IL103757A - Oligodeoxyribonucleotides their preparation and pharmaceutical compositions containing them - Google Patents
Oligodeoxyribonucleotides their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL103757A IL103757A IL10375792A IL10375792A IL103757A IL 103757 A IL103757 A IL 103757A IL 10375792 A IL10375792 A IL 10375792A IL 10375792 A IL10375792 A IL 10375792A IL 103757 A IL103757 A IL 103757A
- Authority
- IL
- Israel
- Prior art keywords
- oligodeoxyribonucleotides
- preparation
- pharmaceutical compositions
- compositions containing
- pharmaceutical
- Prior art date
Links
- 229940124276 oligodeoxyribonucleotide Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913294A IT1252174B (it) | 1991-12-09 | 1991-12-09 | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL103757A true IL103757A (en) | 1997-02-18 |
Family
ID=11361289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10375792A IL103757A (en) | 1991-12-09 | 1992-11-16 | Oligodeoxyribonucleotides their preparation and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6046172A (xx) |
| EP (1) | EP0558833A3 (xx) |
| JP (1) | JPH05247083A (xx) |
| CN (1) | CN1073448A (xx) |
| AU (1) | AU655087B2 (xx) |
| BE (1) | BE1008163A5 (xx) |
| BR (1) | BR9204931A (xx) |
| CA (1) | CA2083416A1 (xx) |
| CH (1) | CH685298A5 (xx) |
| FR (1) | FR2684675B1 (xx) |
| GR (1) | GR1002143B (xx) |
| IL (1) | IL103757A (xx) |
| IT (1) | IT1252174B (xx) |
| LU (1) | LU88197A1 (xx) |
| MX (1) | MX9207137A (xx) |
| PT (1) | PT101113A (xx) |
| ZA (1) | ZA928878B (xx) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1271685B (it) * | 1994-08-03 | 1997-06-04 | Crinos Industria Farmaco | Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche |
| HK1044896A1 (zh) * | 1997-04-28 | 2002-11-08 | Burcoglu Arsinur | 治疗hiv感染和与之有关的继发感染的方法 |
| DE69928778T2 (de) * | 1999-06-08 | 2006-07-06 | Gentium S.P.A., Villa Guardia | Anwendung von Komplexen von kationischen Liposomen und Polydeoxyribonukleotiden wie Arzneimitteln |
| EP1325962A1 (en) * | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
| CA2500996C (en) * | 2002-10-01 | 2010-11-09 | Truck-Lite Co., Inc. | Light emitting diode headlamp and headlamp assembly |
| US7270723B2 (en) * | 2003-11-07 | 2007-09-18 | Kimberly-Clark Worldwide, Inc. | Microporous breathable elastic film laminates, methods of making same, and limited use or disposable product applications |
| ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
| MX2007010407A (es) * | 2005-03-03 | 2007-10-17 | Gentium Spa | Formulacion con accion anti-tumor. |
| ITMI20050336A1 (it) * | 2005-03-03 | 2006-09-04 | Gentium Spa | Formulazione ad attivita' anti-tumorale |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
| EP2103689A1 (en) | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| CN103260627A (zh) | 2010-11-12 | 2013-08-21 | 真蒂奥姆有限公司 | 去纤维蛋白多核苷酸用于预防和/或治疗移植物抗宿主病(gvhd) |
| KR102038357B1 (ko) | 2012-06-22 | 2019-10-31 | 젠티엄 에스알엘 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| CA3071544A1 (en) | 2017-08-03 | 2019-02-07 | Jazz Pharmaceuticals Ireland Limited | Formulations comprising a nucleic acid in a high concentration |
| BR112020020865A2 (pt) | 2018-04-12 | 2021-01-19 | Jazz Pharmaceuticals, Inc. | Defibrotida para prevenção e tratamento da síndrome de liberação de citocinas e neurotoxicidade associadas à imunodepleção |
| US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| EP4110287A1 (en) | 2020-02-28 | 2023-01-04 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| WO2021212055A1 (en) | 2020-04-17 | 2021-10-21 | Jazz Pharmaceuticals Ireland Limited | Defibrotide treatment for the prevention of organ rejection and injury |
| WO2022234101A1 (en) | 2021-05-06 | 2022-11-10 | Jazz Pharmaceuticals Ireland Limited | Defibrotide for the treatment and prevention of acute respiratory distress syndrome |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB808296A (en) * | 1955-10-05 | 1959-02-04 | Roland Vercambre | Process for the extraction of nucleic acid and for the preparation of the salts thereof |
| DE1142365B (de) * | 1955-10-05 | 1963-01-17 | Roland Vercambre | Verfahren zur Gewinnung von Nucleinsaeure und deren Salze aus Fischmilch |
| FR1245818A (fr) * | 1959-11-27 | 1960-10-03 | Procédé de préparation d'acides désoxyribonucléiques à haut degré de polymérisation | |
| FR1408585A (fr) * | 1964-09-22 | 1965-08-13 | Schwarz Biores | Isolement et purification de bases hétérocycliques |
