NO911600L - Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser. - Google Patents

Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser.

Info

Publication number: NO911600L
Authority: NO; Norway
Prior art keywords: fluoro; derivatives; metoxypropyl; phosphonyl; procedure
Prior art date: 1990-04-24

Application number

NO91911600A

Other languages

English (en)

Other versions

NO911600D0 (no

Inventor

Antonin Holy

Jindrich Jindrich

Jan Balzarini

Erik De Clerq

Original Assignee

Ceskoslovenska Akademie Ved

Univ Rega Katholieke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-24

Filing date

1991-04-23

Publication date

1991-10-25

1991-04-23 Application filed by Ceskoslovenska Akademie Ved, Univ Rega Katholieke filed Critical Ceskoslovenska Akademie Ved

1991-04-23 Publication of NO911600D0 publication Critical patent/NO911600D0/no

1991-10-25 Publication of NO911600L publication Critical patent/NO911600L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO91911600A 1990-04-24 1991-04-23 Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser. NO911600L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS902047A CZ285420B6 (cs)	1990-04-24	1990-04-24	N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití

Publications (2)

Publication Number	Publication Date
NO911600D0 NO911600D0 (no)	1991-04-23
NO911600L true NO911600L (no)	1991-10-25

Family

ID=5356430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91911600A NO911600L (no)	1990-04-24	1991-04-23	Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser.

Country Status (15)

Country	Link
US (1)	US5733896A (no)
EP (1)	EP0454427B1 (no)
JP (1)	JP2937532B2 (no)
AT (1)	ATE131171T1 (no)
AU (1)	AU7533091A (no)
CA (1)	CA2040982C (no)
CZ (1)	CZ285420B6 (no)
DE (1)	DE69115108T2 (no)
FI (1)	FI911980L (no)
IE (1)	IE911356A1 (no)
IL (1)	IL98110A0 (no)
NO (1)	NO911600L (no)
PT (1)	PT97478B (no)
SK (1)	SK280313B6 (no)
ZA (1)	ZA913033B (no)

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CZ284678B6 (cs) *	1991-05-20	1999-01-13	Ústav Organické Chemie A Biochemie Avčr	Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
US6057305A (en) *	1992-08-05	2000-05-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiretroviral enantiomeric nucleotide analogs
US5977061A (en) *	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use
US6093816A (en)	1996-06-27	2000-07-25	Isis Pharmaceuticals, Inc.	Cationic lipids
US6245750B1 (en)	1998-01-23	2001-06-12	Newbiotics, Inc.	Enzyme catalyzed therapeutic agents
US7462605B2 (en) *	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
BR0012676A (pt)	1999-07-22	2003-07-01	Newbiotics Inc	Métodos para tratamento de tumores resistentes a terapia
US6683061B1 (en) *	1999-07-22	2004-01-27	Newbiotics, Inc.	Enzyme catalyzed therapeutic activation
AU2583901A (en) *	1999-12-17	2001-06-25	Ariad Pharmaceuticals, Inc.	Proton pump inhibitors
ES2536972T5 (es)	2000-07-21	2022-04-06	Gilead Sciences Inc	Profármacos de análogos de nucleótidos de fosfonato y métodos para seleccionar y preparar los mismos
US6747132B2 (en)	2000-11-29	2004-06-08	Apex Biosciences, Inc.	Methods for the synthesis of a modified hemoglobin solution
AU2002315625B2 (en)	2001-06-29	2008-05-01	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	6-2'-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
DK1644389T3 (da)	2003-06-16	2011-05-09	Acad Of Science Czech Republic	Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
US8101745B2 (en) *	2004-12-16	2012-01-24	The Regents Of The University Of California	Lung-targeted drugs
WO2006130217A2 (en) *	2005-04-01	2006-12-07	The Regents Of The University Of California	Substituted phosphate esters of nucleoside phosphonates
AU2006272521A1 (en) *	2005-07-27	2007-02-01	Gilead Sciences, Inc.	Antiviral phosphonate conjugates for inhibition of HIV
TWI444384B (zh)	2008-02-20	2014-07-11	Gilead Sciences Inc	核苷酸類似物及其在治療惡性腫瘤上的用途
ES2656813T3 (es) *	2008-10-24	2018-02-28	Glaxosmithkline Biologicals Sa	Derivados de imidazoquinolina lipidados
EP3578563B1 (en)	2011-12-22	2021-04-14	Geron Corporation	Guanine analogs as telomerase substrates and telomere length affectors
CN105246902B (zh)	2013-03-15	2018-05-04	加利福尼亚大学董事会	无环核苷膦酸二酯
CN111808136B (zh)	2014-09-15	2024-06-11	加利福尼亚大学董事会	核苷酸类似物
EP3875462A1 (en)	2015-09-15	2021-09-08	The Regents of The University of California	Nucleotide analogs
CN117186092A (zh) *	2018-11-07	2023-12-08	四川科伦博泰生物医药股份有限公司	并环化合物、其制备方法及用途
AU2023310177A1 (en)	2022-07-21	2025-03-06	Antiva Biosciences, Inc.	Compositions and dosage forms for treatment of hpv infection and hpv-induced neoplasia

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Publication number	Priority date	Publication date	Assignee	Title
US4199574A (en) *	1974-09-02	1980-04-22	Burroughs Wellcome Co.	Methods and compositions for treating viral infections and guanine acyclic nucleosides
IL64501A (en) *	1980-12-22	1985-07-31	Astra Laekemedel Ab	9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US5047533A (en) *	1983-05-24	1991-09-10	Sri International	Acyclic purine phosphonate nucleotide analogs
CS264222B1 (en) *	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU8092587A (en) *	1986-11-18	1988-05-19	Bristol-Myers Squibb Company	Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
IL84477A (en) *	1986-11-18	1995-12-08	Bristol Myers Squibb Co	History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
US4808419A (en) *	1987-02-02	1989-02-28	Hsu Edward J	Automated method for a semi-solid fermentation used in the production of ancient quality rice vinegar and/or rice wine
EP0338168A1 (en) *	1988-04-19	1989-10-25	Merrell Dow Pharmaceuticals Inc.	Phosphonoalkylpurine derivatives
ATE98249T1 (de) *	1988-04-19	1993-12-15	Merrell Dow Pharma	Phosphonoalkylpurin-derivate.
JPH0296589A (ja) *	1988-09-30	1990-04-09	Asahi Glass Co Ltd	ヌクレオシド類

1990
- 1990-04-24 SK SK2047-90A patent/SK280313B6/sk not_active IP Right Cessation
- 1990-04-24 CZ CS902047A patent/CZ285420B6/cs not_active IP Right Cessation
1991
- 1991-04-23 AU AU75330/91A patent/AU7533091A/en not_active Abandoned
- 1991-04-23 ZA ZA913033A patent/ZA913033B/xx unknown
- 1991-04-23 NO NO91911600A patent/NO911600L/no unknown
- 1991-04-23 IE IE135691A patent/IE911356A1/en unknown
- 1991-04-23 CA CA002040982A patent/CA2040982C/en not_active Expired - Lifetime
- 1991-04-24 EP EP91303664A patent/EP0454427B1/en not_active Expired - Lifetime
- 1991-04-24 FI FI911980A patent/FI911980L/fi not_active Application Discontinuation
- 1991-04-24 DE DE69115108T patent/DE69115108T2/de not_active Expired - Lifetime
- 1991-04-24 AT AT91303664T patent/ATE131171T1/de not_active IP Right Cessation
- 1991-04-24 PT PT97478A patent/PT97478B/pt not_active IP Right Cessation
- 1991-04-24 JP JP3094138A patent/JP2937532B2/ja not_active Expired - Lifetime
- 1991-05-10 IL IL98110A patent/IL98110A0/xx unknown
1994
- 1994-03-18 US US08/210,255 patent/US5733896A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI911980A7 (fi)	1991-10-25
CZ285420B6 (cs)	1999-08-11
CA2040982C (en)	2001-12-04
SK280313B6 (sk)	1999-11-08
CA2040982A1 (en)	1991-10-25
EP0454427A1 (en)	1991-10-30
ATE131171T1 (de)	1995-12-15
DE69115108D1 (de)	1996-01-18
FI911980A0 (fi)	1991-04-24
IL98110A0 (en)	1992-06-21
ZA913033B (en)	1992-01-29
IE911356A1 (en)	1991-11-06
JP2937532B2 (ja)	1999-08-23
PT97478B (pt)	1998-08-31
FI911980L (fi)	1991-10-25
CS9002047A2 (en)	1991-11-12
DE69115108T2 (de)	1996-07-04
NO911600D0 (no)	1991-04-23
JPH06206888A (ja)	1994-07-26
AU7533091A (en)	1991-11-07
EP0454427B1 (en)	1995-12-06
US5733896A (en)	1998-03-31
PT97478A (pt)	1992-01-31

