IL102004A - Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaeutical compositions containing them - Google Patents

Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaeutical compositions containing them

Info

Publication number: IL102004A
Authority: IL; Israel
Prior art keywords: group; alkyl; substituted; groups; chosen
Prior art date: 1991-06-05

Application number

IL102004A

Other languages

English (en)

Other versions

IL102004A0 (en

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-05

Filing date

1992-05-26

Publication date

1997-04-15

1992-05-26 Application filed by Sanofi Elf filed Critical Sanofi Elf

1992-12-30 Publication of IL102004A0 publication Critical patent/IL102004A0/xx

1997-04-15 Publication of IL102004A publication Critical patent/IL102004A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL102004A 1991-06-05 1992-05-26 Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaeutical compositions containing them IL102004A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106814A FR2677356B1 (fr)	1991-06-05	1991-06-05	Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.

Publications (2)

Publication Number	Publication Date
IL102004A0 IL102004A0 (en)	1992-12-30
IL102004A true IL102004A (en)	1997-04-15

Family

ID=9413505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL102004A IL102004A (en)	1991-06-05	1992-05-26	Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaeutical compositions containing them

Country Status (23)

Country	Link
US (2)	US5314889A (xx)
EP (1)	EP0518731B1 (xx)
JP (1)	JP3199451B2 (xx)
KR (1)	KR100222309B1 (xx)
AT (1)	ATE170186T1 (xx)
AU (1)	AU650754B2 (xx)
BR (2)	BR9202156A (xx)
CA (1)	CA2070526A1 (xx)
CZ (1)	CZ289003B6 (xx)
DE (1)	DE69226729T2 (xx)
ES (1)	ES2121575T3 (xx)
FI (1)	FI922589A7 (xx)
FR (1)	FR2677356B1 (xx)
HU (1)	HU221312B1 (xx)
IE (1)	IE921814A1 (xx)
IL (1)	IL102004A (xx)
MX (1)	MX9202662A (xx)
NO (1)	NO300135B1 (xx)
NZ (1)	NZ243009A (xx)
RU (1)	RU2059637C1 (xx)
TW (1)	TW202448B (xx)
UA (1)	UA26899C2 (xx)
ZA (1)	ZA923981B (xx)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4303676A1 (de) *	1993-02-09	1994-08-11	Bayer Ag	1-Aryltriazolin(thi)one
FR2701708B1 (fr) *	1993-02-19	1995-05-19	Sanofi Elf	Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
FR2703995B1 (fr) *	1993-04-16	1995-07-21	Sanofi Elf	5-acylamino 1,2,4-thiadiazoles, leur preparation et compositions pharmaceutiques en contenant.
WO1995032963A1 (en) *	1994-06-01	1995-12-07	Yoshitomi Pharmaceutical Industries, Ltd.	Thienylazole compound and thienotriazolodiazepine compound
MX9604483A (es) *	1994-09-08	1998-02-28	Jean-Francois Rossignol	Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
AU711575B2 (en) *	1996-06-27	1999-10-14	Janssen Pharmaceutica N.V.	N-(4-(Heteroarylmethyl)Phenyl)-Heteroarylamines
WO1998035707A1 (en)	1997-02-18	1998-08-20	Thomas Jefferson University	Compositions that bind to pancreatic cancer cells and methods of using the same
CO4970713A1 (es) *	1997-09-19	2000-11-07	Sanofi Synthelabo	Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
FR2768737B1 (fr) *	1997-09-19	2000-05-19	Sanofi Sa	Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
GB0028383D0 (en) *	2000-11-21	2001-01-03	Novartis Ag	Organic compounds
WO2002059099A1 (en) *	2001-01-26	2002-08-01	Shionogi & Co., Ltd.	Cyclic compounds having thrombopoietin receptor agonism
WO2002062775A1 (en) *	2001-02-02	2002-08-15	Yamanouchi Pharmaceutical Co., Ltd.	2-acylaminothiazole derivative or its salt
EP2314586B1 (en) *	2002-01-18	2016-09-14	Astellas Pharma Inc.	2-Acylaminothiazole derivative or salt thereof
US20030225054A1 (en) *	2002-06-03	2003-12-04	Jingwu Duan	Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents
FR2854158B1 (fr) *	2003-04-25	2006-11-17	Sanofi Synthelabo	Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
EP1647553A4 (en) *	2003-07-17	2008-12-31	Astellas Pharma Inc	2-ACYLAMINOTHIAZOL DERIVATIVE OR SALT THEREOF
