AR001771A1 - Un derivado del pirrol una composición farmacéutica que lo comprende procesos para prepararlo y uso del mismo - Google Patents
Un derivado del pirrol una composición farmacéutica que lo comprende procesos para prepararlo y uso del mismoInfo
- Publication number
- AR001771A1 AR001771A1 AR33445395A AR33445395A AR001771A1 AR 001771 A1 AR001771 A1 AR 001771A1 AR 33445395 A AR33445395 A AR 33445395A AR 33445395 A AR33445395 A AR 33445395A AR 001771 A1 AR001771 A1 AR 001771A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- alkoxy
- alkylthio
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un derivado del pirrol que tiene la fórmula (I), en donde Z es (II), donde: R1 es -H, alquilo C1-6,alquilo halo-C1-C6,acetilo , acetilo sustituido, -(CHR24)(CH2)nR14,-(CHR24)(CH2)nC(O)R15, (CHR24)(CH2)nC(O)NR16R17 o bien -CHR24R18; n es entero del 0 al 5, R14 es -CN,-OH, alcoxi C1-6, aciloxi C2-7, aciloxi sustituido, dialquilamino en donde cada alquilo es C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6,alqueno C2-6, alquino C2-6 o bien metanosulfonamido; R15 es el grupo alcoxi C1-6; R16 y R17 son -H, alquilo C1-6; R18 es (III), donde R19 y R20 son -CN,halo, alcoxi C1-6 y alquilo C1-6; y R24 es -H, alquilo C1-6 o fenilo; R2 y R3 se seleccionan, independientemente, del grupoformado por -H, halo -CH3; R4 es-H, alquilo C1-6 o -CN; R5 es -H o el alquilo C1-6; R6 y R7 son -H, halo, alquilo C1-6, alcoxi C1-6 y alquiltio C1-6; y R8 es (IV), donde R9 es -H, halo,alquilo C1-6, halo-alquilo C1-6, amino, dialquilamino endonde cada alquilo es C1-6, alquilamido en donde cada alquilo es C1-6, alquiltio C1-6, alcoxi C1-6,alqueno C2-6 o alquino C2-6; R10 y R11 son -H, halo, -CH3; y R12 es -H, -Cl o CH3; y R13 es alcoxi C1-6, mercapto, alquiltio C1-6, -NR21R22 o bien -O-(CH2)m-NR21R22; m es entero del 1 al 6, R21 es -H o alquilo C1-6 y R22 es -H o el grupo alquilo C1-6 y R21 y R22 pueden unirse con N para formar un anillo de 3 a5 átomos de C que puede incluir un -O-, -S-, o bien -N(R23)- donde R23 es -H o alquilo C1-6 o las sales del mismo, aceptables desde un punto de vistafarmacéutico. Además, se refiere a procesos para prepararlo, a una composición farmacéutica que lo comprende y al uso de dicho derivado. Dicho derivado esútil como agente antiinflamatorio en el tratamiento de la inflamación y del dolor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/347,915 US5622948A (en) | 1994-12-01 | 1994-12-01 | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR001771A1 true AR001771A1 (es) | 1997-12-10 |
Family
ID=23365840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR33445395A AR001771A1 (es) | 1994-12-01 | 1995-11-30 | Un derivado del pirrol una composición farmacéutica que lo comprende procesos para prepararlo y uso del mismo |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5622948A (es) |
| EP (1) | EP0714895A1 (es) |
| JP (1) | JPH08208639A (es) |
| KR (1) | KR960022506A (es) |
| CN (1) | CN1066726C (es) |
| AR (1) | AR001771A1 (es) |
| AU (1) | AU3906295A (es) |
| BR (1) | BR9505610A (es) |
| CA (1) | CA2163490A1 (es) |
| CO (1) | CO4650183A1 (es) |
| CZ (1) | CZ316995A3 (es) |
| FI (1) | FI955783L (es) |
| HU (1) | HUT75117A (es) |
| IL (1) | IL116139A0 (es) |
| MA (1) | MA23735A1 (es) |
| NO (1) | NO954878L (es) |
| PL (1) | PL311536A1 (es) |
| TR (1) | TR199501528A1 (es) |
| ZA (1) | ZA9510027B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
| US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| CN1136197C (zh) * | 1996-05-30 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | 新的哒嗪酮衍生物 |
| DE69716061T2 (de) * | 1996-05-30 | 2003-08-14 | F. Hoffmann-La Roche Ag, Basel | Pyrrolderivate |
| US6525053B1 (en) | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| CA2299300C (en) * | 1997-08-22 | 2007-04-17 | Abbott Laboratories | Arylpyridazinones as prostaglandin endoperoxide h synthase bisoynthesis inhibitors |
| US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| HUP0400909A3 (en) * | 1997-08-22 | 2004-10-28 | Abbott Lab | Arylpyridazinone-derivatives having prostaglandin endoperoxide h synthase biosynthesis inhibitor effect and pharmaceutical compositions containing them |
| CN100376560C (zh) * | 1997-10-27 | 2008-03-26 | 雷迪实验室有限公司 | 新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物 |
| US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
| SK286806B6 (sk) * | 1998-10-27 | 2009-05-07 | Abbott Laboratories | Pyridazinónové zlúčeniny ako inhibítory cyklooxygenázy, farmaceutická kompozícia s ich obsahom a ich použitie |
| US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
| EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| AU2003248907B2 (en) * | 2002-07-11 | 2007-04-26 | Merck & Co., Inc. | Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds |
| CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| EP2220073B1 (en) | 2007-11-15 | 2014-09-03 | MSD Italia S.r.l. | Pyridazinone derivatives as parp inhibitors |
| HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| EP2527335B1 (en) | 2011-04-26 | 2013-09-18 | King Saud University | Triazole compounds as anti-inflammatory agents |
| KR102233456B1 (ko) | 2017-05-31 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
| KR102233455B1 (ko) | 2017-06-21 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
| WO2022159980A1 (en) * | 2021-01-25 | 2022-07-28 | Athos Therapeutics, Inc. | Pharmaceutical compounds and methods of making and using the same |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2316942A (en) * | 1937-12-27 | 1943-04-20 | Schlumberger Well Surv Corp | Apparatus for measuring temperatures in boreholes |
| US3586681A (en) * | 1967-11-02 | 1971-06-22 | Sandoz Ag | 1,4,5,6-tetrahydropyridazines |
| US3726978A (en) * | 1967-11-02 | 1973-04-10 | Sandoz Ag | Tetrahydropyridazines and pyridazinones as anti-inflammatory agents |
| US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
| US4048191A (en) * | 1975-06-27 | 1977-09-13 | Mcneil Laboratories, Incorporated | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds |
| JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4247551A (en) * | 1979-09-17 | 1981-01-27 | Gruppo Lepetit S.P.A. | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents |
| US4347187A (en) * | 1980-10-20 | 1982-08-31 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein |
| IT1150070B (it) * | 1980-12-22 | 1986-12-10 | Lepetit Spa | Procedimento per preparare derivati n-pirrolipiridazinamminici |
| AU8509882A (en) * | 1981-06-30 | 1983-01-06 | Merck & Co., Inc. | Tricyclic derivatives of substituted pyrrole acids |
| JPS58501432A (ja) * | 1981-09-11 | 1983-08-25 | エスディ−エス・バイオテック・コ−ポレ−ション | 抗炎症，鎮痛性４−ピリジルピリダジン（２ｈ）−３−オン類 |
| US4816454A (en) * | 1984-09-21 | 1989-03-28 | Cassella Aktiengesellschaft | 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use |
| GB8501372D0 (en) * | 1985-01-18 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
| US5086052A (en) * | 1987-07-17 | 1992-02-04 | Abbott Laboratories | Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity |
| US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
| IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
| JPH08501690A (ja) * | 1992-09-22 | 1996-02-27 | ユニバーシティ・オブ・ロチェスター | 調節性炎症性シクロオキシゲナーゼを発現する安定に形質転換された哺乳動物細胞 |
| US5543297A (en) * | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
| US5332736A (en) * | 1993-11-01 | 1994-07-26 | Ortho Pharmaceutical Corporation | Anti-convulsant aroyl aminoacylpyrroles |
| US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
| KR102081455B1 (ko) * | 2017-06-09 | 2020-04-28 | 선상규 | 다중브러시를 이용한 직류발전장치 |
-
1994
- 1994-12-01 US US08/347,915 patent/US5622948A/en not_active Expired - Fee Related
-
1995
- 1995-11-20 EP EP95118227A patent/EP0714895A1/en not_active Withdrawn
- 1995-11-22 CA CA002163490A patent/CA2163490A1/en not_active Abandoned
- 1995-11-24 ZA ZA9510027A patent/ZA9510027B/xx unknown
- 1995-11-24 AU AU39062/95A patent/AU3906295A/en not_active Abandoned
- 1995-11-27 HU HU9503384A patent/HUT75117A/hu unknown
- 1995-11-27 IL IL11613995A patent/IL116139A0/xx unknown
- 1995-11-29 CZ CZ953169A patent/CZ316995A3/cs unknown
- 1995-11-30 PL PL95311536A patent/PL311536A1/xx unknown
- 1995-11-30 AR AR33445395A patent/AR001771A1/es unknown
- 1995-11-30 CO CO95056926A patent/CO4650183A1/es unknown
- 1995-11-30 CN CN95120375A patent/CN1066726C/zh not_active Expired - Fee Related
- 1995-11-30 KR KR1019950045751A patent/KR960022506A/ko not_active Ceased
- 1995-11-30 NO NO954878A patent/NO954878L/no unknown
- 1995-12-01 BR BR9505610A patent/BR9505610A/pt not_active Application Discontinuation
- 1995-12-01 TR TR95/01528A patent/TR199501528A1/xx unknown
- 1995-12-01 MA MA24084A patent/MA23735A1/fr unknown
- 1995-12-01 FI FI955783A patent/FI955783L/fi unknown
- 1995-12-01 JP JP7313916A patent/JPH08208639A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CZ316995A3 (en) | 1996-06-12 |
| HU9503384D0 (en) | 1996-01-29 |
| ZA9510027B (en) | 1996-06-03 |
| FI955783A0 (fi) | 1995-12-01 |
| HUT75117A (en) | 1997-04-28 |
| NO954878D0 (no) | 1995-11-30 |
| CO4650183A1 (es) | 1998-09-03 |
| BR9505610A (pt) | 1997-09-16 |
| CN1132206A (zh) | 1996-10-02 |
| NO954878L (no) | 1996-06-03 |
| AU3906295A (en) | 1996-06-06 |
| CA2163490A1 (en) | 1996-06-02 |
| JPH08208639A (ja) | 1996-08-13 |
| FI955783A7 (fi) | 1996-06-02 |
| EP0714895A1 (en) | 1996-06-05 |
| TR199501528A1 (tr) | 1996-11-21 |
| US5622948A (en) | 1997-04-22 |
| PL311536A1 (en) | 1996-06-10 |
| CN1066726C (zh) | 2001-06-06 |
| MA23735A1 (fr) | 1996-07-01 |
| IL116139A0 (en) | 1996-01-31 |
| KR960022506A (ko) | 1996-07-18 |
| FI955783L (fi) | 1996-06-02 |
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