IL125377A - Benzyl(idene)-lactam derivatives and pharmaceutical compositions containing them - Google Patents

Benzyl(idene)-lactam derivatives and pharmaceutical compositions containing them

Info

Publication number: IL125377A
Authority: IL; Israel
Prior art keywords: idene; benzyl; pharmaceutical compositions; compositions containing; lactam derivatives
Prior art date: 1996-03-29

Application number

IL12537797A

Other languages

English (en)

Other versions

IL125377A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-29

Filing date

1997-02-03

Publication date

2005-07-25

1997-02-03 Application filed by Pfizer filed Critical Pfizer

1997-02-03 Priority to IL15628497A priority Critical patent/IL156284A/xx

1999-03-12 Publication of IL125377A0 publication Critical patent/IL125377A0/xx

2005-07-25 Publication of IL125377A publication Critical patent/IL125377A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Quinoline Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL12537797A 1996-03-29 1997-02-03 Benzyl(idene)-lactam derivatives and pharmaceutical compositions containing them IL125377A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL15628497A IL156284A (en)	1996-03-29	1997-02-03	1 -(3, 4 - dichlorophenyl) - 3 - [2 -(2- dimethylaminoethoxy) - benzylidene] - pyrrolidin - 2 - one and pharmaceutical compositions containing the same

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1513496P	1996-03-29	1996-03-29
PCT/IB1997/000076 WO1997036867A1 (fr)	1996-03-29	1997-02-03	Derives du benzyl(diene)-lactame, leur preparation et leur utilisation comme antagonistes/agonistes des recepteurs 5-ht1a- et/ou 5-ht1d

Publications (2)

Publication Number	Publication Date
IL125377A0 IL125377A0 (en)	1999-03-12
IL125377A true IL125377A (en)	2005-07-25

Family

ID=21769713

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12537797A IL125377A (en)	1996-03-29	1997-02-03	Benzyl(idene)-lactam derivatives and pharmaceutical compositions containing them

Country Status (39)

Country	Link
US (2)	US6462048B2 (fr)
EP (1)	EP0894085B1 (fr)
JP (1)	JP3118467B2 (fr)
KR (1)	KR100305071B1 (fr)
CN (1)	CN1128788C (fr)
AP (1)	AP824A (fr)
AR (1)	AR006390A1 (fr)
AT (1)	ATE302182T1 (fr)
AU (1)	AU706839B2 (fr)
BG (1)	BG64176B1 (fr)
BR (1)	BR9708581A (fr)
CA (1)	CA2249603A1 (fr)
CO (1)	CO4650033A1 (fr)
CZ (1)	CZ293628B6 (fr)
DE (1)	DE69733996T2 (fr)
DZ (1)	DZ2198A1 (fr)
EA (1)	EA001485B1 (fr)
ES (1)	ES2246058T3 (fr)
HN (1)	HN1997000023A (fr)
HR (1)	HRP970175A2 (fr)
HU (1)	HUP9902160A3 (fr)
ID (1)	ID17781A (fr)
IL (1)	IL125377A (fr)
IS (1)	IS4813A (fr)
MA (1)	MA26425A1 (fr)
MY (1)	MY118498A (fr)
NO (1)	NO312957B1 (fr)
NZ (1)	NZ325914A (fr)
OA (1)	OA10879A (fr)
PL (1)	PL329170A1 (fr)
SK (1)	SK131498A3 (fr)
TN (1)	TNSN97056A1 (fr)
TR (1)	TR199801929T2 (fr)
TW (1)	TW413679B (fr)
UA (1)	UA70284C2 (fr)
UY (1)	UY24498A1 (fr)
WO (1)	WO1997036867A1 (fr)
YU (1)	YU11997A (fr)
ZA (1)	ZA972690B (fr)

Families Citing this family (39)

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JPH041367U (fr) *	1990-04-13	1992-01-08
US6147106A (en)	1997-08-20	2000-11-14	Sugen, Inc.	Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
US6906093B2 (en)	1995-06-07	2005-06-14	Sugen, Inc.	Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6696448B2 (en) *	1996-06-05	2004-02-24	Sugen, Inc.	3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
US6423708B1 (en) *	1996-09-30	2002-07-23	Pfizer Inc	Aralkyl and aralkylidene heterocyclic lactams and imides
UA56185C2 (uk)	1996-09-30	2003-05-15	Пфайзер Інк.	Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування
GB9718913D0 (en)	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
US6531502B1 (en)	1998-01-21	2003-03-11	Sugen, Inc.	3-Methylidenyl-2-indolinone modulators of protein kinase
DE19830201A1 (de) *	1998-07-07	2000-01-13	Boehringer Ingelheim Pharma	Mittel mit antidepressiver Wirkung
CA2301899C (fr) *	1998-07-27	2008-11-18	Boehringer Ingelheim Pharma Kg	Agent antidepresseur
US6492398B1 (en)	1999-03-04	2002-12-10	Smithkline Beechman Corporation	Thiazoloindolinone compounds
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
ES2225031T3 (es) *	1999-12-29	2005-03-16	Pfizer Products Inc.	Compuestos de 3-((2-piperazinil-fenil)metil)-1-(4-(trifluorometil)fenil)-2-pirrolidinona opticamente activos como antagonistas selectivos del receptor de 5-ht1d.
CO5280092A1 (es)	2000-02-15	2003-05-30	Sugen Inc	Indolinas susutituidas con pirroles inhibidoras de proteinquinasas
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
AR042586A1 (es)	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
JP2005508953A (ja)	2001-10-10	2005-04-07	スージェン・インコーポレーテッド	キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体
TW200301701A (en)	2002-01-02	2003-07-16	Ardent Pharmaceuticals Inc	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
TWI263497B (en) *	2002-03-29	2006-10-11	Lilly Co Eli	Pyridinoylpiperidines as 5-HT1F agonists
DE602004028150D1 (de) *	2003-11-26	2010-08-26	Pfizer Prod Inc	Aminopyrazolderivate als gsk-3-inhibitoren
JP2007537151A (ja) *	2004-01-29	2007-12-20	ファイザー・プロダクツ・インク	γ−アミノ酪酸モジュレータと５−ＨＴ１Ｂ受容体アンタゴニストとの組合せ
WO2005090300A1 (fr) *	2004-03-17	2005-09-29	Pfizer Products Inc.	Nouveaux derives de benzyl(idene)-lactame
EP1753460A2 (fr) *	2004-05-11	2007-02-21	Pfizer Products Inc.	Combinaison d'antipsychotiques atypiques et d'antagonistes du recepteur de 5-ht1b
WO2005113535A2 (fr) *	2004-05-21	2005-12-01	Pfizer Products Inc.	Derives pyrazinylmethyle-lactame
MXPA06014473A (es) *	2004-06-25	2007-03-01	Pfizer Prod Inc	Piridil piperazinas para el tratamiento de trastornos de sistema nervioso central.
US8012969B2 (en)	2005-01-13	2011-09-06	Ge Healthcare Limited	11C-labeled benzyl-lactam compounds and their use as imaging agents
WO2006106416A1 (fr) *	2005-04-08	2006-10-12	Pfizer Products Inc.	Pyridil-lactams et leur utilisation comme ligands de recepteurs 5-ht1
JP2008543829A (ja) *	2005-06-17	2008-12-04	ファイザー・プロダクツ・インク	セロトニン受容体アンタゴニストとしての１−［６−（１−エチル−１−ヒドロキシ−プロピル）−ピリジン−３−イル］−３−［２−（４−メチル−ピペラジン−１−イル）−ベンジル］−ピロリジン−２−オンの代謝産物
WO2007012964A1 (fr) *	2005-07-25	2007-02-01	Pfizer Products Inc.	Préparation de composés d'alkylpipérazinylphényle par dédoublement classique
WO2007026219A2 (fr) *	2005-08-31	2007-03-08	Pfizer Products Inc.	Composition d'antagonistes du recepteur 5-ht1b servant au traitement d'etats du systeme nerveux central
WO2007026224A2 (fr) *	2005-08-31	2007-03-08	Pfizer Products Inc.	Composition d'antagoniste 5-ht1b pour le traitement de la depression, de l'anxiete et des troubles de la cognition
US20070096411A1 (en) *	2005-11-02	2007-05-03	Rempe Gary L Ii	Device for retaining a kneeling rider on a gliding board
HK1215170A1 (zh)	2012-11-14	2016-08-19	The Johns Hopkins University	治療精神分裂症的方法和組合物
US10246436B2 (en)	2015-09-02	2019-04-02	Trevena, Inc.	6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
KR20190129867A (ko)	2017-02-17	2019-11-20	트레베나, 인코포레이티드.	5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법
BR112019016775A2 (pt)	2017-02-17	2020-03-31	Trevena, Inc.	Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos
WO2020183011A1 (fr)	2019-03-14	2020-09-17	Institut Curie	Inhibiteurs de htr1d et leurs utilisations dans le traitement du cancer

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US4078062A (en) *	1976-10-28	1978-03-07	E. R. Squibb & Sons, Inc.	Substituted 2H-1,4-benzothiazin-3(4H)-ones
JPS62116557A (ja)	1985-11-15	1987-05-28	Takeda Chem Ind Ltd	置換ベンジルラクタム類
US5189179A (en)	1990-08-29	1993-02-23	Merrell Dow Pharmaceuticals Inc.	Serotonin 5ht1a agonists
DE69232003T2 (de)	1991-09-18	2002-04-25	Glaxo Group Ltd., Greenford	Benzanilidderivate als 5-HT1D-Antagonisten
SK280882B6 (sk) *	1991-10-11	2000-08-14	The Du Pont Merck Pharmaceutical Company	Cyklické močoviny, ich analógy a farmaceutické prípravky na ich báze
US5436246A (en)	1992-09-17	1995-07-25	Merrell Dow Pharmaceuticals Inc.	Serotonin receptor agents
GB9410512D0 (en)	1994-05-25	1994-07-13	Smithkline Beecham Plc	Novel treatment
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
US6467084B1 (en) *	1999-12-16	2002-10-15	Emware, Inc.	Systems and methods for reprogramming an embedded device with program code using relocatable program code

1997
- 1997-02-03 DE DE69733996T patent/DE69733996T2/de not_active Expired - Fee Related
- 1997-02-03 EA EA199800771A patent/EA001485B1/ru not_active IP Right Cessation
- 1997-02-03 CA CA002249603A patent/CA2249603A1/fr not_active Abandoned
- 1997-02-03 TR TR1998/01929T patent/TR199801929T2/xx unknown
- 1997-02-03 BR BR9708581A patent/BR9708581A/pt not_active Application Discontinuation
- 1997-02-03 PL PL97329170A patent/PL329170A1/xx unknown
- 1997-02-03 CN CN97193251A patent/CN1128788C/zh not_active Expired - Fee Related
- 1997-02-03 AU AU13170/97A patent/AU706839B2/en not_active Ceased
- 1997-02-03 IL IL12537797A patent/IL125377A/xx not_active IP Right Cessation
- 1997-02-03 CZ CZ19983052A patent/CZ293628B6/cs not_active IP Right Cessation
- 1997-02-03 JP JP09535074A patent/JP3118467B2/ja not_active Expired - Fee Related
- 1997-02-03 WO PCT/IB1997/000076 patent/WO1997036867A1/fr not_active Ceased
- 1997-02-03 NZ NZ325914A patent/NZ325914A/en unknown
- 1997-02-03 SK SK1314-98A patent/SK131498A3/sk unknown
- 1997-02-03 EP EP97900717A patent/EP0894085B1/fr not_active Expired - Lifetime
- 1997-02-03 ES ES97900717T patent/ES2246058T3/es not_active Expired - Lifetime
- 1997-02-03 HU HU9902160A patent/HUP9902160A3/hu unknown
- 1997-02-03 KR KR1019980707713A patent/KR100305071B1/ko not_active Expired - Fee Related
- 1997-02-03 US US09/155,215 patent/US6462048B2/en not_active Expired - Fee Related
- 1997-02-03 AT AT97900717T patent/ATE302182T1/de not_active IP Right Cessation
- 1997-02-04 TW TW086101295A patent/TW413679B/zh active
- 1997-02-06 HN HN1997000023A patent/HN1997000023A/es unknown
- 1997-03-02 UA UA98095077A patent/UA70284C2/uk unknown
- 1997-03-13 CO CO97013714A patent/CO4650033A1/es unknown
- 1997-03-21 UY UY24498A patent/UY24498A1/es not_active IP Right Cessation
- 1997-03-25 AR ARP970101200A patent/AR006390A1/es not_active Application Discontinuation
- 1997-03-26 HR HR60/015,134A patent/HRP970175A2/hr not_active Application Discontinuation
- 1997-03-26 MA MA24535A patent/MA26425A1/fr unknown
- 1997-03-26 TN TNTNSN97056A patent/TNSN97056A1/fr unknown
- 1997-03-26 DZ DZ970045A patent/DZ2198A1/fr active
- 1997-03-27 AP APAP/P/1997/000955A patent/AP824A/en active
- 1997-03-27 ZA ZA972690A patent/ZA972690B/xx unknown
- 1997-03-27 ID IDP971025A patent/ID17781A/id unknown
- 1997-03-27 YU YU11997A patent/YU11997A/sh unknown
- 1997-03-28 MY MYPI97001340A patent/MY118498A/en unknown
1998
- 1998-07-29 IS IS4813A patent/IS4813A/is unknown
- 1998-09-16 OA OA9800170A patent/OA10879A/en unknown
- 1998-09-24 BG BG102791A patent/BG64176B1/bg unknown
- 1998-09-28 NO NO19984513A patent/NO312957B1/no unknown
2002
- 2002-08-15 US US10/219,692 patent/US6924289B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HK1019446A1 (en)	2000-02-11
CA2249603A1 (fr)	1997-10-09
EA199800771A1 (ru)	1999-06-24
MY118498A (en)	2004-11-30
ATE302182T1 (de)	2005-09-15
ID17781A (id)	1998-01-29
DZ2198A1 (fr)	2002-12-02
CO4650033A1 (es)	1998-09-03
NZ325914A (en)	1999-09-29
HN1997000023A (es)	1997-06-05
PL329170A1 (en)	1999-03-15
AP824A (en)	2000-04-28
HUP9902160A2 (hu)	1999-11-29
EP0894085B1 (fr)	2005-08-17
BG102791A (en)	1999-11-30
YU11997A (sh)	1999-09-27
JP3118467B2 (ja)	2000-12-18
WO1997036867A1 (fr)	1997-10-09
BG64176B1 (bg)	2004-03-31
AP9700955A0 (en)	1997-04-30
KR100305071B1 (ko)	2001-12-12
US20030027812A1 (en)	2003-02-06
BR9708581A (pt)	1999-08-03
NO984513L (no)	1998-09-28
JPH11506472A (ja)	1999-06-08
IS4813A (is)	1998-07-29
TW413679B (en)	2000-12-01
US20020028821A1 (en)	2002-03-07
DE69733996T2 (de)	2006-07-20
IL125377A0 (en)	1999-03-12
NO312957B1 (no)	2002-07-22
UY24498A1 (es)	2000-09-29
MA26425A1 (fr)	2004-12-20
CN1214043A (zh)	1999-04-14
KR20000005083A (ko)	2000-01-25
UA70284C2 (en)	2004-10-15
AR006390A1 (es)	1999-08-25
CN1128788C (zh)	2003-11-26
EP0894085A1 (fr)	1999-02-03
AU1317097A (en)	1997-10-22
OA10879A (en)	2001-10-05
TNSN97056A1 (fr)	2005-03-15
EA001485B1 (ru)	2001-04-23
AU706839B2 (en)	1999-06-24
ZA972690B (en)	1998-09-28
ES2246058T3 (es)	2006-02-01
US6462048B2 (en)	2002-10-08
DE69733996D1 (de)	2005-09-22
US6924289B2 (en)	2005-08-02
CZ293628B6 (cs)	2004-06-16
NO984513D0 (no)	1998-09-28
CZ305298A3 (cs)	1999-07-14
HRP970175A2 (en)	1998-12-31
HUP9902160A3 (en)	2001-02-28
TR199801929T2 (xx)	1998-12-21
SK131498A3 (en)	2000-09-12

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HUP9602196A3 (en)	1998-07-28	Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof
IL134538A (en)	2005-11-20	Lactacystin derivatives and pharmaceutical compositions containing the same
HUP9904301A3 (en)	2001-07-30	Benzimidazole derivatives and pharmaceutical compositions containing them
IL120722A0 (en)	1997-08-14	Carbohydrate derivatives and pharmaceutical compositions containing them

Legal Events

Date	Code	Title
2006-02-05	FF	Patent granted
2006-02-21	KB	Patent renewed
2007-09-20	MM9K	Patent not in force due to non-payment of renewal fees