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AR005423A1 - Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados. - Google Patents

Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados.

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Publication number
AR005423A1
AR005423A1 ARP970100077A ARP970100077A AR005423A1 AR 005423 A1 AR005423 A1 AR 005423A1 AR P970100077 A ARP970100077 A AR P970100077A AR P970100077 A ARP970100077 A AR P970100077A AR 005423 A1 AR005423 A1 AR 005423A1
Authority
AR
Argentina
Prior art keywords
group
same meaning
derivatives
prepare
hydrogen
Prior art date
Application number
ARP970100077A
Other languages
English (en)
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI960029 external-priority patent/IT1282950B1/it
Priority claimed from IT96MI002291 external-priority patent/IT1287130B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of AR005423A1 publication Critical patent/AR005423A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P11/14—Antitussive agents
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    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
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    • C07F7/0838—Compounds with one or more Si-O-Si sequences
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    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/48—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
    • C08G77/50—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages
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    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/54—Silicon-containing compounds
    • C08K5/541—Silicon-containing compounds containing oxygen
    • C08K5/5415—Silicon-containing compounds containing oxygen containing at least one Si—O bond
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    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
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    • H—ELECTRICITY
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    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K3/00—Apparatus or processes for manufacturing printed circuits
    • H05K3/22—Secondary treatment of printed circuits
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  • Health & Medical Sciences (AREA)
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  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Estos derivados tienen la fórmula (I), en la cual R1 es hidrógeno, alquilo C1-6 estando opcionalmente sustituidos cada uno de los tres últimos grupos oR1 es un grupo A-B en el que A representa alquileno C1-10 y B representa arilo o heteroarilosust ituido o sin sustituir; R2 es hidrógeno, hidroxi o alcoxiC1-7, halógeno, nitro, NR10R11, SR10 en donde R10 y R11 tienen el mismo significado anteriormente descrito y, además, R10 es COR1; R3 es hidrógeno,alquilo C1-4, lineal oramificado, hid roxi, alcoxi C1-3, halógeno, o (CH2)mCOR en donde m y R tienen el mismo significado anteriormente descrito, SR10, nitro,NR10R11, NHCOR10, NHSO2R10, en donde R10 y R11 tienen el mismo significado anteriormente descrito; R4 y R5,que pueden ser i guales o diferentes, son cadauno independientemente hidrógeno, hidroxi, alcoxi C1-3, o fenilo, o pueden formar conjuntamente un grupo oxi (-O-); o R4 junto con R5 pueden formar ungrupo metilendioxi (-OCH2O-); R6 en un grupo(II) o un grupo heter oaromático de cinco o seis miembros que contienen hasta tres heteroátomos sustituido conR3, en el que R3 tiene el mismo significado anteriormente descrito, habiendo hasta tres grupos R3 en el anillo; o R6 es un grupoC(Z)R12, en el que Z esoxíg eno o azufre; o R6 es un grupo CH2WA, en el que W es oxígeno, azufre o NR14, y A es hidrógeno, alquilo lineal o ramificado o COR14, en donde R14se define anteriormente; o R6 es un grupo COCOR12, en el que R12 tiene elmismo significado anteriorme nte descrito; o R6 es un grupo NR13R14, en el que R13 yR14 tienen el mismo significado anteriormente descrito, o R13 puede ser un grupo (CH2)mCOR en el que m y R tienen los mismos significadosanteriormentedescritos; o R6 es un grupo R(Z)R12 en el Z y R12 tienen el mismo significado anteriormente descrito; o R16 es un grupo S(O)iR12 en el que i es 1,2 y R12
ARP970100077A 1996-01-10 1997-01-08 Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados. AR005423A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI960029 IT1282950B1 (it) 1996-01-10 1996-01-10 Derivati eterociclo-condensati di morfinoidi
IT96MI002291 IT1287130B1 (it) 1996-11-05 1996-11-05 Derivati eterociclo-condensati di morfinoidi

Publications (1)

Publication Number Publication Date
AR005423A1 true AR005423A1 (es) 1999-06-23

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ARP970100077A AR005423A1 (es) 1996-01-10 1997-01-08 Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados.

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US (1) US6365594B1 (es)
EP (1) EP0880526B1 (es)
JP (1) JP2000503019A (es)
KR (1) KR19990077125A (es)
CN (1) CN1090190C (es)
AR (1) AR005423A1 (es)
AT (1) ATE229958T1 (es)
AU (1) AU706370B2 (es)
BR (1) BR9707136A (es)
CA (1) CA2242609A1 (es)
CZ (1) CZ218298A3 (es)
DE (1) DE69717967T2 (es)
ES (1) ES2188888T3 (es)
HU (1) HUP9900974A3 (es)
IL (1) IL125226A0 (es)
NO (1) NO983169L (es)
NZ (1) NZ326331A (es)
PL (1) PL327943A1 (es)
TR (1) TR199801348T2 (es)
TW (1) TW357148B (es)
WO (1) WO1997025331A1 (es)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
IT1312083B1 (it) * 1999-04-20 2002-04-04 Smithkline Beecham Spa Derivati morfinoidi, procedimento per la loro preparazione e loroimpiego terapeutico.
CA2380814A1 (en) * 1999-08-13 2001-02-22 Southern Research Institute Pyridomorphinans, thienomorphinans and use thereof
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US6284769B1 (en) * 1999-12-03 2001-09-04 The Board Of Trustees Of The University Of Illinois Nonpeptide kappa opioid receptor antagonists
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US6365594B1 (en) 2002-04-02
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DE69717967T2 (de) 2003-08-28
JP2000503019A (ja) 2000-03-14
TW357148B (en) 1999-05-01
AU1441097A (en) 1997-08-01
HUP9900974A2 (hu) 1999-08-30
CN1090190C (zh) 2002-09-04
CZ218298A3 (cs) 1999-08-11
TR199801348T2 (xx) 1998-10-21
WO1997025331A1 (en) 1997-07-17
NZ326331A (en) 2000-01-28
EP0880526A1 (en) 1998-12-02
DE69717967D1 (de) 2003-01-30
HUP9900974A3 (en) 2000-09-28
BR9707136A (pt) 1999-08-31
IL125226A0 (en) 1999-03-12
AU706370B2 (en) 1999-06-17
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CN1213372A (zh) 1999-04-07
ES2188888T3 (es) 2003-07-01
PL327943A1 (en) 1999-01-04
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