IL164166A0 - Process to prepare eplerenone - Google Patents

Process to prepare eplerenone

Info

Publication number: IL164166A0
Authority: IL; Israel
Prior art keywords: prepare eplerenone; eplerenone; prepare; 7alpha; processes
Prior art date: 2002-03-22

Application number

IL16416603A

Other languages

English (en)

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-22

Filing date

2003-03-21

Publication date

2005-12-18

2003-03-21 Application filed by Upjohn Co filed Critical Upjohn Co

2005-12-18 Publication of IL164166A0 publication Critical patent/IL164166A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catalysts (AREA)

IL16416603A 2002-03-22 2003-03-21 Process to prepare eplerenone IL164166A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US36678402P	2002-03-22	2002-03-22
US41187402P	2002-09-19	2002-09-19
US42559602P	2002-11-12	2002-11-12
PCT/US2003/007793 WO2003082895A2 (en)	2002-03-22	2003-03-21	Process to prepare eplerenone

Publications (1)

Publication Number	Publication Date
IL164166A0 true IL164166A0 (en)	2005-12-18

Family

ID=28678917

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16416603A IL164166A0 (en)	2002-03-22	2003-03-21	Process to prepare eplerenone
IL16415903A IL164159A0 (en)	2002-03-22	2003-03-21	C-17 spirolactonization and 6,7 oxidation of steroids

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL16415903A IL164159A0 (en)	2002-03-22	2003-03-21	C-17 spirolactonization and 6,7 oxidation of steroids

Country Status (22)

Country	Link
US (2)	US20040024202A1 (zh)
EP (2)	EP1490390A2 (zh)
JP (2)	JP2005528371A (zh)
KR (3)	KR20100131018A (zh)
CN (2)	CN1653081A (zh)
AT (1)	ATE404577T1 (zh)
AU (2)	AU2003220251A1 (zh)
BR (2)	BR0308660A (zh)
CA (2)	CA2480151A1 (zh)
CY (1)	CY1108453T1 (zh)
DE (1)	DE60322852D1 (zh)
DK (1)	DK1487859T3 (zh)
ES (1)	ES2310666T3 (zh)
IL (2)	IL164166A0 (zh)
MX (2)	MXPA04009216A (zh)
MY (1)	MY138479A (zh)
PL (2)	PL372460A1 (zh)
PT (1)	PT1487859E (zh)
RS (2)	RS90504A (zh)
SI (1)	SI1487859T1 (zh)
TW (2)	TW200401781A (zh)
WO (2)	WO2003082894A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235655B2 (en)	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone
CL2004000574A1 (es) *	2003-03-21	2005-02-11	Pharmacia Corp Sa Organizada B	Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
HUP0402466A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
CN1310941C (zh) *	2005-07-13	2007-04-18	南京大学	依普利酮的合成方法
CN1321128C (zh) *	2005-07-15	2007-06-13	浙江医药股份有限公司新昌制药厂	孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) *	2005-09-02	2007-03-08	Recordati Ireland Limited	Aldosterone receptor antagonists
JP2007297352A (ja) *	2006-05-02	2007-11-15	Toho Earthtech Inc	ヨウ化アルキルの製造方法および２−アルキル置換シクロヘキサノンの製造方法
WO2009007460A2 (en) *	2007-07-11	2009-01-15	Dsm Ip Assets B.V.	Enantioselective reduction
WO2009111574A2 (en) *	2008-03-05	2009-09-11	Evestra, Inc.	BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
US8222237B2 (en) *	2008-11-25	2012-07-17	Evestra, Inc.	Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
CN102464551B (zh) *	2010-11-17	2014-03-26	中国石油化工股份有限公司	异丁烯歧化反应制四甲基乙烯的方法
EP3009443B1 (en)	2014-10-17	2018-09-12	INDUSTRIALE CHIMICA S.r.l.	Process for the preparation of 7alfa-(methoxycarbonyl)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
CN105753930A (zh) *	2016-03-30	2016-07-13	北京万全德众医药生物技术有限公司	依普利酮的一种合成方法
CN108003156B (zh) *	2018-01-29	2021-04-20	辽宁科技大学	一种咪唑并吡啶基1,2-乙二酮衍生物的合成方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US464741A (en) *		1891-12-08		Seed-planter
US3053856A (en) *	1958-10-29	1962-09-11	Shell Oil Co	Epoxidation of ethylenic compounds with peroxycarboximidic acids
US3200113A (en) *	1963-01-09	1965-08-10	Sterling Drug Inc	7-cyano steroids and derivatives thereof
US3300489A (en) *	1964-07-24	1967-01-24	Smith Kline French Lab	Steroidal c-17 spirolactones and processes and intermediates used in the preparation thereof
US3413288A (en) *	1965-07-07	1968-11-26	Parke Davis & Co	Process for the production of steroidal c-17 spirolactones
US3759791A (en) *	1970-12-10	1973-09-18	Searle & Co	Selective microbiological preparation of androst-4-ene-3,17-dione
FR2216273B1 (zh) *	1973-02-06	1977-07-22	Roussel Uclaf
FR2216276B1 (zh) *	1973-02-06	1976-11-05	Roussel Uclaf
DE2404946C3 (de) *	1973-02-06	1978-03-02	Roussel-Uclaf S.A., Paris	Verfahren zur Herstellung von 7alpha-Acylthio-Steroidspirolactonen
FR2260569B1 (zh) *	1974-02-08	1978-06-16	Ugine Kuhlmann
US3957826A (en) *	1974-03-04	1976-05-18	Hoffmann-La Roche Inc.	Spirolactone production
FR2281357A1 (fr) *	1974-08-08	1976-03-05	Roussel Uclaf	Nouveau procede de preparation de spirolactones steroides
FR2285137A1 (fr) *	1974-09-18	1976-04-16	Roussel Uclaf	Nouveaux derives steroides 17-spirosultines, les g-hydroxyacides correspondants, leur procede de preparation et leur application comme medicament
IE44711B1 (en) *	1976-03-05	1982-03-10	Schering Ag	17 -hydroxypropyl-4-3-keto-steroids and esters thereof, and process for their manufacture
US4069219A (en) *	1976-12-27	1978-01-17	G. D. Searle & Co.	7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters
US4270994A (en) *	1980-02-20	1981-06-02	G. D. Searle & Co.	Electrochemical dehydrogenation of steroidal Δ3,5 enol ethers under basic conditions to provide steroidal Δ4,6 dienones
DE3344057A1 (de) *	1982-12-09	1984-06-14	Ciba-Geigy Ag, Basel	Eine neue lactonverbindung und pharmazeutische zusammensetzungen davon, sowie verfahren zu ihrer herstellung
JPS59139400A (ja) *	1983-01-31	1984-08-10	Shionogi & Co Ltd	抗アルドステロン活性ステロイド誘導体
FI77669C (fi) *	1983-04-13	1989-04-10	Ciba Geigy Ag	20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
NZ222103A (en) *	1986-10-10	1990-08-28	Gist Brocades Nv	9-alpha-hydroxy steroids and pharmaceutical preparations containing them
FR2610933B1 (fr) *	1987-02-18	1989-06-09	Roussel Uclaf	Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
DE3903988A1 (de) *	1989-02-10	1990-08-30	Basf Ag	Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
US5227375A (en) *	1990-02-08	1993-07-13	Endorecherche, Inc.	Aromatase inhibitors
AU680818B2 (en) *	1992-05-21	1997-08-14	Endorecherche Inc.	Improved antiandrogens
US5502222A (en) *	1994-06-01	1996-03-26	Schering Corporation	Process for preparing delta 9,11 and 21-chloro corticosteroids
US5981744A (en) *	1995-12-11	1999-11-09	G. D. Searle And Co.	Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
JP2001509792A (ja) *	1996-12-11	2001-07-24	ジー．ディー．サールアンドカンパニー	９，１１−エポキシステロイドの製造法ならびに該方法に有用な中間体
US6887991B1 (en) *	1996-12-11	2005-05-03	G. D. Searle & Company	Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US7235655B2 (en) *	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone

2003
- 2003-03-21 SI SI200331329T patent/SI1487859T1/sl unknown
- 2003-03-21 TW TW092106344A patent/TW200401781A/zh unknown
- 2003-03-21 KR KR1020107027095A patent/KR20100131018A/ko not_active Ceased
- 2003-03-21 CN CNA038113430A patent/CN1653081A/zh active Pending
- 2003-03-21 RS YU90504A patent/RS90504A/sr unknown
- 2003-03-21 JP JP2003580358A patent/JP2005528371A/ja not_active Withdrawn
- 2003-03-21 US US10/392,857 patent/US20040024202A1/en not_active Abandoned
- 2003-03-21 WO PCT/US2003/007792 patent/WO2003082894A2/en not_active Ceased
- 2003-03-21 KR KR10-2004-7014916A patent/KR20040097201A/ko not_active Abandoned
- 2003-03-21 MX MXPA04009216A patent/MXPA04009216A/es unknown
- 2003-03-21 RS YU83104A patent/RS83104A/sr unknown
- 2003-03-21 DK DK03745535T patent/DK1487859T3/da active
- 2003-03-21 ES ES03745535T patent/ES2310666T3/es not_active Expired - Lifetime
- 2003-03-21 MX MXPA04009178A patent/MXPA04009178A/es not_active Application Discontinuation
- 2003-03-21 CA CA002480151A patent/CA2480151A1/en not_active Abandoned
- 2003-03-21 IL IL16416603A patent/IL164166A0/xx unknown
- 2003-03-21 AT AT03745535T patent/ATE404577T1/de active
- 2003-03-21 CA CA002474072A patent/CA2474072A1/en not_active Abandoned
- 2003-03-21 PL PL03372460A patent/PL372460A1/xx unknown
- 2003-03-21 TW TW092106310A patent/TWI283245B/zh active
- 2003-03-21 EP EP03716548A patent/EP1490390A2/en not_active Withdrawn
- 2003-03-21 JP JP2003580359A patent/JP2005523306A/ja not_active Ceased
- 2003-03-21 PL PL03373189A patent/PL373189A1/xx unknown
- 2003-03-21 PT PT03745535T patent/PT1487859E/pt unknown
- 2003-03-21 AU AU2003220251A patent/AU2003220251A1/en not_active Abandoned
- 2003-03-21 DE DE60322852T patent/DE60322852D1/de not_active Expired - Lifetime
- 2003-03-21 IL IL16415903A patent/IL164159A0/xx unknown
- 2003-03-21 AU AU2003259022A patent/AU2003259022A1/en not_active Abandoned
- 2003-03-21 BR BR0308660-7A patent/BR0308660A/pt not_active IP Right Cessation
- 2003-03-21 BR BR0308466-3A patent/BR0308466A/pt not_active IP Right Cessation
- 2003-03-21 CN CNB038065908A patent/CN100473660C/zh not_active Expired - Lifetime
- 2003-03-21 EP EP03745535A patent/EP1487859B1/en not_active Expired - Lifetime
- 2003-03-21 WO PCT/US2003/007793 patent/WO2003082895A2/en not_active Ceased
- 2003-03-21 KR KR1020047014956A patent/KR20050028907A/ko not_active Withdrawn
- 2003-03-22 MY MYPI20031014A patent/MY138479A/en unknown
2006
- 2006-12-21 US US11/614,538 patent/US20070129332A1/en not_active Abandoned
2008
- 2008-10-24 CY CY20081101205T patent/CY1108453T1/el unknown

Also Published As

Publication number	Publication date
TW200404079A (en)	2004-03-16
BR0308660A (pt)	2005-01-25
AU2003220251A1 (en)	2003-10-13
EP1490390A2 (en)	2004-12-29
CN1653081A (zh)	2005-08-10
TW200401781A (en)	2004-02-01
RS83104A (sr)	2006-10-27
EP1487859A2 (en)	2004-12-22
CA2474072A1 (en)	2003-10-09
CN1633445A (zh)	2005-06-29
MY138479A (en)	2009-06-30
BR0308466A (pt)	2005-04-26
CN100473660C (zh)	2009-04-01
SI1487859T1 (sl)	2008-10-31
RS90504A (sr)	2006-10-27
KR20040097201A (ko)	2004-11-17
DE60322852D1 (de)	2008-09-25
PL372460A1 (en)	2005-07-25
WO2003082895A2 (en)	2003-10-09
CA2480151A1 (en)	2003-10-09
PT1487859E (pt)	2008-10-23
ES2310666T3 (es)	2009-01-16
AU2003259022A1 (en)	2003-10-13
WO2003082894A3 (en)	2004-04-15
CY1108453T1 (el)	2014-04-09
KR20050028907A (ko)	2005-03-23
DK1487859T3 (da)	2008-10-06
MXPA04009216A (es)	2005-01-25
IL164159A0 (en)	2005-12-18
KR20100131018A (ko)	2010-12-14
JP2005528371A (ja)	2005-09-22
WO2003082894A2 (en)	2003-10-09
ATE404577T1 (de)	2008-08-15
PL373189A1 (en)	2005-08-22
EP1487859B1 (en)	2008-08-13
JP2005523306A (ja)	2005-08-04
US20040024202A1 (en)	2004-02-05
MXPA04009178A (es)	2004-11-26
WO2003082895A3 (en)	2004-04-22
US20070129332A1 (en)	2007-06-07
TWI283245B (en)	2007-07-01
HK1078588A1 (zh)	2006-03-17

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