IL127911A0 - Substituted triazolo-pyridazine derivatives as ligands for gaba receptors - Google Patents

Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Info

Publication number: IL127911A0
Authority: IL; Israel
Prior art keywords: ligands; pyridazine derivatives; gaba receptors; substituted triazolo; triazolo
Prior art date: 1996-07-25

Application number

IL12791197A

Other languages

English (en)

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-17

Publication date

1999-11-30

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1997-07-17 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1999-11-30 Publication of IL127911A0 publication Critical patent/IL127911A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL12791197A 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors IL127911A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
IL127911A0 true IL127911A0 (en)	1999-11-30

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12791197A IL127911A0 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Country Status (24)

Country	Link
US (1)	US6255305B1 (xx)
EP (1)	EP0915875B1 (xx)
JP (1)	JP4216905B2 (xx)
KR (1)	KR20000029548A (xx)
CN (1)	CN1251589A (xx)
AT (1)	ATE236904T1 (xx)
AU (1)	AU723098B2 (xx)
BG (1)	BG103112A (xx)
BR (1)	BR9710729A (xx)
CZ (1)	CZ18199A3 (xx)
DE (1)	DE69720732T2 (xx)
EA (1)	EA002436B1 (xx)
EE (1)	EE9900027A (xx)
ES (1)	ES2194205T3 (xx)
HU (1)	HUP0600527A2 (xx)
IL (1)	IL127911A0 (xx)
IS (1)	IS4949A (xx)
NO (1)	NO990304L (xx)
NZ (1)	NZ333768A (xx)
PL (1)	PL331072A1 (xx)
SK (1)	SK9399A3 (xx)
TR (1)	TR199900047T2 (xx)
WO (1)	WO1998004559A2 (xx)
YU (1)	YU2899A (xx)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
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ES2179490T3 (es) *	1997-05-08	2003-01-16	Merck Sharp & Dohme	Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en) *	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (en) *	1998-01-14	2000-11-02	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
PL341652A1 (en) *	1998-01-21	2001-04-23	Merck Sharp & Dohme	Derivatives of triazolopyridazine as ligands for gaba receptors
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en) *	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
WO1999065904A1 (en) *	1998-06-16	1999-12-23	Merck Sharp & Dohme Limited	Triazolo-pyridine derivatives as ligands for gaba receptors
GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
GB9813576D0 (en) *	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
US6610694B1 (en) *	1998-10-06	2003-08-26	Takeda Chemical Industries, Ltd.	Condensed pyridazine compounds, their production and use
DE69936998T2 (de)	1998-10-16	2008-05-21	Merck Sharp & Dohme Ltd., Hoddesdon	Pyrazolotriazinderivate als gaba-rezeptorliganden
IT1303272B1 (it)	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
EP1149102B1 (en) *	1999-01-27	2004-12-08	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) *	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en)	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en)	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en)	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
GB0108475D0 (en) *	2001-04-04	2001-05-23	Merck Sharp & Dohme	New compounds
WO2002083675A2 (en)	2001-04-10	2002-10-24	Merck Sharp & Dohme Limited	Inhibitors of akt activity
WO2002083064A2 (en) *	2001-04-10	2002-10-24	Merck & Co., Inc.	A method of treating cancer
WO2002083139A1 (en)	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
US6958334B2 (en)	2001-04-10	2005-10-25	Merck & Co., Inc.	Inhibitors of Akt activity
GB0122696D0 (en)	2001-09-20	2001-11-14	Merck Sharp & Dohme	Therapeutic agents
GB0128499D0 (en) *	2001-11-28	2002-01-23	Merck Sharp & Dohme	Therapeutic agents
WO2003084473A2 (en) *	2002-04-08	2003-10-16	Merck & Co., Inc.	Method of treating cancer
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
DE60325865D1 (de) *	2002-08-13	2009-03-05	Merck Sharp & Dohme	Phenylpyridazin derivative als liganden für gaba-rezeptoren
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ES2347337T3 (es)	2004-09-02	2010-10-28	Nycomed Gmbh	Triazoloftalazinas.
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EA012505B1 (ru)	2005-01-05	2009-10-30	Никомед Гмбх	Триазолофталазины в качестве ингибиторов pde-2
WO2006072612A2 (en)	2005-01-05	2006-07-13	Nycomed Gmbh	Triazolophthalazines as pde2- inhibitors
US7572807B2 (en)	2005-06-09	2009-08-11	Bristol-Myers Squibb Company	Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
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JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
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US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
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US7638541B2 (en)	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
KR20100033419A (ko) *	2007-07-19	2010-03-29	메타볼렉스, 인코포레이티드	당뇨병 및 대사 장애의 치료를 위한 ｒｕｐ3 또는 ｇｐｒ119 수용체의 작용제로서 ｎ-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체
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CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
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CA1080712A (en)	1976-09-22	1980-07-01	Jay D. Albright	Hypotensive agents
FI81350C (fi) *	1982-01-18	1990-10-10	Lepetit Spa	Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
US4487930A (en) *	1982-09-07	1984-12-11	The Dow Chemical Company	6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) *	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
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FR2562071B1 (fr) *	1984-03-30	1986-12-19	Sanofi Sa	Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9321162D0 (en)	1993-10-13	1993-12-01	Boots Co Plc	Therapeutic agents
GB9507348D0 (en) *	1995-04-08	1995-05-31	Knoll Ag	Therapeutic agents
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use

1997
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
CN1251589A (zh)	2000-04-26
KR20000029548A (ko)	2000-05-25
CZ18199A3 (cs)	1999-06-16
DE69720732D1 (de)	2003-05-15
HUP0600527A2 (en)	2006-11-28
AU723098B2 (en)	2000-08-17
SK9399A3 (en)	2000-04-10
TR199900047T2 (xx)	1999-03-22
EP0915875B1 (en)	2003-04-09
JP2002514169A (ja)	2002-05-14
ES2194205T3 (es)	2003-11-16
BG103112A (en)	1999-09-30
BR9710729A (pt)	1999-08-17
DE69720732T2 (de)	2004-01-29
EA199900164A1 (ru)	2000-04-24
NO990304D0 (no)	1999-01-22
IS4949A (is)	1999-01-19
EA002436B1 (ru)	2002-04-25
EP0915875A2 (en)	1999-05-19
PL331072A1 (en)	1999-06-21
NO990304L (no)	1999-03-25
JP4216905B2 (ja)	2009-01-28
EE9900027A (et)	1999-08-16
ATE236904T1 (de)	2003-04-15
NZ333768A (en)	2000-09-29
AU3553997A (en)	1998-02-20
WO1998004559A2 (en)	1998-02-05
YU2899A (sh)	2000-03-21
US6255305B1 (en)	2001-07-03

Publication	Publication Date	Title
IL127911A0 (en)	1999-11-30	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
US5789416B1 (en)	1999-10-05	N6 mono heterocyclic substituted adenosine derivatives
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
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