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WO1997004750A3 - Process for preparing solid dosage forms of very low-dose drugs - Google Patents

Process for preparing solid dosage forms of very low-dose drugs Download PDF

Info

Publication number
WO1997004750A3
WO1997004750A3 PCT/EP1996/003326 EP9603326W WO9704750A3 WO 1997004750 A3 WO1997004750 A3 WO 1997004750A3 EP 9603326 W EP9603326 W EP 9603326W WO 9704750 A3 WO9704750 A3 WO 9704750A3
Authority
WO
WIPO (PCT)
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1996/003326
Other languages
French (fr)
Other versions
WO1997004750A2 (en
Inventor
James Albert Napper
Neil Mortimer
Karen Triona O'brien
Sultan James Manek
Rajinder Kumar
Michael Sidney George Clark
Julia Mary Loudon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Priority to JP9507243A priority Critical patent/JPH11510493A/en
Priority to APAP/P/1998/001170A priority patent/AP858A/en
Priority to EP96927621A priority patent/EP0841902A2/en
Priority to EA199901055A priority patent/EA199901055A1/en
Priority to AU67384/96A priority patent/AU716961B2/en
Priority to MX9800809A priority patent/MX9800809A/en
Priority to BR9609804A priority patent/BR9609804A/en
Priority to IL12289796A priority patent/IL122897A0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to IL14957996A priority patent/IL149579A0/en
Priority to EA199800179A priority patent/EA000740B1/en
Priority to NZ315632A priority patent/NZ315632A/en
Priority to SK110-98A priority patent/SK11098A3/en
Publication of WO1997004750A2 publication Critical patent/WO1997004750A2/en
Publication of WO1997004750A3 publication Critical patent/WO1997004750A3/en
Priority to NO980384A priority patent/NO980384L/en
Anticipated expiration legal-status Critical
Priority to BG102266A priority patent/BG102266A/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A drug formulation process which comprises admixing carrier particles with a solution of drug in water in a quantity of 1-3 % by weight of solution to total mix and a method of treatment and/or prophylaxis of dementia, which method comprises administering to the patient [R-(Z)]-α-(methoxyimino)-α-(1-azabicyclo [2.2.2]oct-3-yl)acetonitrile monohydrochloride at a daily dose below 0.01 mg/kg and pharmaceutical compositions used therein.
PCT/EP1996/003326 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs Ceased WO1997004750A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NZ315632A NZ315632A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs comprising admixing 1-3% by weight of carrier particles with a solution of drug in water
SK110-98A SK11098A3 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
IL14957996A IL149579A0 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of low-dose drugs
EP96927621A EP0841902A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
EA199901055A EA199901055A1 (en) 1995-07-29 1996-07-29 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA
AU67384/96A AU716961B2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
MX9800809A MX9800809A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs.
BR9609804A BR9609804A (en) 1995-07-29 1996-07-29 Process for the preparation of solid dosage forms with very low dosage drugs
IL12289796A IL122897A0 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
JP9507243A JPH11510493A (en) 1995-07-29 1996-07-29 Method of making solid dosage forms of very low dose drugs
APAP/P/1998/001170A AP858A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs.
EA199800179A EA000740B1 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs and a pharmaceutical obtained therein
NO980384A NO980384L (en) 1995-07-29 1998-01-28 Process for the preparation of solid dosage forms of very low-dose drugs
BG102266A BG102266A (en) 1995-07-29 1998-02-20 Method for the preparation of solid batched forms having very low doses of the medicamentous form

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GB9515624.6 1995-07-29
GB9606684.0 1996-03-29
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09000252 A-371-Of-International 1998-07-08
US09/759,575 Continuation US20010018074A1 (en) 1995-07-29 2001-01-12 Process for preparing solid dosage forms of very low-dose drugs

Publications (2)

Publication Number Publication Date
WO1997004750A2 WO1997004750A2 (en) 1997-02-13
WO1997004750A3 true WO1997004750A3 (en) 1997-03-27

Family

ID=26307485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/003326 Ceased WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Country Status (25)

Country Link
EP (1) EP0841902A2 (en)
JP (1) JPH11510493A (en)
KR (1) KR19990035972A (en)
CN (1) CN1196677A (en)
AP (1) AP858A (en)
AR (1) AR004178A1 (en)
AU (1) AU716961B2 (en)
BG (1) BG102266A (en)
BR (1) BR9609804A (en)
CA (1) CA2228048A1 (en)
CZ (1) CZ24798A3 (en)
DZ (1) DZ2077A1 (en)
EA (2) EA000740B1 (en)
HU (1) HUP9900521A3 (en)
IL (1) IL122897A0 (en)
MA (1) MA23953A1 (en)
MX (1) MX9800809A (en)
NO (1) NO980384L (en)
NZ (1) NZ315632A (en)
OA (1) OA10659A (en)
PL (1) PL325242A1 (en)
SK (1) SK11098A3 (en)
TR (1) TR199800156T1 (en)
UY (1) UY24297A1 (en)
WO (1) WO1997004750A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
TR200002626T2 (en) 1998-03-11 2001-03-21 Smithkline Beecham Plc compound
FR2796840B1 (en) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION
ES2253451T3 (en) 2000-12-14 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. PRODUCTS BASED ON STEROID HORMONE AND ITS MANUFACTURING PROCEDURES.
JP2007532511A (en) * 2004-04-09 2007-11-15 スミスクライン ビーチャム コーポレーション Low dose medicine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5970614A (en) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd Wet solid pharmaceutical preparation of very small amount of main drug
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
EP0392803A1 (en) * 1989-04-13 1990-10-17 Beecham Group p.l.c. Novel compounds
WO1995017168A1 (en) * 1993-12-21 1995-06-29 Applied Analytical Industries, Inc. Method for preparing low dose pharmaceutical products

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (en) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd Wet solid pharmaceutical preparation of very small amount of main drug
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
EP0392803A1 (en) * 1989-04-13 1990-10-17 Beecham Group p.l.c. Novel compounds
WO1995017168A1 (en) * 1993-12-21 1995-06-29 Applied Analytical Industries, Inc. Method for preparing low dose pharmaceutical products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 8, 20 August 1984, Columbus, Ohio, US; abstract no. 60165, XP002024576 *

Also Published As

Publication number Publication date
HUP9900521A3 (en) 2001-04-28
CZ24798A3 (en) 1998-06-17
UY24297A1 (en) 1997-01-23
BR9609804A (en) 1999-07-06
AP858A (en) 2000-07-12
EA000740B1 (en) 2000-02-28
NO980384L (en) 1998-03-26
EP0841902A2 (en) 1998-05-20
BG102266A (en) 1998-10-30
AR004178A1 (en) 1998-11-04
AU6738496A (en) 1997-02-26
MA23953A1 (en) 1997-04-01
IL122897A0 (en) 1998-08-16
CA2228048A1 (en) 1997-02-13
TR199800156T1 (en) 1998-04-21
PL325242A1 (en) 1998-07-06
AP9801170A0 (en) 1998-01-31
HUP9900521A2 (en) 1999-06-28
EA199901055A1 (en) 2000-06-26
JPH11510493A (en) 1999-09-14
SK11098A3 (en) 1998-07-08
DZ2077A1 (en) 2002-07-22
OA10659A (en) 2002-09-18
CN1196677A (en) 1998-10-21
NZ315632A (en) 1999-11-29
EA199800179A1 (en) 1998-10-29
NO980384D0 (en) 1998-01-28
WO1997004750A2 (en) 1997-02-13
AU716961B2 (en) 2000-03-09
MX9800809A (en) 1998-04-30
KR19990035972A (en) 1999-05-25

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