IL166748A0 - Pyrazole derivative medicinal composition containing the same medicinal use thereof and intermediatefor production thereof - Google Patents
Pyrazole derivative medicinal composition containing the same medicinal use thereof and intermediatefor production thereofInfo
- Publication number
- IL166748A0 IL166748A0 IL16674805A IL16674805A IL166748A0 IL 166748 A0 IL166748 A0 IL 166748A0 IL 16674805 A IL16674805 A IL 16674805A IL 16674805 A IL16674805 A IL 16674805A IL 166748 A0 IL166748 A0 IL 166748A0
- Authority
- IL
- Israel
- Prior art keywords
- optionally substituted
- group etc
- alkyl group
- production
- chem
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 101000716688 Homo sapiens Sodium/glucose cotransporter 1 Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000052194 human SLC5A1 Human genes 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002232074 | 2002-08-08 | ||
| JP2002321729 | 2002-11-05 | ||
| PCT/JP2003/010048 WO2004014932A1 (ja) | 2002-08-08 | 2003-08-07 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166748A0 true IL166748A0 (en) | 2006-01-15 |
Family
ID=31719857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16674805A IL166748A0 (en) | 2002-08-08 | 2005-02-08 | Pyrazole derivative medicinal composition containing the same medicinal use thereof and intermediatefor production thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7375087B2 (no) |
| EP (1) | EP1544208B1 (no) |
| JP (1) | JP4540475B2 (no) |
| KR (1) | KR100985502B1 (no) |
| AT (1) | ATE469161T1 (no) |
| AU (1) | AU2003254847B2 (no) |
| BR (1) | BRPI0313290B1 (no) |
| CA (1) | CA2494179C (no) |
| DE (1) | DE60332743D1 (no) |
| ES (1) | ES2345250T3 (no) |
| IL (1) | IL166748A0 (no) |
| MX (1) | MXPA05001549A (no) |
| NO (1) | NO330456B1 (no) |
| NZ (1) | NZ538117A (no) |
| PL (1) | PL213095B1 (no) |
| RU (1) | RU2356906C2 (no) |
| TW (1) | TW200413401A (no) |
| WO (1) | WO2004014932A1 (no) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1031500A (en) | 1998-11-03 | 2000-05-22 | Dandy A/S | Sucrose fatty acid esters for use as increased release of active ingredients |
| JP4540475B2 (ja) * | 2002-08-08 | 2010-09-08 | キッセイ薬品工業株式会社 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| AU2003262262A1 (en) * | 2002-08-27 | 2004-03-19 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivatives, medicinal composition containing the same, and medicinal use thereof |
| CA2507665A1 (en) * | 2002-12-04 | 2004-06-17 | Kissei Pharmaceutical Co., Ltd. | Preventive or remedy for diseases caused by hyperglycemia |
| CA2509835A1 (en) * | 2002-12-25 | 2004-07-15 | Kissei Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| WO2006054629A1 (ja) | 2004-11-18 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | １－置換－３－（β－Ｄ－グリコピラノシル）含窒素ヘテロ環化合物、及びそれを含有する医薬 |
| FR2878523B1 (fr) * | 2004-11-30 | 2007-09-14 | Oreal | Nouveaux derives sulfamides et leur utilisation cosmetique |
| US7887824B2 (en) | 2004-11-30 | 2011-02-15 | L'oreal | Sulfamide derivatives and cosmetic use thereof |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| AR054852A1 (es) * | 2005-07-22 | 2007-07-18 | Boehringer Ingelheim Int | Procesos para preparar derivados de pirazol 0- glucosido y nuevos intermediarios de dichos procesos |
| KR100982088B1 (ko) * | 2005-08-31 | 2010-09-13 | 에프. 호프만-라 로슈 아게 | 11베타-ｈｓｄ1 억제제로서의 피라졸론 유도체 |
| UY30082A1 (es) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos |
| JP2009167103A (ja) * | 2006-05-02 | 2009-07-30 | Taisho Pharmaceutical Co Ltd | ピラゾリル５−チオグリコシド化合物 |
| PE20080697A1 (es) * | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US7973012B2 (en) | 2006-05-19 | 2011-07-05 | Taisho Pharmaceutical Co., Ltd | C-phenyl glycitol compound |
| EP2019679B1 (en) | 2006-05-23 | 2018-06-20 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| BRPI0713058A2 (pt) | 2006-06-29 | 2012-04-10 | Taisho Pharmaceutical Co., Ltd. | composto de 1-tioglucitol de c-fenila |
| CN101611023A (zh) | 2006-12-14 | 2009-12-23 | 大正制药株式会社 | 1－苯基1－硫代－d－山梨醇衍生物 |
| EP2064222B1 (en) * | 2007-04-02 | 2014-05-07 | Theracos, Inc. | Benzylic glycoside derivatives and methods of use |
| RU2355396C2 (ru) * | 2007-07-09 | 2009-05-20 | Государственное учреждение Научно-исследовательский институт акушерства, гинекологии и перинатологии Томского научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ АГиП ТНЦ СО РАМН) | Средство и способ профилактики гемореологических нарушений у беременных со стертыми формами гиперандрогении и фето-плацентарной недостаточностью |
| CL2008002427A1 (es) * | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| BRPI0815708B8 (pt) | 2007-08-23 | 2021-05-25 | Theracos Sub Llc | composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição |
| UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| EP2228378B1 (en) * | 2007-12-27 | 2015-09-09 | Kissei Pharmaceutical Co., Ltd. | Monosebacate of pyrazole derivative |
| DK2324002T3 (en) * | 2008-08-22 | 2016-12-19 | Theracos Sub Llc | Methods of making of sglt2 inhibitors |
| EP2334687B9 (en) * | 2008-08-28 | 2012-08-08 | Pfizer Inc. | Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives |
| PT2395983T (pt) | 2009-02-13 | 2020-07-03 | Boehringer Ingelheim Int | Composição farmacêutica compreendendo um inibidor de sglt2, um inibidor de dp-iv e opcionalmente um agente antidiabético adicional e suas utilizações |
| CN102316875A (zh) | 2009-02-13 | 2012-01-11 | 贝林格尔.英格海姆国际有限公司 | 用于治疗i型糖尿病、ii型糖尿病、葡萄糖耐量降低或高血糖症的sglt-2抑制剂 |
| CA2752212C (en) | 2009-02-23 | 2016-08-16 | Taisho Pharmaceutical Co., Ltd. | 4-isopropylphenyl glucitol compounds as sglt1 inhibitors |
| EP2298782A1 (en) * | 2009-08-26 | 2011-03-23 | Sanofi-Aventis | Method for producing pyrazole glycoside derivatives |
| IN2012DN02711A (no) * | 2009-09-15 | 2015-09-11 | Janssen Pharmaceutica Nv | |
| ES2546762T3 (es) | 2009-09-30 | 2015-09-28 | Boehringer Ingelheim International Gmbh | Procedimientos para preparar derivados de bencil-benceno sustituidos con glucopiranosilo |
| EA020798B1 (ru) * | 2009-09-30 | 2015-01-30 | Бёрингер Ингельхайм Интернациональ Гмбх | СПОСОБ ПОЛУЧЕНИЯ КРИСТАЛЛИЧЕСКОЙ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА |
| UY32919A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos |
| JP2013506635A (ja) | 2009-10-02 | 2013-02-28 | サノフイ | 骨疾患を処置するための薬剤を製造するためのｓｇｌｔ−１／ｓｇｌｔ−２阻害剤活性を有する化合物の使用 |
| KR101426180B1 (ko) | 2009-11-02 | 2014-07-31 | 화이자 인코포레이티드 | 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| MY161846A (en) | 2010-07-09 | 2017-05-15 | James Trinca Green | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
| JP2013224263A (ja) * | 2010-08-19 | 2013-10-31 | Taisho Pharmaceutical Co Ltd | ４−イソプロピルフェニルグルシトール化合物 |
| EP2607360B1 (en) | 2010-08-20 | 2015-08-19 | Taisho Pharmaceutical Co., Ltd. | 4-Isopropyl-6-methoxyphenyl glucitol compound |
| PH12013500302A1 (en) | 2010-08-20 | 2017-05-19 | Taisho Pharmaceutical Co Ltd | Crystal form of 4-isopropylphenyl glucitol compound and process for production thereof |
| UY33937A (es) | 2011-03-07 | 2012-09-28 | Boehringer Ingelheim Int | Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina |
| WO2012176804A1 (ja) * | 2011-06-20 | 2012-12-27 | キッセイ薬品工業株式会社 | グルコピラノシルオキシピラゾール誘導体 |
| EP2726482B1 (en) | 2011-07-01 | 2016-07-20 | Bayer Intellectual Property GmbH | Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors |
| AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
| UA113086C2 (xx) | 2012-05-10 | 2016-12-12 | Піразольні сполуки як інгібітори sglt1 | |
| TW201425326A (zh) * | 2012-10-05 | 2014-07-01 | Lilly Co Eli | 新穎脲化合物 |
| ES2694110T3 (es) | 2013-02-04 | 2018-12-18 | Taisho Pharmaceutical Co., Ltd. | Fármaco profiláctico o terapéutico para el estreñimiento |
| EP2774619B1 (de) | 2013-03-04 | 2016-05-18 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| ES2702174T3 (es) | 2013-04-05 | 2019-02-27 | Boehringer Ingelheim Int | Usos terapéuticos de empagliflozina |
| HK1213818A1 (zh) | 2013-04-05 | 2016-07-15 | 勃林格殷格翰国际有限公司 | 依帕列净的治疗用途 |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| DK2986304T3 (da) | 2013-04-18 | 2022-04-04 | Boehringer Ingelheim Int | Farmaceutisk sammensætning, fremgangsmåder til behandling og anvendelser deraf. |
| CN105611920B (zh) | 2013-10-12 | 2021-07-16 | 泰拉科斯萨普有限责任公司 | 羟基-二苯甲烷衍生物的制备 |
| AR098670A1 (es) | 2013-11-08 | 2016-06-08 | Lilly Co Eli | Inhibidor de sglt1 |
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| CN109922813A (zh) | 2016-11-10 | 2019-06-21 | 勃林格殷格翰国际有限公司 | 药物组合物、治疗方法及其用途 |
| CN110054657B (zh) * | 2018-01-18 | 2021-06-29 | 亚宝药业集团股份有限公司 | 吡喃葡萄糖取代的吡唑化合物及其制备方法 |
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|---|---|---|---|---|
| DE2319280A1 (de) * | 1973-04-17 | 1974-11-07 | Bayer Ag | 1-substituierte pyrazolone-(5), verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
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| US6683056B2 (en) * | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| JP3915116B2 (ja) * | 2000-11-02 | 2007-05-16 | 味の素株式会社 | 新規ピラゾール誘導体及びそれらを含有する糖尿病治療薬 |
| KR100701437B1 (ko) * | 2000-12-28 | 2007-03-30 | 깃세이 야쿠힌 고교 가부시키가이샤 | 글루코피라노실옥시피라졸 유도체 및 그 의약 용도 |
| JP4540475B2 (ja) * | 2002-08-08 | 2010-09-08 | キッセイ薬品工業株式会社 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| US7576063B2 (en) * | 2002-10-04 | 2009-08-18 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| JP4285338B2 (ja) * | 2004-06-14 | 2009-06-24 | トヨタ自動車株式会社 | スターリングエンジン |
-
2003
- 2003-08-07 JP JP2004527355A patent/JP4540475B2/ja not_active Expired - Fee Related
- 2003-08-07 PL PL375473A patent/PL213095B1/pl unknown
- 2003-08-07 EP EP03784564A patent/EP1544208B1/en not_active Expired - Lifetime
- 2003-08-07 DE DE60332743T patent/DE60332743D1/de not_active Expired - Lifetime
- 2003-08-07 CA CA2494179A patent/CA2494179C/en not_active Expired - Fee Related
- 2003-08-07 BR BRPI0313290A patent/BRPI0313290B1/pt not_active IP Right Cessation
- 2003-08-07 AU AU2003254847A patent/AU2003254847B2/en not_active Ceased
- 2003-08-07 ES ES03784564T patent/ES2345250T3/es not_active Expired - Lifetime
- 2003-08-07 NZ NZ538117A patent/NZ538117A/en not_active IP Right Cessation
- 2003-08-07 KR KR1020057002286A patent/KR100985502B1/ko not_active Expired - Fee Related
- 2003-08-07 RU RU2005106259/04A patent/RU2356906C2/ru not_active IP Right Cessation
- 2003-08-07 US US10/523,820 patent/US7375087B2/en not_active Expired - Fee Related
- 2003-08-07 MX MXPA05001549A patent/MXPA05001549A/es active IP Right Grant
- 2003-08-07 WO PCT/JP2003/010048 patent/WO2004014932A1/ja not_active Ceased
- 2003-08-07 AT AT03784564T patent/ATE469161T1/de not_active IP Right Cessation
- 2003-08-08 TW TW092121803A patent/TW200413401A/zh not_active IP Right Cessation
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2005
- 2005-02-08 IL IL16674805A patent/IL166748A0/xx active IP Right Grant
- 2005-03-08 NO NO20051209A patent/NO330456B1/no not_active IP Right Cessation
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2008
- 2008-04-17 US US12/104,890 patent/US7655632B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2494179C (en) | 2012-04-24 |
| TW200413401A (en) | 2004-08-01 |
| MXPA05001549A (es) | 2005-05-05 |
| HK1082743A1 (zh) | 2006-06-16 |
| AU2003254847A1 (en) | 2004-02-25 |
| EP1544208A1 (en) | 2005-06-22 |
| PL375473A1 (en) | 2005-11-28 |
| US7375087B2 (en) | 2008-05-20 |
| AU2003254847B2 (en) | 2009-06-04 |
| KR100985502B1 (ko) | 2010-10-05 |
| NO330456B1 (no) | 2011-04-18 |
| US7655632B2 (en) | 2010-02-02 |
| RU2356906C2 (ru) | 2009-05-27 |
| US20060166899A1 (en) | 2006-07-27 |
| KR20050059067A (ko) | 2005-06-17 |
| WO2004014932A1 (ja) | 2004-02-19 |
| EP1544208A4 (en) | 2007-05-02 |
| BRPI0313290B1 (pt) | 2016-12-06 |
| RU2005106259A (ru) | 2005-08-27 |
| JPWO2004014932A1 (ja) | 2005-12-02 |
| ATE469161T1 (de) | 2010-06-15 |
| PL213095B1 (pl) | 2013-01-31 |
| CA2494179A1 (en) | 2004-02-19 |
| US20080312153A1 (en) | 2008-12-18 |
| NZ538117A (en) | 2007-01-26 |
| ES2345250T3 (es) | 2010-09-20 |
| EP1544208B1 (en) | 2010-05-26 |
| DE60332743D1 (de) | 2010-07-08 |
| NO20051209L (no) | 2005-04-15 |
| TWI341843B (no) | 2011-05-11 |
| BR0313290A (pt) | 2005-07-05 |
| JP4540475B2 (ja) | 2010-09-08 |
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