[go: up one dir, main page]

HUP0600527A2 - Substituted triazolo-pyridazine derivatives as ligands for gaba receptors, process for their preparation and pharmaceutical compositions containing them - Google Patents

Substituted triazolo-pyridazine derivatives as ligands for gaba receptors, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
HUP0600527A2
HUP0600527A2 HU0600527A HUP0600527A HUP0600527A2 HU P0600527 A2 HUP0600527 A2 HU P0600527A2 HU 0600527 A HU0600527 A HU 0600527A HU P0600527 A HUP0600527 A HU P0600527A HU P0600527 A2 HUP0600527 A2 HU P0600527A2
Authority
HU
Hungary
Prior art keywords
ligands
preparation
pharmaceutical compositions
compositions containing
pyridazine derivatives
Prior art date
Application number
HU0600527A
Other languages
English (en)
Inventor
Howard Barff Broughton
William Robert Carling
Pineiro Jose Luis Castro
Alexander Richard Guiblin
Andrew Madin
Kevin William Moore
Michael Geoffrey Neil Russell
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en
Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en
Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HUP0600527A2 publication Critical patent/HUP0600527A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU0600527A 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors, process for their preparation and pharmaceutical compositions containing them HUP0600527A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9615645.0A GB9615645D0 (en) 1996-07-25 1996-07-25 Therapeutic agents
GBGB9625397.6A GB9625397D0 (en) 1996-12-06 1996-12-06 Therapeutic agents
GBGB9714420.8A GB9714420D0 (en) 1997-07-09 1997-07-09 Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en) 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
HUP0600527A2 true HUP0600527A2 (en) 2006-11-28

