[go: up one dir, main page]

HUS1900034I1 - 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok - Google Patents

6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok

Info

Publication number
HUS1900034I1
HUS1900034I1 HUS1900034C HUS1900034C HUS1900034I1 HU S1900034 I1 HUS1900034 I1 HU S1900034I1 HU S1900034 C HUS1900034 C HU S1900034C HU S1900034 C HUS1900034 C HU S1900034C HU S1900034 I1 HUS1900034 I1 HU S1900034I1
Authority
HU
Hungary
Prior art keywords
carbamoyl
unsaturated
morphinan derivatives
substituted morphinan
substituted
Prior art date
Application number
HUS1900034C
Other languages
English (en)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of HUS1900034I1 publication Critical patent/HUS1900034I1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUS1900034C 2005-05-25 2019-07-03 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok HUS1900034I1 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2006065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP06746833.0A EP1889848B8 (en) 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl substituted morphinan derivative

Publications (1)

Publication Number Publication Date
HUS1900034I1 true HUS1900034I1 (hu) 2019-07-29

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
HUS1900034C HUS1900034I1 (hu) 2005-05-25 2019-07-03 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok

Country Status (20)

Country Link
US (4) US8084460B2 (hu)
EP (1) EP1889848B8 (hu)
JP (1) JP4323547B2 (hu)
KR (1) KR100912782B1 (hu)
CN (1) CN101228172B (hu)
AU (1) AU2006250390B2 (hu)
BE (1) BE2019C533I2 (hu)
BR (1) BRPI0610343B8 (hu)
CA (1) CA2609733C (hu)
DK (1) DK1889848T3 (hu)
ES (1) ES2525215T3 (hu)
FR (1) FR19C1042I2 (hu)
HU (1) HUS1900034I1 (hu)
MX (1) MX2007014588A (hu)
NL (1) NL300996I2 (hu)
PL (1) PL1889848T3 (hu)
PT (1) PT1889848E (hu)
RU (1) RU2403255C2 (hu)
TW (1) TWI311056B (hu)
WO (2) WO2006126529A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
JP5714910B2 (ja) * 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
CA2734333A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
AU2010295464B2 (en) * 2009-09-18 2015-11-26 Merck Sharp & Dohme Corp. Use of opioid receptor antagonist for gastrointestinal tract disorders
WO2011142620A2 (en) * 2010-05-13 2011-11-17 Green Cross Corporation (+)-3-hydroxymorphinan-based polycycle derivatives as neuroprotectants
KR101486686B1 (ko) 2010-11-12 2015-01-26 시오노기세야쿠 가부시키가이샤 6,7-불포화-7-카르바모일 모르피난 유도체의 결정 및 그의 제조 방법
PL2851075T3 (pl) 2012-05-14 2022-02-21 Shionogi & Co., Ltd. Preparat zawierający pochodną 6,7-nienasyconego-7-karbamoilomorfinanu
EP3560487A4 (en) * 2016-12-26 2020-07-29 Shionogi & Co., Ltd. PRODUCTION METHOD FOR FORMULATION WITH IMPROVED UNIFORMITY OF CONTENT
TWI856956B (zh) 2018-04-12 2024-10-01 美商莫菲克醫療股份有限公司 人類整合素α４β７拮抗劑
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
KR20220102669A (ko) 2019-10-16 2022-07-20 모픽 테라퓨틱, 인코포레이티드 인간 인테그린 α4β7의 억제
EP4062973A4 (en) 2019-11-20 2023-11-29 Shionogi & Co., Ltd 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4275205A (en) 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4347361A (en) 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4370333A (en) 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
US4443605A (en) 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4440932A (en) 1982-09-09 1984-04-03 Miles Laboratories, Inc. 7β-Arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
AU686203B2 (en) * 1993-07-23 1998-02-05 Toray Industries, Inc. Morphinan derivative and medicinal use
US5464841A (en) 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
AR005423A1 (es) 1996-01-10 1999-06-23 Smithkline Beecham Spa Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados.
AU5891600A (en) 1999-07-01 2001-01-22 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
US6451806B2 (en) * 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
JP2003528819A (ja) 1999-11-29 2003-09-30 アドラー コーポレーション オピオイドおよびそのアンタゴニストに関する新規方法および組成物
US20040024004A1 (en) 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
JP2004515455A (ja) 2000-05-05 2004-05-27 ペイン・セラピューティクス・インコーポレイテッド オピオイドアンタゴニスト組成物および投薬形態
WO2001085150A2 (en) 2000-05-05 2001-11-15 Pain Therapeutics, Inc. Opioid antagonist containing composition for enchaching the potency or reducing adverse side effects ofopioid agonists
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
JP4292738B2 (ja) 2000-11-22 2009-07-08 東レ株式会社 インドール誘導体およびその医薬用途
IL160193A0 (en) * 2001-08-23 2004-07-25 Akzo Nobel Nv Process for the preparation of a 14-hydroxynormorphinone derivative
DE10161963A1 (de) 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
CN1288158C (zh) 2002-07-11 2006-12-06 东丽株式会社 用于预防恶心和呕吐的治疗剂或预防剂
CA2498046A1 (en) * 2002-09-18 2004-04-01 The Curators Of The University Of Missouri Opiate analogs selective for the delta-opioid receptor
US20040157784A1 (en) 2003-02-10 2004-08-12 Jame Fine Chemicals, Inc. Opiod tannate compositions
WO2005105093A2 (en) 2003-08-26 2005-11-10 Duke University METHOD OF ARRESTING THE SIDE EFFECTS OF µ-OPIOID RECEPTOR AGONISTS DURING THEIR ADMINISTRATION
ES2623362T3 (es) 2004-05-28 2017-07-11 Human Biomolecular Research Institute Analgésicos metabólicamente estables y medicaciones para el dolor
US20060063792A1 (en) 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US7142420B2 (en) 2004-09-20 2006-11-28 Qualcomm, Incorporated Devices and methods for controlling relative movement between layers of an electronic device
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
KR101486686B1 (ko) 2010-11-12 2015-01-26 시오노기세야쿠 가부시키가이샤 6,7-불포화-7-카르바모일 모르피난 유도체의 결정 및 그의 제조 방법

Also Published As

Publication number Publication date
EP1889848A1 (en) 2008-02-20
WO2006126637A1 (ja) 2006-11-30
CA2609733C (en) 2011-07-19
WO2006126529A1 (ja) 2006-11-30
BRPI0610343B8 (pt) 2021-05-25
FR19C1042I1 (hu) 2019-08-09
EP1889848B1 (en) 2014-10-15
CA2609733A1 (en) 2006-11-30
BRPI0610343B1 (pt) 2020-03-10
TWI311056B (en) 2009-06-21
DK1889848T3 (en) 2014-12-01
RU2007148412A (ru) 2009-06-27
KR20080014791A (ko) 2008-02-14
USRE46365E1 (en) 2017-04-11
US8084460B2 (en) 2011-12-27
US20090203723A1 (en) 2009-08-13
BRPI0610343A2 (pt) 2010-06-15
KR100912782B1 (ko) 2009-08-18
NL300996I1 (nl) 2019-07-03
CN101228172A (zh) 2008-07-23
US8536192B2 (en) 2013-09-17
USRE46375E1 (en) 2017-04-25
PT1889848E (pt) 2014-12-09
ES2525215T3 (es) 2014-12-19
RU2403255C2 (ru) 2010-11-10
FR19C1042I2 (fr) 2020-06-19
EP1889848A4 (en) 2011-08-10
CN101228172B (zh) 2013-04-03
US20120135978A1 (en) 2012-05-31
JPWO2006126637A1 (ja) 2008-12-25
AU2006250390A1 (en) 2006-11-30
PL1889848T3 (pl) 2015-04-30
AU2006250390B2 (en) 2010-07-08
TW200726470A (en) 2007-07-16
NL300996I2 (nl) 2019-07-30
JP4323547B2 (ja) 2009-09-02
MX2007014588A (es) 2008-01-24
BE2019C533I2 (hu) 2025-12-10
EP1889848B8 (en) 2014-12-17

Similar Documents

Publication Publication Date Title
HUS1900034I1 (hu) 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok
ATE481383T1 (de) 3-aza-bicycloä3.1.0ühexanderivate
ATE469145T1 (de) 4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-
BRPI0811718A2 (pt) Derivados de 3,3-espiroindolinona
ZA200606974B (en) Substituted 1,2,3,4-tetrahydrolsoquinoline derivatives
IS8578A (is) 3- karbamoýl - 2- pýridón afleiður
DK1824856T3 (da) 2,4 (4,6)-pyrimidinderivater
DE602008005634D1 (de) 1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
ATE394399T1 (de) Tetrahydropyridoindolderivate
ATE434613T1 (de) Isochinolinderivate
ATE540935T1 (de) Chinazolinderivate
DK1761541T3 (da) Pyrrazolo-pyrimidin-derivater
DE602007001681D1 (de) 1,3-dioxan-carboxylsäuren
ATE417830T1 (de) Sulfonylbenzimidazolderivate
NL2000937A1 (nl) Piperidinederivaten.
DE602006010581D1 (de) 4-phenyl-6-substituierte pyrimidin-2-carbonitrilderivate
ATE485294T1 (de) Azaindol-2-carboxamid-derivate
ATE430142T1 (de) Phenylpiperazin-methanon-derivate
ATE527255T1 (de) Aryl-isoxazol-4-yl-imidazol-derivate
DK1971588T3 (da) Tiglien-3-onderivater
NL2000336A1 (nl) Spirocyclische derivaten.
DK1963295T3 (da) 3,6-dihydro-2-oxo-6H-(1,3,4)thiazinderivater
ATE404542T1 (de) 4-phenylpyrimidin-2-carbonitrilderivate
DK1740574T3 (da) 4-amino-5-cyanopyrimidinderivater
TWI315670B (en) Substituted aryl 1,4-pyrazine derivatives