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GB1351261A - Preparation of vincamine alkaloids - Google Patents

Preparation of vincamine alkaloids

Info

Publication number
GB1351261A
GB1351261A GB2578671*A GB2578671A GB1351261A GB 1351261 A GB1351261 A GB 1351261A GB 2578671 A GB2578671 A GB 2578671A GB 1351261 A GB1351261 A GB 1351261A
Authority
GB
United Kingdom
Prior art keywords
preparation
vincamine
alkaloids
afford compound
vincamine alkaloids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2578671*A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7011406A external-priority patent/FR2081593A1/en
Priority claimed from FR7032889A external-priority patent/FR2104959A2/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1351261A publication Critical patent/GB1351261A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1351261 A process for vincamine alkaloids; related compounds ROUSSEL UCLAF 19 April 1971 [31 March 1970 10 Sept 1970] 25786/71 Heading C2C The invention comprises reacting compound (V) with an alkali metal methoxide to afford compound (I), or with acid or base furnishing hydroxyl ions to afford compound (VI) which is thereafter esterified to yield (I). The intermediates (II), (III) and (IV) are also prepared (Y is O, S or two hydrogen atoms). Geometric and optical isomers, racemates and salts are also described.
GB2578671*A 1970-03-31 1971-04-19 Preparation of vincamine alkaloids Expired GB1351261A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7011406A FR2081593A1 (en) 1970-03-31 1970-03-31 Vincamine process
FR7032889A FR2104959A2 (en) 1970-09-10 1970-09-10 Vincamine process

Publications (1)

Publication Number Publication Date
GB1351261A true GB1351261A (en) 1974-04-24

Family

ID=26215644

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2578671*A Expired GB1351263A (en) 1970-03-31 1971-04-19 Eburnane derivatives
GB2578671*A Expired GB1351261A (en) 1970-03-31 1971-04-19 Preparation of vincamine alkaloids
GB2578671*A Expired GB1351262A (en) 1970-03-31 1971-04-19 Quinolizine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2578671*A Expired GB1351263A (en) 1970-03-31 1971-04-19 Eburnane derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2578671*A Expired GB1351262A (en) 1970-03-31 1971-04-19 Quinolizine derivatives

Country Status (16)

Country Link
US (1) US3770724A (en)
JP (3) JPS5144960B1 (en)
AT (1) AT309699B (en)
BE (1) BE765006A (en)
CA (1) CA937570A (en)
CH (1) CH546777A (en)
DE (3) DE2167043A1 (en)
DK (1) DK149345C (en)
GB (3) GB1351263A (en)
HU (1) HU163769B (en)
IL (1) IL36474A (en)
IT (1) IT8048032A0 (en)
NL (1) NL158497B (en)
PL (1) PL83152B1 (en)
SE (2) SE390414B (en)
SU (1) SU505365A3 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL153199B (en) * 1971-10-25 1977-05-16 Omnium Chimique Sa PROCESS FOR THE PREPARATION OF VINCAMIC ACID ESTERS AND PROCEDURE FOR THE PREPARATION OF A MEDICINAL PRODUCT CONTAINING SUCH ESTER AND FORMED MEDICINAL PRODUCT THEREFORE OBTAINED.
CH578001A5 (en) * 1972-04-14 1976-07-30 Sandoz Ag
FR2179620B1 (en) * 1972-04-14 1975-12-26 Roussel Uclaf
US4033969A (en) * 1972-06-19 1977-07-05 Agence Nationale De Valorisation De La Recherche (Anvar) Vincamine derivatives
FR2259612B1 (en) * 1974-01-31 1977-09-09 Synthelabo
CH625239A5 (en) * 1974-08-09 1981-09-15 Buskine Sa
JPS536264U (en) * 1976-06-30 1978-01-20
HU174502B (en) * 1976-12-30 1980-01-28 Richter Gedeon Vegyeszet SPOSOB POLUCHENIJA NOVYKH PROIZVODNYKH OKTAGIDRO-INDOLO / 2,3-A / -KHINOLIZINA
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
US4428877A (en) 1978-07-12 1984-01-31 Richter Gedeon Vegyeszeti Gyar Rt. Cis-10-bromo-E-homoeburnanes
CH649295A5 (en) * 1978-07-12 1985-05-15 Richter Gedeon Vegyeszet OPTICALLY ACTIVE OR RAZEMIC BROM E-HOMO-EBURAN DERIVATIVES.
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
US4316028A (en) * 1978-11-20 1982-02-16 Sumitomo Chemical Company, Limited Process for producing eburnane derivatives
HU179292B (en) * 1978-12-01 1982-09-28 Richter Gedeon Vegyeszet Process for preparing ester derivatives of apovincaminic acid
HU180928B (en) * 1979-08-06 1983-05-30 Richter Gedeon Vegyeszet Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives
HU181496B (en) * 1979-08-13 1983-07-28 Richter Gedeon Vegyeszet Process for preparing 10-bromo-15-hydroxy-e-homo-eburnanes
JPS5689589U (en) * 1979-12-13 1981-07-17
JPS5693693U (en) * 1979-12-14 1981-07-25
HU185305B (en) 1981-08-23 1985-01-28 Richter Gedeon Vegyeszet Process for preparing vincine and apovincine
HU183234B (en) * 1980-10-17 1984-04-28 Richter Gedeon Vegyeszet Process for the enantioselective synthesis of optically active cys-14-oxo-e-homo-eburnan
HU182411B (en) * 1981-11-03 1984-01-30 Richter Gedeon Vegyeszet Process for preparing eburnamonine derivatives
HU186891B (en) * 1981-06-12 1985-10-28 Richter Gedeon Vegyeszet Process for producing esters of apovincaminic acid
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid
JPS59258U (en) * 1982-06-24 1984-01-05 日本ピラ−工業株式会社 Flat type electron tube display device
HU187733B (en) * 1982-06-30 1986-02-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing apovincaminic acid derivatives
HU187139B (en) * 1982-06-30 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new eburnan derivatives
HU187140B (en) * 1982-06-30 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new aburnan-oxima ethers
JPS6032240A (en) * 1983-07-30 1985-02-19 Sony Corp Phosphor display device
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2382009T3 (en) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company N - ((3-Benzyl) -2,2- (bis-phenyl -) - propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
BR112015026513A2 (en) 2013-04-17 2017-07-25 Pfizer n-piperidin-3-ylbenzamide derivatives to treat cardiovascular disease
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
FI3911648T3 (en) 2019-01-18 2025-01-10 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof
CN111205288B (en) * 2020-02-19 2021-03-30 四川大学 A kind of synthetic method of (1S,12bS) lactam ester compound

Also Published As

Publication number Publication date
DK149345B (en) 1986-05-12
DE2115718C3 (en) 1979-07-19
SE386179B (en) 1976-08-02
NL7104275A (en) 1971-10-04
IL36474A0 (en) 1971-05-26
SU505365A3 (en) 1976-02-28
JPS5163198A (en) 1976-06-01
IT8048032A0 (en) 1980-02-28
JPS5337360B2 (en) 1978-10-07
JPS5227160B2 (en) 1977-07-19
DE2115718A1 (en) 1971-10-14
AT309699B (en) 1973-07-15
GB1351262A (en) 1974-04-24
GB1351263A (en) 1974-04-24
HU163769B (en) 1973-10-27
SE390414B (en) 1976-12-20
CH546777A (en) 1974-03-15
NL158497B (en) 1978-11-15
DE2115718B2 (en) 1978-11-02
US3770724A (en) 1973-11-06
CA937570A (en) 1973-11-27
BE765006A (en) 1971-09-30
DE2167044A1 (en) 1977-11-10
DE2167043A1 (en) 1977-10-13
PL83152B1 (en) 1975-12-31
JPS5144960B1 (en) 1976-12-01
DE2167044C2 (en) 1983-07-14
JPS5163197A (en) 1976-06-01
DK149345C (en) 1986-10-13
IL36474A (en) 1975-08-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee