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HUP9900521A2 - Eljárás nagyon kis dózisú hatóanyagok szilárd dózisformáinak előállítására - Google Patents

Eljárás nagyon kis dózisú hatóanyagok szilárd dózisformáinak előállítására

Info

Publication number
HUP9900521A2
HUP9900521A2 HU9900521A HUP9900521A HUP9900521A2 HU P9900521 A2 HUP9900521 A2 HU P9900521A2 HU 9900521 A HU9900521 A HU 9900521A HU P9900521 A HUP9900521 A HU P9900521A HU P9900521 A2 HUP9900521 A2 HU P9900521A2
Authority
HU
Hungary
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Application number
HU9900521A
Other languages
English (en)
Inventor
Michael Sidney George Clark
Rajinder Kumar
Julia Mary Loudon
Sultan James Manek
Neil Mortimer
James Albert Napper
Karen Triona O'brien
Original Assignee
Smithkline Beecham Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Smithkline Beecham Plc. filed Critical Smithkline Beecham Plc.
Publication of HUP9900521A2 publication Critical patent/HUP9900521A2/hu
Publication of HUP9900521A3 publication Critical patent/HUP9900521A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány egyik tárgya őlyan hatóanyag-főrmálási eljárásravőnatkőzik, amelynek sőrán hőrdőzórészecskéket összekevernek egyhatóanyag vizes őldatával, ahől a teljes keverékre vőnatkőztatva azőldatőt 1-3 tömeg% mennyiségben alkalmazzák. A találmány tővábbitárgyát egy dementia kezelésére és/vagy megelőzésére szőlgáló eljárásképezi, amelynek sőrán a betegnek 0,01 mg/kg- nál kisebb napi dózisban[R-(Z)]-a-(metőxi-iminő)-a-1-aza-3-biciklő[2.2.2]őktil}-acetőnitril-mőnőhidrőklőridőt adnak be. A találmány kiterjed a találmány szerintifőrmálási eljárással főrmált hatóanyagőt tartalmazó, illetve atalálmány szerinti kezelési eljárásban alkalmazőttgyógyszerkészítményekre is. ŕ
HU9900521A 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs HUP9900521A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process

Publications (2)

Publication Number Publication Date
HUP9900521A2 true HUP9900521A2 (hu) 1999-06-28
HUP9900521A3 HUP9900521A3 (en) 2001-04-28

Family

ID=26307485

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900521A HUP9900521A3 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Country Status (25)

Country Link
EP (1) EP0841902A2 (hu)
JP (1) JPH11510493A (hu)
KR (1) KR19990035972A (hu)
CN (1) CN1196677A (hu)
AP (1) AP858A (hu)
AR (1) AR004178A1 (hu)
AU (1) AU716961B2 (hu)
BG (1) BG102266A (hu)
BR (1) BR9609804A (hu)
CA (1) CA2228048A1 (hu)
CZ (1) CZ24798A3 (hu)
DZ (1) DZ2077A1 (hu)
EA (2) EA199901055A1 (hu)
HU (1) HUP9900521A3 (hu)
IL (1) IL122897A0 (hu)
MA (1) MA23953A1 (hu)
MX (1) MX9800809A (hu)
NO (1) NO980384L (hu)
NZ (1) NZ315632A (hu)
OA (1) OA10659A (hu)
PL (1) PL325242A1 (hu)
SK (1) SK11098A3 (hu)
TR (1) TR199800156T1 (hu)
UY (1) UY24297A1 (hu)
WO (1) WO1997004750A2 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
KR20010034588A (ko) * 1998-03-11 2001-04-25 피터 기딩스 조성물
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
CZ306435B6 (cs) 2000-12-14 2017-01-25 Ortho-Mcneil Pharmaceutical, Inc. Steroidní hormonální přípravek a způsob jeho přípravy
US20070202179A1 (en) * 2004-04-09 2007-08-30 FAULKNER Patrick Low Dose Pharmaceutical Products
WO2026018155A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with long-acting non-cns penetrant muscarinic antagonists
WO2026018154A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with non-cns penetrant muscarinic antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (ja) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd 微量主薬系湿式固形製剤方法
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
DE69034146T2 (de) * 1989-04-13 2005-07-14 Beecham Group P.L.C., Brentford Chemische Verbindungen
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
NZ315632A (en) 1999-11-29
NO980384D0 (no) 1998-01-28
AR004178A1 (es) 1998-11-04
MX9800809A (es) 1998-04-30
EA199901055A1 (ru) 2000-06-26
CZ24798A3 (cs) 1998-06-17
EP0841902A2 (en) 1998-05-20
DZ2077A1 (fr) 2002-07-22
BR9609804A (pt) 1999-07-06
AP9801170A0 (en) 1998-01-31
JPH11510493A (ja) 1999-09-14
PL325242A1 (en) 1998-07-06
UY24297A1 (es) 1997-01-23
SK11098A3 (en) 1998-07-08
EA199800179A1 (ru) 1998-10-29
CN1196677A (zh) 1998-10-21
KR19990035972A (ko) 1999-05-25
TR199800156T1 (xx) 1998-04-21
CA2228048A1 (en) 1997-02-13
AU6738496A (en) 1997-02-26
NO980384L (no) 1998-03-26
EA000740B1 (ru) 2000-02-28
WO1997004750A3 (en) 1997-03-27
HUP9900521A3 (en) 2001-04-28
WO1997004750A2 (en) 1997-02-13
OA10659A (en) 2002-09-18
AU716961B2 (en) 2000-03-09
AP858A (en) 2000-07-12
BG102266A (en) 1998-10-30
MA23953A1 (fr) 1997-04-01
IL122897A0 (en) 1998-08-16

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