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HUP0100757A1 - Foszfilopáz enzim inhibitor hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Foszfilopáz enzim inhibitor hatású indolszármazékok és ezeket a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0100757A1
HUP0100757A1 HU0100757A HUP0100757A HUP0100757A1 HU P0100757 A1 HUP0100757 A1 HU P0100757A1 HU 0100757 A HU0100757 A HU 0100757A HU P0100757 A HUP0100757 A HU P0100757A HU P0100757 A1 HUP0100757 A1 HU P0100757A1
Authority
HU
Hungary
Prior art keywords
inhibitors
pharmaceutical compositions
compositions containing
indole derivatives
phospholipase enzymes
Prior art date
Application number
HU0100757A
Other languages
English (en)
Inventor
Jean E. Bemis
Neelu Kaila
Frank Lovering
John C. Mckew
Jasbir Sheera
Yibin Xiang
Original Assignee
Genetics Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute, Inc. filed Critical Genetics Institute, Inc.
Publication of HUP0100757A1 publication Critical patent/HUP0100757A1/hu
Publication of HUP0100757A3 publication Critical patent/HUP0100757A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A jelen találmány emlősök gyulladásos állapotainak kezelésére vagymegelőzésére hasznosítható (I) és (II) általános képletű vegyületekreés a szóban forgó vegyületeket tartalmazó gyógyászati készítményekrevonatkozik. A szubsztituensek jelentése az igénypontok szerinti. Ó
HU0100757A 1998-02-25 1999-02-24 Indole derivatives as inhibitors of phospholipase enzymes and pharmaceutical compositions containing them HUP0100757A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3006298A 1998-02-25 1998-02-25
PCT/US1999/003899 WO1999043651A2 (en) 1998-02-25 1999-02-24 Inhibitors of phospholipase enzymes

Publications (2)

Publication Number Publication Date
HUP0100757A1 true HUP0100757A1 (hu) 2001-08-28
HUP0100757A3 HUP0100757A3 (en) 2001-11-28

Family

ID=21852314

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100757A HUP0100757A3 (en) 1998-02-25 1999-02-24 Indole derivatives as inhibitors of phospholipase enzymes and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP1056719A2 (hu)
JP (1) JP2002504539A (hu)
KR (1) KR20010041343A (hu)
CN (1) CN1299347A (hu)
AU (1) AU2782699A (hu)
BG (1) BG104780A (hu)
BR (1) BR9908280A (hu)
CA (1) CA2322161A1 (hu)
EA (1) EA200000868A1 (hu)
EE (1) EE200000486A (hu)
HR (1) HRP20000552A2 (hu)
HU (1) HUP0100757A3 (hu)
ID (1) ID27280A (hu)
IL (1) IL137718A0 (hu)
NO (1) NO20004220L (hu)
PL (1) PL342995A1 (hu)
SK (1) SK12742000A3 (hu)
TR (1) TR200002446T2 (hu)
WO (1) WO1999043651A2 (hu)

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US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
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Also Published As

Publication number Publication date
AU2782699A (en) 1999-09-15
NO20004220D0 (no) 2000-08-23
EE200000486A (et) 2002-02-15
BR9908280A (pt) 2000-10-31
SK12742000A3 (sk) 2001-05-10
WO1999043651A3 (en) 1999-12-16
BG104780A (en) 2001-10-31
HRP20000552A2 (en) 2001-04-30
TR200002446T2 (tr) 2000-12-21
CN1299347A (zh) 2001-06-13
IL137718A0 (en) 2001-10-31
JP2002504539A (ja) 2002-02-12
HUP0100757A3 (en) 2001-11-28
CA2322161A1 (en) 1999-09-02
ID27280A (id) 2001-03-22
KR20010041343A (ko) 2001-05-15
NO20004220L (no) 2000-10-05
EA200000868A1 (ru) 2001-04-23
PL342995A1 (en) 2001-07-16
WO1999043651A2 (en) 1999-09-02
EP1056719A2 (en) 2000-12-06

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