IL128601A0 - 7alpha-(epsilon-aminoalkyl) estratrienes, process for preparing the same, pharmaceutical preparation containing said 7alpha-(epsilon-aminoalkyl) estratrienes and their use for preparing medicaments - Google Patents

7alpha-(epsilon-aminoalkyl) estratrienes, process for preparing the same, pharmaceutical preparation containing said 7alpha-(epsilon-aminoalkyl) estratrienes and their use for preparing medicaments

Info

Publication number: IL128601A0
Authority: IL; Israel
Prior art keywords: estratrienes; 7alpha; epsilon; aminoalkyl; preparing
Prior art date: 1996-08-20

Application number

IL12860197A

Other versions

IL128601A (en

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-20

Filing date

1997-08-20

Publication date

2000-01-31

1997-08-20 Application filed by Schering Ag filed Critical Schering Ag

2000-01-31 Publication of IL128601A0 publication Critical patent/IL128601A0/en

2003-07-31 Publication of IL128601A publication Critical patent/IL128601A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL12860197A 1996-08-20 1997-08-20 7alpha-(epsilon-AMINOALKYL) ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7alpha-(epsilon-AMINOALKYL) ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS IL128601A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19635525A DE19635525A1 (en)	1996-08-20	1996-08-20	New 7-alpha-(xi-aminoalkyl)- oestratriene derivatives
PCT/EP1997/004517 WO1998007740A1 (en)	1996-08-20	1997-08-20	7α-(κ-AMINOALKYL)ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7α-(κ-AMINOALKYL)ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS

Publications (2)

Publication Number	Publication Date
IL128601A0 true IL128601A0 (en)	2000-01-31
IL128601A IL128601A (en)	2003-07-31

Family

ID=7804367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12860197A IL128601A (en)	1996-08-20	1997-08-20	7alpha-(epsilon-AMINOALKYL) ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7alpha-(epsilon-AMINOALKYL) ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENTS

Country Status (29)

Country	Link
EP (1)	EP0920441B1 (en)
JP (1)	JP2001503024A (en)
KR (1)	KR20000068261A (en)
CN (1)	CN1231670A (en)
AR (1)	AR009278A1 (en)
AT (1)	ATE231882T1 (en)
AU (1)	AU728843B2 (en)
BG (1)	BG62972B1 (en)
BR (1)	BR9711328A (en)
CA (1)	CA2263708A1 (en)
CZ (1)	CZ57999A3 (en)
DE (2)	DE19635525A1 (en)
DK (1)	DK0920441T3 (en)
EA (1)	EA001577B1 (en)
EE (1)	EE04021B1 (en)
ES (1)	ES2191857T3 (en)
HU (1)	HUP9903106A3 (en)
IL (1)	IL128601A (en)
IS (1)	IS4976A (en)
NO (1)	NO315655B1 (en)
NZ (1)	NZ334277A (en)
PL (1)	PL186309B1 (en)
PT (1)	PT920441E (en)
SK (1)	SK18899A3 (en)
TR (1)	TR199900432T2 (en)
TW (1)	TW552267B (en)
UA (1)	UA50792C2 (en)
WO (1)	WO1998007740A1 (en)
ZA (1)	ZA977482B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR015500A1 (en) *	1997-12-23	2001-05-02	Schering Ag	11 BETA-HALOGEN-STRATRIENS REPLACED IN 7 ALPHA, PROCEDURE FOR PREPARING PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH 11 BETA-HALOGEN-STRATRIENS REPLACED IN 7 ALPHA, AS WELL AS USED IN THE PREPARATION OF MEDICINES.
US6548491B2 (en)	1997-12-24	2003-04-15	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6054446A (en)	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en)	1997-12-24	2003-01-07	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19807791A1 (en)	1998-02-19	1999-08-26	Schering Ag	Combination preparation of estrogen with 7-aminoalkyl-estratriene antiestrogen, useful in hormone replacement therapy, e.g. for treatment osteoporosis, Alzheimer's disease and hot flushes
DE19833786A1 (en) *	1998-07-18	2000-01-20	Schering Ag	New diphenyl-benzocycloheptene derivatives, are tissue-selective estrogens and antiestrogens useful e.g. for treating osteoporosis or hormone-dependent tumors or in hormone replacement therapy
DE19842123C1 (en) *	1998-09-05	2000-07-13	Schering Ag	11beta-fluoro-7alpha- (14,14,15,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl) estra-1,3,5 (10) - triene-3,17beta-diol as crystalline solvate
DE19906159A1 (en) *	1999-02-09	2000-08-10	Schering Ag	16-hydroxyestratrienes as selectively active estrogens
JP2003507376A (en) *	1999-08-18	2003-02-25	シエーリングアクチエンゲゼルシャフト	Piperidine and pyrrolidine derivatives showing neuronal activity
GB0000313D0 (en) *	2000-01-10	2000-03-01	Astrazeneca Uk Ltd	Formulation
DE10019171A1 (en) *	2000-04-07	2001-10-18	Schering Ag	Compositions for use as penetration enhancers in transdermal formulations for highly lipophilic active ingredients
DE10159217A1 (en)	2001-11-27	2003-06-05	Schering Ag	17alpha-alkyl-17ß-oxy-estratrienes and intermediates for their preparation, use of 17alpha-alkyl-17ß-oxy-estratriene for the preparation of medicaments and pharmaceutical preparations
AU2006202187B2 (en) *	2001-11-27	2008-11-06	Bayer Schering Pharma Aktiengesellschaft	17alpah-alkyl-17beta-oxy-estratrienes and intermediate products for their production, uses thereof and pharmaceutical preparations
US20040242551A1 (en) *	2003-05-28	2004-12-02	Schering Ag	Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
ATE482966T1 (en) *	2004-07-27	2010-10-15	Sicor Inc	METHOD FOR PRODUCING 7-ALPHA-ALKYLATED 19-NORSTEROIDS
CN101312944B (en)	2005-11-22	2013-03-06	住友化学株式会社	Organosulfur compounds and their use as arthropodicides
DE102007023614A1 (en)	2007-05-21	2008-11-27	Bayer Schering Pharma Aktiengesellschaft	New amide compounds used for treatment of gynecological diseases e.g. endometriosis, for female fertility control and female hormone replacement therapy, has general formula
DE102007049630A1 (en)	2007-10-11	2009-10-29	Bayer Schering Pharma Aktiengesellschaft	New amide compounds used for therapy and/or prophylaxis of gynecological diseases e.g. endometriosis, for female fertility control and female hormone replacement therapy
JP2009001551A (en)	2007-05-18	2009-01-08	Sumitomo Chemical Co Ltd	Organic sulfur compounds and their use for controlling harmful arthropods
JP5298631B2 (en)	2007-05-18	2013-09-25	住友化学株式会社	Organic sulfur compounds and their use for controlling harmful arthropods
TW200904329A (en)	2007-05-18	2009-02-01	Sumitomo Chemical Co	Organic sulfur compound and its use for controlling harmful arthropod
DE102007032800A1 (en)	2007-07-10	2009-01-15	Bayer Schering Pharma Aktiengesellschaft	Nonsteroidal progesterone receptor modulators
NZ585389A (en)	2007-10-16	2011-10-28	Repros Therapeutics Inc	Trans-clomiphene for metabolic syndrome
DE102007058747A1 (en)	2007-12-05	2009-06-10	Bayer Schering Pharma Aktiengesellschaft	Nonsteroidal progesterone receptor modulators
EP2070909A1 (en)	2007-12-15	2009-06-17	Bayer Schering Pharma AG	Non-steroidal progesterone receptor modulators
EP2070941A1 (en)	2007-12-14	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Stereoselective synthesis of selective estrogen receptor down-regulators
DE102008057230A1 (en)	2008-11-11	2010-05-12	Bayer Schering Pharma Aktiengesellschaft	Synergistic pharmaceutical combination with an estrogen receptor antagonist and a progestin
JP5212350B2 (en) *	2008-12-24	2013-06-19	住友化学株式会社	Halogen-containing organic sulfur compounds and uses thereof
EP2258375A1 (en)	2009-06-04	2010-12-08	Bayer Schering Pharma Aktiengesellschaft	17B-alkyl-17alpha-oxy-estratrienes
DE102009034367A1 (en)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-benzylidene derivatives, process for their preparation and their use for the treatment of diseases
DE102009034362A1 (en)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034366A1 (en)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-methyleneoxyalkylene aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034368A1 (en)	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-acyloxyalkylenephenyl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034525A1 (en)	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-aryl derivatives, process for their preparation and their use for the treatment of diseases
DE102009034526A1 (en)	2009-07-21	2011-02-10	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-ethynylphenyl derivatives, process for their preparation and their use for the treatment of diseases
WO2011092127A1 (en)	2010-01-26	2011-08-04	Bayer Schering Pharma Aktiengesellschaft	14,17-bridged estratriene derivatives comprising heterocyclic bioisosteres for the phenolic a-ring
DE102010007719A1 (en)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesterone receptor antagonist
DE102010007722A1 (en)	2010-02-10	2011-08-11	Bayer Schering Pharma Aktiengesellschaft, 13353	Progesterone receptor antagonist
KR20170127044A (en)	2010-06-16	2017-11-20	앙도르쉐르슈 인코포레이티드	Methods of treating or preventing estrogen-related diseases
DE102010030538A1 (en)	2010-06-25	2011-12-29	Bayer Schering Pharma Aktiengesellschaft	6,7-Dihydro-5H-benzo [7] annulene derivatives, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicaments
DE102011004899A1 (en)	2011-03-01	2012-09-06	Bayer Pharma Aktiengesellschaft	New 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl-derivatives are progesterone receptor antagonists useful to treat and prevent e.g. uterine fibroids, endometriosis, heavy menstrual bleeding and meningioma
PT2753632T (en)	2011-09-08	2023-08-17	Sage Therapeutics Inc	Neuroactive steroids, compositions, and uses thereof
DE102011087987A1 (en)	2011-12-08	2013-06-13	Bayer Intellectual Property Gmbh	6,7-Dihydro-5H-benzo [7] annulene derivatives, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicaments
ES2681023T3 (en)	2012-02-29	2018-09-11	Repros Therapeutics Inc.	Combination therapy to treat androgen deficit
SMT202500336T1 (en)	2013-03-13	2025-11-10	Sage Therapeutics Inc	Neuroactive steriods and methods of use thereof
KR102198059B1 (en)	2013-04-11	2021-01-05	바이엘 파마 악티엔게젤샤프트	Progesterone receptor antagonist dosage form
EP2987799B1 (en) *	2013-04-18	2020-04-08	Xi'an Libang Pharmaceutical Technology Co.,ltd.	Ester derivative of 7-alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol having antitumour activity and preparation method thereof
WO2015195967A1 (en)	2014-06-18	2015-12-23	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
CN113292623A (en)	2015-07-06	2021-08-24	萨奇治疗股份有限公司	Pregnansterol and methods of use thereof
US11633382B2 (en)	2015-11-10	2023-04-25	Paracrine Therapeutics Ab	Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
JP7112331B2 (en)	2016-04-01	2022-08-03	セージセラピューティクス，インコーポレイテッド	Oxysterols and their uses
US10752653B2 (en)	2016-05-06	2020-08-25	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
TWI752976B (en)	2016-07-07	2022-01-21	美商賽吉醫療公司	Oxysterols and methods of use thereof
CA3038900A1 (en)	2016-09-30	2018-04-05	Sage Therapeutics, Inc.	C7 substituted oxysterols and methods as nmda modulators
CN115322238A (en)	2016-10-18	2022-11-11	萨奇治疗股份有限公司	Oxysterol and methods of use thereof
CN115505019B (en) *	2022-11-07	2024-01-26	南宁师范大学	7-amide substituted estrogen compounds and their preparation methods and applications
CN116041412A (en) *	2023-01-13	2023-05-02	香港中文大学（深圳）	Fulvestrant derivative and its preparation method, application and medicine for treating breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8327256D0 (en) *	1983-10-12	1983-11-16	Ici Plc	Steroid derivatives
HU208150B (en) *	1988-10-31	1993-08-30	Endorecherche Inc	Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
DE3925507A1 (en) *	1989-07-28	1991-01-31	Schering Ag	14,17 (ALPHA) ETHENO AND ETHANOESTRATRIA, METHOD FOR PRODUCING THESE COMPOUNDS, AND THEIR USE FOR PRODUCING MEDICINAL PRODUCTS
DE4218743C2 (en) *	1992-06-04	2001-10-25	Schering Ag	Process for the preparation of C (7) -substituted Estra-1,3,5 (10) -trienes and new starting products for this process

1996
- 1996-08-20 DE DE19635525A patent/DE19635525A1/en not_active Withdrawn
1997
- 1997-08-20 ZA ZA9707482A patent/ZA977482B/en unknown
- 1997-08-20 HU HU9903106A patent/HUP9903106A3/en unknown
- 1997-08-20 DE DE59709239T patent/DE59709239D1/en not_active Expired - Fee Related
- 1997-08-20 CN CN97198245A patent/CN1231670A/en active Pending
- 1997-08-20 UA UA99031552A patent/UA50792C2/en unknown
- 1997-08-20 BR BR9711328A patent/BR9711328A/en unknown
- 1997-08-20 WO PCT/EP1997/004517 patent/WO1998007740A1/en not_active Ceased
- 1997-08-20 PL PL97331863A patent/PL186309B1/en not_active IP Right Cessation
- 1997-08-20 EP EP97943814A patent/EP0920441B1/en not_active Expired - Lifetime
- 1997-08-20 TW TW086111927A patent/TW552267B/en active
- 1997-08-20 IL IL12860197A patent/IL128601A/en not_active IP Right Cessation
- 1997-08-20 NZ NZ334277A patent/NZ334277A/en unknown
- 1997-08-20 ES ES97943814T patent/ES2191857T3/en not_active Expired - Lifetime
- 1997-08-20 EA EA199900210A patent/EA001577B1/en not_active IP Right Cessation
- 1997-08-20 DK DK97943814T patent/DK0920441T3/en active
- 1997-08-20 JP JP10510412A patent/JP2001503024A/en not_active Ceased
- 1997-08-20 AR ARP970103779A patent/AR009278A1/en not_active Application Discontinuation
- 1997-08-20 CZ CZ99579A patent/CZ57999A3/en unknown
- 1997-08-20 TR TR1999/00432T patent/TR199900432T2/en unknown
- 1997-08-20 CA CA002263708A patent/CA2263708A1/en not_active Abandoned
- 1997-08-20 KR KR1019997001396A patent/KR20000068261A/en not_active Ceased
- 1997-08-20 SK SK188-99A patent/SK18899A3/en unknown
- 1997-08-20 EE EEP199900075A patent/EE04021B1/en not_active IP Right Cessation
- 1997-08-20 PT PT97943814T patent/PT920441E/en unknown
- 1997-08-20 AU AU45520/97A patent/AU728843B2/en not_active Ceased
- 1997-08-20 AT AT97943814T patent/ATE231882T1/en not_active IP Right Cessation
1999
- 1999-02-11 IS IS4976A patent/IS4976A/en unknown
- 1999-02-16 BG BG103185A patent/BG62972B1/en unknown
- 1999-02-19 NO NO19990793A patent/NO315655B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP9903106A2 (en)	2000-03-28
PL331863A1 (en)	1999-08-16
EP0920441A1 (en)	1999-06-09
DK0920441T3 (en)	2003-05-26
IS4976A (en)	1999-02-11
PT920441E (en)	2003-06-30
CA2263708A1 (en)	1998-02-26
BR9711328A (en)	1999-08-17
NO990793D0 (en)	1999-02-19
CZ57999A3 (en)	1999-08-11
CN1231670A (en)	1999-10-13
DE19635525A1 (en)	1998-02-26
NO315655B1 (en)	2003-10-06
HUP9903106A3 (en)	2000-05-29
BG103185A (en)	1999-11-30
DE59709239D1 (en)	2003-03-06
NO990793L (en)	1999-04-20
EA001577B1 (en)	2001-06-25
ATE231882T1 (en)	2003-02-15
IL128601A (en)	2003-07-31
JP2001503024A (en)	2001-03-06
WO1998007740A1 (en)	1998-02-26
PL186309B1 (en)	2003-12-31
ZA977482B (en)	1998-02-23
AR009278A1 (en)	2000-04-12
SK18899A3 (en)	1999-08-06
AU728843B2 (en)	2001-01-18
ES2191857T3 (en)	2003-09-16
UA50792C2 (en)	2002-11-15
EE9900075A (en)	1999-10-15
KR20000068261A (en)	2000-11-25
EE04021B1 (en)	2003-04-15
EP0920441B1 (en)	2003-01-29
TW552267B (en)	2003-09-11
TR199900432T2 (en)	1999-04-21
AU4552097A (en)	1998-03-06
BG62972B1 (en)	2000-12-29
NZ334277A (en)	2000-10-27
EA199900210A1 (en)	1999-08-26

Publication	Publication Date	Title
IL128601A0 (en)	2000-01-31	7alpha-(epsilon-aminoalkyl) estratrienes, process for preparing the same, pharmaceutical preparation containing said 7alpha-(epsilon-aminoalkyl) estratrienes and their use for preparing medicaments
HUP9900974A3 (en)	2000-09-28	Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0001508A3 (en)	2003-01-28	4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
HUP9603495A2 (en)	1997-12-29	1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-compounds, pharmaceutical compositions containing the same and process for their preparation
HRP950217B1 (en)	2004-06-30	Novel erythromycin derivatives, method for preparing the same and use thereof as drugs
IL136938A0 (en)	2001-06-14	11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
HUP9702534A3 (en)	1999-01-28	Propiophenone derivatives, process for preparing them and medicaments containing the said compounds
AP9901556A0 (en)	1999-06-30	Sulpponamide derivatives process for their preparation and their use as medicaments
EP0412350A3 (en)	1992-03-25	Renininhibitors, procedure for their preparation and use as medicaments
HUP9700328A3 (en)	1998-09-28	Heteroaryl-oxazolidinones, process for their preparation, pharmaceutical compositions containing the same, their use and intermediates
HUP0002718A3 (en)	2001-11-28	Piperazine derivatives, process for their preparation and medicaments containing the same
HUP0000426A3 (en)	2001-04-28	Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation
HRP970450B1 (en)	2003-02-28	Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or diagnostic agents and drugs containing them
HRP980258B1 (en)	2002-08-31	New triazole derivatives, process for the preparation thereof and pharmaceutical preparations containing them
AU1166895A (en)	1995-08-24	Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-onederivatives, process for their preparation and the pharmaceutical compositions containing them
HUP9901485A3 (en)	2001-03-28	Heterocyclylcarboxamide derivatives, pharmaceutical compositions containing the same, process for their preparation and their use
GB8917687D0 (en)	1989-09-20	Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
HUP9600665A2 (en)	1997-10-28	Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
GB9310075D0 (en)	1993-06-30	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
HU9701316D0 (en)	1997-09-29	Substituted indanylideneacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
HU9700989D0 (en)	1997-07-28	Ortho-substituted benzoyl-guanidines, process for producing them, their use as medicament and diagnosticment, pharmaceutical compositions containing them
HRP960532A2 (en)	1998-06-30	Novel imidazole n-benzyldioxol derivatives, method for preparing the same, their use as medicaments, pharmaceutical preparations and novel use
HUP0003104A3 (en)	2002-01-28	Amino-spiropiperidin-quinazoline derivatives, their use, process for their preparation and pharmaceutical compositions containing them
HRP980527B1 (en)	2002-12-31	Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them
ZA9810403B (en)	2000-05-15	New epothilon derivatives, process for their preparation and their pharmaceutical use.

Legal Events

Date	Code	Title	Description
2004-01-04	FF	Patent granted
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees