[go: up one dir, main page]

IL116139A0 - Pyrrole derivatives their preparation and use - Google Patents

Pyrrole derivatives their preparation and use

Info

Publication number
IL116139A0
IL116139A0 IL11613995A IL11613995A IL116139A0 IL 116139 A0 IL116139 A0 IL 116139A0 IL 11613995 A IL11613995 A IL 11613995A IL 11613995 A IL11613995 A IL 11613995A IL 116139 A0 IL116139 A0 IL 116139A0
Authority
IL
Israel
Prior art keywords
preparation
pyrrole derivatives
pyrrole
derivatives
Prior art date
Application number
IL11613995A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL116139A0 publication Critical patent/IL116139A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IL11613995A 1994-12-01 1995-11-27 Pyrrole derivatives their preparation and use IL116139A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/347,915 US5622948A (en) 1994-12-01 1994-12-01 Pyrrole pyridazine and pyridazinone anti-inflammatory agents

Publications (1)

Publication Number Publication Date
IL116139A0 true IL116139A0 (en) 1996-01-31

Family

ID=23365840

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11613995A IL116139A0 (en) 1994-12-01 1995-11-27 Pyrrole derivatives their preparation and use

Country Status (19)

Country Link
US (1) US5622948A (hu)
EP (1) EP0714895A1 (hu)
JP (1) JPH08208639A (hu)
KR (1) KR960022506A (hu)
CN (1) CN1066726C (hu)
AR (1) AR001771A1 (hu)
AU (1) AU3906295A (hu)
BR (1) BR9505610A (hu)
CA (1) CA2163490A1 (hu)
CO (1) CO4650183A1 (hu)
CZ (1) CZ316995A3 (hu)
FI (1) FI955783A7 (hu)
HU (1) HUT75117A (hu)
IL (1) IL116139A0 (hu)
MA (1) MA23735A1 (hu)
NO (1) NO954878L (hu)
PL (1) PL311536A1 (hu)
TR (1) TR199501528A1 (hu)
ZA (1) ZA9510027B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
CN1136197C (zh) * 1996-05-30 2004-01-28 霍夫曼-拉罗奇有限公司 新的哒嗪酮衍生物
CN1225629A (zh) * 1996-05-30 1999-08-11 霍夫曼-拉罗奇有限公司 新的吡咯衍生物
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
EP1007515A1 (en) * 1997-08-22 2000-06-14 Abbott Laboratories Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
AU741317B2 (en) * 1997-08-22 2001-11-29 Abbott Laboratories Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
BR9812772A (pt) * 1997-10-27 2000-10-10 Reddy Research Foundation "compostos tricìclicos inéditos e o seu emprego na medicina;processo para a sua preparação e composições farmacêuticas contendo os mesmos"
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
HUP0105248A3 (en) * 1998-10-27 2002-09-30 Abbott Lab Prostaglandin endoperoxide h synthase biosynthesis inhibitors pyridazinone-derivatives, pharmaceutical compositions containing them as active inaredient and process for preparation the compounds
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004006836A2 (en) * 2002-07-11 2004-01-22 Merck & Co., Inc. Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
MX2010005070A (es) * 2007-11-15 2010-05-24 Angeletti P Ist Richerche Bio Derivados de piridazinona como inhibidores de parp.
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2527335B1 (en) 2011-04-26 2013-09-18 King Saud University Triazole compounds as anti-inflammatory agents
KR102233456B1 (ko) 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102233455B1 (ko) 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
WO2022159980A1 (en) * 2021-01-25 2022-07-28 Athos Therapeutics, Inc. Pharmaceutical compounds and methods of making and using the same

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2316942A (en) * 1937-12-27 1943-04-20 Schlumberger Well Surv Corp Apparatus for measuring temperatures in boreholes
US3726978A (en) * 1967-11-02 1973-04-10 Sandoz Ag Tetrahydropyridazines and pyridazinones as anti-inflammatory agents
US3586681A (en) * 1967-11-02 1971-06-22 Sandoz Ag 1,4,5,6-tetrahydropyridazines
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US4048191A (en) * 1975-06-27 1977-09-13 Mcneil Laboratories, Incorporated Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4247551A (en) * 1979-09-17 1981-01-27 Gruppo Lepetit S.P.A. N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
IT1150070B (it) * 1980-12-22 1986-12-10 Lepetit Spa Procedimento per preparare derivati n-pirrolipiridazinamminici
AU8509882A (en) * 1981-06-30 1983-01-06 Merck & Co., Inc. Tricyclic derivatives of substituted pyrrole acids
WO1983000863A1 (en) * 1981-09-11 1983-03-17 Diamond Shamrock Corp Antiinflammatory and analgetic 4-pyridylpyridazin(2h)-3-ones
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
GB8501372D0 (en) * 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
DE69324820T2 (de) * 1992-09-22 2000-01-13 The University Of Rochester, Rochester Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren
US5543297A (en) * 1992-12-22 1996-08-06 Merck Frosst Canada, Inc. Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
US5332736A (en) * 1993-11-01 1994-07-26 Ortho Pharmaceutical Corporation Anti-convulsant aroyl aminoacylpyrroles
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
KR102081455B1 (ko) * 2017-06-09 2020-04-28 선상규 다중브러시를 이용한 직류발전장치

Also Published As

Publication number Publication date
ZA9510027B (en) 1996-06-03
FI955783L (fi) 1996-06-02
CN1132206A (zh) 1996-10-02
HU9503384D0 (en) 1996-01-29
CA2163490A1 (en) 1996-06-02
TR199501528A1 (tr) 1996-11-21
AU3906295A (en) 1996-06-06
MA23735A1 (fr) 1996-07-01
CN1066726C (zh) 2001-06-06
CO4650183A1 (es) 1998-09-03
KR960022506A (ko) 1996-07-18
PL311536A1 (en) 1996-06-10
FI955783A0 (fi) 1995-12-01
AR001771A1 (es) 1997-12-10
JPH08208639A (ja) 1996-08-13
EP0714895A1 (en) 1996-06-05
NO954878D0 (no) 1995-11-30
NO954878L (no) 1996-06-03
FI955783A7 (fi) 1996-06-02
CZ316995A3 (en) 1996-06-12
HUT75117A (en) 1997-04-28
BR9505610A (pt) 1997-09-16
US5622948A (en) 1997-04-22

Similar Documents

Publication Publication Date Title
IL116851A0 (en) 3-arylidene-2-oxindole derivatives their preparation and use
IL118825A (en) Substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane derivatives their preparation and use
IL116139A0 (en) Pyrrole derivatives their preparation and use
IL116325A0 (en) Substituted 1h-imidazoles their preparation and use
IL114795A0 (en) N-benzylindole- and benmzopyrazole derivatives their preparation and use
IL115717A0 (en) Heterocyclic compounds and their preparation and use
IL120124A0 (en) Heteroaryl-oxazolidinones their preparation and use
IL119864A0 (en) 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-OL compounds their preparation and use
IL120016A0 (en) Heteroatom-containing cyclopentanopyridyl-oxazolidinones their preparation and use
HUP0000369A3 (en) 3-thiocarbamoylpyrazole derivatives and their use as pesticides
ZA982478B (en) Compounds their use and preparation
IL118442A0 (en) Triazolymethyl-cyclopentanols their preparation and use
ZA979175B (en) Novel piperidineketocarboxylic acid derivatives their preparation and use
IL118441A0 (en) Triazolymethyl-oxiranes their preparation and use
IL116525A0 (en) Piperazinedione derivatives their preparation and use
ZA973097B (en) Novel aspire-hydroxy acid derivatives their preparation and use
EG21121A (en) 13 Substituted milbemycin derivatives their preparation and use
IL116014A0 (en) Iminooxymethyleneanilides their preparation and their use
IL118443A0 (en) Cycloalkane-benzylidene derivatives their preparation and use
IL123092A0 (en) Pyrazol-4-ylbenzoyl derivatives their preparation and use
IL114490A0 (en) Heterocyclic compounds their preparation and their use
IL107726A0 (en) Pyrrole derivatives their preparation and their therapeutic use
IL123535A0 (en) Benzoxazindione derivatives and their use
IL122686A0 (en) Benzylhydroxylamines their preparation and use
IL118444A0 (en) Mercapto-triazolyl-silanes their preparation and use