TWI336697B (en) *	2003-09-19	2011-02-01	Solvay Pharm Bv	Thiazole derivatives as cannabinoid receptor modulators
ATE384058T1 (de) *	2003-12-08	2008-02-15	Hoffmann La Roche	Thiazolderivate
ES2629414T3 (es)	2003-12-26	2017-08-09	Kyowa Hakko Kirin Co., Ltd.	Derivados de tiazol
GB0401336D0 (en) *	2004-01-21	2004-02-25	Novartis Ag	Organic compounds
CA2904275C (en)	2004-05-23	2020-09-01	Gerard M. Housey	Theramutein modulators
FR2872813B1 (fr) *	2004-07-09	2007-01-19	Sanofi Synthelabo	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
BRPI0515012A (pt) *	2004-08-13	2008-07-01	Genentech Inc	substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso
FR2876692B1 (fr) *	2004-10-19	2007-02-23	Sanofi Aventis Sa	Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
JP4774995B2 (ja) *	2005-01-12	2011-09-21	アステラス製薬株式会社	アシルアミノチアゾール誘導体を有効成分とする医薬組成物
MX2007015216A (es) *	2005-06-03	2008-02-22	Xenon Pharmaceuticals Inc	Derivados de aminotiazol y sus usos como agentes terapeuticos.
JPWO2006137527A1 (ja)	2005-06-23	2009-01-22	協和発酵キリン株式会社	チアゾール誘導体
US7928098B2 (en)	2005-08-02	2011-04-19	Kyowa Hakko Kirin Co., Ltd.	Therapeutic and/or preventive agents for a sleep disorder
CA2628848A1 (en) *	2005-11-08	2007-05-18	Astellas Pharma Inc.	Compositions and methods for treating thrombocytopenia
FR2895989B1 (fr) *	2006-01-06	2010-04-30	Sanofi Aventis	Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
US8455658B2 (en) *	2006-01-25	2013-06-04	Synta Pharmaceuticals Corp.	Thiazole and thiadiazole compounds for inflammation and immune-related uses
CN101096363B (zh) *	2006-06-27	2011-05-11	中国人民解放军军事医学科学院毒物药物研究所	2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US20080039475A1 (en) *	2006-08-08	2008-02-14	Akarx, Inc.	Compositions and methods for increasing blood platelet levels in humans
CA2711644A1 (en) *	2008-01-07	2009-07-16	Synta Pharmaceuticals Corp.	Compounds for inflammation and immune-related uses
EP2276767B1 (en) *	2008-03-31	2014-05-07	Genentech, Inc.	Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use
EP2464352A1 (en) *	2009-08-14	2012-06-20	Eisai Inc.	Use of e5501 for stimulating platelet production
SI2483278T1 (sl)	2009-09-28	2014-03-31	F. Hoffmann-La Roche Ag	Inhibitorske spojine benzoksazepina pi3k in njihova uporaba pri zdravljenju raka
SG10201407781SA (en) *	2009-09-28	2015-01-29	Hoffmann La Roche	Benzoxepin PI3K Inhibitor Compounds And Methods Of Use
CA2793311C (en) *	2010-03-17	2019-01-15	Taivex Therapeutics Inc.	Modulators of hec1 activity and methods therefor
WO2012126901A1 (en)	2011-03-21	2012-09-27	F. Hoffmann-La Roche Ag	Benzoxazepin compounds selective for pi3k p110 delta and methods of use
BR112014019209A2 (pt)	2012-02-17	2017-07-04	Hoffmann La Roche	compostos tricíclicos e métodos de uso para os mesmos
JP2022500499A (ja)	2018-09-07	2022-01-04	ピクセラピューティクス，インコーポレイテッド	Ｅｉｆ４ｅ阻害剤およびその使用
MX2022010944A (es)	2020-03-03	2022-11-09	Pic Therapeutics Inc	Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
JP7592158B2 (ja)	2021-05-06	2024-11-29	三菱電機株式会社	ピッキングシステム
CN118019739A (zh)	2021-08-25	2024-05-10	皮克医疗公司	Eif4e抑制剂及其用途
WO2023028235A1 (en)	2021-08-25	2023-03-02	PIC Therapeutics, Inc.	Eif4e inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3210368A (en) *	1964-09-29	1965-10-05	Ciba Geigy Corp	Certain 2-amino-4-aryl-5-n, n-disubstituted amino-lower alkyl-thiazole compounds
DE3681358D1 (de) *	1985-07-09	1991-10-17	Pfizer	Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
DE3705934A1 (de) *	1987-02-25	1988-09-08	Nattermann A & Cie	Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971978A (en) *	1987-09-21	1990-11-20	Nadzan Alex M	Derivatives of D-glutamic acid and D-aspartic acid
EP0348523A4 (en) *	1987-12-22	1991-10-09	Yoshitomi Pharmaceutical Industries, Ltd.	Thienodiazepine compounds and their medicinal use
IE68593B1 (en) *	1989-12-06	1996-06-26	Sanofi Sa	Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them

1991
- 1991-06-05 FR FR9106814A patent/FR2677356B1/fr not_active Expired - Fee Related
1992
- 1992-05-26 IL IL102004A patent/IL102004A/xx not_active IP Right Cessation
- 1992-05-28 AU AU17279/92A patent/AU650754B2/en not_active Ceased
- 1992-05-29 US US07/889,910 patent/US5314889A/en not_active Expired - Fee Related
- 1992-06-01 TW TW081104270A patent/TW202448B/zh active
- 1992-06-01 ZA ZA923981A patent/ZA923981B/xx unknown
- 1992-06-03 NZ NZ243009A patent/NZ243009A/en unknown
- 1992-06-03 AT AT92401518T patent/ATE170186T1/de not_active IP Right Cessation
- 1992-06-03 ES ES92401518T patent/ES2121575T3/es not_active Expired - Lifetime
- 1992-06-03 EP EP92401518A patent/EP0518731B1/fr not_active Expired - Lifetime
- 1992-06-03 DE DE69226729T patent/DE69226729T2/de not_active Expired - Fee Related
- 1992-06-04 HU HU9201870A patent/HU221312B1/hu not_active IP Right Cessation
- 1992-06-04 RU SU5011874/04A patent/RU2059637C1/ru not_active IP Right Cessation
- 1992-06-04 MX MX9202662A patent/MX9202662A/es not_active IP Right Cessation
- 1992-06-04 NO NO922215A patent/NO300135B1/no not_active IP Right Cessation
- 1992-06-04 JP JP14415092A patent/JP3199451B2/ja not_active Expired - Fee Related
- 1992-06-04 CA CA002070526A patent/CA2070526A1/en not_active Abandoned
- 1992-06-04 FI FI922589A patent/FI922589A7/fi not_active Application Discontinuation
- 1992-06-04 CZ CS19921693A patent/CZ289003B6/cs not_active IP Right Cessation
- 1992-06-05 KR KR1019920009859A patent/KR100222309B1/ko not_active Expired - Fee Related
- 1992-06-05 BR BR929202156A patent/BR9202156A/pt not_active Application Discontinuation
- 1992-07-01 IE IE181492A patent/IE921814A1/en not_active IP Right Cessation
1993
- 1993-06-15 UA UA93002939A patent/UA26899C2/uk unknown
1994
- 1994-03-03 US US08/205,408 patent/US5380736A/en not_active Expired - Fee Related
1997
- 1997-05-12 BR BR1100786-9A patent/BR1100786A/pt active IP Right Grant

Also Published As

Publication number	Publication date
KR930000492A (ko)	1993-01-15
US5380736A (en)	1995-01-10
NO922215D0 (no)	1992-06-04
KR100222309B1 (ko)	1999-10-01
FR2677356A1 (fr)	1992-12-11
IL102004A0 (en)	1992-12-30
DE69226729T2 (de)	1999-05-06
UA26899C2 (uk)	1999-12-29
MX9202662A (es)	1992-12-31
BR1100786A (pt)	2000-03-14
FI922589A0 (fi)	1992-06-04
NO300135B1 (no)	1997-04-14
CA2070526A1 (en)	1992-12-06
FI922589A7 (fi)	1992-12-06
TW202448B (xx)	1993-03-21
HU9201870D0 (en)	1992-08-28
FR2677356B1 (fr)	1995-03-17
NO922215L (no)	1992-12-07
JP3199451B2 (ja)	2001-08-20
CS169392A3 (en)	1992-12-16
HUT75870A (en)	1997-05-28
EP0518731A1 (fr)	1992-12-16
ES2121575T3 (es)	1998-12-01
HU221312B1 (en)	2002-09-28
US5314889A (en)	1994-05-24
EP0518731B1 (fr)	1998-08-26
ATE170186T1 (de)	1998-09-15
CZ289003B6 (cs)	2001-10-17
NZ243009A (en)	1995-05-26
JPH05155871A (ja)	1993-06-22
AU1727992A (en)	1992-12-10
AU650754B2 (en)	1994-06-30
DE69226729D1 (de)	1998-10-01
RU2059637C1 (ru)	1996-05-10
BR9202156A (pt)	1993-02-02
ZA923981B (en)	1993-12-01
IE921814A1 (en)	1992-12-16
HK1012397A1 (en)	1999-07-30

Publication	Publication Date	Title
IL102004A (en)	1997-04-15	Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaeutical compositions containing them
NO931433D0 (no)	1993-04-19	4,1-benzoksazepinderivater og deres anvendelse
ATE73797T1 (de)	1992-04-15	Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel.
ES2092651T3 (es)	1996-12-01	Derivados heterociclicos diazotados n-sustituidos por un grupo bifenilmetilo, su preparacion, las composiciones farmaceuticas que los contienen.
NO952208L (no)	1995-08-02	Amin-derivater
ATE165095T1 (de)	1998-05-15	Heterocyclische derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
NO915068D0 (no)	1991-12-20	Fremgangsmaate for fremstilling av nye amino- og nitro-holdige tricykliske forbindelser
FR2613719B1 (fr)	1991-03-22	Derives aromatiques, leur preparation et leur utilisation comme antimicrobiens
NZ221141A (en)	1990-05-28	Triazolopyridine and traizoloquinoline derivatives, pharmaceutical compositions
ES8604543A1 (es)	1986-02-01	Procedimiento para la obtencion de derivados piperazinicos
IL108258A0 (en)	1994-04-12	Piperazine derivates, their preparation and pharmaceutical compositions containing them
EA200101237A1 (ru)	2002-04-25	Пирролидинил-, пиперидинил- или гомопиперидинил-замещенные (бензодиоксан, бензофуран или бензопиран) производные
DE3768457D1 (de)	1991-04-11	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
NZ335975A (en)	2000-11-24	Heterocyclic substituted pyrrolidine amide derivatives useful in treating respiratory diseases
DK0419360T3 (da)	1993-08-16	Phenothiazinderivater, deres fremstilling og farmaceutiske præparater indeholdende disse
DE69104155D1 (de)	1994-10-27	6-Alkylpyridazinderivate, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen.
WO2001046147A8 (en)	2002-06-06	A process for preparing 4-substituted piperidines
GB770625A (en)	1957-03-20	Substituted endoxy-perhydrophthalimides
AR005123A1 (es)	1999-04-14	Derivados de acidos carboxilicos, procedimiento para su preparracion, composiciones farmaceuticas que los comprenden y empleos de dichos derivados
GB897158A (en)	1962-05-23	Therapeutic cyanophenoxazine derivatives
MX9804789A (es)	1998-10-31	Soluciones de hidroxilamina estabilizadas.

Legal Events

Date	Code	Title
1997-11-20	FF	Patent granted
1998-02-22	KB	Patent renewed
1998-11-26	KB	Patent renewed
2000-07-16	HC	Change of name of proprietor(s)
2002-07-25	KB	Patent renewed
2007-02-12	MM9K	Patent not in force due to non-payment of renewal fees