IL157615A0 - 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands - Google Patents

4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

Info

Publication number: IL157615A0
Authority: IL; Israel
Prior art keywords: methoxypyrid; pyrazolo; butylamino; enantiomers; triazine
Prior art date: 2001-03-13

Application number

IL15761502A

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-13

Filing date

2002-03-06

Publication date

2004-03-28

2002-03-06 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-03-28 Publication of IL157615A0 publication Critical patent/IL157615A0/xx

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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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IL15761502A 2001-03-13 2002-03-06 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands IL157615A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27540301P	2001-03-13	2001-03-13
PCT/US2002/006837 WO2002072202A1 (en)	2001-03-13	2002-03-06	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

Publications (1)

Publication Number	Publication Date
IL157615A0 true IL157615A0 (en)	2004-03-28

Family

ID=23052141

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15761502A IL157615A0 (en)	2001-03-13	2002-03-06	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands
IL157615A IL157615A (en)	2001-03-13	2003-08-27	4-(2-butylamino)-2,7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a] - 1,3,5 - triazine, its enantiomers and pharmaceutically acceptable salts as cortocotropin releasing factor receptor ligands

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL157615A IL157615A (en)	2001-03-13	2003-08-27	4-(2-butylamino)-2,7-dimethyl-8- (2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a] - 1,3,5 - triazine, its enantiomers and pharmaceutically acceptable salts as cortocotropin releasing factor receptor ligands

Country Status (35)

Country	Link
US (4)	US20030125330A1 (es)
EP (1)	EP1368094B1 (es)
JP (1)	JP4549630B2 (es)
KR (1)	KR100875595B1 (es)
CN (1)	CN100427093C (es)
AR (1)	AR032986A1 (es)
AT (1)	ATE355102T1 (es)
AU (1)	AU2002245605B2 (es)
BG (1)	BG66331B1 (es)
BR (1)	BR0208357A (es)
CA (1)	CA2440553C (es)
CY (1)	CY1106607T1 (es)
CZ (1)	CZ20032481A3 (es)
DE (1)	DE60218434T2 (es)
DK (1)	DK1368094T3 (es)
EE (1)	EE05433B1 (es)
ES (1)	ES2282401T3 (es)
GE (1)	GEP20053608B (es)
HR (1)	HRP20030822B1 (es)
HU (1)	HU229317B1 (es)
IL (2)	IL157615A0 (es)
IS (1)	IS2839B (es)
MX (1)	MXPA03008185A (es)
MY (1)	MY146935A (es)
NO (1)	NO328580B1 (es)
NZ (1)	NZ528207A (es)
PL (1)	PL208278B1 (es)
PT (1)	PT1368094E (es)
RS (1)	RS50863B (es)
RU (1)	RU2292347C2 (es)
SK (1)	SK287603B6 (es)
TW (1)	TWI257388B (es)
UA (1)	UA74634C2 (es)
WO (1)	WO2002072202A1 (es)
ZA (1)	ZA200306995B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AR041470A1 (es) *	2002-10-17	2005-05-18	Upjohn Co	Compuestos de pirrolo (1,2 - b) piridazina y sus usos
US7329658B2 (en) *	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) *	2003-02-10	2007-02-13	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7041671B2 (en)	2003-04-02	2006-05-09	Pfizer Inc	Pyrrolo[1,2-b]pyridazine compounds and their uses
US7056920B2 (en)	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7034023B2 (en) *	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
EP1615929A1 (en) *	2003-04-15	2006-01-18	Pharmacia & Upjohn Company LLC	Pyrrolo [1,2-b] pyridazine compounds and their uses
US7208596B2 (en)	2003-11-25	2007-04-24	Bristol-Myers Squibb Pharma Company	Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US7153961B2 (en) *	2003-11-25	2006-12-26	Bristol-Myers Squibb Pharma Co.	Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
EP2094709B1 (en)	2006-09-20	2010-09-15	Eli Lilly And Company	Thiazole pyrazolopyrimidines as crf1 receptor antagonists
WO2013160317A2 (en) *	2012-04-23	2013-10-31	Holsboermaschmeyer Neurochemie Gmbh	Crhr1 antagonists for use in the treatment of patients having crh overactivity
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
KR102079844B1 (ko) *	2016-09-20	2020-02-20	가톨릭대학교 산학협력단	담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물
US20210361664A1 (en)	2017-08-14	2021-11-25	Spruce Biosciences, Inc.	Corticotropin releasing factor receptor antagonists
MX2023001688A (es)	2020-08-12	2023-02-22	Spruce Biosciences Inc	Metodos y composiciones para tratar el sindrome de ovario poliquistico.
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW444018B (en)	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
CN1142817A (zh)	1993-10-12	1997-02-12	杜邦麦克制药有限公司	1n-烷基-n-芳基嘧啶胺及其衍生物
TW574214B (en)	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
AU725254B2 (en)	1996-03-26	2000-10-12	Du Pont Pharmaceuticals Company	Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives
US6107300A (en)	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
AU3064397A (en)	1996-05-24	1997-12-09	Dow Chemical Company, The	Process for preparing aliphatic ester compounds and alkanols
US6191131B1 (en) *	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
EE04316B1 (et) *	1996-07-24	2004-06-15	Dupont Pharmaceuticals Company	Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks
HU229024B1 (en)	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
JP3621706B2 (ja) *	1996-08-28	2005-02-16	ファイザー・インク	置換された６，５―ヘテロ―二環式誘導体
IL133800A0 (en) *	1997-07-03	2001-04-30	Du Pont Pharm Co	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
WO1999001439A1 (en)	1997-07-03	1999-01-14	Du Pont Pharmaceuticals Company	Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists
UA62972C2 (en)	1997-07-03	2004-01-15		Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
JP2001514260A (ja)	1997-09-02	2001-09-11	デュポンファーマシューティカルズカンパニー	Ｃｎｓおよびストレス関連疾患の治療に有用な、副腎皮質刺激ホルモン放出ホルモン拮抗剤としての、複素環基が置換した環縮合ピリジン類およびピリミジン類
CA2614603C (en) *	1998-01-28	2011-08-16	Bristol-Myers Squibb Pharma Company	Azolo triazines and pyrimidines
US6194410B1 (en) *	1998-03-11	2001-02-27	Hoffman-La Roche Inc.	Pyrazolopyrimidine and pyrazolines and process for preparation thereof
EP1068212A1 (en)	1998-04-03	2001-01-17	Bristol-Myers Squibb Pharma Company	THIAZOLO 4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
US6124463A (en)	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
KR100666514B1 (ko) *	1999-05-21	2007-02-28	브리스톨-마이어즈 스퀴브 컴페니	키나제의 피롤로트리아진 저해제
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.

2002
- 2002-03-06 ES ES02713776T patent/ES2282401T3/es not_active Expired - Lifetime
- 2002-03-06 DK DK02713776T patent/DK1368094T3/da active
- 2002-03-06 EE EEP200300435A patent/EE05433B1/xx not_active IP Right Cessation
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- 2002-03-06 MX MXPA03008185A patent/MXPA03008185A/es active IP Right Grant
- 2002-03-06 HR HR20030822A patent/HRP20030822B1/xx not_active IP Right Cessation
- 2002-03-06 JP JP2002571157A patent/JP4549630B2/ja not_active Expired - Fee Related
- 2002-03-06 RS YUP-715/03A patent/RS50863B/sr unknown
- 2002-03-06 AT AT02713776T patent/ATE355102T1/de active
- 2002-03-06 BR BR0208357-4A patent/BR0208357A/pt active Search and Examination
- 2002-03-06 HU HU0303480A patent/HU229317B1/hu not_active IP Right Cessation
- 2002-03-06 RU RU2003130093/04A patent/RU2292347C2/ru not_active IP Right Cessation
- 2002-03-06 US US10/092,312 patent/US20030125330A1/en not_active Abandoned
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- 2002-06-03 UA UA2003109244A patent/UA74634C2/uk unknown
2003
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- 2003-09-08 ZA ZA200306995A patent/ZA200306995B/en unknown
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- 2003-09-11 NO NO20034023A patent/NO328580B1/no not_active IP Right Cessation
- 2003-09-23 BG BG108189A patent/BG66331B1/bg unknown
2006
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2007
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Also Published As

Publication number	Publication date
JP2004530662A (ja)	2004-10-07
US7662817B2 (en)	2010-02-16
HU229317B1 (en)	2013-10-28
CA2440553C (en)	2010-06-08
DE60218434T2 (de)	2007-11-08
ES2282401T3 (es)	2007-10-16
NO328580B1 (no)	2010-03-22
YU71503A (sh)	2006-05-25
RU2292347C2 (ru)	2007-01-27
US7358252B2 (en)	2008-04-15
HRP20030822B1 (en)	2008-01-31
BR0208357A (pt)	2004-06-29
US20070054913A1 (en)	2007-03-08
BG108189A (bg)	2004-09-30
CN100427093C (zh)	2008-10-22
WO2002072202A1 (en)	2002-09-19
EP1368094A4 (en)	2004-03-31
US20040014760A1 (en)	2004-01-22
NO20034023D0 (no)	2003-09-11
EP1368094B1 (en)	2007-02-28
US20030125330A1 (en)	2003-07-03
IS6947A (is)	2003-09-10
AU2002245605B2 (en)	2006-02-02
US20080139567A1 (en)	2008-06-12
SK11572003A3 (sk)	2004-02-03
JP4549630B2 (ja)	2010-09-22
RS50863B (sr)	2010-08-31
PT1368094E (pt)	2007-05-31
DE60218434D1 (en)	2007-04-12
KR100875595B1 (ko)	2008-12-23
NZ528207A (en)	2006-02-24
EE200300435A (et)	2003-12-15
UA74634C2 (uk)	2006-01-16
MXPA03008185A (es)	2004-01-29
GEP20053608B (en)	2005-09-12
HRP20030822A2 (en)	2004-04-30
KR20030080086A (ko)	2003-10-10
CN1509196A (zh)	2004-06-30
HUP0303480A3 (en)	2005-12-28
HUP0303480A2 (hu)	2004-01-28
RU2003130093A (ru)	2005-03-20
HK1057182A1 (en)	2004-03-19
CZ20032481A3 (cs)	2007-12-27
IS2839B (is)	2013-06-15
AR032986A1 (es)	2003-12-03
ATE355102T1 (de)	2006-03-15
US7157578B2 (en)	2007-01-02
BG66331B1 (bg)	2013-06-28
PL368644A1 (en)	2005-04-04
PL208278B1 (pl)	2011-04-29
CY1106607T1 (el)	2012-01-25
TWI257388B (en)	2006-07-01
ZA200306995B (en)	2004-09-08
SK287603B6 (sk)	2011-03-04
EE05433B1 (et)	2011-06-15
NO20034023L (no)	2003-09-11
IL157615A (en)	2009-09-01
MY146935A (en)	2012-10-15
DK1368094T3 (da)	2007-07-02
EP1368094A1 (en)	2003-12-10
CA2440553A1 (en)	2002-09-19

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ATE388713T1 (de)	2008-03-15	4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate
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