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HUP9700997A1 - Benzimidazolszármazékok és e vegyületeket tartalmazó, antihisztamin hatású gyógyászati készítmények - Google Patents

Benzimidazolszármazékok és e vegyületeket tartalmazó, antihisztamin hatású gyógyászati készítmények

Info

Publication number
HUP9700997A1
HUP9700997A1 HU9700997A HUP9700997A HUP9700997A1 HU P9700997 A1 HUP9700997 A1 HU P9700997A1 HU 9700997 A HU9700997 A HU 9700997A HU P9700997 A HUP9700997 A HU P9700997A HU P9700997 A1 HUP9700997 A1 HU P9700997A1
Authority
HU
Hungary
Prior art keywords
pipe powder
general formula
powder
ethyl
pharmaceutical compositions
Prior art date
Application number
HU9700997A
Other languages
English (en)
Inventor
Maravillas Bordell
Aurelio Orjales
Victor Rubio
Original Assignee
Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. filed Critical Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A.
Publication of HU9700997D0 publication Critical patent/HU9700997D0/hu
Publication of HUP9700997A1 publication Critical patent/HUP9700997A1/hu
Publication of HU227598B1 publication Critical patent/HU227598B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány az (I) általánős képletű, antihisztaminhatásúvegyületekre, valamint azők gyógyászati szempőntból elfőgadhatósavakkal és bázisőkkal alkőtőtt addíciós sóira, valamint kezelésieljárásra vőnatkőzik. Az (I) általánős képletben R1 jelentése hidrőgénatőm vagy rövid szénláncú szénhidrőgéncsőpőrt,így metil-, etil-, izőprőpil-, ciklőprőpil- vagy vinilcsőpőrt; és R2 jelentése CH2OH, COOH, COOR3 általánős képletű csőpőrt vagy 4,4-dimetil-2-őxazőlinil-csőpőrt, ahől R3 jelentése rövid szénláncúalkilcsőpőrt, példáűl metil- vagy etilcsőpőrt. A találmány szerintivegyületek igen erős, szelektív H1-antihisztamin hatást ésantiallergiás hatást fejtenek ki, és különleges előnyük, hőgy számősmás antihisztamin közpőnti idegrendszeri és kardiővaszkűlárisrendszeren előidézett kárős mellékhatásaitól mentesek. ŕ
HU9700997A 1996-06-04 1997-06-04 Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them HU227598B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (3)

Publication Number Publication Date
HU9700997D0 HU9700997D0 (en) 1997-07-28
HUP9700997A1 true HUP9700997A1 (hu) 1999-09-28
HU227598B1 HU227598B1 (en) 2011-09-28

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700997A HU227598B1 (en) 1996-06-04 1997-06-04 Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US5877187A (hu)
EP (1) EP0818454B1 (hu)
JP (1) JP4218991B2 (hu)
CN (1) CN1105716C (hu)
AR (1) AR008386A1 (hu)
AT (1) ATE264317T1 (hu)
AU (1) AU725700B2 (hu)
BR (1) BR9703276A (hu)
CA (1) CA2206754C (hu)
CZ (1) CZ289278B6 (hu)
DE (2) DE69728608T2 (hu)
DK (1) DK0818454T3 (hu)
ES (1) ES2124167B1 (hu)
FR (1) FR11C0023I2 (hu)
HR (1) HRP970307B1 (hu)
HU (1) HU227598B1 (hu)
IN (1) IN186319B (hu)
LU (1) LU91798I2 (hu)
MX (1) MXPA97004127A (hu)
NO (2) NO313195B1 (hu)
PL (1) PL188908B1 (hu)
PT (1) PT818454E (hu)
RU (1) RU2182150C2 (hu)
SI (1) SI0818454T1 (hu)
TR (1) TR199700464A3 (hu)
TW (1) TW438794B (hu)
ZA (1) ZA974893B (hu)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4394799A (en) 1998-07-01 2000-01-24 Takeda Chemical Industries Ltd. Retinoid-associated receptor regulators
ES2216625T3 (es) 1998-11-27 2004-10-16 ABBOTT GMBH & CO. KG Bencimidazoles substituidos y su empleo como inhibidores de parp.
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
CA2484460C (en) * 2002-04-19 2009-09-29 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-.alpha..alpha. dimethyl-benzeneacetic acid
AU2003245442B2 (en) * 2002-06-13 2009-02-05 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) * 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
RU2671577C2 (ru) * 2013-03-15 2018-11-02 Геркулес Ллк Состав и способ получения композиций для личной гигиены, обладающих улучшенными характеристиками осаждения
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
LT3327012T (lt) * 2015-07-24 2021-09-10 Urquima, S.A. Bilastino kristalinės formos ir jų gamybos būdai
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
CA3079303A1 (en) 2017-10-16 2019-04-25 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
US20210128544A1 (en) 2018-01-18 2021-05-06 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331B1 (en) 2020-11-18 2025-10-08 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE701443T1 (de) * 1992-08-03 1997-01-30 Georgetown University, Washington, D.C. Terfanadin Metaboliten und deren optische reine Isomeren zur Behandlung vonallegischen Krankheiten
EP2261208A1 (en) * 1993-06-25 2010-12-15 Aventisub II Inc. Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives

Also Published As

Publication number Publication date
CA2206754C (en) 2007-01-23
NO2011008I1 (no) 2011-06-06
PL320358A1 (en) 1997-12-08
ES2124167B1 (es) 1999-09-16
JP4218991B2 (ja) 2009-02-04
CN1176964A (zh) 1998-03-25
DE122011000006I1 (de) 2011-06-16
ZA974893B (en) 1997-12-30
LU91798I2 (fr) 2011-05-23
HRP970307B1 (en) 2002-02-28
SI0818454T1 (en) 2004-08-31
HRP970307A2 (en) 1998-04-30
TR199700464A2 (xx) 1997-12-21
CA2206754A1 (en) 1997-12-04
HU9700997D0 (en) 1997-07-28
AU725700B2 (en) 2000-10-19
NO972525D0 (no) 1997-06-03
ES2124167A1 (es) 1999-01-16
JPH1059961A (ja) 1998-03-03
DE69728608T2 (de) 2005-04-21
AU2467297A (en) 1997-12-11
FR11C0023I1 (hu) 2011-08-19
FR11C0023I2 (fr) 2012-03-16
HU227598B1 (en) 2011-09-28
CZ289278B6 (cs) 2001-12-12
NO2011008I2 (no) 2012-05-14
EP0818454A1 (en) 1998-01-14
CN1105716C (zh) 2003-04-16
NO313195B1 (no) 2002-08-26
AR008386A1 (es) 2000-01-19
TR199700464A3 (tr) 1997-12-21
CZ172397A3 (en) 1997-12-17
MXPA97004127A (es) 2005-07-25
BR9703276A (pt) 2004-08-17
PT818454E (pt) 2004-08-31
RU2182150C2 (ru) 2002-05-10
DE69728608D1 (de) 2004-05-19
TW438794B (en) 2001-06-07
ATE264317T1 (de) 2004-04-15
DK0818454T3 (da) 2004-07-12
PL188908B1 (pl) 2005-05-31
US5877187A (en) 1999-03-02
NO972525L (no) 1997-12-05
IN186319B (hu) 2001-08-04
EP0818454B1 (en) 2004-04-14

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Legal Events

Date Code Title Description
AA1S Information on application for a supplementary protection certificate

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG. NO: IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG.: EU IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

FG4S Grant of supplementary protection certificate

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG. NO: IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

Extension date: 20220604