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HUP9801725A1 - Új benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Új benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9801725A1
HUP9801725A1 HU9801725A HUP9801725A HUP9801725A1 HU P9801725 A1 HUP9801725 A1 HU P9801725A1 HU 9801725 A HU9801725 A HU 9801725A HU P9801725 A HUP9801725 A HU P9801725A HU P9801725 A1 HUP9801725 A1 HU P9801725A1
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
aryl
substituted
aryl group
Prior art date
Application number
HU9801725A
Other languages
English (en)
Inventor
Jacqueline Bonnet
Guillaume De Nanteuil
Armel Fradin
Bernard Portevin
Original Assignee
ADIR et CIE, Société en nom Collectif
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR et CIE, Société en nom Collectif filed Critical ADIR et CIE, Société en nom Collectif
Publication of HU9801725D0 publication Critical patent/HU9801725D0/hu
Publication of HUP9801725A1 publication Critical patent/HUP9801725A1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

(I) általános képletű vegyületek, ahol R1 jelentése halogénatom, hidroxi-, adott esetben arilcsoporttalszubsztituált 1-6 szénatomos alkoxicsoport, trihalogén-metil-, aril-metil-, ciano-, szulfo-, aminocsoport (ez utóbbi adott esetbenalkilcsoporttal, adott esetben szubsztituált arilcsoporttal, acil-,aril-szulfonil- vagy alkil-szulfonil-csoporttal szubsztituálva van),merkapto-, alkil-tio-, tri-alkil-ammónium-csoport, aril-oxi-, aril-tio-, aril-amino-karbonil-, aril-karbonil-amino-, aril-szulfonil-amino-, aril-amino-szulfonil-, aril-ureido-, aril-tio-ureido-, aril-szulfonil-, aril-szulfonil-oxi-, cikloalkoxi-, cikloalkil-tio-,bicikloalkil-oxi- (adott esetben arilcsoporttal szubsztituálva)bicikloalkil-tio- (adott esetben arilcsoporttal szubsztituálva)csoport, azzal a feltétellel, hogy valamennyi arilcsoport adottesetben szubsztituálva lehet, Ra, Rb jelentése egymástól függetlenül hidrogénatom, hidroxilcsoport,adott esetben arilcsoporttal szubsztituált alkilcsoport, X jelentése oxigén- vagy kénatom, vagy egy NR általános képletűcsoport, ahol R jelentése hidrogénatom vagy alkilcsoport, R2 jelentése imidazolil-, benzimidazol-1-il-, naftil-, piridil-,tiazolil-, oxazolil-, benzotiazolil-, benzoxazolil-, pirrolil-,furil-, tienil-, imidazopiridinil-, triazolil- vagy tetrazolilcsoport,ahol az említett valamennyi csoport adott esetben szubsztituálva van, R2' jelentése hidrogénatom vagy adott esetben szubsztituáltarilcsoport, és izomerjeik, valamint gyógyszerészetileg alkalmazhatósavaddíciós és bázisaddíciós sóik hatékonyan gátolják az interleukin-1bétát és annak képződését. Ó
HU9801725A 1997-07-30 1998-07-30 Új benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények HUP9801725A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709710A FR2766822B1 (fr) 1997-07-30 1997-07-30 Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
HU9801725D0 HU9801725D0 (en) 1998-09-28
HUP9801725A1 true HUP9801725A1 (hu) 2000-11-28

Family

ID=9509817

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801725A HUP9801725A1 (hu) 1997-07-30 1998-07-30 Új benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Country Status (19)

Country Link
US (1) US6040327A (hu)
EP (1) EP0894795B1 (hu)
JP (1) JPH11100368A (hu)
CN (1) CN1087740C (hu)
AT (1) ATE201868T1 (hu)
AU (1) AU734447B2 (hu)
BR (1) BR9802804A (hu)
CA (1) CA2244438A1 (hu)
DE (1) DE69800882T2 (hu)
DK (1) DK0894795T3 (hu)
ES (1) ES2159922T3 (hu)
FR (1) FR2766822B1 (hu)
GR (1) GR3036473T3 (hu)
HU (1) HUP9801725A1 (hu)
NO (1) NO983493L (hu)
NZ (1) NZ331153A (hu)
PL (1) PL327748A1 (hu)
PT (1) PT894795E (hu)
ZA (1) ZA986814B (hu)

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TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
EP3492100B1 (en) 2001-06-26 2021-12-08 Amgen Inc. Antibodies to opgl
WO2003002187A2 (en) * 2001-06-26 2003-01-09 Photomed Technologies, Inc. Multiple wavelength illuminator
ES2292937T3 (es) * 2002-02-21 2008-03-16 Eli Lilly And Company Moduladores para el receptor activado por el proliferador de peroxisomas.
MXPA05007019A (es) * 2002-12-30 2005-08-18 Amgen Inc Terapia de combinacion con factores co-estimuladores.
EP1720862A1 (en) * 2004-02-03 2006-11-15 Eli Lilly And Company Kinase inhibitors
TWI387592B (zh) * 2005-08-30 2013-03-01 Novartis Ag 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
EP1924579B1 (en) * 2005-09-02 2011-02-09 F. Hoffmann-La Roche AG Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives
MX2009006473A (es) * 2006-12-15 2009-08-25 Janssen Pharmaceutica Nv Inhibidores de receptor vainilloide de bencimidazol.
CN101687790B (zh) * 2007-05-25 2015-02-11 Abbvie公司 作为代谢型谷氨酸受体2(mglu2受体)的正向调节剂的杂环化合物
EP2234487A4 (en) * 2007-12-19 2011-09-07 Scripps Research Inst ANILIDES AND ANALOGUES AS INHIBITORS OF RHO KINASE
US20110150833A1 (en) * 2007-12-21 2011-06-23 The Scripps Research Institute Benzopyrans and analogs as rho kinase inhibitors
EP2352374B1 (en) * 2008-10-29 2014-09-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9745328B2 (en) 2013-02-04 2017-08-29 Janssen Pharmaceutica Nv Flap modulators
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP3350177B1 (en) * 2015-09-18 2021-07-07 Merck Patent GmbH Heteroaryl compounds as irak inhibitors and uses thereof
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof

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Also Published As

Publication number Publication date
BR9802804A (pt) 2000-05-02
NO983493L (no) 1999-02-01
AU7860898A (en) 1999-02-11
EP0894795A1 (fr) 1999-02-03
HU9801725D0 (en) 1998-09-28
CN1210859A (zh) 1999-03-17
ATE201868T1 (de) 2001-06-15
CN1087740C (zh) 2002-07-17
PT894795E (pt) 2001-09-28
CA2244438A1 (fr) 1999-01-30
ZA986814B (en) 1999-02-02
EP0894795B1 (fr) 2001-06-06
DK0894795T3 (da) 2001-09-03
FR2766822A1 (fr) 1999-02-05
GR3036473T3 (en) 2001-11-30
FR2766822B1 (fr) 2001-02-23
NZ331153A (en) 1999-07-29
AU734447B2 (en) 2001-06-14
NO983493D0 (no) 1998-07-29
HK1018440A1 (en) 1999-12-24
ES2159922T3 (es) 2001-10-16
DE69800882D1 (de) 2001-07-12
PL327748A1 (en) 1999-02-01
US6040327A (en) 2000-03-21
DE69800882T2 (de) 2002-03-28
JPH11100368A (ja) 1999-04-13

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