BR9710729A - Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto - Google Patents

Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto

Info

Publication number: BR9710729A
Authority: BR; Brazil
Prior art keywords: compound; seizures; anxiety; screening; prevention
Prior art date: 1996-07-25

Application number

BR9710729A

Other languages

English (en)

Inventor

Howard Barff Broughton

William Robert Carling

Jose Luis Castro Pineiro

Alexander Richard Guiblin

Andrew Madin

Kevin William Moore

Michael Geoffrey Russel

Leslie Joseph Street

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-17

Publication date

1999-08-17

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1997-07-17 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1999-08-17 Publication of BR9710729A publication Critical patent/BR9710729A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BR9710729A 1996-07-25 1997-07-17 Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto BR9710729A (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
BR9710729A true BR9710729A (pt)	1999-08-17

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9710729A BR9710729A (pt)	1996-07-25	1997-07-17	Composto composi-Æo farmac-utica utiliza-Æo de um composto e processo para o tratamento e/ou a preven-Æo da ansiedade e de convuls{es para a triagem de compostos ansioliticos nÆo-sedativos e para a prepara-Æo de um composto

Country Status (24)

Country	Link
US (1)	US6255305B1 (pt)
EP (1)	EP0915875B1 (pt)
JP (1)	JP4216905B2 (pt)
KR (1)	KR20000029548A (pt)
CN (1)	CN1251589A (pt)
AT (1)	ATE236904T1 (pt)
AU (1)	AU723098B2 (pt)
BG (1)	BG103112A (pt)
BR (1)	BR9710729A (pt)
CZ (1)	CZ18199A3 (pt)
DE (1)	DE69720732T2 (pt)
EA (1)	EA002436B1 (pt)
EE (1)	EE9900027A (pt)
ES (1)	ES2194205T3 (pt)
HU (1)	HUP0600527A2 (pt)
IL (1)	IL127911A0 (pt)
IS (1)	IS4949A (pt)
NO (1)	NO990304L (pt)
NZ (1)	NZ333768A (pt)
PL (1)	PL331072A1 (pt)
SK (1)	SK9399A3 (pt)
TR (1)	TR199900047T2 (pt)
WO (1)	WO1998004559A2 (pt)
YU (1)	YU2899A (pt)

Families Citing this family (89)

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JP4672820B2 (ja) *	1997-05-08	2011-04-20	メルクシャープエンドドームリミテッド	ＧＡＢＡα５リガンドとしての置換１，２，４−トリアゾロ［３，４−ａ］フタラジン誘導体
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en)	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
JP2002509150A (ja) *	1998-01-14	2002-03-26	メルクシャープエンドドームリミテッド	Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
SK10922000A3 (sk) *	1998-01-21	2001-03-12	Merck Sharp & Dohme Limited	Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
GB9801210D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en) *	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en) *	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
CA2334836A1 (en)	1998-06-16	1999-12-23	Merck Sharp & Dohme Limited	Triazolo-pyridine derivatives as ligands for gaba receptors
GB9813576D0 (en) *	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
EP1120418A4 (en) *	1998-10-06	2005-01-26		CONDENSED PYRIDAZINE COMPOUNDS, METHOD FOR PREPARING SAME AND USE THEREOF
AU760688B2 (en) *	1998-10-16	2003-05-22	Merck Sharp & Dohme Limited	Pyrazolo-triazine derivatives as ligands for GABA receptors
IT1303272B1 (it)	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) *	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
EP1149102B1 (en) *	1999-01-27	2004-12-08	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en)	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en) *	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en) *	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en) *	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
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US6960584B2 (en) *	2001-04-10	2005-11-01	Merck & Co., Inc.	Inhibitors of Akt activity
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JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
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CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
CN107344938B (zh) *	2016-05-06	2022-05-06	上海赛默罗生物科技有限公司	吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
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1997
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
EA002436B1 (ru)	2002-04-25
HUP0600527A2 (en)	2006-11-28
JP4216905B2 (ja)	2009-01-28
PL331072A1 (en)	1999-06-21
ES2194205T3 (es)	2003-11-16
EA199900164A1 (ru)	2000-04-24
EP0915875B1 (en)	2003-04-09
CN1251589A (zh)	2000-04-26
NZ333768A (en)	2000-09-29
NO990304D0 (no)	1999-01-22
AU3553997A (en)	1998-02-20
DE69720732D1 (de)	2003-05-15
US6255305B1 (en)	2001-07-03
TR199900047T2 (xx)	1999-03-22
SK9399A3 (en)	2000-04-10
KR20000029548A (ko)	2000-05-25
WO1998004559A2 (en)	1998-02-05
JP2002514169A (ja)	2002-05-14
CZ18199A3 (cs)	1999-06-16
YU2899A (sh)	2000-03-21
EE9900027A (et)	1999-08-16
ATE236904T1 (de)	2003-04-15
NO990304L (no)	1999-03-25
IS4949A (is)	1999-01-19
BG103112A (en)	1999-09-30
EP0915875A2 (en)	1999-05-19
AU723098B2 (en)	2000-08-17
IL127911A0 (en)	1999-11-30
DE69720732T2 (de)	2004-01-29

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