Publication	Publication Date	Title
NO911600L (no)	1991-10-25	Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser.
ATE269290T1 (de)	2004-07-15	Benzoylderivate
NO861481L (no)	1986-10-20	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive heterocykliske amid-derivater.
YU101791A (sh)	1997-08-22	Supstituisani ftalidi i heterociklični ftalidi
NO880740D0 (no)	1988-02-19	Fremgangsmaate for fremstilling av mettede heterocykliske carboxamidderivater.
ATE70833T1 (de)	1992-01-15	Piperazinyl-heterocyclische derivate.
NO892083D0 (no)	1989-05-24	Fremgangsmaate for fremstilling av arylmetylenyl-derivaterav tiazolidinoner, imidazolidinoner og oksazolidinoner.
DK0396083T3 (da)	1995-02-06	Heterocykliske N-oxidderivater af substituerede benzo(5,6)-cycloheptapyridiner, præparater og anvendelsesfremgangsmåder
NO874955L (no)	1988-05-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive heteroaromatiske aminderivater.
ATE74132T1 (de)	1992-04-15	Imid-derivate, ihre herstellung und ihre verwendung.
ATE81653T1 (de)	1992-11-15	Dideoxydidehydrocarbocyclische nukleoside.
NO871044L (no)	1987-09-15	Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidinderivater.
NO167734C (no)	1991-12-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte aminderivater.
DE3774347D1 (de)	1991-12-12	Sechsgliedrige heterocyclische derivate von n'-substituierten n,n'-diacylhydrazinen.
FI892222A0 (fi)	1989-05-09	Peptidalkoholer med antikoagulantverkan.
NO884175D0 (no)	1988-09-20	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
ATE83481T1 (de)	1993-01-15	Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
NO853551L (no)	1986-03-13	Fremgangsmaate ved fremstilling av prolinderivater og lignende forbindelser med antihypertensiv aktivitet.
FI912963A0 (fi)	1991-06-18	Hjaernverksamheten oekande pyrimidinylderivat.
ES2080336T3 (es)	1996-02-01	Derivados de metilpiperazinoazepina, su preparacion y su utilizacion.
DE3778642D1 (de)	1992-06-04	Therapeutikum zur behandlung von magengeschwueren.
CZ281393B6 (cs)	1996-09-11	Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu
DE3766425D1 (de)	1991-01-10	Triazinderivate von piperidinylamidinen.
GR910100041A (el)	1992-06-25	Παράγωγα ουρίας, δρώντα σαν ζιζανιοκτόνα και μέ?οδος παρασκευής των.
DK553587A (da)	1988-04-24	Acylerede 9,10-anthracendicarboxaldehyd-bis-(2-imidazolin-2-ylhydrazoner), fremgangsmaade til deres fremstilling samt deres anvendelse