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HUP9701297A1 - Benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9701297A1
HUP9701297A1 HU9701297A HUP9701297A HUP9701297A1 HU P9701297 A1 HUP9701297 A1 HU P9701297A1 HU 9701297 A HU9701297 A HU 9701297A HU P9701297 A HUP9701297 A HU P9701297A HU P9701297 A1 HUP9701297 A1 HU P9701297A1
Authority
HU
Hungary
Prior art keywords
atom
pipe
pipe dust
dust
powder
Prior art date
Application number
HU9701297A
Other languages
English (en)
Inventor
Jacqueline Bonnet
Armel Fradin
Bernard Portevin
Guillaume De Nanteuil
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU9701297D0 publication Critical patent/HU9701297D0/hu
Publication of HUP9701297A1 publication Critical patent/HUP9701297A1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány szerinti új vegyületek (I) általánős képletében R1 jelentése halőgénatőm, hidrőxilcsőpőrt, alkőxicsőpőrt, trihalőgén-metil-csőpőrt, aminőcsőpőrt, merkaptőcsőpőrt, alkil-tiő-csőpőrt,trialkil-ammóniűm-csőpőrt, aril-őxi-csőpőrt, aril-tiő-csőpőrt, aril-szűlfőnil-csőpőrt, aril-szűlfőnil-őxi-csőpőrt, ciklőalkil-őxi-csőpőrt,ciklőalkil-tiő-csőpőrt, biciklőalkil-őxi-csőpőrt vagy biciklő-alkil-tiő-csőpőrt, Ra és Rb jelentése azőnős vagy különböző, és lehet hidrőgénatőm vagyalkilcsőpőrt, X jelentése őxigénatőm, kénatőm vagy -NR- általánős képletű csőpőrt, Y jelentése -(CH2)m-Z-(CH2)n- általánős képletű csőpőrt, ahől m értéke 0, 1 vagy 2, n értéke 0, 1 vagy 2, Z jelentése őxigénatőm, kénatőm, adőtt esetben szűbsztitűáltaminőcsőpőrt, -SO2-, -CHOH-, -CH2- vagy -CH(CH2OH)- képletű csőpőrt, R2 jelentése adőtt esetben szűbsztitűált arilcsőpőrt. A találmányszerinti vegyületek interleűkin -1 inhibitőr hatásúak. ŕ
HU9701297A 1996-07-26 1997-07-25 Benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények HUP9701297A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9609416A FR2751649B1 (fr) 1996-07-26 1996-07-26 Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
HU9701297D0 HU9701297D0 (en) 1997-09-29
HUP9701297A1 true HUP9701297A1 (hu) 1999-09-28

Family

ID=9494506

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701297A HUP9701297A1 (hu) 1996-07-26 1997-07-25 Benzimidazol-, benzoxazol- és benzotiazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Country Status (19)

Country Link
US (1) US5972968A (hu)
EP (1) EP0820990B1 (hu)
JP (1) JPH1067753A (hu)
CN (1) CN1090620C (hu)
AT (1) ATE198744T1 (hu)
AU (1) AU715751B2 (hu)
BR (1) BR9704076A (hu)
CA (1) CA2211444C (hu)
DE (1) DE69703915T2 (hu)
DK (1) DK0820990T3 (hu)
ES (1) ES2155660T3 (hu)
FR (1) FR2751649B1 (hu)
GR (1) GR3035434T3 (hu)
HU (1) HUP9701297A1 (hu)
NO (1) NO308602B1 (hu)
NZ (1) NZ328431A (hu)
PL (1) PL321336A1 (hu)
PT (1) PT820990E (hu)
ZA (1) ZA976655B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602029D0 (en) * 1996-02-01 1996-04-03 Fujisawa Pharmaceutical Co New heterocyclic compounds
FR2766822B1 (fr) * 1997-07-30 2001-02-23 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6248770B1 (en) * 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
CN1148190C (zh) 1998-10-23 2004-05-05 东丽株式会社 用于免疫调节的药物组合物
US6451832B2 (en) 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
EP1253921A4 (en) 2000-01-28 2004-10-13 Merck & Co Inc TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
MX2007005290A (es) * 2004-11-02 2007-07-09 Pfizer Derivados de sulfonilbencimidazol.
PE20070427A1 (es) 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
FR2891273B1 (fr) * 2005-09-27 2007-11-23 Aventis Pharma Sa NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
EP2379533A4 (en) * 2009-01-22 2012-07-04 Raqualia Pharma Inc N-SUBSTITUTED SATURATED HETEROCYCLIC SULFON COMPOUNDS WITH CB2 RECEPTOR AGONIST EFFECT
SG172469A1 (en) 2009-03-05 2011-08-29 Daiichi Sankyo Co Ltd Pyridine derivative
WO2011057208A2 (en) 2009-11-06 2011-05-12 Vanderbilt University Aryl and heteroaryl sulfones as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
TW201534597A (zh) 2013-06-20 2015-09-16 Ab Science 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2290430A1 (fr) * 1974-11-06 1976-06-04 Aries Robert Nouveau mode de synthese d'esters carbamiques derives du benzimidazole
LU75684A1 (hu) * 1976-08-27 1978-04-13
DE3067431D1 (en) * 1979-07-20 1984-05-17 Ciba Geigy Ag Coumarine compounds, processes for their manufacture as well as the intermediate products used perse and their utilisation for the dyeing or printing of textiles
GR78209B (hu) * 1982-04-15 1984-09-26 May & Baker Ltd
US4430502A (en) * 1982-08-13 1984-02-07 The Upjohn Company Pyridinyl substituted benzimidazoles and quinoxalines
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
JPH06759B2 (ja) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
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JPH08294229A (ja) * 1995-04-20 1996-11-05 Nec Corp 半導体集積回路装置
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Also Published As

Publication number Publication date
FR2751649A1 (fr) 1998-01-30
NO973443L (no) 1998-01-27
DE69703915T2 (de) 2001-08-02
PL321336A1 (en) 1998-02-02
CN1090620C (zh) 2002-09-11
DE69703915D1 (de) 2001-02-22
AU715751B2 (en) 2000-02-10
AU3017297A (en) 1998-02-05
EP0820990A2 (fr) 1998-01-28
CA2211444C (fr) 2002-07-09
NO973443D0 (no) 1997-07-25
CA2211444A1 (fr) 1998-01-26
CN1174192A (zh) 1998-02-25
JPH1067753A (ja) 1998-03-10
HU9701297D0 (en) 1997-09-29
EP0820990A3 (fr) 1998-07-29
BR9704076A (pt) 1999-05-11
GR3035434T3 (en) 2001-05-31
ZA976655B (en) 1998-02-10
PT820990E (pt) 2001-06-29
NZ328431A (en) 1997-12-19
ES2155660T3 (es) 2001-05-16
NO308602B1 (no) 2000-10-02
EP0820990B1 (fr) 2001-01-17
DK0820990T3 (da) 2001-05-07
US5972968A (en) 1999-10-26
FR2751649B1 (fr) 1998-08-28
ATE198744T1 (de) 2001-02-15

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