GB1202110A - Novel quinoline derivatives and their preparation - Google Patents
Novel quinoline derivatives and their preparationInfo
- Publication number
- GB1202110A GB1202110A GB5846268A GB5846268A GB1202110A GB 1202110 A GB1202110 A GB 1202110A GB 5846268 A GB5846268 A GB 5846268A GB 5846268 A GB5846268 A GB 5846268A GB 1202110 A GB1202110 A GB 1202110A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- general formula
- quinoline
- group
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000003248 quinolines Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 alkyl 5-aminoacetamido-quinoline-8-carboxylate Chemical compound 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 241000235388 Mucorales Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,202,110. Quinoline derivatives. STERLING DRUG Inc. 9 Dec., 1968 [15 Dec., 1967], No. 58462/68. Heading C2C. Novel quinoline derivatives of the general formula wherein X is a halogen atom, R is a hydrogen atom or a C 1-6 alkyl or C 1-6 alkanoyl group, Y is a C 2-6 alkylene group, R 1 is a hydrogen atom or a C 1-6 alkyl or 2-hydroxyl-C 2-6 -alkyl group R 2 is a C 1-6 alkyl or 2-hydroxy-C 2-6 alkyl group, or R 1 and R 2 , together with the nitrogen atom to which they are attached, form a 5-7 membered saturated monocyclic radical, and acid addition salts thereof are prepared (a) by reduction of an alkyl 5-aminoalkylamino-quinoline-8-carboxylate of the general formula wherein R<SP>1</SP> is a C 1-6 alkyl group; (b) when Y is an ethylene group, by reduction of an alkyl 5-aminoacetamido-quinoline-8-carboxylate of the general formula or (c) by subjection of a 5-(R 1 R 2 N-Y-NH)-6 or 7-halo-8-methylquinoline to the fermentative enzymatic action of a micro-organism of the order Moniliales, Mucorales, Sphaeriaeles, Sphaeropsidales, Melanconiales or Antinomycetales; followed optionally by reaction of the resulting quinoline derivative of the first general formula above wherein R is a hydrogen atom with a C 1-6 alkanol in the presence of an acid or with a C 1-6 alkanoyl halide, anhydride or other C 1-6 alkanoylating agent; and/or followed optionally by salification. Pharmaceutical compositions having schistosomacidal activity comprise, as active ingredient, a quinoline derivative of the first general formula above or an acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US882723A US3692790A (en) | 1968-12-09 | 1969-12-05 | 5-(aminoalkylamino)-6(or)-halo-8-quinolinemethanols, their alkyl ethers and alkanoyl esters |
| US882722A US3622457A (en) | 1968-12-09 | 1969-12-05 | Process for preparing 5-(aminoalkylamino)-6 (or 7)-halo-8-quinoline methanols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69079567A | 1967-12-15 | 1967-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1202110A true GB1202110A (en) | 1970-08-12 |
Family
ID=24774005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5846268A Expired GB1202110A (en) | 1967-12-15 | 1968-12-09 | Novel quinoline derivatives and their preparation |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BR6804817D0 (en) |
| GB (1) | GB1202110A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0104389A3 (en) * | 1982-09-07 | 1984-10-10 | Basf Aktiengesellschaft | Quinoline derivatives, process for their preparation and their use in the control of undesired plant growth |
| US5932401A (en) * | 1997-08-21 | 1999-08-03 | Eastman Kodak Company | Reversal photographic elements comprising an additional layer containing an imaging emulsion and a non-imaging emulsion |
-
1968
- 1968-12-09 GB GB5846268A patent/GB1202110A/en not_active Expired
- 1968-12-13 BR BR20481768A patent/BR6804817D0/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0104389A3 (en) * | 1982-09-07 | 1984-10-10 | Basf Aktiengesellschaft | Quinoline derivatives, process for their preparation and their use in the control of undesired plant growth |
| US4715889A (en) * | 1982-09-07 | 1987-12-29 | Basf Aktiengesellschaft | Quinoline derivatives and their use for controlling undesirable plant growth |
| US5932401A (en) * | 1997-08-21 | 1999-08-03 | Eastman Kodak Company | Reversal photographic elements comprising an additional layer containing an imaging emulsion and a non-imaging emulsion |
Also Published As
| Publication number | Publication date |
|---|---|
| BR6804817D0 (en) | 1973-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1413648A (en) | Hypolipedemic acitve alkoxy and alkylthio-furoic acids and esters | |
| GB1265279A (en) | ||
| GB1202110A (en) | Novel quinoline derivatives and their preparation | |
| GB1174880A (en) | Derivatives of alpha-Piperazinophenylacetonitrile and process for manufacture of same | |
| GB1245155A (en) | NOVEL 5-SUBSTITUTED-gamma-CARBOLINE DERIVATIVES AND THE SALTS THEREOF | |
| GB1529251A (en) | 9,10-dihydroergopeptines | |
| GB1195319A (en) | Alkyl Sulfate Salts of 1-(p-Chlorobenzhydryl)-4-Methylhomopiperazines | |
| GB1276719A (en) | Benzomorphan derivatives and their salts | |
| GB1415682A (en) | Amides and thioamides | |
| GB1181295A (en) | Improvements in or relating to Naphthalene Derivatives and the Manufacture Thereof | |
| GB1377610A (en) | 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof | |
| GB1246117A (en) | Pharmaceutical preparations containing glucose compounds, glucose derivatives and process for their manufacture | |
| SE300011B (en) | ||
| GB1362400A (en) | 1-amino-isoquinoline derivatives | |
| GB1204809A (en) | Novel quinoline derivatives, the preparation thereof and compositions containing the same | |
| GB1169807A (en) | p-Chlorobenzyl Compounds and their Serotonin Lowering Ability | |
| IL41758A (en) | Alpha-aminoalkyl 4-hydroxy-3-alkylsulfonyl-methylbenzyl alcohols | |
| GB1179051A (en) | Phenethylamino-Propan-2-ones and -Propan-2-Ols | |
| GB1261660A (en) | alpha-HYDRAZINO ACIDS | |
| GB1158954A (en) | N-(4-Carboxy-Phenyl)-Anthranilic Acid, derivatives thereof and a process for their preparation | |
| GB1193521A (en) | Novel Esters of 1-Phenyl-1-Benzyl-2-Methyl-3-Dimethylaminopropanol, the preparation thereof and Compositions containing the same | |
| GB1457950A (en) | Antibacterial compositions | |
| GB1509778A (en) | Pharmaceutical composition and dosage units thereof | |
| GB1165099A (en) | 2-Aryl-2-Imidazolines | |
| GB1211387A (en) | 0-benzylpiperidine derivative and a process for the preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |