives.
FI931574A7 (fi)	1993-04-07	4-substituerade pyrazolo/3,4-d/pyrimidinderivat