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| JPS5217040B2 (xx) * | 1972-12-07 | 1977-05-12 | ||
| SU780444A1 (ru) * | 1979-06-25 | 1985-04-23 | Специальное Конструкторско-Технологическое Бюро Биологически Активных Веществ Главного Управления Микробиологической Промышленности При Совете Министров Ссср | Способ получени дезоксирибонуклеиновой кислоты |
| US4417046A (en) * | 1981-08-24 | 1983-11-22 | Eli Lilly And Company | Process for isolating oligonucleotide product from a coupling reaction mixture |
| DE3308932A1 (de) * | 1983-03-12 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | Verfahren zur abtrennung von ribonukleinsaeuren aus einer loesung, die desoxyribonukleinsaeuren enthaelt |
| SU1161511A1 (ru) * | 1983-07-01 | 1985-06-15 | Институт биоорганической химии АН БССР | Способ осаждени нуклеиновых кислот из растворов,содержащих фосфатный буфер |
| JPS6036493A (ja) * | 1983-08-08 | 1985-02-25 | Nippon Zeon Co Ltd | 保護された核酸関連物質の分離法 |
| IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| US4605644A (en) * | 1985-02-07 | 1986-08-12 | Regents Of The University Of Minnesota | Method for stimulating recovery from ischemia employing ribose and adenine |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| JP2930589B2 (ja) * | 1986-10-06 | 1999-08-03 | ザ ユニバーシィティ オブ バージニア アルミニ パテンツ ファンデーション | 外科手術中における改善された心臓保護のためのアデノシン，ヒポキサンチン及びリボース含有溶液の使用 |
| US4833239A (en) * | 1987-01-29 | 1989-05-23 | Genetics Institute, Inc. | Method for the isolation and purification of DNA molecules |
| US5063162A (en) * | 1987-04-24 | 1991-11-05 | Hoffmann-La Roche Inc. | Process for isolating nucleic acids utilizing protease digestion |
| WO1990014416A1 (en) * | 1989-05-22 | 1990-11-29 | Genetics Institute, Inc. | Improved composition for isolating and purifying nucleic acid and improved method using same |
| IT1232318B (it) * | 1989-09-07 | 1992-01-28 | Crinos Industria Farmaco | Composizioni ad uso topico contenenti acidi nucleici depolimerizzati per la cosmesi della pelle e del corpo. |
| US4997932A (en) * | 1989-11-13 | 1991-03-05 | Boehringer Mannheim Corporation | Method and kit for purifying nucleic acids |
-
1991
- 1991-12-09 IT ITMI913294A patent/IT1252174B/it active IP Right Grant
-
1992
- 1992-11-16 IL IL10375792A patent/IL103757A/xx not_active IP Right Cessation
- 1992-11-17 ZA ZA9228878A patent/ZA928878B/xx unknown
- 1992-11-20 CA CA002083416A patent/CA2083416A1/en not_active Abandoned
- 1992-11-26 GR GR920100527A patent/GR1002143B/el unknown
- 1992-11-27 AU AU29685/92A patent/AU655087B2/en not_active Ceased
- 1992-12-02 EP EP92203723A patent/EP0558833A3/en not_active Withdrawn
- 1992-12-04 US US07/985,726 patent/US6046172A/en not_active Expired - Lifetime
- 1992-12-07 PT PT101113A patent/PT101113A/pt not_active Application Discontinuation
- 1992-12-08 BE BE9201080A patent/BE1008163A5/fr not_active IP Right Cessation
- 1992-12-08 CH CH3759/92A patent/CH685298A5/fr not_active IP Right Cessation
- 1992-12-08 LU LU88197A patent/LU88197A1/fr unknown
- 1992-12-08 BR BR9204931A patent/BR9204931A/pt not_active Application Discontinuation
- 1992-12-09 CN CN92113711A patent/CN1073448A/zh active Pending
- 1992-12-09 FR FR9214810A patent/FR2684675B1/fr not_active Expired - Fee Related
- 1992-12-09 JP JP4329713A patent/JPH05247083A/ja active Pending
- 1992-12-09 MX MX9207137A patent/MX9207137A/es unknown
-
1995
- 1995-08-03 US US08/510,622 patent/US5646127A/en not_active Expired - Lifetime
-
1996
- 1996-01-31 US US08/594,522 patent/US5646268A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GR1002143B (en) | 1996-02-16 |
| PT101113A (pt) | 1994-02-28 |
| MX9207137A (es) | 1993-08-01 |
| GR920100527A (el) | 1994-03-31 |
| LU88197A1 (fr) | 1993-05-17 |
| US5646268A (en) | 1997-07-08 |
| US5646127A (en) | 1997-07-08 |
| FR2684675B1 (fr) | 1996-10-18 |
| BR9204931A (pt) | 1993-06-15 |
| US6046172A (en) | 2000-04-04 |
| EP0558833A3 (en) | 1995-09-06 |
| CA2083416A1 (en) | 1993-06-10 |
| JPH05247083A (ja) | 1993-09-24 |
| ITMI913294A1 (it) | 1993-06-09 |
| BE1008163A5 (fr) | 1996-02-06 |
| CH685298A5 (fr) | 1995-05-31 |
| EP0558833A2 (en) | 1993-09-08 |
| ITMI913294A0 (it) | 1991-12-09 |
| CN1073448A (zh) | 1993-06-23 |
| IT1252174B (it) | 1995-06-05 |
| ZA928878B (en) | 1993-06-22 |
| AU655087B2 (en) | 1994-12-01 |
| AU2968592A (en) | 1993-06-10 |
| FR2684675A1 (fr) | 1993-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |