HUP9900475D0 - O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component - Google Patents
O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active componentInfo
- Publication number
- HUP9900475D0 HUP9900475D0 HU9900475A HUP9900475A HUP9900475D0 HU P9900475 D0 HUP9900475 D0 HU P9900475D0 HU 9900475 A HU9900475 A HU 9900475A HU P9900475 A HUP9900475 A HU P9900475A HU P9900475 D0 HUP9900475 D0 HU P9900475D0
- Authority
- HU
- Hungary
- Prior art keywords
- hiyroximic
- halogenid
- piperidino
- propyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9900475A HUP9900475D0 (en) | 1999-02-26 | 1999-02-26 | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| RU2001126126/04A RU2250901C2 (ru) | 1999-02-26 | 2000-02-24 | N-[2-гидрокси-3-(1-пиперидинил)пропокси]пиридин-1-оксид-3- карбоксиимидоилхлорид, фармацевтическая композиция на его основе и способ лечения |
| ES00909542T ES2193055T3 (es) | 1999-02-26 | 2000-02-24 | Cloruro de n- (2-hidroxi-3- (1-piperidinil) piridina-1-oxido-3-carboximidoilo y su uso en el tratamiento de la resistencia a la insulina. |
| DK00909542T DK1163224T3 (da) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperiinyl)propoxy]pyridin-1-oxid-3-carboximidoylchlorid og dets anvendelse i behandlingen af insulinresistens |
| AT00909542T ATE237590T1 (de) | 1999-02-26 | 2000-02-24 | N-(2-hydroxy-3-(1-piperidinyl)propoxy)pyridin-1 oxid-3-carboximidoyl chlorid und seine verwendung als mittel zur behandlung von insulinresistenz |
| SI200030080T SI1163224T1 (en) | 1999-02-26 | 2000-02-24 | N-(2-hydroxy-3-(1-piperidinyl)propoxy)pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| DE60002187T DE60002187T2 (de) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridin-1-oxid-3-carboximidoyl chlorid und seine verwendung als mittel zur behandlung von insulinresistenz |
| PL350915A PL197692B1 (pl) | 1999-02-26 | 2000-02-24 | Chlorek 1-tlenku N-[2-hydroksy-3-(1-piperydynylo)propoksy]pirydyno-3-karboksyimidoilu, jego zastosowanie i środek farmaceutyczny |
| EP00909542A EP1163224B1 (en) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| IL14486600A IL144866A0 (en) | 1999-02-26 | 2000-02-24 | N- [2-hydroxy-3- (1-piperidinyl) propoxy] pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| CA2360451A CA2360451C (en) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| JP2000600986A JP4689838B2 (ja) | 1999-02-26 | 2000-02-24 | N−[2−ヒドロキシ−3−(1−ピペリジニル)プロポキシ]ピリジン−1−オキシド−3−カルボキシイミドイルクロライド及びそのインスリン抵抗性の治療における使用 |
| AU31824/00A AU779096B2 (en) | 1999-02-26 | 2000-02-24 | N-(2-hydroxy-3-(1-piperidinyl)propoxy)pyridine-1-oxide-3- carboximidoyl chloride and its use in the treatment of insulin resistance |
| US09/913,263 US6649628B1 (en) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| CZ20013053A CZ297386B6 (cs) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridin-1-oxid-3-karboximidoylchlorid, N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridin-1-oxid-3-karboximidoylchlorid pro pouzití pri lécbe rezistence vuci inzulínua farmaceutický prípravek ho obsahující |
| HR20010584A HRP20010584B1 (en) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| BR0008969-9A BR0008969A (pt) | 1999-02-26 | 2000-02-24 | Cloreto den-[2-hidróxi-3-(1-piperidinil)-(propóxi]piridina-1-óxido-3-carboximidoìla e seu uso no tratamento deresistência à insulina |
| YUP-603/01A RS50083B (sr) | 1999-02-26 | 2000-02-24 | N-/2-hidroksi-3-(1-piperidinil) propoksi/piridin-1-oksid- 3-karbo ksimidoil hlorid i njegova upotreba u tretiranju insulinske rezistencije |
| KR1020017010932A KR100676124B1 (ko) | 1999-02-26 | 2000-02-24 | 엔-[2-히드록시-3-(1-피페리디닐)프로폭시]피리딘-1-옥사이드-3-카르복시미도일 클로라이드 및 인슐린 내성 치료에 있어서의 이의 용도 |
| SK1158-2001A SK287063B6 (sk) | 1999-02-26 | 2000-02-24 | Chlorid N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridín-1-oxid-3- karboximidoylu, jeho použitie na liečenie inzulínovej rezistencie a farmaceutická kompozícia s jeho obsahom |
| UA2001085933A UA72495C2 (uk) | 1999-02-26 | 2000-02-24 | N-[2-гідрокси-3-(1-піперидиніл)пропокси]піридин-1-оксид-3-карбоксіімідоїлхлорид, фармацевтична композиція та спосіб лікування інсулінорезистентності з його використанням |
| EEP200100447A EE04961B1 (et) | 1999-02-26 | 2000-02-24 | N-[2-hdroks-3-(1-piperidinl)propoks]pridiin-1-oksiid-3-karboksimidolkloriid ning selle kasutamine insuliiniresistentsuse ravis |
| PCT/HU2000/000015 WO2000050403A1 (en) | 1999-02-26 | 2000-02-24 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance |
| PT00909542T PT1163224E (pt) | 1999-02-26 | 2000-02-24 | Cloreto de n-¬2-hidroxi-3-(1-piperidinil) propoxi|piridina-1-oxido-3-carboximidoilo e sua utilizacao no tratamento da resistencia a insulina |
| ZA200106488A ZA200106488B (en) | 1999-02-26 | 2001-08-07 | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance. |
| IL144866A IL144866A (en) | 1999-02-26 | 2001-08-13 | N - [2 - Hydroxy - 3 - (1 - piperidinyl) propoxy] Pyridine - 1 - Oxide - 3 - Carboxymidoyl chloride and its uses in the treatment of insulin resistance |
| BG105837A BG65178B1 (bg) | 1999-02-26 | 2001-08-22 | N-[2-хидрокси-3-(1-пиперидинил)пропокси]пиридин-1-оксид-3-карбоксимидоил хлорид и неговото приложение за лечение на инсулинова резистентност |
| NO20014103A NO319793B1 (no) | 1999-02-26 | 2001-08-23 | N-[2-hydroksy-3-(1-piperidinyl)propoksy]pyridin-1-oksid-3-karboksimidoylklorid og dets anvendelse til fremstilling av et farmasoytisk preparat, samt farmasoytisk preparat. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9900475A HUP9900475D0 (en) | 1999-02-26 | 1999-02-26 | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9900475D0 true HUP9900475D0 (en) | 1999-04-28 |
Family
ID=90014224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900475A HUP9900475D0 (en) | 1999-02-26 | 1999-02-26 | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6649628B1 (hu) |
| EP (1) | EP1163224B1 (hu) |
| JP (1) | JP4689838B2 (hu) |
| KR (1) | KR100676124B1 (hu) |
| AT (1) | ATE237590T1 (hu) |
| AU (1) | AU779096B2 (hu) |
| BG (1) | BG65178B1 (hu) |
| BR (1) | BR0008969A (hu) |
| CA (1) | CA2360451C (hu) |
| CZ (1) | CZ297386B6 (hu) |
| DE (1) | DE60002187T2 (hu) |
| DK (1) | DK1163224T3 (hu) |
| EE (1) | EE04961B1 (hu) |
| ES (1) | ES2193055T3 (hu) |
| HR (1) | HRP20010584B1 (hu) |
| HU (1) | HUP9900475D0 (hu) |
| IL (2) | IL144866A0 (hu) |
| NO (1) | NO319793B1 (hu) |
| PL (1) | PL197692B1 (hu) |
| PT (1) | PT1163224E (hu) |
| RS (1) | RS50083B (hu) |
| RU (1) | RU2250901C2 (hu) |
| SI (1) | SI1163224T1 (hu) |
| SK (1) | SK287063B6 (hu) |
| UA (1) | UA72495C2 (hu) |
| WO (1) | WO2000050403A1 (hu) |
| ZA (1) | ZA200106488B (hu) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
| MXPA04006716A (es) * | 2002-01-11 | 2004-11-10 | Biorex Kutato Es Rejleszt Rt | Derivados de carboxamidina y su uso en el tratamiento de enfermedades vasculares. |
| HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| TW200831479A (en) * | 2006-09-26 | 2008-08-01 | Cytrx Corp | Pharmaceutical compositions and methods for treating diseases |
| DK2318032T3 (da) | 2008-06-26 | 2012-06-11 | Orphazyme Aps | Anvendelse af Hsp70 som regulator af enzymatisk aktivitet |
| WO2010058779A1 (ja) | 2008-11-18 | 2010-05-27 | 参天製薬株式会社 | ピリジン-3-カルバルデヒド o-(ピペリジン-1-イル-プロピル)-オキシム誘導体を有効成分として含有する網脈絡膜変性疾患の治療剤 |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| NZ706356A (en) * | 2012-09-06 | 2018-02-23 | Mcpharma Biotech Inc | Treatment of diarrhea and post-weaning diarrhea with resistant potato starch |
| CA2884777C (en) | 2012-09-14 | 2018-02-27 | Saint-Gobain Glass France | Pane with an electrical connection element |
| WO2015015248A1 (en) * | 2013-07-30 | 2015-02-05 | Debreceni Egyetem 67% | The use of compounds showing heat shock protein (hsp) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes |
| CN107106494B (zh) * | 2014-09-15 | 2021-12-21 | 奥菲泽米有限公司 | 阿瑞洛莫制剂 |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| HRP20210047T1 (hr) | 2016-04-29 | 2021-04-16 | Orphazyme A/S, c/o COBIS A/S | Arimoclomol za liječenje poremećaja povezanih s glukocerebrozidazom |
| BR112019024667A2 (pt) | 2017-05-24 | 2020-06-16 | Orphazyme A/S | Uso de um agente bioativo, e, de uma composição |
| AU2019276048B2 (en) | 2018-05-28 | 2025-09-04 | Zevra Denmark A/S | Hsp70 protein levels in PBMC samples as biomarker for disease |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| WO2021116487A1 (en) | 2019-12-13 | 2021-06-17 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of niemann-pick c disease |
| IL299250A (en) | 2020-06-24 | 2023-02-01 | Kempharm Denmark As | Arimoclomol for the treatment of Gaucher disease |
| CN116783164A (zh) * | 2020-11-19 | 2023-09-19 | 泽维拉丹麦股份有限公司 | 制备柠檬酸阿瑞洛莫及其中间体的方法 |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
| MX2023007551A (es) | 2020-12-24 | 2023-09-04 | Zevra Denmark As | Arimoclomol para el tratamiento de la enfermedad de niemann pick, tipo c, en pacientes con mutaciones de sentido erroneo de tipo reticulo endoplasmatico (er). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUT78138A (hu) * | 1995-12-22 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt | Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) * | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
-
1999
- 1999-02-26 HU HU9900475A patent/HUP9900475D0/hu unknown
-
2000
- 2000-02-24 KR KR1020017010932A patent/KR100676124B1/ko not_active Expired - Fee Related
- 2000-02-24 JP JP2000600986A patent/JP4689838B2/ja not_active Expired - Lifetime
- 2000-02-24 ES ES00909542T patent/ES2193055T3/es not_active Expired - Lifetime
- 2000-02-24 CA CA2360451A patent/CA2360451C/en not_active Expired - Lifetime
- 2000-02-24 IL IL14486600A patent/IL144866A0/xx active IP Right Grant
- 2000-02-24 AU AU31824/00A patent/AU779096B2/en not_active Expired
- 2000-02-24 RU RU2001126126/04A patent/RU2250901C2/ru active
- 2000-02-24 RS YUP-603/01A patent/RS50083B/sr unknown
- 2000-02-24 EP EP00909542A patent/EP1163224B1/en not_active Expired - Lifetime
- 2000-02-24 DE DE60002187T patent/DE60002187T2/de not_active Expired - Lifetime
- 2000-02-24 US US09/913,263 patent/US6649628B1/en not_active Expired - Lifetime
- 2000-02-24 AT AT00909542T patent/ATE237590T1/de active
- 2000-02-24 PL PL350915A patent/PL197692B1/pl unknown
- 2000-02-24 HR HR20010584A patent/HRP20010584B1/xx not_active IP Right Cessation
- 2000-02-24 EE EEP200100447A patent/EE04961B1/xx not_active IP Right Cessation
- 2000-02-24 SI SI200030080T patent/SI1163224T1/xx unknown
- 2000-02-24 PT PT00909542T patent/PT1163224E/pt unknown
- 2000-02-24 WO PCT/HU2000/000015 patent/WO2000050403A1/en not_active Ceased
- 2000-02-24 BR BR0008969-9A patent/BR0008969A/pt not_active IP Right Cessation
- 2000-02-24 DK DK00909542T patent/DK1163224T3/da active
- 2000-02-24 UA UA2001085933A patent/UA72495C2/uk unknown
- 2000-02-24 SK SK1158-2001A patent/SK287063B6/sk not_active IP Right Cessation
- 2000-02-24 CZ CZ20013053A patent/CZ297386B6/cs not_active IP Right Cessation
-
2001
- 2001-08-07 ZA ZA200106488A patent/ZA200106488B/xx unknown
- 2001-08-13 IL IL144866A patent/IL144866A/en not_active IP Right Cessation
- 2001-08-22 BG BG105837A patent/BG65178B1/bg unknown
- 2001-08-23 NO NO20014103A patent/NO319793B1/no not_active IP Right Cessation
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