Family

ID=27268403

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0600527A HUP0600527A2 (en) 1996-07-25 1997-07-17 Substituted triazolo-pyridazine derivatives as ligands for gaba receptors, process for their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US6255305B1 (hu)
EP (1) EP0915875B1 (hu)
JP (1) JP4216905B2 (hu)
KR (1) KR20000029548A (hu)
CN (1) CN1251589A (hu)
AT (1) ATE236904T1 (hu)
AU (1) AU723098B2 (hu)
BG (1) BG103112A (hu)
BR (1) BR9710729A (hu)
CZ (1) CZ18199A3 (hu)
DE (1) DE69720732T2 (hu)
EA (1) EA002436B1 (hu)
EE (1) EE9900027A (hu)
ES (1) ES2194205T3 (hu)
HU (1) HUP0600527A2 (hu)
IL (1) IL127911A0 (hu)
IS (1) IS4949A (hu)
NO (1) NO990304L (hu)
NZ (1) NZ333768A (hu)
PL (1) PL331072A1 (hu)
SK (1) SK9399A3 (hu)
TR (1) TR199900047T2 (hu)
WO (1) WO1998004559A2 (hu)
YU (1) YU2899A (hu)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179490T3 (es) * 1997-05-08 2003-01-16 Merck Sharp & Dohme Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en) 1997-08-28 1997-11-05 Merck Sharp & Dohme Therapeutic agents
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
AU1041599A (en) * 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (en) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
PL341652A1 (en) * 1998-01-21 2001-04-23 Merck Sharp & Dohme Derivatives of triazolopyridazine as ligands for gaba receptors
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) * 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
WO1999065904A1 (en) * 1998-06-16 1999-12-23 Merck Sharp & Dohme Limited Triazolo-pyridine derivatives as ligands for gaba receptors
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9813576D0 (en) * 1998-06-24 1998-08-19 Merck Sharp & Dohme Therapeutic agents
GB9821179D0 (en) * 1998-09-30 1998-11-25 Merck Sharp & Dohme Therapeutic use
US6610694B1 (en) * 1998-10-06 2003-08-26 Takeda Chemical Industries, Ltd. Condensed pyridazine compounds, their production and use
DE69936998T2 (de) 1998-10-16 2008-05-21 Merck Sharp & Dohme Ltd., Hoddesdon Pyrazolotriazinderivate als gaba-rezeptorliganden
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
GB2345443A (en) * 1999-01-08 2000-07-12 Merck Sharp & Dohme Use of triazolo-pyridazines for treating premenstrual syndrome
EP1149102B1 (en) * 1999-01-27 2004-12-08 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9903119D0 (en) * 1999-02-11 1999-04-07 Merck Sharp & Dohme Therapeutic agents
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) * 1999-08-23 1999-10-27 Merck Sharp & Dohme Therapeutic agents
GB9921351D0 (en) 1999-09-09 1999-11-10 Merck Sharp & Dohme Therapeutic agents
US6355638B1 (en) * 1999-11-25 2002-03-12 Merck Sharp & Dohme Ltd. Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en) 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929685D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
GB0008696D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
GB0017518D0 (en) 2000-07-17 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0018473D0 (en) * 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
WO2002083675A2 (en) 2001-04-10 2002-10-24 Merck Sharp & Dohme Limited Inhibitors of akt activity
WO2002083064A2 (en) * 2001-04-10 2002-10-24 Merck & Co., Inc. A method of treating cancer
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
US6958334B2 (en) 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
GB0122696D0 (en) 2001-09-20 2001-11-14 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
WO2003084473A2 (en) * 2002-04-08 2003-10-16 Merck & Co., Inc. Method of treating cancer
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
DE60325865D1 (de) * 2002-08-13 2009-03-05 Merck Sharp & Dohme Phenylpyridazin derivative als liganden für gaba-rezeptoren
KR101075812B1 (ko) * 2002-12-18 2011-10-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서의 트리아졸로피리다진
DK1697371T3 (da) * 2003-12-19 2007-09-17 Bristol Myers Squibb Co Azabicykliske heterocykliske forbindelser som cannabinoidreceptormodulatorer
ES2347337T3 (es) 2004-09-02 2010-10-28 Nycomed Gmbh Triazoloftalazinas.
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EA012505B1 (ru) 2005-01-05 2009-10-30 Никомед Гмбх Триазолофталазины в качестве ингибиторов pde-2
WO2006072612A2 (en) 2005-01-05 2006-07-13 Nycomed Gmbh Triazolophthalazines as pde2- inhibitors
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
WO2007053596A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
KR20100033419A (ko) * 2007-07-19 2010-03-29 메타볼렉스, 인코포레이티드 당뇨병 및 대사 장애의 치료를 위한 ｒｕｐ3 또는 ｇｐｒ119 수용체의 작용제로서 ｎ-아자시클릭 치환된 피롤, 피라졸, 이미다졸, 트리아졸 및 테트라졸 유도체
CN102046627B (zh) * 2008-04-04 2013-09-04 瑞典创新专利公司 Gabaa受体调节剂
WO2010025407A1 (en) 2008-08-29 2010-03-04 Concert Pharmaceuticals Inc. Substituted triazolo-pyridazine derivatives
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011005520A1 (en) 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
CA2888324A1 (en) * 2012-11-07 2014-05-15 Alexander Flohr Triazolo compounds
CA3012791C (en) * 2016-01-27 2024-01-23 Universitat Zurich Use of gabaa receptor modulators for treatment of itch
CN107344938B (zh) * 2016-05-06 2022-05-06 上海赛默罗生物科技有限公司 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
US10292983B2 (en) 2016-08-03 2019-05-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
EP3796907A4 (en) 2018-05-22 2021-11-03 Neurocycle Therapeutics, Inc. GABAA POSITIVE ALLOSTERIC MODULATING COMPOUNDS FOR THE TREATMENT OF PRURITUS AND / OR DERMATITIS
CA3155618A1 (en) * 2019-10-23 2021-04-29 Jed Hubbs Treatment of epileptic conditions with gabaa receptor modulators
US20250136617A1 (en) * 2022-02-07 2025-05-01 The Regents Of The University Of Colorado, A Body Corporate Small molecules cxcr4 agonists, method of synthesis, and method of use
CN115433137B (zh) * 2022-04-15 2025-03-07 内蒙古京科医药科技有限公司 1-甲基-1，2，4-三氮唑-3-甲醇的制备方法
CN114591352B (zh) * 2022-05-11 2022-09-09 上海赛默罗生物科技有限公司 一种三唑并哒嗪类化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1080712A (en) 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
FI81350C (fi) * 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4578464A (en) * 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9321162D0 (en) 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
GB9507348D0 (en) * 1995-04-08 1995-05-31 Knoll Ag Therapeutic agents
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use

Also Published As

Publication number Publication date
CN1251589A (zh) 2000-04-26
KR20000029548A (ko) 2000-05-25
CZ18199A3 (cs) 1999-06-16
DE69720732D1 (de) 2003-05-15
AU723098B2 (en) 2000-08-17
SK9399A3 (en) 2000-04-10
TR199900047T2 (xx) 1999-03-22
EP0915875B1 (en) 2003-04-09
JP2002514169A (ja) 2002-05-14
ES2194205T3 (es) 2003-11-16
BG103112A (en) 1999-09-30
BR9710729A (pt) 1999-08-17
DE69720732T2 (de) 2004-01-29
EA199900164A1 (ru) 2000-04-24
NO990304D0 (no) 1999-01-22
IS4949A (is) 1999-01-19
EA002436B1 (ru) 2002-04-25
EP0915875A2 (en) 1999-05-19
PL331072A1 (en) 1999-06-21
NO990304L (no) 1999-03-25
IL127911A0 (en) 1999-11-30
JP4216905B2 (ja) 2009-01-28
EE9900027A (et) 1999-08-16
ATE236904T1 (de) 2003-04-15
NZ333768A (en) 2000-09-29
AU3553997A (en) 1998-02-20
WO1998004559A2 (en) 1998-02-05
YU2899A (sh) 2000-03-21
US6255305B1 (en) 2001-07-03

Similar Documents

Publication Publication Date Title
HUP0600527A2 (en) Substituted triazolo-pyridazine derivatives as ligands for gaba receptors, process for their preparation and pharmaceutical compositions containing them
HUP9700358A3 (en) New oxazolidinon derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9602122A2 (en) Camptothecin derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP9603494A3 (en) Hydroxycarboxamide derivatives, pharmaceutical compositions containing them, process for the preparation thereof
HUP9904680A3 (en) Thienopyrimidine derivatives, pharmaceutical compositions containing them and process for their preparation
HUP9802200A3 (en) Rapamycin derivatives, process for their preparation, pharmaceutical compositions containing them and their use
IL117598A (en) Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0100431A3 (en) Adamantana derivatives, pharmaceutical compositions comprising them and process for preparing them
HUP9802422A3 (en) Substituted isoquinoline-3-carboxamide derivatives, process for producing them and pharmaceutical compositions containing them
HUP0000721A3 (en) Gemcitabine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0001607A3 (en) Thienopyrimidine derivatives, pharmaceutical compositions containing them, process for their preparation and use of the compounds
HUP0001555A3 (en) Tetrahydro-imidazo-naphthyridine derivatives, pharmaceutical compositions thereof and process for their preparation
HUP9900974A3 (en) Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP9701264A3 (en) Aminoacid derivatives, process for producing them and pharmaceutical compositions containing them
HUP0002480A3 (en) Pyrrolo[2,1-c][1,4]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them
HUP9900056A2 (hu) Szubsztituált 4-fenil-amino-tiazol-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
HUP0103637A3 (en) Phenyl xanthine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9702400A3 (en) Substituted camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9602635A3 (en) 4-aciloxy-benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0002300A3 (en) Quinoline-4-carboxamide derivatives, process for producing them, pharmaceutical compositions containing them and their use
HUP9900987A3 (en) Camptothecin derivatives process for their preparation, use thereof as antitumor agents and pharmaceutical compositions containing them
IL141955A0 (en) Benzothiazolone derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9901485A3 (en) Heterocyclylcarboxamide derivatives, pharmaceutical compositions containing the same, process for their preparation and their use
AU4070995A (en) Substituted 4-phenylthiazole derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9601062A3 (en) Chromone derivatives, pharmaceutical compositions containing them and process for their preparation

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees