IE34665B1 - Isothioureas and their derivatives - Google Patents
Isothioureas and their derivativesInfo
- Publication number
- IE34665B1 IE34665B1 IE1345/70A IE134570A IE34665B1 IE 34665 B1 IE34665 B1 IE 34665B1 IE 1345/70 A IE1345/70 A IE 1345/70A IE 134570 A IE134570 A IE 134570A IE 34665 B1 IE34665 B1 IE 34665B1
- Authority
- IE
- Ireland
- Prior art keywords
- oct
- pharmaceutically acceptable
- nucleus
- forms
- gb1296544a
- Prior art date
Links
- 150000002541 isothioureas Chemical class 0.000 title 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1296544 Antihistamines SMITH KLINE & FRENCH LABORATORIES Ltd 26 Oct 1970 [29 Oct 1969] 52890/69 Heading A5B [Also in Division C2] Pharmaceutical compositions in conventional forms and having antihistamine activity other than at the H1 site comprise a pharmaceutically acceptable carrier and a comcompound of formula wherein n is from 2 to 4; A is such that it forms with the carbon and nitrogen atom shown an unsaturated heterocyclic basic nucleus having five or six atoms, which nucleus may be substituted by one or more halogen or aralkyl groups; R 1 is hydrogen or lower alkyl, R 2 together form an ethylene bridge; or its pharmaceutically acceptable acid addition salts, but excluding simple solutions in absolute ethanol of S-[2-(4(5)-imidazolyl) ethyl] isothiourea.
[GB1296544A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5289069 | 1969-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34665L IE34665L (en) | 1971-04-29 |
| IE34665B1 true IE34665B1 (en) | 1975-07-09 |
Family
ID=10465720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1345/70A IE34665B1 (en) | 1969-10-29 | 1970-10-19 | Isothioureas and their derivatives |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4917262B1 (en) |
| BE (1) | BE758145A (en) |
| CA (1) | CA953725A (en) |
| DE (1) | DE2052692A1 (en) |
| FR (1) | FR2070177B1 (en) |
| GB (1) | GB1296544A (en) |
| IE (1) | IE34665B1 (en) |
| SE (1) | SE390303B (en) |
| ZA (1) | ZA707150B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA938556A (en) * | 1970-06-25 | 1973-12-18 | Smith Kline And French Laboratories Limited | Pharmaceutical compositions containing thiourea derivatives |
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| IE47044B1 (en) | 1977-04-20 | 1983-12-14 | Ici Ltd | Guanidine derivatives |
| US4262125A (en) * | 1979-07-23 | 1981-04-14 | American Home Products Corporation | (1H-Imidazol-5-ylmethyl)isothioureas |
| IT1201523B (en) * | 1982-05-18 | 1989-02-02 | Angeli Inst Spa | HETEROCYCLYLPHENYLPHOMRAMIDIN, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE |
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| FR2660862B1 (en) * | 1990-04-13 | 1994-09-23 | Bioprojet Soc Civ | THERAPEUTIC APPLICATION OF HISTAMINE DERIVATIVES, NEW HISTAMINE DERIVATIVE AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS. |
| US5321039A (en) * | 1990-04-13 | 1994-06-14 | Societe Civile Bioprojet | Method of inducing a histamine agonist action on H2 receptors |
| ES2108107T3 (en) * | 1991-02-27 | 1997-12-16 | Seed Capital Investments | IMIDAZOLE DERIVATIVES THAT HAVE ANTAGONIST ACTIVITY IN THE H3 RECEPTOR OF HISTAMINE. |
| NL9100365A (en) * | 1991-02-27 | 1992-09-16 | Seed Capital Investments | New imidazole compounds with activity at histamine H3 receptor - e.g. S-(2-(4-imidazolyl)ethyl)isothiourea (VUF 8325) |
| GB0404434D0 (en) * | 2004-02-27 | 2004-03-31 | Novartis Ag | Organic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2548746A (en) * | 1947-10-10 | 1951-04-10 | Sharp & Dohme Inc | S-(4-thiazolylmethyl)-isothioureas |
| IL25931A (en) * | 1965-07-07 | 1972-01-27 | Merck & Co Inc | New 4-or 5-nitro imidazole and 5,6-dihydroimidazo(1,2-a)pyrrol-7-yl-carbamates and pseudo thioureido imidazoles and their preparation |
-
0
- BE BE758145D patent/BE758145A/en unknown
-
1969
- 1969-10-29 GB GB5289069A patent/GB1296544A/en not_active Expired
-
1970
- 1970-10-19 IE IE1345/70A patent/IE34665B1/en unknown
- 1970-10-22 SE SE7014259A patent/SE390303B/en unknown
- 1970-10-24 JP JP45093878A patent/JPS4917262B1/ja active Pending
- 1970-10-27 DE DE19702052692 patent/DE2052692A1/en active Pending
- 1970-10-27 CA CA096,673A patent/CA953725A/en not_active Expired
- 1970-10-29 FR FR7039077A patent/FR2070177B1/fr not_active Expired
- 1970-10-29 ZA ZA707150A patent/ZA707150B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA953725A (en) | 1974-08-27 |
| DE2052692A1 (en) | 1971-05-06 |
| GB1296544A (en) | 1972-11-15 |
| ZA707150B (en) | 1971-07-28 |
| FR2070177A1 (en) | 1971-09-10 |
| BE758145A (en) | 1971-04-28 |
| FR2070177B1 (en) | 1974-10-11 |
| IE34665L (en) | 1971-04-29 |
| JPS4917262B1 (en) | 1974-04-27 |
| SE390303B (en) | 1976-12-13 |
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