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DE122011000006I1 - Benzimidazol-Derivate mit antihistaminischer Wirkung - Google Patents

Benzimidazol-Derivate mit antihistaminischer Wirkung

Info

Publication number
DE122011000006I1
DE122011000006I1 DE122011000006C DE122011000006C DE122011000006I1 DE 122011000006 I1 DE122011000006 I1 DE 122011000006I1 DE 122011000006 C DE122011000006 C DE 122011000006C DE 122011000006 C DE122011000006 C DE 122011000006C DE 122011000006 I1 DE122011000006 I1 DE 122011000006I1
Authority
DE
Germany
Prior art keywords
benzimidazole derivatives
antihistaminic action
antihistaminic
action
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE122011000006C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Faes Farma SA
Original Assignee
Faes Farma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma SA filed Critical Faes Farma SA
Publication of DE122011000006I1 publication Critical patent/DE122011000006I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE122011000006C 1996-06-04 1997-06-03 Benzimidazol-Derivate mit antihistaminischer Wirkung Pending DE122011000006I1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.
DE69728608T DE69728608T2 (de) 1996-06-04 1997-06-03 Benzimidazol-Derivate mit antihistaminischer Wirkung

Publications (1)

Publication Number Publication Date
DE122011000006I1 true DE122011000006I1 (de) 2011-06-16

Family

ID=8295035

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69728608T Expired - Lifetime DE69728608T2 (de) 1996-06-04 1997-06-03 Benzimidazol-Derivate mit antihistaminischer Wirkung
DE122011000006C Pending DE122011000006I1 (de) 1996-06-04 1997-06-03 Benzimidazol-Derivate mit antihistaminischer Wirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69728608T Expired - Lifetime DE69728608T2 (de) 1996-06-04 1997-06-03 Benzimidazol-Derivate mit antihistaminischer Wirkung

Country Status (27)

Country Link
US (1) US5877187A (de)
EP (1) EP0818454B1 (de)
JP (1) JP4218991B2 (de)
CN (1) CN1105716C (de)
AR (1) AR008386A1 (de)
AT (1) ATE264317T1 (de)
AU (1) AU725700B2 (de)
BR (1) BR9703276A (de)
CA (1) CA2206754C (de)
CZ (1) CZ289278B6 (de)
DE (2) DE69728608T2 (de)
DK (1) DK0818454T3 (de)
ES (1) ES2124167B1 (de)
FR (1) FR11C0023I2 (de)
HR (1) HRP970307B1 (de)
HU (1) HU227598B1 (de)
IN (1) IN186319B (de)
LU (1) LU91798I2 (de)
MX (1) MXPA97004127A (de)
NO (2) NO313195B1 (de)
PL (1) PL188908B1 (de)
PT (1) PT818454E (de)
RU (1) RU2182150C2 (de)
SI (1) SI0818454T1 (de)
TR (1) TR199700464A3 (de)
TW (1) TW438794B (de)
ZA (1) ZA974893B (de)

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AU4394799A (en) 1998-07-01 2000-01-24 Takeda Chemical Industries Ltd. Retinoid-associated receptor regulators
ES2216625T3 (es) 1998-11-27 2004-10-16 ABBOTT GMBH & CO. KG Bencimidazoles substituidos y su empleo como inhibidores de parp.
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
CA2484460C (en) * 2002-04-19 2009-09-29 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-.alpha..alpha. dimethyl-benzeneacetic acid
AU2003245442B2 (en) * 2002-06-13 2009-02-05 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) * 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
RU2671577C2 (ru) * 2013-03-15 2018-11-02 Геркулес Ллк Состав и способ получения композиций для личной гигиены, обладающих улучшенными характеристиками осаждения
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (de) 2014-12-29 2016-07-06 Faes Farma, S.A. Neue Benzimidazolderivate als Antihistaminmittel
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
LT3327012T (lt) * 2015-07-24 2021-09-10 Urquima, S.A. Bilastino kristalinės formos ir jų gamybos būdai
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (de) 2015-11-20 2017-05-24 Faes Farma, S.A. Übersättigte zusammensetzungen von benzimidazolverbindungen
EP3170817A1 (de) 2015-11-20 2017-05-24 Faes Farma, S.A. Cokristalle von benzimidazolverbindungen
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (de) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Feststoffformen von 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methyl-propansäure und verfahren zur herstellung davon
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
CA3079303A1 (en) 2017-10-16 2019-04-25 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3470062B1 (de) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmazeutische tablettenzusammensetzung mit bilastin polymorph form 3 und magnesiumaluminometasilikat
US20210128544A1 (en) 2018-01-18 2021-05-06 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (de) 2019-04-16 2020-10-21 Faes Farma, S.A. Stabile und konservierte pharmazeutische zusammensetzungen von bilastin
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331B1 (de) 2020-11-18 2025-10-08 BioPharma Synergies, S. L. Im mund dispergierbare pulverzusammensetzung mit einer antihistaminverbindung
EP4267109A1 (de) 2020-12-23 2023-11-01 Noucor Health S.A. Nichtmikronisierte bilastinzusammensetzung
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE701443T1 (de) * 1992-08-03 1997-01-30 Georgetown University, Washington, D.C. Terfanadin Metaboliten und deren optische reine Isomeren zur Behandlung vonallegischen Krankheiten
EP2261208A1 (de) * 1993-06-25 2010-12-15 Aventisub II Inc. Zwischenprodukte zur Herstellung antihistaminischer 4-Diphenylmethyl-/Diphenylmethoxy- Piperidinderivate

Also Published As

Publication number Publication date
CA2206754C (en) 2007-01-23
NO2011008I1 (no) 2011-06-06
PL320358A1 (en) 1997-12-08
ES2124167B1 (es) 1999-09-16
JP4218991B2 (ja) 2009-02-04
CN1176964A (zh) 1998-03-25
ZA974893B (en) 1997-12-30
LU91798I2 (fr) 2011-05-23
HRP970307B1 (en) 2002-02-28
SI0818454T1 (en) 2004-08-31
HRP970307A2 (en) 1998-04-30
TR199700464A2 (xx) 1997-12-21
CA2206754A1 (en) 1997-12-04
HU9700997D0 (en) 1997-07-28
AU725700B2 (en) 2000-10-19
NO972525D0 (no) 1997-06-03
ES2124167A1 (es) 1999-01-16
JPH1059961A (ja) 1998-03-03
DE69728608T2 (de) 2005-04-21
AU2467297A (en) 1997-12-11
FR11C0023I1 (de) 2011-08-19
FR11C0023I2 (fr) 2012-03-16
HU227598B1 (en) 2011-09-28
CZ289278B6 (cs) 2001-12-12
NO2011008I2 (no) 2012-05-14
EP0818454A1 (de) 1998-01-14
CN1105716C (zh) 2003-04-16
NO313195B1 (no) 2002-08-26
AR008386A1 (es) 2000-01-19
TR199700464A3 (tr) 1997-12-21
CZ172397A3 (en) 1997-12-17
MXPA97004127A (es) 2005-07-25
BR9703276A (pt) 2004-08-17
PT818454E (pt) 2004-08-31
RU2182150C2 (ru) 2002-05-10
DE69728608D1 (de) 2004-05-19
TW438794B (en) 2001-06-07
ATE264317T1 (de) 2004-04-15
DK0818454T3 (da) 2004-07-12
PL188908B1 (pl) 2005-05-31
US5877187A (en) 1999-03-02
NO972525L (no) 1997-12-05
HUP9700997A1 (hu) 1999-09-28
IN186319B (de) 2001-08-04
EP0818454B1 (de) 2004-04-14

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