IE34145B1 - A process for the manufacture of amino acids and derivatives thereof - Google Patents
A process for the manufacture of amino acids and derivatives thereofInfo
- Publication number
- IE34145B1 IE34145B1 IE609/70A IE60970A IE34145B1 IE 34145 B1 IE34145 B1 IE 34145B1 IE 609/70 A IE609/70 A IE 609/70A IE 60970 A IE60970 A IE 60970A IE 34145 B1 IE34145 B1 IE 34145B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- represents hydrogen
- lower alkyl
- hydroxy
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940093740 amino acid and derivative Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical class OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000003262 carboxylic acid ester group Chemical class [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1283804 3,4 - Dihydroxyphenylalanine derivatives F HOFFMANN-LA ROCHE & CO AG 12 May 1970 [14 May 1969] 22808/70 Heading C2C Compounds of Formula I in which R 1 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino, n stands for 1, 2 or 3, R 2 represents hydrogen or lower alkyl, R 3 represents hydroxy or optionally mono- or di-lower alkyl-substituted amino, R 4 represents hydrogen, lower alkyl, lower alkanoyl or aroyl and R 5 represents hydrogen or lower alkyl, "lower" denoting groups containing up to 6 carbon atoms, and salts thereof, which process comprises subjecting a compound of the general Formula II wherein one of the substituents R 6 and R 7 is hydroxy and the other substituent is lower alkanoyl, aroyl or carboxy, or a salt of such a compound to an oxidative rearrangement and saponifying the carboxylic acid ester obtained and, in any desired sequence, hydrolysing the product obtained if desired, resolving a racemate obtained into its optically active forms, if desired, and converting a product obtained into a salt if desired. Pharmaceutical compositions in conventional forms and having hypotensive and anti- Parkison activity comprise a novel compound of Formula I above, i.e. one in which n is 1 and R 1 is halogen or C 1-6 alkyl provided that R 2 is alkyl when R 1 is in the 2-position and R 2 is alkyl when R 1 is alkyl, and a carrier or diluent. Reference has been directed by the Comptroller to Specification 1,023,204.
[GB1283804A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH735269A CH521313A (en) | 1969-05-14 | 1969-05-14 | Process for the preparation of phenylalamine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34145L IE34145L (en) | 1970-11-14 |
| IE34145B1 true IE34145B1 (en) | 1975-02-19 |
Family
ID=4323785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE609/70A IE34145B1 (en) | 1969-05-14 | 1970-05-11 | A process for the manufacture of amino acids and derivatives thereof |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5220470B1 (en) |
| AT (1) | AT300768B (en) |
| BE (1) | BE750209A (en) |
| CH (1) | CH521313A (en) |
| ES (1) | ES379619A1 (en) |
| FR (1) | FR2051524B1 (en) |
| GB (1) | GB1283804A (en) |
| IE (1) | IE34145B1 (en) |
| IL (1) | IL34505A (en) |
| NL (1) | NL144592B (en) |
| NO (1) | NO127534B (en) |
| RO (1) | RO58401A (en) |
| SU (1) | SU376935A3 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE48715B1 (en) * | 1978-12-22 | 1985-05-01 | Elan Corp Plc | New galencial forms for administration of medicaments by oral route,with programmed release and processes for preparing same |
| FR2452922A2 (en) * | 1979-04-02 | 1980-10-31 | Panoz Donald | Controlled release oral galenical formulation - contains active components in micro-granules prepd. under high compression |
| JPS5596436A (en) * | 1979-01-19 | 1980-07-22 | Nippon Hodo Co Ltd | Method of preserving soil sample |
| JPS6033001U (en) * | 1983-08-12 | 1985-03-06 | 株式会社 長崎機器製作所 | Upper residual air removal device for flexible container containers |
| JPS618501U (en) * | 1984-06-19 | 1986-01-18 | 雪印乳業株式会社 | Deaeration bag packaging equipment for powder, etc. |
-
1969
- 1969-05-14 CH CH735269A patent/CH521313A/en not_active IP Right Cessation
-
1970
- 1970-05-08 RO RO63301A patent/RO58401A/ro unknown
- 1970-05-10 IL IL34505A patent/IL34505A/en unknown
- 1970-05-11 NO NO01786/70A patent/NO127534B/no unknown
- 1970-05-11 IE IE609/70A patent/IE34145B1/en unknown
- 1970-05-11 BE BE750209D patent/BE750209A/en unknown
- 1970-05-12 NL NL707006842A patent/NL144592B/en not_active IP Right Cessation
- 1970-05-12 SU SU1443804A patent/SU376935A3/ru active
- 1970-05-12 GB GB22808/70A patent/GB1283804A/en not_active Expired
- 1970-05-13 AT AT430870A patent/AT300768B/en not_active IP Right Cessation
- 1970-05-13 FR FR7017384A patent/FR2051524B1/fr not_active Expired
- 1970-05-13 ES ES379619A patent/ES379619A1/en not_active Expired
- 1970-05-14 JP JP45040578A patent/JPS5220470B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SU376935A3 (en) | 1973-04-05 |
| GB1283804A (en) | 1972-08-02 |
| IL34505A0 (en) | 1970-07-19 |
| RO58401A (en) | 1975-09-15 |
| JPS5220470B1 (en) | 1977-06-03 |
| IL34505A (en) | 1974-10-22 |
| CH521313A (en) | 1972-04-15 |
| FR2051524A1 (en) | 1971-04-09 |
| NO127534B (en) | 1973-07-09 |
| ES379619A1 (en) | 1973-01-16 |
| AT300768B (en) | 1972-08-10 |
| NL7006842A (en) | 1970-11-17 |
| DE2023461A1 (en) | 1970-11-19 |
| BE750209A (en) | 1970-11-12 |
| DE2023461B2 (en) | 1977-06-08 |
| NL144592B (en) | 1975-01-15 |
| IE34145L (en) | 1970-11-14 |
| FR2051524B1 (en) | 1974-03-22 |
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